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Preparation method of minocycline hydrochloride chitosan microsphere and application thereof

A technology of minocycline hydrochloride and chitosan microspheres, applied in the directions of tetracycline active ingredient, bulk delivery, digestive system, etc.

Inactive Publication Date: 2006-12-27
北京华禧联合科技发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the feedback from patients, minocycline ordinary capsules are quite effective in treating periodontal diseases, but there are certain side effects, and clinicians also report that there is an urgent need for minocycline oral topical preparations to solve this problem

Method used

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  • Preparation method of minocycline hydrochloride chitosan microsphere and application thereof
  • Preparation method of minocycline hydrochloride chitosan microsphere and application thereof

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Embodiment Construction

[0015] The method for preparing the microspheres of the present invention includes the following steps:

[0016] (1) Prepare a dilute acid solution with a molar concentration of 0.01M-1M;

[0017] (2) Weigh a certain quality of chitosan, add it to the dilute acid solution, and fully dissolve it to prepare a 0.5-6% (W / V) chitosan solution;

[0018] (3) Weigh a certain amount of minocycline hydrochloride and add it to the chitosan solution to fully dissolve it;

[0019] (4) React in the oil phase to prepare microspheres: a. Take the chitosan solution containing minocycline hydrochloride as the inner water phase and add it to the oil phase. The volume ratio of the inner water phase to the outer oil phase is 1: 4-15, stir and disperse under the condition of 500-3500 rpm; b. Add preservatives, which can be methyl, ethyl and propyl p-hydroxybenzoic acid, benzalkonium bromide, benzalkonium chloride, trichloro One or more of tert-butanol, benzoic acid, sorbic acid or phenol; c. Add a non-...

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Abstract

The invention discloses a Minocycline hydrochloride chitosan microsphere and the process for preparing the microsphere. The prepared microsphere can be used for the treatment of oral diseases such as periodontitis.

Description

Technical field [0001] The invention relates to a biodegradable minocycline hydrochloride chitosan microsphere, a preparation method of the microsphere, and a preparation of the microsphere for treating oral periodontitis. Background technique [0002] Minocycline is a tetracycline derivative. In addition to the advantages of tetracycline antibacterial spectrum and inhibition of collagenase, the antibacterial effect on periodontal pathogenic microorganisms is the strongest in the tetracycline family. 98% of periodontal pathogens can be protected by 5μg / mL of minocycline inhibits, promotes the regeneration of periodontal tissues, and acts on androgen metabolism in periodontal tissues. However, when administered systemically, the concentration of the drug in GCF (Gingival Crevicular Fluid) is low, which easily induces drug-resistant strains and double infections. In the treatment of periodontal disease, topical medication is gradually replacing systemic medication, because on the ...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K9/16A61K47/36A61P1/02
Inventor 仰振球
Owner 北京华禧联合科技发展有限公司
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