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Drug-containing medical catheter coating and synthetic method and application thereof

A technology for medical catheter and drug coating, applied in catheter, coating and other directions, can solve the problems of limited grafting amount, incomplete catheter flushing, and short anticoagulation time, and achieves simple synthesis and application process, suitable for Large-scale production, the effect of avoiding thrombosis

Active Publication Date: 2017-03-15
苏州乐术智慧医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, because heparin with a larger molecular weight has more links in the anticoagulant effect, the effect is more complicated, and it is easy to cause bleeding tendency.
[0007] With heparin grafted on the surface of the catheter, no matter what treatment method is adopted, first, the amount of grafting is very limited, and the anticoagulant effect is poor; Significantly prolong the indwelling time; the third is that it cannot solve the problem of tube blockage caused by infusion of special and high-concentration drug deposition and incomplete flushing of the catheter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Dissolve 10 grams of polyester polyurethane in 100 mL of tetrahydrofuran, and form a film by casting method, add 0.1 grams of riboflavin and 10 grams of N-vinylpyrrolidone under the protection of nitrogen, and irradiate with ultraviolet light with a wavelength of 200nm for 24 hours. Form the homopolymer of polyurethane grafted polyvinylpyrrolidone, rinse it with pure water, and keep it sealed at low temperature for later use;

[0040] 2) Add 40 grams of poly-1,4-butylene glycol adipate diol into the vacuum reactor, dehydrate in vacuum at 100°C for 5 hours until the water content is less than 0.01%, and fill with nitrogen , then lower the temperature to 40°C, add 10 grams of toluene diisocyanate (TDI) dehydrated by molecular sieves dropwise, stir and heat to 75°C under vacuum, and react for 10 hours until the NCO content of the system reaches 1%, that is Obtain isocyanato polyurethane prepolymer;

[0041] 3) Add rifampicin 250 mg, minocycline hydrochloride 750 mg, bu...

Embodiment 2

[0043] 1) Dissolve 10 grams of polyester polyurethane in 100 mL of tetrahydrofuran, and form a film by casting method, add 0.1 grams of riboflavin and 10 grams of N-vinylpyrrolidone under the protection of nitrogen, and irradiate with ultraviolet light with a wavelength of 200nm for 18 hours. Form the homopolymer of polyurethane grafted polyvinylpyrrolidone, rinse it with pure water, and keep it sealed at low temperature for later use;

[0044] 2) Add 40 grams of poly-1,4-butylene glycol adipate diol into the vacuum reactor, vacuum dehydrate at 110°C for 3 hours until the water content is less than 0.01%, and fill with nitrogen , then lower the temperature to 45°C, add 10 grams of diphenylmethane diisocyanate (MDI) dehydrated by molecular sieves dropwise, stir and heat to 85°C under vacuum, and react for 6 hours until the NCO content of the system reaches 5%. , to obtain the isocyanate-based polyurethane prepolymer;

[0045] 3) At room temperature, add 500 mg of rifampicin, 5...

Embodiment 3

[0047] 1) Dissolve 10 grams of polyester polyurethane in 100 mL of tetrahydrofuran, and form a film by casting method, add 0.1 grams of riboflavin and 10 grams of N-vinylpyrrolidone under the protection of nitrogen, and irradiate with ultraviolet light with a wavelength of 300 nm for 12 hours. Form the homopolymer of polyurethane grafted polyvinylpyrrolidone, rinse it with pure water, and keep it sealed at low temperature for later use;

[0048] 2) Add 40 grams of poly-1,4-butylene glycol adipate diol into the vacuum reactor, vacuum dehydrate at 120°C for 1 hour until the water content is less than 0.01%, and fill with nitrogen , then lower the temperature to 50°C, add 10 grams of 1,6-hexamethylene diisocyanate (HMDI) which has been dehydrated by molecular sieves dropwise, stir and heat to 90°C under vacuum, and react for 3 hours until the NCO content of the system reaches 8%, namely obtain isocyanate-based polyurethane prepolymer;

[0049] 3) At room temperature, add 333 mg ...

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Abstract

The invention belongs to the field of drug-containing medical apparatus and instruments, and particularly relates to a drug-containing medical catheter coating and a synthetic method and application thereof. The coating comprises drugs and a drug carrier, drugs are rifampin and minocycline hydrochloride in the mass ratio of 1:1-3, the drug carrier is a polyurethane coating reagent, and the polyurethane coating reagent comprises, by mass, 50-54% of butanone, 25-30.6% of ethyl lactate, 10-12% of tetrahydrofuran, 2.4-2.8% of N-methyl pyrrolidone, 0.8-1% of polyurethane polyvinylpyrrolidone and 3-8% of isocyanate group polyurethane prepolymer. The coating has the biggest advantages that after the coatign is applied to medical catheters, friction coefficient of the catheters is lowered by 97%, bacteriostasis rate reaches 99%, sustained drug release effect reaches one month, and the coating has functions of hydrophilic lubrication, infection resistance, blood congestion resistance, sustained drug release and the like.

Description

technical field [0001] The invention belongs to the field of drug-containing medical devices, and in particular relates to a drug-containing medical catheter coating and a synthesis method and application thereof. Background technique [0002] It is becoming more and more common to treat various diseases by introducing medical devices into a patient's vasculature. For example, medical devices used to treat vascular diseases include: stents, catheters, balloon catheters, guide wires, catheters, and the like. In order to improve the biocompatibility and therapeutic effects of interventional medical devices in vivo, drugs and / or polymers can be coated on a part or all of the surfaces of these device bodies. For example, the surface of the stent can be coated with a drug-containing polymer coating. When the stent containing the drug coating is implanted in the human body, it can not only expand the blocked blood vessels, but also the drug coating on it can continuously extend t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/16
Inventor 于山凤
Owner 苏州乐术智慧医学科技有限公司
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