53 results about "Minocycline Hydrochloride" patented technology

The present invention provides a remedy for sarcoidosis, one of systemic granulomatous diseases, and a method for treating sarcoidosis. A remedy for sarcoidosis containing a Propionibacterium acnes-targeting antibiotic such as minocycline hydrochloride and clindamycin as an active component is prepared. Further, sarcoidosis is treated by administering this remedy for sarcoidosis to sarcoidosis patients.

A freeze dried minocycline hydrochloride powder as antibacterial injection is prepared from minocycline hydrochloride (0.05-10 wt.portions), freeze dried power supporting agent (10-100) and pH regulator. Its advantages are broad antibacterial sprectrum, high stability to light, heat, oxygen and water, and no pollution.

The invention relates to a minocycline hydrochloride microsphere, a preparation method thereof and the application thereof in medicine preparation; the invention is technically characterized in that the components comprise minocycline hydrochloride drug, biodegradable polymer material, emulsifier and chemical cross-linking reagent; the weight percentage of the components is 10 percent to 20 percent (W/W) of minocycline hydrochloride, 15 percent to 40 percent (W/W) of biodegradable polymer material; the ratio between biodegradable polymer material and chemical cross-linking reagent is 1g : 5mL to 1g : 20mL; the volume ratio between aqueous phase and fat phase is 1 : 10 to 1 : 20 (V/V). The minocycline hydrochloride microsphere and the related preparation thereof (such as jellies) prepared by the invention not only has the remarkable advantages of avoiding the toxic and side effects resulted from systemic antibiotics use, being able to reach the depth of periodontal pocket, sustained-release of the medicine at the bottom (one dose can result in continuous release for 7 days), etc., but also greatly reduces the marketing price owing to the cost reduction resulted from totally using home-made excipients, which is beneficial for reducing the patient burden.

The invention relates to a preparation method of a tissue suitable type composite material dental implant. The preparation method comprises the steps of performing micro-arc oxidation treatment on a surface part, in contact with a bone tissue, of a titanium or titanium alloy implant to generate a layer of porous composite ceramic membrane which contains calcium phosphate and has biological activity; performing surface etching treatment on a surface part, in contact with a soft tissue, of the implant in a mixed acid etching agent consisting of hydrofluoric acid and hydrochloric acid; soaking the dental implant subjected to the micro-arc oxidation and surface etching treatment into composite simulated body fluid containing minocycline hydrochloride and bone morphogenetic protein to ensure that an anti-inflammatory drug namely minocycline hydrochloride and the bone morphogenetic protein are simultaneously loaded in surface holes of the implant. The bonding strength between the ceramic membrane on the surface of the implant and a titanium or titanium alloy matrix is improved to 20-30MPa from 10-20Mpa; the bone interface maturation period is shortened to be within 3 months from 3-6 months of the current titanium dental implant; the biological properties of the composite material dental implant accord with relevant regulations of ISO (International Standardization Organization), Chinese Pharmacopoeia and United States Pharmacopoeia.

The invention discloses a nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor with high sensitivity and a preparation method of the nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor. The minocycline hydrochloride is taken as a template molecule, 20(s)-O-3beta-acetoxyl-5-androstene-17beta-acyl camptothecin is taken as a functional monomer, azodiisobutyronitrile is taken as an initiator, nano cobaltous oxide is taken as a dopant, and maleic rosin ethylene glycol acrylate synthesized from rosin as a raw material is taken as a cross-linking agent, so as to prepare the nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor with high sensitivity. The analysis method is simple and practical, and the defects that the traditional analysis method is complicated, expensive in equipment, and low in sensitivity are overcome.

The invention relates to a minocycline hydrochloride sustained release tablet and a preparation method thereof. In the technical scheme, the minocycline hydrochloride sustained release tablet is composed of a tablet core and a film coat, the tablet core is composed of minocycline hydrochloride, a sustained release material, a bonding agent, a filling agent and a lubricating agent, the film coat is composed of a film forming material, in the preparation method, the granule is manufactured by means of the high shear wet method and obtained through the drying of a boiling bed, the temperature of the material dried by a fluidized bed is controlled to be 25-35 DEG C, and the moisture content of the granule is controlled to be 2.0-4.0 percent. The invention belongs to the technical field of pharmaceutical preparation, which aims to provide an available preparation process for the minocycline hydrochloride sustained release tablet and greatly reduce the relevant materials introduced druing the preparation by controlling the key parameters in the preparation process. The preparation method of the minocycline hydrochloride sustained release tablet and the method for controlling of the relevant materials aim to develop a sustained release formulation of minocycline hydrochloride, and various specifications can be issued based on the body weight of a patient, thereby reducing the peak valley fluctuation of the blood concentration, effectively controlling the adverse drug reaction, and improving the drug bioavailability.

The invention relates to a method for preparing a standard substance for detecting antibiotics in cosmetics. The standard substance is formed by mixing aqueous solution of the antibiotics or solution of propylene glycol and cosmetic cream, wherein the cosmetic cream comprises the following components in percentage by weight: 73 to 78 percent of de-ionized water, 3 to 3.5 percent of propylene glycol and 0.2 to 0.25 percent of carbomer in phase A, 4.5 to 5 percent of stearate, 3 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of 26# white oil in phase B and 1.2 to 1.25 percent of phenoxyethanol and ethylhexylglycerin in phase C; and the concentration of the antibiotics in the standard substance reaches 0.1g/100mL. The method has the advantages that: the antibiotics and the cosmetic cream are mixed to form the standard substance for detecting the antibiotics such as minocycline hydrochloride, oxytetracycline dehydrate, tetracycline hydrochloride, chlortetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol in the cosmetic; and the standard substance is the same as a sample of the cosmetic containing the antibiotics in the actual use; thus the detection of the antibiotics in the cosmetic conforms to the state of the actual application better and is more accurate.

The invention discloses a preparation prepared from active fractions of baikal skullcap root and fortune's drynaria rhizome for treating periodontitis. The preparation comprises the following raw material components in parts by mass: 10-15 parts of baikal skullcap root active fraction water extract containing over 80 percent of baicalein and 5-10 parts of fortune's drynaria rhizome active fraction water extract containing over 30.71 percent of naringin. The raw material components are prepared into 'baikal skullcap root-fortune's drynaria rhizome tooth-strengthening capsules' for systemic administration, or novel external Chinese medicinal long-acting compound ointment, namely, 'baikal skullcap root-fortune's drynaria rhizome tooth-strengthening ointment' by adding auxiliary materials such as hydroxyethyl cellulose, concentrated glycerol and polyacrylic resin. The preparation is easy for local injector type administration on periodontal pocket. The preparation has a good treatment effect on periodontitis, and has the characteristics of small prescription dosage, remarkable curative effect and no any toxic and side effects. In particular, after the preparation is applied locally for a long time, the anti-inflammation effect is similar to that of minocycline hydrochloride ointment (periocline), but the bone-forming effect is remarkably superior to that of the periocline. The preparation is an oral Chinese patent medicine of a new dosage form with long residual action and usability similar to Western medicine.

The invention relates to a method for preparing control-release paste medium, comprising cyclodextrin, drug, macromolecule and elasticizer. The invention uses package and macromolecule mixing technique to prepare the control-release paste medium with needed rigidity and rheological property. The invention is characterized in that it uses insoluble cellulose ethyl ether and low-permeability acrylic resin mixture medium as the skeleton control-release material, and uses cyclodextrin and ealsticizer to adjust the rheological property and drug release speed of the paste, uses glycerin and drug grind method to pack the drug. Via external release degree test, the paste which contains Minocycline Hydrochloride, polycyclic acid or the like, via slurry method (at 37Deg. C, 100rpm) can reach 20-40% in 1h, 40-60% in 3h, 50-80% in 7h, and 80-90% in 12h. The inventive paste can be used to treat mouth and vaginal diseases.

The invention discloses an application of minocycline hydrochloride to preparation of a medicine for treating autoimmune uveitis and a treatment method of the autoimmune uveitis. The inventor finds that the minocycline hydrochloride can be used as an early intervention medicine by exploring the treatment effect of minocycline with different administration dosages on the autoimmune uveitis. By inhibiting microglial cell activation of retina tissue, reducing immune cell infiltration and reconstructing a steady state in gastrointestinal tract flora, generation and development of the uveitis are effectively inhibited, a new application is provided for application of the minocycline hydrochloride, and besides, a new strategy and method are provided for early prevention and intervention of the autoimmune uveitis.

The invention relates to a preparation method of high-purity tigecycline, which comprises the steps of taking minocycline hydrochloride as an initial raw material, and conducting nitration, hydrogenation, acid conversion, amidation and purification. According to the preparation method, the hydrogenation pressure is reasonable; time used for a purification technology is shorter; the use amount of a solvent is reduced by more than 30%; when the prepared high-purity tigecycline with the purity of over 99.5% is used for a complicated skin and skin texture infected patient, compared with the existing tigecycline, the incidences of nausea and vomit are decreased to 15.1% and 10.2% respectively; and when tigecycline is used for treating a complicated intra-abdominal infected patient, the incidences of the nausea and the vomit are decreased to 15.4% and 11.3% respectively.

The invention provides an anti-infection and anti-coagulation coating for a central venous catheter. The anti-infection and anti-coagulation coating comprises the following raw materials in parts by weight: 0.1-1% of polyvinylpyrrolidone, 0.2-2% of minocycline hydrochloride, 0.7-1% of a KH560 silane coupling agent, 2-3% of povidone iodine and 90-93% of medical disinfectant fluid. The preparation method of the anti-infection and anti-coagulation coating for the central venous catheter comprises the following steps: a central venous catheter antibacterial sterilization elimination procedure, povidone iodine liquid layer preparation work, anti-infection and anti-coagulation blood layer preparation work, anti-infection and anti-coagulation central venous catheter preparation and finished product obtaining. The anti-infection and anti-coagulation coating is cured to the surface of the central venous catheter at high temperature, dip-coating processing is conducted in a multiple dip-coatingmode, the smoothness of the central venous catheter can be improved, the friction coefficient of the central venous catheter is reduced, and convenience of medical use and operation is guaranteed; andthe process is simple, the used raw materials are easy to obtain, the medical effect is obvious, the antibacterial and anti-infection rate is high, medical accidents can be reduced, and the medical operation safety is guaranteed.

The invention relates to a preparation utilizing a compatibility prescription of the effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis. The preparation comprises the following components by mass: 10-15 parts of a rhizoma coptidis effective part's water extract with a berberine content of more than 80%; and a rhizoma drynariae effective part's water extract with a naringin content of more than 30.71%. The preparation can be prepared into a ''rhizoma coptidis-rhizoma drynariae tooth strengthening capsule'' for systemic administration, or can be added with hydroxyethyl cellulose, concentrated glycerol, polyacrylic resin and other auxiliary materials to make a novel topical Chinese medicinal long-acting compound ointment ''rhizoma coptidis-rhizoma drynariae tooth strengthening ointment'', and a syringe administration mode is easy for operation at local parts of a periodontal pocket. With a good therapeutical effect on periodontitis, the preparation provided by the invention has the characteristics of small prescription, significant curative effect, no toxic or side effect. Especially in local application, after long-term use, the anti-inflammatory effect is similar to that of minocycline hydrochloride ointment (Periocline), but the osteogenic effect is obviously superior to that of Periocline. Thus, the preparation is a novel oral Chinese patent medicine with long-term efficacy and usability similar to western medicines.

The invention belongs to the field of drug-containing medical apparatus and instruments, and particularly relates to a drug-containing medical catheter coating and a synthetic method and application thereof. The coating comprises drugs and a drug carrier, drugs are rifampin and minocycline hydrochloride in the mass ratio of 1:1-3, the drug carrier is a polyurethane coating reagent, and the polyurethane coating reagent comprises, by mass, 50-54% of butanone, 25-30.6% of ethyl lactate, 10-12% of tetrahydrofuran, 2.4-2.8% of N-methyl pyrrolidone, 0.8-1% of polyurethane polyvinylpyrrolidone and 3-8% of isocyanate group polyurethane prepolymer. The coating has the biggest advantages that after the coatign is applied to medical catheters, friction coefficient of the catheters is lowered by 97%, bacteriostasis rate reaches 99%, sustained drug release effect reaches one month, and the coating has functions of hydrophilic lubrication, infection resistance, blood congestion resistance, sustained drug release and the like.

The invention relates to an oral liquid for treating pyretic periodontitis. The oral liquid is made of the following raw materials in parts by weight: 4-13 parts of sodium deoxycholate, 2-9 parts of tetracycline, and 5-11 parts of metronidazole powder 3-7 parts of minocycline hydrochloride, 6-10 parts of mountain bean root, 3-14 parts of nutmeg, 1-6 parts of Bupleurum, 1-4 parts of gypsum, 4-10 parts of tangerine peel, 3-3 catechu 12 parts, appropriate amount of water; the oral liquid prepared by the present invention makes up for the inconspicuous antibacterial effect and limited effect of treating periodontitis in the existing traditional Chinese medicine composition for treating periodontitis.

The invention provides a method for in vitro dissolution of minocycline hydrochloride sustained-release tablets. The method for the vitro dissolution of the minocycline hydrochloride sustained-releasetablets includes the following steps of: (1) preparation of dissolution medium, wherein a solution 1 is HCl (hydrochloric acid) of 500 milliliters and 0.05 mol per liter, an adjusting solution is a mixed solution of trisodium phosphate dodecahydrate and anhydrous sodium acetate, and a solution 2 is the final solution of 900 milliliters mixed with 500 millititers and 0.05 mol per liter of HCl and400 milliliters of the adjusting solution; (2) preparation of a test solution; (3) preparation of a reference solution, which includes the steps of taking the minocycline hydrochloride sustained-release tablets as control substances to prepare to obtain the control solution with the final solution diluted and containing 12-17 micrograms of the minocycline hydrochloride sustained-release tablets per 1 milliliter; (4) determination, which includes the steps of taking the above control and test solution to respectively conduct absorbance measurement at a wavelength of 348 nanometres according toultraviolet spectrophotometry in two appendix IVA, Chinese pharmacopoeia 2015 edition, and calculating dissolution amount of the tablets according to the external standard method for determination.

The invention discloses a minocycline hydrochloride sustained release pellet and a preparation method thereof. The minocycline hydrochloride sustained release pellet consists of a coating layer and a drug-containing pellet body, wherein the coating layer is composed of Eudragit NE30D, talcum powder and lauryl sodium sulfate or polyethylene glycol; and the drug-containing pellet is composed of minocycline hydrochloride, a blank pellet core, a filling agent, a lubricating agent and a binding agent. The minocycline hydrochloride sustained release pellet disclosed by the invention makes use of a relatively novel sustained release preparation and a relatively novel pellet preparation; sustained release is to delay the release rate of drugs from the dosage form (the sustained release preparation) and to reduce the absorption rate of the drugs entering a body, so that a more stable therapeutic effect is achieved; by virtue of the pellet, the distribution area of the drugs on the surface of gastrointestinal tract is increased, irritation is relieved and bioavailability is enhanced, and meanwhile, influence of a gastric emptying factor is avoided and the drugs are uniformly absorbed in vivo and are low in individual difference; and with the simultaneous application of two advanced technologies, the technological superiority of the sustained release pellet is more enhanced. Compared with oral liquid, the sustained release pellet has the characteristics of being good in drug stability, convenient in packaging, transportation and storage, and the like; and the preparation method is simple and easy to implement and is applicable to industrial production.

The invention discloses a preparation method of a rhodium-carbon catalyst for synthesis of minocycline hydrochloride. The rhodium-carbon catalyst comprises a carrier and rhodium nanoparticles dispersed on the carrier, the carrier is powdered activated carbon treated with a sodium hydroxide aqueous solution under microwave conditions, and the mass percentage of rhodium in the rhodium-carbon catalyst is 5%. The rhodium-carbon catalyst is prepared by adopting one-pot method, the activity of the rhodium-carbon catalyst is improved by introducing a chelating agent, the activity of the rhodium-carbon catalyst is properly reduced by microwave heating, and the selectivity of the rhodium-carbon catalyst is improved with ensured activity of the rhodium-carbon catalyst. The prepared rhodium-carbon catalyst is applied to a dehydroxylation step in minocycline hydrochloride synthesis, is high in selectivity, can effectively reduce the generation of side reaction dehydration impurities and improve the yield of target product sancycline hydrochloride, and is of great significance on reduction of production cost of minocycline hydrochloride and the improvement of the product quality.

The invention discloses a Minocycline hydrochloride chitosan microsphere and the process for preparing the microsphere. The prepared microsphere can be used for the treatment of oral diseases such as periodontitis.

The invention relates to a xerostomia gel film and a preparation method thereof, and belongs to the technical field of medicinal materials. By the combination of traditional Chinese medicines and minocycline hydrochloride and with the compatibility of medicines such as radix scrophulariae, radix rehmanniae, dark plum, polyghace seche, Radix Ophiopogonis and the like, the good effects of cooling the blood and clearing heat, promoting the production of body fluid to quench thirst and tonifying Qi and nourishing yin can be achieved, patient's condition is effectively improved, the amount of saliva secretion is increased, and pathogenic bacteria are reduced. Thereby, loss of tooth and gum diseases are prevented, natural infection resistance of the body can be enhanced, and special pathogenic bacteria can be specifically targeted to be killed. The chitosan can help protect mouth mucosa and teeth and reduce acidity of tooth surface, help keep a good pH value, assist the natural healing mechanism of the oral cavity, relieve xerostomia symptom and affect and inhibit bad breath, tooth decay and oral diseases, form high concentration in local parts to play the antibacterial action, achieve the effects of diminishing inflammation, promoting tissue regeneration and promoting dental care and raise the clinical efficacy.

The invention provides a sewage treatment technology of a chemical engineering plant. The sewage treatment technology comprises the following steps of S1, primary adjusting of the pH (potential of hydrogen) value of the sewage; S2, primary settling of the sewage: adding polyferric sulfate and polystyrenedivinylbenzene resin microspheres to settle, transferring the clean water into a nitrogen and phosphor removal tank, and discharging the sludge; S3, nitrogen and phosphor removal of the sludge: adding a nitrogen and phosphor removal agent, wherein the nitrogen and phosphor removal agent comprises the following raw materials of polyaluminum ferric silicate, aluminum potassium dodecahydrate, ceramic powder, hydroxyethyl-beta-cyclodextrin, minocycline hydrochloride, and carrageenan selenide; stirring and aerating, adding polyaluminum ferric silicate, settling, transferring the clean water into a pH final conditioning tank, and transferring the sludge into a sludge re-processing collectingtank; S4, post-treatment of the clean water: adjusting the pH value of the clean water, discoloring, filtering and detecting, and draining after the clean water is qualified in detection, so as to complete the sewage treatment technology of the chemical engineering plant. The sewage treatment technology has the advantages that the treatment cost is low, the operation is simple, the nitrogen and phosphor removal effect is good, and the utilization rate of resources is high.