43 results about "Linear gradient" patented technology

The invention belongs to the technical field of 3D printing, and particularly relates to a 3D printing control method based on multi-material gradient transition, which comprises the steps of model processing, multi-material distribution, path planning, dynamic parameter control, online monitoring and feedback optimization. According to the method, through dynamic mixing of a nonlinear gradient function and multiple materials, limitation of traditional discrete material switching is broken through, continuous smooth transition of material attributes is achieved, printing parameters are dynamically adjusted, and the forming consistency of gradient materials under complex working conditions is remarkably improved; local strengthening is carried out according to the thermodynamic property difference of a multi-material interface, interface embrittlement caused by a traditional single process is avoided, the curing degree is detected in real time through a spectrum sensor, the problem that the curing degree of a traditional light curing process is uncontrollable is solved by combining partitioned UV light intensity adjustment and control, and precise gradient forming of a soft and hard alternate structure is achieved.

The invention is suitable for the technical field of filters, and particularly relates to a manufacturing method of a linear gradient filter and the linear gradient filter. The manufacturing method of the linear gradient filter comprises the following steps that a glass wafer serves as a substrate, and a lower reflecting layer is plated on the surface of the glass wafer; wherein the lower reflecting layer is formed by alternately stacking a plurality of layers of low-refractive-index materials and a plurality of layers of high-refractive-index materials; coating a resonant cavity layer on one side, far away from the glass wafer, of the lower reflecting layer through a stepped coating process; plating a reflecting layer on one side, far away from the glass wafer, of the resonant cavity layer; and plating a long-wave-pass layer on one side, far away from the glass wafer, of the upper reflecting layer and in an area larger than the central wavelength to obtain the linear gradient filter. Compared with the prior art, the linear gradient filter provided by the invention is better in spectral resolution in a long wave band, smaller in energy difference of channels, excellent in wavelength selection performance and capable of being applied to spectrum applications such as a miniaturized infrared spectrometer and the like.

The invention provides a wafer detection method and system based on multichannel C scanning, and aims to solve the problems of multichannel sensitivity difference, Z-axis height deviation, splicing artifacts and the like in a traditional system. The maximum defect point and the defect-free point of the standard sheet are selected before detection, the gain of each channel is adjusted to a unified amplitude, and the echo amplitude is recorded, so that sensitivity calibration is realized; in the detection process, a laser displacement sensor is used for collecting wafer surface height data in real time, modeling is conducted in combination with an ARIMA + Kalman filtering or Gaussian process regression algorithm, the Z-axis focusing distance is dynamically adjusted through PID feedback, and signal attenuation caused by surface warping is compensated; during image splicing, channel response is optimized by adopting three gray mapping modes of linear self-adaption, Gamma self-adaption (automatic alignment channel mean value after reference gamma setting) and manual setting, sub-pixel level offset is calculated based on a two-dimensional cross-correlation function to realize coordinate alignment, and a 5% overlapping area is set at a channel junction. Gray transition is completed through linear gradient weight weighted averaging.

The invention provides a method for identifying polymers in ceftazidime / ceftazidime for injection. The method is characterized in that the ceftazidime / ceftazidime for injection is analyzed by adopting an RP-HPLC (Reverse Phase-High Performance Liquid Chromatography) method; the chromatographic conditions of the RP-HPLC are as follows: a 10-20 mmol / L ammonium formate solution with the pH value of 3.4-3.6 is used as a mobile phase A; methanol / acetonitrile in a ratio of 1: (1-2) is taken as a mobile phase B; linear gradient elution is carried out, and the flow velocity is 1.0-2.0 ml / min; the detection wavelength is 254 nm. The method can be used for effectively detecting the polymer in the ceftazidime / the ceftazidime for injection.

The invention relates to the technical field of rock mechanics true triaxial tests, in particular to a rock cylinder sample true triaxial test analysis method which comprises the following steps: applying a point load to the cylindrical surface of a cylinder sample, performing integration by using a linear superposition principle, and calculating an analytical solution of an internal stress field in the circular surface of the rock cylinder sample; applying a symmetry plane load to the cylindrical surface of the cylinder sample, and calculating an internal stress field of the circular surface of the cylinder sample under the symmetry plane load by using an analytical solution; setting a constraint condition of a stress state similar region, calculating a relation function between symmetrical surface loads in a corresponding loading mode, and determining the relation function as a linear gradient loading mode; and performing finite element analysis on the cylindrical sample of the rock, and verifying the feasibility of the linear gradient loading mode determined by the analytical solution. According to the invention, true triaxial test analysis of the cylinder sample is realized, the internal stress state of a larger area of the sample is ensured to be similar, and the problems of boundary effect, friction effect, fluid channeling and the like of a cubic sample are avoided.

The invention belongs to the field of liquid chromatography-mass spectrometry detection, and discloses a liquid chromatography-mass spectrometry detection method for trace target objects in seawater, which comprises the following steps: firstly, configuring and precisely calibrating parameters such as flow velocity, column temperature, ion source voltage and the like for a liquid chromatography system, a chromatographic column, an automatic sampler and a tandem mass spectrometer; then, a methanol-water (containing 0.1% formic acid) system is adopted to implement linear gradient elution, polar difference component separation is considered, and analysis duration is compressed; a sample is subjected to solid-phase extraction, purification and concentration, then is automatically injected, is subjected to chromatographic separation and then enters an electrospray ion source; a mass spectrum end selects a dynamic multi-reaction monitoring (dMRM) mode, characteristic ion pairs are collected in a preset time window, and selective scanning and baseline noise suppression are achieved; and finally, utilizing retention time matching and internal standard correction to obtain a pg.L <-1 > magnitude quantitative result.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating and determining nafamostat mesylate SM2 and related impurities thereof. The method is a high performance liquid chromatography, and comprises the following steps: by taking octadecylsilane chemically bonded silica as a chromatographic column filler, a potassium hexafluorophosphate solution as a mobile phase A and acetonitrile as a mobile phase B, separating nafamostat mesylate SM2 and related impurities thereof through linear gradient elution; and detecting by using detection wavelengths of 200 nm to 240 nm and 250 nm to 280 nm to obtain a chromatogram, so that effective determination of the nafamostat mesylate SM2 and the related impurities thereof is realized. The method provided by the invention adopts common buffer salt as a mobile phase, and has the characteristics of short analysis time, strong specificity, high sensitivity and good reproducibility.

The provided method includes: determining an energy parameter and a co-volume parameter of a pure gas by a PR state equation, and determining a material parameter and a co-volume parameter of a mixed gas by a Waals one-fluid mixing rule and a combination rule; determining a Helmholtz free energy density and an equilibrium density of the pure gas by a Wertheim molecular association theory, and determining Helmholtz free energy and an equilibrium density of a (H2+N2) mixed gas with different components by a density mixing rule; determining an influence parameter of the pure gas by a gradient theory (GT), and determining an influence parameter of the mixed gas by the influence parameter of the pure gas and an interaction coefficient; simplifying a GT model; and obtaining the surface tension of the (H2+N2) / H2O system at different temperatures by combining the LGT model and the PR state equation.

The application provides a coating method for realizing a linearly graded filter and an angle adjusting device for an intermediate layer of the filter, and the coating method comprises the following operation steps: S1. correcting the uniformity of a plane; S2. establishing a database; S3. matching the product tilt angle through the angle and slope database; and S4. completing the preparation of the interval layer. The method utilizes the uniformity principle of an evaporation coating machine, changes the substrate tilt angle, changes the included angle between the normal line of the substrate and the single point-evaporation source connecting line, makes the included angles and distances of each point on the substrate present linear changes, and finally realizes the linear change of the film thickness in the substrate tilt direction.

The invention discloses a scanning type hyperspectral imaging device and method based on a linear gradient filter. The device sequentially comprises an imaging objective lens, a gradient filter assembly, a telecentric imaging lens group and a camera along the incident direction of a light path, during working, the one-dimensional linear displacement table drives the gradient filter assembly to perform linear scanning motion in the direction perpendicular to the optical axis, so that light in an imaging view field penetrates through band-pass filtering areas with different central wavelengths on the gradient filter in a time-sharing manner. The filtered monochromatic or narrow-band light is projected to a photosensitive target surface of the camera through the telecentric imaging lens group, and multiple frames of spectral images with different wavebands are continuously acquired. Collected sequence images are processed and reconstructed to form a hyperspectral three-dimensional data cube containing spatial information and spectral information. The system has the advantages of high imaging speed, high luminous flux, compact system structure, low cost and the like, and is suitable for hyperspectral data acquisition scenes with higher real-time requirements.

The invention discloses a pH value real-time regulation and stabilization method and system for online column separation, and belongs to the technical field of ion exchange chromatographic separation.The method comprises the steps that a proton disturbance signal is applied to a chromatographic column, an outflow response signal of the chromatographic column is detected, and a parameter map representing the dynamic buffer capacity characteristic of the chromatographic column is obtained; the parameter atlas and the target pH gradient are input into a physical transmission model based on convection, diffusion and adsorption coupling equations, and the physical transmission model outputs a predistortion pH gradient program used for compensating dynamic buffer capacity characteristics; according to a fluid proportion requirement which is defined by a pre-distortion pH gradient program and changes along with time; according to the method, dynamic buffer capacity characteristics can be obtained through a proton disturbance test, a pre-distortion pH gradient program is constructed, and closed-loop iterative optimization is combined, so that interference of the dynamic buffer capacity of the chromatographic column on proton transfer is effectively counteracted, a post-column effluent pH curve is accurately matched with a target linear gradient, and the problems of pH nonlinear distortion and a platform area are eliminated.

The invention relates to the technical field of preparation of natural products, in particular to a high-efficiency preparation method of active ingredients of semen cassiae seeds, anthraquinone compounds are purified by adopting linear gradient countercurrent chromatography, and two gradient mobile phases are adopted: n-hexane / ethyl acetate / methanol / water (5: 5: 5: 5, v / v) and (5: 5: 8: 2, v / v); n-hexane / ethyl acetate / methanol / water (5: 5: 5.5: 4.5, v / v) and (5: 5: 7: 3, v / v) are solvent systems for internal circulation separation; n-hexane / ethanol / water (1: 1: 0.2, v / v) is used as a solvent system of an off-line two-dimensional separation mode, and the separated substances are detected and analyzed through high performance liquid chromatography to obtain nine anthraquinone compounds.

The invention discloses a method for detecting related substances in an enconazole solution, and relates to the technical field of medicine detection. High performance liquid chromatography is adopted, octadecylsilane chemically bonded silica is used as a chromatographic column of a filler, a 0.025 mol / L monopotassium phosphate buffer solution (the pH value is adjusted to 2.6-3.0 by phosphoric acid) is used as a mobile phase A, acetonitrile is used as a mobile phase B, linear gradient elution is carried out, and the flow velocity of the mobile phase is 0.8-1.2 ml / min; the column temperature of the chromatographic column is 27-33 DEG C; the detection method can be used for effectively separating and determining the related substances of the enconazole solution, under the chromatographic conditions of the invention, each impurity peak is completely separated, the linear relationship between the concentration and the peak area within a limit range is good (r is greater than or equal to 0.999), and the recovery rate is 90.0-110.0%. The analysis method is easy and convenient to operate, good in specificity, high in accuracy, stable, reliable and suitable for determining the related substances of the enconazole solution.

The invention discloses an on-chip optical system based on linear gradient device design, which is used for generating a coherent optical pattern with a sparse lattice structure. The cross section of the on-chip device sequentially comprises a waveguide layer, a bottom cladding layer and a substrate layer from top to bottom, a plurality of input waveguides are used, a linear gradual change device is coupled with an on-chip system, input light is guided into an interference area, and an optical lattice structure with specific symmetry is generated. Through the disclosed calculation method, a specified coherent lattice structure can be obtained by calculating a corresponding light beam configuration scheme. According to the method, while the periodicity and symmetry of the crystal lattice are kept, the movement of the crystal lattice pattern on a two-dimensional plane can be realized by regulating and controlling the phase of the input light beam through the phase modulator. Compared with a traditional method, the system has the advantages of being compact in structure, high in interference efficiency, flexible and adjustable in pattern and the like, and is suitable for application of biosensing, quantum calculation, microscopic imaging and the like.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to an HPLC (High Performance Liquid Chromatography) method for separating and determining nafamostat mesylate X1 and impurities thereof. The impurities comprise an impurity NAA-SM2, an impurity NAA-SM2a, an impurity NAA-SM2f, an impurity NAA-X1d, an impurity NAA-X1b, an impurity NAA-X1e, an impurity NAA-X1f and isopropyl p-aminobenzoate. According to the method, octadecyl silane bonded silica gel is adopted as a chromatographic column filler, a potassium hexafluorophosphate solution is adopted as a mobile phase A, acetonitrile is adopted as a mobile phase B, and nafamostat mesylate X1 and impurities thereof are separated through linear gradient elution; and then calculating the content of each impurity by adopting an external standard method and / or a principal component self-contrast method multiplied by a correction factor according to a chromatogram. The method has the characteristics of good separation degree, good durability, high sensitivity and good reproducibility.

This invention belongs to the field of pharmaceutical analysis technology, specifically relating to a method for separating and detecting rifabutin and its impurities. The impurities include impurity B, impurity D, impurity E, impurity F, impurity G, impurity I, impurity J, impurity K, and impurity Z. 3b Impurity Z 3c Any one or more of the following. This method is a reversed-phase high-performance liquid chromatography (RP-HPLC) method. The chromatographic column uses octadecyl-bonded silica gel as the packing material, and a linear gradient elution is performed using mobile phases A and B. The chromatogram is obtained by detection using a detector. Mobile phase A is a mixture of phosphate buffer solution and organic solvent, and mobile phase B is a mixture of acid aqueous solution and organic solvent. This method can completely separate and detect rifabutin and its 10 impurities within 60 minutes, and features good resolution, robustness, high sensitivity, and good reproducibility.

The present application relates to a method and system for additive manufacturing of continuous gradient materials with nonlinear composition transitions, which can solve the problem that traditional functional gradient materials with linear composition changes are prone to brittle phases and insufficient performance in composition-sensitive intervals. The method includes: determining the gradient step size according to the part size, and calculating the composition change rate of each layer based on the printing layer thickness and height; preparing full-composition functional gradient materials by linear transition, and identifying the brittle phase generation interval in combination with microstructure characterization methods; designing a nonlinear composition transition method for sensitive intervals to suppress element segregation and brittle phase generation, and optimize interface bonding strength and comprehensive performance. The composition of the gradient material prepared by this application is continuously controllable in any direction, and there is no sudden interface in the composition distribution. The strength, high-temperature oxidation resistance and thermal fatigue life are significantly better than those of traditional linear gradient materials, and it is suitable for high-performance demand scenarios such as aerospace, nuclear energy heat dissipation and biological implants.

The application provides an image processing method based on a feathering mask and related components, and the technical scheme points are as follows: obtaining an inferred image sub-block and a position thereof; initializing a full-one mask for each sub-block; respectively calculating linear gradient weight maps in horizontal and vertical directions; multiplying the three to generate a target feathering mask with four-side gradient attenuation; and finally, weighting each sub-block and the corresponding mask, and then adding to a canvas according to the position to obtain a fusion image. Compared with the prior art, the application makes the corresponding pixel points of adjacent sub-blocks in the overlapping area satisfy a weight complementary relationship, reduces the condition that a traditional simple average or fixed weight fusion produces obvious joint lines at the splicing position, and thus improves the visual continuity of the fusion image.

This invention provides a wafer inspection method and system based on multi-channel C-scanning, aiming to address issues such as multi-channel sensitivity differences, Z-axis height deviation, and stitching artifacts in traditional systems. Before inspection, the maximum defect point and defect-free point on a standard wafer are selected, the gain of each channel is adjusted to a uniform amplitude, and the echo amplitude is recorded to achieve sensitivity calibration. During inspection, a laser displacement sensor is used to collect wafer surface height data in real time. Modeling is combined with ARIMA+Kalman filtering or Gaussian process regression algorithms, and the Z-axis focus distance is dynamically adjusted through PID feedback to compensate for signal attenuation caused by surface warping. For image stitching, three grayscale mapping methods are used to optimize channel response: linear adaptive, gamma adaptive (automatically aligning channel means after a reference γ is set), and manual setting. Coordinate alignment is achieved by calculating sub-pixel offsets based on a two-dimensional cross-correlation function. A 5% overlap area is set at the channel junction, and grayscale transitions are achieved through linear gradient weighted averaging.

The application relates to a coating equipment and a linear gradient filter film thickness uniformity correction method, and solves the problem that the film thickness uniformity of a linear gradient filter prepared by using an existing deposition method of electron beam evaporation cannot be corrected. A revolution correction plate is arranged below a workpiece disc, the revolution correction plate rotates with the workpiece disc around the center of a rotating disc, the workpiece disc has self-rotation motion, the film thickness distribution of Ta2O5 and SiO2 is corrected to the middle linearity by the revolution correction plate, at this time, the film thickness distribution of Ta2O5 and SiO2 after being corrected by the revolution correction plate has not reached the final target, and the difference from the final target is respectively corrected for the second time by a first fixed correction plate and a second fixed correction plate, so that the film thickness distribution of Ta2O5 and SiO2 finally reaches the final target, and the film thickness distribution of Ta2O5 and SiO2 is corrected to the film thickness distribution state required by the linear gradient filter by the combination of the revolution correction plate and the fixed correction plate.

The present disclosure is directed to methods of purifying a dulaglutide composition. For example, the methods comprise loading the dulaglutide composition in-line with a buffer B solution onto a hydrophobic interaction chromatography (HIC) column in a downflow direction, washing the HIC column with a buffer mixture of a buffer A solution and the buffer B solution in the downflow direction, and eluting dulaglutide from the HIC column. A linear gradient of a percentage of the buffer A and buffer B solutions is used for eluting dulaglutide, which is then followed by an isocratic hold based on a UV absorbance reading of an eluate. The methods further comprise maintaining the isocratic hold until a front side cut is made, and then dropping the buffer B solution for dulaglutide to elute from the HIC column.

The invention relates to a separation and quality control detection method for related substances in deoxycholic acid, which adopts a high performance liquid chromatography method, a chromatographic column takes octadecyl bonded silica gel as a filler, 0.010 mol / L dipotassium phosphate solution as a mobile phase A and acetonitrile as a mobile phase B, linear gradient elution is carried out, and the related substances are subjected to separation and quality control detection. Wherein the related substance is pyridine. The quality control detection method for related substances in deoxycholic acid provided by the invention comprises the following steps: preparing a pyridine reference substance solution with a certain concentration, determining the peak area of pyridine in a reference substance and a test solution by using a high performance liquid chromatography, and calculating the content of pyridine by using an external standard method. Therefore, the content of pyridine in deoxycholic acid can be accurately and quantitatively determined.

The invention belongs to the technical field of chemical analysis, and particularly relates to a method for separating and determining related substances in a rupatadine fumarate intermediate Z2. The related substances comprise any one or more of an impurity SM1, an impurity Z1, an impurity Z2a and an enantiomer thereof, an impurity Z2b and an enantiomer thereof, and an impurity Z2e and an enantiomer thereof. According to the self-built high performance liquid chromatography, octadecyl silane bonded silica gel is adopted as a chromatographic column filler, a phosphate solution is adopted as a mobile phase A, acetonitrile is adopted as a mobile phase B, and related substances in the rupatadine fumarate intermediate Z2 are separated through linear gradient elution; then detecting in a detector to obtain a chromatogram; and calculating the content of each impurity by adopting a correction factor-added principal component self-contrast method. The analysis method has the characteristics of short separation time, high sensitivity, strong specificity, good reproducibility, strong durability and simplicity and feasibility in operation.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for separating, detecting and determining an initial raw material SM3 and impurities thereof of ibrutinib. The impurities comprise one or more of propionyl chloride, 3-chloropropionyl chloride and benzoyl chloride. A mobile phase is a phosphate buffer solution as a mobile phase A, acetonitrile is a mobile phase B, a chromatographic column adopts octadecylsilane chemically bonded silica as a filler, and linear gradient elution of high performance liquid chromatography is carried out after pre-column derivatization. And then, according to a chromatogram, an external standard method is adopted to calculate the impurities according to a peak area. The method has the characteristics of good separation degree, good durability, high sensitivity and good reproducibility.

The invention discloses a double-gradient design method for a sound bunching emission lens and the sound bunching emission lens, and the method comprises the steps: constructing a cavity type circular ring structure unit based on a Helmholtz resonator, adjusting the geometric parameters of the cavity type circular ring structure unit, and enabling the height of the cavity type circular ring structure unit to be in linear gradient distribution from the center to the outside along the radial direction; adjusting the structure parameters of the cavity type circular ring structure units according to a design frequency band, so that the refractive index of each cavity type circular ring structure unit in the design frequency band is in linear gradient distribution along the radial direction; constructing a model structure of the sound bunching emission lens by using the dual linear gradient characteristics of the height and the refractive index; the sound field distribution and directivity of the sound bunching emission lens are verified through simulation calculation, and a physical model is manufactured for experimental testing.

This invention discloses a method and system for real-time pH control and stabilization in online column separation, belonging to the field of ion exchange chromatography separation technology. The method includes: applying a proton perturbation signal to the chromatographic column and detecting its elution response signal to obtain a parameter spectrum characterizing the dynamic buffer capacity of the chromatographic column; inputting the parameter spectrum and the target pH gradient into a physical transport model based on convection, diffusion, and adsorption coupling equations; the physical transport model outputs a pre-distorted pH gradient program to compensate for the dynamic buffer capacity characteristics; and based on the fluid ratio requirements defined by the pre-distorted pH gradient program and varying over time. This allows for the acquisition of dynamic buffer capacity characteristics through proton perturbation testing and the construction of a pre-distorted pH gradient program. Combined with closed-loop iterative optimization, this effectively counteracts the interference of the chromatographic column's dynamic buffer capacity on proton transport, ensuring that the pH curve of the post-column elution accurately matches the target linear gradient and eliminating pH nonlinear distortion and plateau problems.

The present application relates to the field of optical microscopic imaging technology, and provides a three-dimensional differential phase contrast refractive index tomographic reconstruction method, system, device and program, the method comprising: collecting multi-mode intensity data; the multi-mode intensity comprises a three-dimensional intensity image stack and a focus and defocus angle change intensity set; determining a transfer function according to the three-dimensional intensity image stack, and obtaining an initial scattering potential spectrum by using a deconvolution algorithm; based on the focus and defocus angle change intensity set, performing a loop single LED intensity constraint update on the initial scattering potential spectrum to obtain a scattering potential estimate; using the three-dimensional intensity image stack, performing a linear gradient constraint update on the scattering potential estimate, and executing the linear gradient constraint update cyclically until a convergence condition is met, performing a three-dimensional inverse Fourier transform according to the final obtained scattering potential spectrum, and outputting a three-dimensional refractive index distribution result. The present application substantially improves the accuracy and quality of three-dimensional refractive index reconstruction while keeping the advantages of non-interference and label-free imaging and the simplicity of system hardware.

The invention relates to a non-linear component transition continuous gradient material additive manufacturing method and system. The problems that a traditional component linear change functionally gradient material is prone to generating a brittle phase in a component sensitive interval and is insufficient in performance can be solved. The method comprises the steps of determining a gradient step size according to the part size, and calculating the component change rate of each layer based on the printing layer thickness and height; the full-component functionally graded material is prepared in a linear transition mode, and a brittle phase generation interval is recognized in combination with a microstructure characterization means; a component nonlinear transition mode is designed for a sensitive interval, element segregation and brittle phase generation are inhibited, and the interface bonding strength and comprehensive performance are optimized. Components of the gradient material prepared through the method are continuously controllable in any direction, component distribution is free of a mutation interface, the strength, the high-temperature oxidation resistance and the thermal fatigue life of the gradient material are remarkably better than those of a traditional linear gradient material, and the gradient material is suitable for aerospace, nuclear energy heat dissipation, biological implantation and other high-performance requirement scenes.

The application provides a multispectral coating method of a linear gradient filter and the linear gradient filter, and the method comprises the following steps: S1, placing optical glass into a cleaning agent for ultrasonic cleaning to obtain a substrate of the linear gradient filter to be coated; S2, placing the substrate into a reaction cavity of a radio frequency magnetron, closing the reaction cavity, and setting environmental parameters for multispectral coating; S3, under the environmental parameters, using a double-target radio frequency magnetron to sputter and deposit target materials on the surface of the substrate, wherein SiO2 and Si are used as the target materials of the double-target, and the power interval of the radio frequency magnetron is adjusted to switch the sputtering and deposition of the target materials of different target positions alternately; and S4, closing the radio frequency magnetron, keeping the reaction cavity airtight, naturally cooling the reaction cavity to a preset cooling temperature, opening the reaction cavity, and taking out the substrate with the coating as the linear gradient filter. The application has a simple process, good infrared spectral performance of the filter product, and is suitable for various scenes.

The present invention relates to a high performance liquid chromatography detection method for minocycline hydrochloride and its impurities. The method for determining related substances in minocycline hydrochloride comprises the following operations: according to the specifications of the high performance liquid chromatography method, a test solution, a reference solution, a system suitability solution, and a sensitivity solution are prepared, and a chromatographic column with octadecylsilane bonded silica gel as a filler is used; a mixture of ammonium acetate solution-methanol containing disodium ethylenediaminetetraacetic acid is used as mobile phase A, and acetonitrile-methanol is used as mobile phase B, and linear gradient elution is performed, and the separation degree of the minocycline peak and the RS12 peak should be not less than 1.5; if there is an impurity peak corresponding to the relative retention time in the chromatogram of the test solution, the percentage of the impurity is calculated according to the main component reference substance external standard method with a correction factor. The present invention also provides a minocycline hydrochloride. The method of the present invention has the excellent technical effect as described in the specification.