The invention discloses a
minocycline hydrochloride sustained release pellet and a preparation method thereof. The
minocycline hydrochloride sustained release pellet consists of a
coating layer and a
drug-containing pellet body, wherein the
coating layer is composed of Eudragit NE30D, talcum
powder and lauryl
sodium sulfate or
polyethylene glycol; and the
drug-containing pellet is composed of
minocycline hydrochloride, a blank pellet core, a filling agent, a lubricating agent and a binding agent. The
minocycline hydrochloride sustained release pellet disclosed by the invention makes use of a relatively novel sustained release preparation and a relatively novel pellet preparation; sustained release is to
delay the release rate of drugs from the
dosage form (the sustained release preparation) and to reduce the
absorption rate of the drugs entering a body, so that a more stable
therapeutic effect is achieved; by virtue of the pellet, the distribution area of the drugs on the surface of
gastrointestinal tract is increased,
irritation is relieved and
bioavailability is enhanced, and meanwhile, influence of a
gastric emptying factor is avoided and the drugs are uniformly absorbed
in vivo and are low in individual difference; and with the simultaneous application of two advanced technologies, the technological superiority of the sustained release pellet is more enhanced. Compared with oral liquid, the sustained release pellet has the characteristics of being good in
drug stability, convenient in packaging, transportation and storage, and the like; and the preparation method is simple and easy to implement and is applicable to industrial production.