149results about How to "Repair damage" patented technology

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses a solar single-crystal efficient TOPCon + SE battery piece ultrahigh sheet resistance diffusion process which mainly comprises a front boron process, an SE process and a rear oxidation process, and the front boron process comprises high-temperature oxidation before diffusion and a diffusion process composed of three-step diffusion and heating propulsion. According to the invention, a layer of SiO2 can be coated on the surface of the silicon wafer through high-temperature oxidation before diffusion and is used as an anti-reflection film layer; the PN junction is prepared by adopting a step-by-step diffusion method, so that the advantage of good junction uniformity can be realized, boron can be uniformly distributed on the surface of a silicon wafer through a specific boron diffusion method, and meanwhile, boron elements can be better deposited on the surface of the silicon wafer through variable-temperature diffusion and propulsion; by adding the SE process, the square resistance can reach 700-800 ohms, the junction depth in the grid line area is deeper, the increase of ohms becomes better, the cell center recombination is reduced due to the lower surface concentration, and the open-circuit voltage of the cell is improved; and the post-oxidation process has an annealing effect and can repair lattice damage and the like.

The invention belongs to the technical field of food biology, and particularly relates to an antioxidant peptide derived from cantharellus cibarius sporocarp, an antioxidant peptide detection reagent and application, and the amino acid sequence of the antioxidant peptide is at least one of FPYPY, YPPYF, YYPF and MPWY. The antioxidant peptide provided by the invention is derived from chanterelle, is an enzymolysis product of chanterelle protein, and is derived from edible and medicinal fungus chanterelle, so that the antioxidant peptide is small in toxic and side effects and high in safety. Meanwhile, the antioxidant peptide disclosed by the invention has good biological activity and a relatively strong antioxidant effect, can remarkably scavenge free radicals, and can be applied to repair damage caused by oxidative stress.

The invention provides a tightening and repairing gynecological gel. Preparation raw materials comprise carbomer, sodium hyaluronate, an animal umbilical cord extract, madecassoside, carnosine, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea leaf extract, a chamomile flower extract, elastic collagen, arginine, pentanediol, butanediol, glycerin, p-hydroxyacetophenone, capryloyl hydroximic acid and purified water. The gynecological gel can maintain balanced strains, so that the microenvironment of the vagina is kept normal; vaginal atrophy is improved, the tight state of the vagina is recovered, and vaginal dryness is relieved; damaged mucosa can be repaired, the natural defense function of women is enhanced, and gynecological infection is prevented. The gynecological gel has good biocompatibility, cell affinity and mechanical properties, and can supplement collagen to female private parts, repair damaged vaginal mucosa and promote wound healing; the vagina can be moisturized and moistened, the looseness and dryness of the vagina are improved, the micro-ecological balance of the vagina is adjusted, and the immunity of a female reproductive system is improved.

The invention belongs to the technical field of anti-aging products, and particularly relates to an anti-aging composition as well as a preparation method and application thereof. The anti-aging composition is prepared by mixing the following raw materials in percentage by mass: 0.5%-1% of xanthophyll, 0.1%-0.3% of pyrroloquinoline quinone, 0.01%-0.02% of sodium propyl paraben, 0.5%-1% of an emulsifier and the balance of water. The emulsifier is a non-ionic emulsifier. The anti-aging composition prepared by the invention has definite components, is free of allergic reactions such as skin redness, rash and itching through tests of multiple testees, and is milder and significantly reduced in sensitization rate compared with products in the prior art.

The invention discloses a composition containing amur corktree bark extract as well as a preparation method and application thereof, and particularly belongs to the field of daily chemical preparations. The composition containing the amur corktree bark extract comprises the following components: the amur corktree bark extract, a schisandra chinensis extract, a rheum palmatum extract and a kochia scoparia fruit extract. The kochia scoparia fruit extract is prepared by fermenting lysimachia christinae hance and pholiota adipose. The composition containing the amur corktree bark extract, provided by the invention, has excellent capability of inhibiting propionibacterium acnes and relatively good anti-inflammatory and soothing effects; the resident skin external preparation provided by the invention can effectively inhibit the growth of skin epidermis bacteria, reduce the occurrence of skin inflammations, promote the renewal and aging of skin cuticle, improve facial gloss and repair acne damaged skin, and has the remarkable effects of removing acnes, inhibiting bacteria, resisting inflammation and relieving.

The invention belongs to the technical field of cell small molecule compound reprogramming and bone tissue engineering material culture, and discloses a method for inducing fibroblasts to be reprogrammed into osteoblasts. According to the invention, small molecule compounds act on fibroblasts, each small molecule is endowed with characteristics of a set of characteristic gene expression mode, and the small molecules are divided into different modules according to the expression characteristic mode, so that the fibroblasts of the cells are converted into osteogenic differentiation, the osteogenic differentiation effect is enhanced and maintained, and the in-vivo development of the cells is simulated to a great extent; therefore, healthy osteoblasts can be prepared from the skin fibroblasts, cell stress pressure can be resisted, and the prepared cells are free of tumorigenicity, safe and healthy. The osteoblast disclosed by the invention can be applied to preparation of bone materials and medicines for treating bone defects, for example, the osteoblast and a traditional bone material are used for constructing an active bone tissue engineering material, so that the use of allogeneic bones commonly used in clinic at present is avoided, and the occurrence of adverse ethical events is reduced.

The present application relates to the technical field of nematicides for pine wood nematode disease, and specifically discloses a highly efficient compound nematicide for pine wood nematode disease and a preparation method thereof. The components of the compound nematicide include nematicides and adjuvants, the adjuvants include synergists, surfactants, solvents and rejuvenation agents, the nematicide is a mixture of emamectin benzoate and rudol, the synergist is piperonyl butoxide, the solvent includes DMF and chloride solution, and the rejuvenation agent includes amino oligosaccharide aqueous solution; in the compound nematicide, the mass fraction of rudol is 10-20%, the mass fraction of emamectin benzoate is 0.5-3.5%, and the mass fraction of the rejuvenation agent is 2-8%. The compound nematicide of the present application can also have a significant killing effect on nematodes that have developed emamectin benzoate resistance, and the selection of rejuvenation agents reduces the nematode's gnawing on pine trees, promotes the repair of internal damage to pine trees, and fully realizes the treatment of pine trees infected with pine wood nematode disease.

The invention belongs to the technical field of biological medicine, and particularly relates to peptide slow-release temperature-sensitive hydrogel as well as a composition, a preparation method and application thereof. The composition consists of a hydrogel monomer polymer and biological peptide, wherein the biological peptide is Leucokinin VIII, and the biological peptide is Leucokinin VIII The hydrogel monomer polymer is prepared by mixing and heating polyethylene glycol, lactide and stannous zincate. The preparation method of the peptide slow-release temperature-sensitive hydrogel comprises the following steps: mixing polyethylene glycol, lactide and stannous zincate, and carrying out heating and stirring reaction to prepare a hydrogel monomer polymer; and then mixing the hydrogel monomer polymer with the Leucokinin VIII, so as to obtain the peptide slow-release temperature-sensitive hydrogel. The peptide sustained-release temperature-sensitive hydrogel has the advantages of excellent temperature-sensitive characteristic, injectability, drug sustained-release performance, biocompatibility and biological safety.

The invention discloses a wind turbine blade repair wall-climbing robot and a repair method thereof, belonging to the technical field of robots. The invention comprises a wall-climbing device and a turntable-type repair device on a main body. The wall-climbing device comprises an adsorption duct fixed on the middle part of the main body and a driving mechanism fixed on the side of the main body, and a reinforcement mechanism is arranged on the main body; the turntable-type repair device comprises a mechanical arm and a repair turntable arranged on the mechanical arm, and a grinding mechanism, a liner filling mechanism, a wet laying mechanism, a vacuum glue injection mechanism and a painting mechanism are arranged in sequence on the circumferential side of the repair turntable, and an image collector is arranged on the end face of the repair turntable. At the same time, a repair method based on the above-mentioned wind turbine blade repair wall-climbing robot is disclosed. The above-mentioned wind turbine blade repair wall-climbing robot and the repair method thereof are adopted to realize the repair of deep damage, and at the same time, the energy consumption is low and the fixation is reliable.

The invention relates to the technical field of dental oral treatment, and discloses a repair method for treating periodontitis by using dental pulp stem cells, which comprises the following steps: S1, extracting dental pulp tissues from the oral cavity of a patient; s2, obtaining dental pulp stem cells; s3, culturing the dental pulp stem cells under specific conditions; s4, inducing the dental pulp stem cells to differentiate in the direction of osteogenesis, chondrogenesis or periodontal ligament cell formation; s5, transplanting the differentiated dental pulp stem cells to a periodontitis injury area of the patient, and using a biocompatible material; s6, applying a proper local stimulation means around the cell transplantation area; s7, by applying anti-inflammatory drugs locally or systemically, local immune response and inflammatory response are retarded, and repair and regeneration of periodontium are promoted. The problems that an existing treatment method is not lasting in effect, long in recovery period and the like are solved, the damaged periodontium is repaired through the dental pulp stem cells, the treatment effect can be remarkably improved, and the dental pulp stem cells have high clinical application value.

The invention discloses 3D printing biological material ink based on a drug sustained-release polycitrate material and a preparation method and a printing method of the 3D printing biological material ink, and relates to the technical field of 3D printing biologication.The 3D printing biological material ink is prepared from a medical polycitrate polymer, nano-hydroxyapatite and an active drug ingredient; the addition amount of the hydroxyapatite is 5-65% of the total mass of the obtained biological material ink; the active pharmaceutical ingredients are gastrodin, notoginsenoside, recombinant wnt3a protein and LL-37 peptide; when the active medicines are gastrodin and notoginsenoside, the addition amount of the active medicines is 4-12% of the total mass of the obtained biological material ink; when the used active drugs are recombinant wnt3a protein and LL-37 peptide, the addition amount of the active drugs is 0.001-0.002% of the total mass of the obtained biological material ink; and the particle size of the nano hydroxyapatite is 60-80 nm. According to the method, 3D printing process parameters are selected, post-treatment is adopted to adjust a cross-linked network structure of a poly-citrate polymer, biological material scaffolds with different mechanical properties and degradation properties are obtained, and stable and long-acting release of carried drugs is ensured.

The invention discloses a fermented tea drink capable of protecting gastric mucosa and a preparation method thereof, and the preparation method comprises the following steps: S1, adding tea leaves into distilled water, heating to boiling, preserving heat, and cooling to room temperature to obtain tea soup; s2, uniformly mixing radix puerariae, poria cocos and lily bulbs, then performing freeze crushing, then adding the crushed materials into deionized water, then adding cellulase and pectinase, performing enzymolysis, and after enzymolysis is completed, performing enzyme deactivation, extraction, filtration and concentration so as to obtain a plant extracting solution; s3, adding a carbon source, a plant extract, pomegranate juice and polyglycerol fatty acid ester into the tea soup, uniformly stirring and mixing, and sterilizing to obtain a fermentation substrate; and S4, inoculating the mixed bacteria into a fermentation substrate, then performing fermentation, and after fermentation is completed, performing filtration and sterilization to obtain the fermented tea drink. The fermented tea drink has good stability, flavor and taste, also has the efficacy of assisting in protecting gastric mucosa, promotes intestinal health, and has a good application prospect.

The invention provides a lithospermum erythrorhizon extract nano microcrystal particle. The lithospermum erythrorhizon extract nano microcrystal particle is prepared from 5 to 100 parts of lithospermum erythrorhizon naphthoquinone active ingredient extract, 1 to 100 parts of ionic cellulose gum, 1 to 100 parts of chitosan, 5 to 100 parts of polylactic acid and 5 to 100 parts of sodium alginate. The invention also provides a preparation method of the lithospermum erythrorhizon extract nano-microcrystal particles, a self-microemulsion containing the lithospermum erythrorhizon extract nano-microcrystals, and a preparation method and application of the self-microemulsion. According to the lithospermum erythrorhizon extract nano-microcrystal particles and the self-microemulsion system prepared from the lithospermum erythrorhizon extract nano-microcrystal particles, the stability of the lithospermum erythrorhizon extract can be improved, the problem that the lithospermum erythrorhizon extract is insoluble in water is solved, the solubility and the absorptivity of the lithospermum erythrorhizon extract are improved, and the biological activity of the lithospermum erythrorhizon extract nano-microcrystal particles is improved.

The invention relates to the technical field of food processing, in particular to a composition for improving intestinal infectious injury and a preparation method and application thereof. The composition for improving the intestinal infectious injury is prepared from the following components in parts by weight: 30 to 50 parts of lactic acid bacteria, 20 to 50 parts of lactobacillus reuteri metagen and 50 to 120 parts of dietary fiber. According to the composition disclosed by the invention, the lactobacillus plantarum, the lactobacillus delbrueckii, the lactobacillus reuteri, the lactobacillus mucilaginosus, and the prebiotics are compounded and have a synergistic effect, so that the intestinal injury can be better and faster repaired.

The present application belongs to the technical field of oral care, and particularly relates to an oral care composition and a preparation method thereof. The oral care composition comprises, by mass percentage, chitosan oligosaccharide 0.1-0.3%, sea hao polysaccharide 0.08-0.14%, forskolin 0.07-0.12%, corn sprout extract 0.05-0.09%, thickening agent 1-3%, humectant 40-50%, and the balance being water. The oral care composition of the present application can effectively inhibit the activity of glucosyltransferase, inhibit the production of dextran, interfere with the formation process of dental plaque, and reduce the adhesion sites of pathogenic bacteria in the oral cavity. In addition, the composition of the present application can promote the proliferation and repair of oral mucosa epithelial cells, and help repair oral mucosa damage. Furthermore, the use of each component in the composition of the present application can balance the oral microbial flora, while achieving the effect of inhibiting pathogenic bacteria and improving the oral environment.

This invention provides novel stem cell activators, topical skin agents containing the aforementioned stem cell activators, and skin cosmetics containing the aforementioned stem cell activators. The stem cell activator of this invention comprises at least one compound selected from compounds (including optically active agents) shown in formula (1), salts of the aforementioned compounds, and hydrates thereof as active ingredients. In the following formula, R... 1 R 2 Represents a hydrogen atom or a hydrocarbon group. R 3 Represents a hydrogen atom or an organic group. n represents an integer greater than or equal to 1. The above hydrocarbon groups may have substituents. [Chemical Formula 1]

The invention belongs to the technical field of medicines, and particularly relates to a composition for relieving and repairing testis injury caused by heat stress and application of the composition. The composition for alleviating and repairing testis injury caused by heat stress comprises the following raw materials: a lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent, the use amount of the modified chitosan nanoparticles is 10 to 15 weight percent of the ginsenoside Re. A combined formula with lycopene and ginsenoside Re as cores is innovatively designed, the two main effective components in the formula are natural plant or traditional Chinese medicine extracts, conflicts between traditional Chinese medicine properties are effectively avoided, and the lycopene and ginsenoside Re combined formula has good biological safety and is suitable for being used as a traditional Chinese medicine preparation. The composition can be used for remarkably repairing testis injury caused by heat stress and accelerating recovery after heat stress injury.

The invention discloses an intestinal organoid culture system and application thereof in a combined stem cell regeneration therapy, and the intestinal mucosal injury is repaired by utilizing the regeneration capacity of intestinal organoids cultured in vitro and crypt stem cells, so that intestinal diseases are relieved and treated. The intestinal organoids and the combined stem cells have obvious treatment and repair effects on ulcerative colitis of mice, and the combined stem cells of the small intestine organoids and the crypts have better effects on repair of intestinal inflammation damage than pure organoids. Therefore, the intestinal tracts and the combined stem cells have good effects and application prospects in preparation of medicines for treating ulcerative colitis.

The invention discloses a composite coating material for repairing the inner diameter corrosion surface of a hydraulic cylinder and a preparation method of the composite coating material, belongs to the field of metal anti-corrosion coatings, can effectively solve the problems that the inner diameter of the hydraulic cylinder is corroded, a matched sealing ring is seriously abraded and the like, and has the advantages that thermal stress is not introduced, the repairing efficiency is high and the accessibility is good. A corrosion inhibitor is stably combined on the surface of a porous polyether-ether-ketone nano-particle material by adopting a layer-by-layer self-assembly method to obtain polyether-ether-ketone nano-particles loaded with the corrosion inhibitor, and then the polyether-ether-ketone nano-particles loaded with the corrosion inhibitor are mixed with epoxy resin to obtain a uniform and stable modified epoxy resin anticorrosive coating. The obtained modified epoxy resin coating has excellent mechanical performance, corrosion resistance and machinability, can effectively inhibit the corrosion of the inner diameter of the cylinder body, maintains the dimensional precision and surface quality of the inner diameter of the cylinder body through machining, meets the service requirements of cylinder body parts, is simple and rapid in repairing process, can effectively repair damage caused by corrosion, and has a good application prospect. And the maintenance time and cost are reduced.

The invention provides a dressing. The dressing comprises trehalose, macromolecular hyaluronic acid or salt thereof, middle-molecular hyaluronic acid or salt thereof, and small-molecular hyaluronic acid or salt thereof, the molecular weight of the macromolecular hyaluronic acid or the salt thereof is 2.00-2.30 MDa, the molecular weight of the middle molecular hyaluronic acid or the salt thereof is 1.20-1.60 MDa, and the molecular weight of the small molecular hyaluronic acid or the salt thereof is 0.50-0.70 MDa. The hyaluronic acid gel contains hyaluronic acid or salts thereof with different molecular weights, a phosphate buffer pair, trehalose and sodium chloride, the hyaluronic acid or salts thereof with different molecular weights have different effects, can simultaneously meet the requirements of skin for water absorption, water replenishing and water retention, is matched with glycerol for use, has a synergistic moisturizing effect, and provides a good microenvironment for wound healing.

The invention discloses a medicine-food combination and a preparation process, wherein the medicine-food combination is prepared from the following raw materials in parts by weight: 25-35 parts of yam, 10-15 parts of tremella, 5-10 parts of longan pulp, 5-10 parts of jujube, 10-15 parts of malt, 15-20 parts of atractylodes macrocephala, 10-15 parts of mulberry, 15-20 parts of lotus seeds, 10-15 parts of hemp seeds, 3-6 parts of tangerine peel, 10-15 parts of coix seeds, 15-20 parts of short-stemmed acanthopanax fruit, 5-10 parts of kaempferia galanga, and 9-18 parts of chicory. The raw materials of the invention synergize with each other, can be dissolved in a gastric acid environment to form mucus to protect the gastric mucosa, and have the effects of repairing mucosal damage, promoting gastrointestinal peristalsis, and anti-anxiety.

The present invention discloses the application of cyanidin-3,5-O-diglucoside in the preparation of a drug for treating colitis and colonic fibrosis. The present invention has found that after treatment with cyanidin-3,5-O-diglucoside, the clinical symptoms of colitis and colonic pathological damage can be improved, the level of inflammatory factors in serum of chronic colitis induced by DSS can be reduced, the intestinal epithelial permeability can be reduced and the mucosal barrier damage can be repaired, the level of oxidative stress in the body of colitis can be improved, and the degree of colonic fibrosis can be reduced, and the normal function of the colon can be protected. Compared with the therapeutic effect of the positive drug 5-aminosalicylic acid, there is no significant difference in multiple indicators, and cyanidin-3,5-O-diglucoside has higher safety and lower side effects.

The present application relates to a kind of fat powder for reducing weaning piglet dead rate and its preparation method and application, and the composite lipid in the preparation raw material of fat powder includes 1,3-di-oleic acid-2-palmitic acid triglyceride, 24 degrees palm oil, rice bran oil, coconut oil, linseed oil, caprylic triglyceride, capric acid triglyceride, alpha-lauric acid monoglyceride and tributyrin.The present application develops the fat acid composition close to pig milk fat structure, let piglet continue lactation period in weaning period to enable approach mainly with lipid, meet the compound energy demand of fast, medium and slow, avoid falling into energy potential difference;And the specific combination of medium and short chain fatty acids, both can improve the energy efficiency of weaning piglet, also have bacteriostatic disease characteristics, can improve the immunity of piglet, reduce the diarrhea rate.This composite lipid overcomes the problem such as piglet energy deficiency and indigestion caused by single raw material oil due to unsuitable lipid structure, can significantly reduce weaning stress, reduce the diarrhea rate and dead rate.

The invention discloses a pharmaceutical composition for treating corpus luteum insufficiency type infertility as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is to provide the pharmaceutical composition for treating the LPD type infertility, which is simpler in formula, lower in cost and better in treatment effect. According to the technical scheme, the pharmaceutical composition is prepared from the following raw materials: codonopsis pilosula, astragalus membranaceus, fried rhizoma atractylodis macrocephalae, angelica sinensis, semen cuscutae, fried eucommia ulmoides, fried teasel root, honey-fried licorice root, processed radix aconiti carmichaeli and cornu cervi degelatinatum. The pharmaceutical composition provided by the invention can improve ovarian injury, ferroptosis phenomenon, embryo implantation disorder, uterine artery blood perfusion and the like caused by LPD, and is helpful for various pathological problems related to LPD.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

The invention discloses a liver-protecting chewable tablet containing yellow tea powder and a preparation method thereof, and relates to the technical field of chewable tablet preparation, comprising the following steps: S1, crushing various raw materials of the liver-protecting chewable tablet into powder by a crushing device, and then putting various raw material powders into a feed hopper at the top of a mixer according to proportion; the invention adopts a designed grinding and crushing mechanism, and various crushed raw materials are put into the feed hopper during use, and then the raw material powders fall into a screen box below, and the powders in the raw materials that meet the requirements after crushing directly fall into a mixing tank below from the sieve holes in the screen box, and some granular raw materials that are not completely crushed enter the grinding box through a conveying pipe, and are crushed and ground by a rotating grinding disc and a coarse particle grinding head in the grinding box, so that the granular raw materials meet the requirements and fall into the mixing tank from a discharge port for mixing, thereby improving the effect of preparing the chewable tablet.

The present invention discloses a self-repairing and anti-scouring device for offshore wind power pile foundation, which relates to the technical field of offshore wind power pile foundation protection. The key points of the technical solution are: comprising a pile foundation column, a track connection component, a self-repairing component and an anti-scouring component, wherein the pile foundation column is fixedly connected with the anti-scouring component at one end near the bottom, and the pile foundation column is fixedly connected with a fixed column at one end near the top, and the fixed column is fixedly connected with a connecting ring, and the connecting ring is fixedly connected with a movable track, and the tail of the movable track is connected with the anti-scouring component, and the movable track is movably connected with the self-repairing component. The device can effectively prevent the loss of sand and soil near the offshore wind power pile foundation, and can autonomously repair the corroded parts of the wind power pile foundation.

The invention belongs to the technical field of medical materials, and particularly relates to a biomimetic mineralized collagen membrane, a preparation method thereof and application of the biomimetic mineralized collagen membrane in preparation of medical materials. The invention provides a biomimetic mineralized collagen membrane. The biomimetic mineralized collagen membrane comprises collagen fibrils, the inorganic matter is distributed on the outer surface of the collagen fibril and in the collagen fibril along the long axis of the collagen fibril; the inorganic matter is hydroxyapatite; the mass percentage of inorganic matters in the biomimetic mineralized collagen membrane is 6-62%. The biomimetic mineralized collagen membrane provided by the invention can induce mesenchymal stem cells to be differentiated into fibrocartilage cells in vitro, can induce fibrocartilage tissue regeneration in vivo, and can promote tendon bone tissue healing, and the maximum mechanics can be recovered to 67% of normal. Therefore, the biomimetic mineralized collagen membrane provided by the invention is used for a biomimetic tendon bone tissue scaffold as a medical material for repairing tendon bone injury, and has great market potential.

The invention belongs to the field of food, and provides a honey crisp cake and a preparation method thereof.The honey crisp cake comprises 50%-80% of pollen, 15%-35% of honey, 2%-15% of propolis and 3%-15% of beewax. The pollen, the honey, the propolis and the beeswax are combined together according to a certain proportion, better nutrition can be provided for a human body, the honey and the pollen have the effects of moistening intestines and relaxing bowels, the gastrointestinal tract function can be more effectively improved after the honey and the pollen are combined together, antioxidant ingredients in the honey and nutritional ingredients in the pollen are combined, and the health care effect is better. The propolis can promote skin tissue regeneration, improve skin elasticity and delay skin aging, flavonoid compounds in the propolis can enhance the immunity of the organism and are combined with nutritional ingredients in the pollen, the disease resistance of the organism can be more comprehensively improved, and the propolis can reduce the brittleness and permeability of blood vessels and regulate blood fat and blood pressure; the active substances in the pollen are combined, so that the formation of arteriosclerosis and thrombus can be resisted.