The invention relates to an incombustible mixed refrigerant suitable for the copious cooling temperature of 90-140DEG C below zero, which comprises the following five groups of substances: the first group is nitrogen, argon, methane or mixture; the second group is R14; the third group is R23, R116, R170, R1150, R41 or mixture; the fourth group is R218, R125, R32, R143a, R290, R1270, R13I1, R134, R134a, R152a, R1216 or mixture; the fifth group is R1234ze, R245cb, R227ea, R3110, R236fa, R254cb, R143, R236ea, R245fa, R329mcc, R347mcc, R338mcf, R245eb, R245ca, R338mee, R338mcc or mixture; the molar concentrations of the five groups are respectively 5-35%, 10-40%, 5-20%, 5-20% and 5-25%. The incombustible mixed refrigerant suitable for the copious cooling temperature of 90-140DEG C below zero has the advantages of low integral greenhouse effect, no ozone damage and the like, is safe in a regeneration type throttling and refrigerating system, and refrigeration in the temperature zone of 90-140DEG C below zero can be realized.