27results about How to "Repair damage" patented technology

The present application belongs to the technical field of oral care, and particularly relates to an oral care composition and a preparation method thereof. The oral care composition comprises, by mass percentage, chitosan oligosaccharide 0.1-0.3%, sea hao polysaccharide 0.08-0.14%, forskolin 0.07-0.12%, corn sprout extract 0.05-0.09%, thickening agent 1-3%, humectant 40-50%, and the balance being water. The oral care composition of the present application can effectively inhibit the activity of glucosyltransferase, inhibit the production of dextran, interfere with the formation process of dental plaque, and reduce the adhesion sites of pathogenic bacteria in the oral cavity. In addition, the composition of the present application can promote the proliferation and repair of oral mucosa epithelial cells, and help repair oral mucosa damage. Furthermore, the use of each component in the composition of the present application can balance the oral microbial flora, while achieving the effect of inhibiting pathogenic bacteria and improving the oral environment.

This invention provides novel stem cell activators, topical skin agents containing the aforementioned stem cell activators, and skin cosmetics containing the aforementioned stem cell activators. The stem cell activator of this invention comprises at least one compound selected from compounds (including optically active agents) shown in formula (1), salts of the aforementioned compounds, and hydrates thereof as active ingredients. In the following formula, R... 1 R 2 Represents a hydrogen atom or a hydrocarbon group. R 3 Represents a hydrogen atom or an organic group. n represents an integer greater than or equal to 1. The above hydrocarbon groups may have substituents. [Chemical Formula 1]

The present application relates to a kind of fat powder for reducing weaning piglet dead rate and its preparation method and application, and the composite lipid in the preparation raw material of fat powder includes 1,3-di-oleic acid-2-palmitic acid triglyceride, 24 degrees palm oil, rice bran oil, coconut oil, linseed oil, caprylic triglyceride, capric acid triglyceride, alpha-lauric acid monoglyceride and tributyrin.The present application develops the fat acid composition close to pig milk fat structure, let piglet continue lactation period in weaning period to enable approach mainly with lipid, meet the compound energy demand of fast, medium and slow, avoid falling into energy potential difference;And the specific combination of medium and short chain fatty acids, both can improve the energy efficiency of weaning piglet, also have bacteriostatic disease characteristics, can improve the immunity of piglet, reduce the diarrhea rate.This composite lipid overcomes the problem such as piglet energy deficiency and indigestion caused by single raw material oil due to unsuitable lipid structure, can significantly reduce weaning stress, reduce the diarrhea rate and dead rate.

The invention discloses a pharmaceutical composition for treating corpus luteum insufficiency type infertility as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is to provide the pharmaceutical composition for treating the LPD type infertility, which is simpler in formula, lower in cost and better in treatment effect. According to the technical scheme, the pharmaceutical composition is prepared from the following raw materials: codonopsis pilosula, astragalus membranaceus, fried rhizoma atractylodis macrocephalae, angelica sinensis, semen cuscutae, fried eucommia ulmoides, fried teasel root, honey-fried licorice root, processed radix aconiti carmichaeli and cornu cervi degelatinatum. The pharmaceutical composition provided by the invention can improve ovarian injury, ferroptosis phenomenon, embryo implantation disorder, uterine artery blood perfusion and the like caused by LPD, and is helpful for various pathological problems related to LPD.

The application belongs to the technical field of medicine, and particularly relates to a composition for alleviating and repairing testicular damage caused by heat stress and application thereof. The composition for alleviating and repairing testicular damage caused by heat stress comprises the following raw materials: lycopene inclusion compound, ginsenoside Re, modified chitosan nanoparticles and a solvent. The amount of the modified chitosan nanoparticles is 10-15 wt% of the ginsenoside Re. The application innovatively designs a combination formula with lycopene and ginsenoside Re as the core. Both of the two main effective components in the formula are natural plant or traditional Chinese medicine extract, which effectively avoids the conflict between the medicinal properties of traditional Chinese medicines and has good biological safety. The composition can significantly repair the testicular damage caused by heat stress and accelerate the recovery after heat stress damage.

This invention discloses the application of milk fat globule membranes in improving the tolerance of *Lactobacillus casei*, regulating the surface components of *Lactobacillus casei*, or preparing protective agents for *Lactobacillus casei*. Milk fat globule membranes can regulate protein expression in *Lactobacillus casei* to enhance its performance. Its characteristics include: promoting the synthesis of terpenoids, improving the antioxidant and antibacterial capabilities of *Lactobacillus casei* CGMCC NO.15956 and influencing changes in its surface properties; promoting the synthesis of cell wall teichoic acid and lipoteichoic acid, which helps maintain cell wall integrity, improves environmental tolerance, and affects the surface properties of lactic acid bacteria; and reducing the surface hydrophobicity of *Lactobacillus casei* CGMCC NO.15956. Based on these characteristics, milk fat globule membranes can protect *Lactobacillus casei* under oxidative stress, improve its survival rate, and reduce cell membrane damage. Therefore, this milk fat globule membrane can be used for encapsulation and protection of lactic acid bacteria.

The invention relates to the technical field of photovoltaic devices, in particular to a composite electrode, a flexible perovskite photovoltaic device thereof and a packaging method. According to the technical scheme, the composite electrode is of a multi-layer structure and sequentially comprises a stress buffering and interface bonding layer, a conductive grid layer and a self-repairing functional layer from bottom to top. A buffer interface with modulus gradient transition is constructed, a three-dimensional composite conductive network is formed by reducing graphene through a silver nanowire / carbon nanotube / chemical vapor deposition method, a self-repairing functional layer integrating a dynamic disulfide bond and microcapsule dual mechanism is combined with an atomic layer deposition inorganic layer and an organic buffer layer for composite packaging, and the three-dimensional composite conductive network and the self-repairing functional layer are formed. The key problems of mechanical mismatch between an electrode and a substrate in a flexible perovskite photovoltaic device, easy damage of a conductive network under bending and stability reduction caused by water and oxygen invasion are systematically solved, so that high photoelectric efficiency is ensured, and repeated bending resistance, damage self-repairing capability and long-term environmental stability of the device are remarkably improved.

The invention discloses a preparation method and application of ganoderma lucidum outer vesicles without sporocarp waste sources. The ganoderma lucidum external vesicles are used for preparing medicines for treating ischemic cerebral apoplexy sequelae, and can improve core symptoms such as dyskinesia (including limb paralysis, imbalance and gait abnormity), cognitive decline and the like after apoplexy. The spore-free sporocarp waste sourced ganoderma lucidum outer vesicles are prepared from spore-free sporocarp waste which is completely released by spores after a ganoderma lucidum powder spraying period through raw material pretreatment, differential centrifugation, tangential flow concentration and filter membrane filtration. According to the preparation method, the waste is used as a raw material to prepare the high-value medical outer vesicle, green circulation of agricultural waste-high-added-value medical raw materials is achieved, the ganoderma lucidum outer vesicle can effectively penetrate through the blood-brain barrier, brain-targeted delivery is achieved, and the problems that traditional ganoderma lucidum active ingredients are low in blood-brain barrier penetration rate and poor in blood-brain barrier penetration rate are solved. The effective treatment concentration in the brain tissue is difficult to achieve, and the traditional drug delivery bottleneck is broken through.

This invention discloses the application of N-acetyl-L-tryptophan, including the following applications: a. application in the preparation of drugs or health products that improve ovarian reserve function; b. application in the preparation of drugs or health products that improve or treat oocyte maturation disorders. This invention also discloses a drug comprising: N-acetyl-L-tryptophan or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier, or an excipient; said drug can improve or treat oocyte maturation disorders and improve ovarian reserve function. This invention also discloses a health product comprising: N-acetyl-L-tryptophan or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier, or an excipient; said health product can improve or treat oocyte maturation disorders and improve ovarian reserve function. This invention is the first to discover that N-acetyl-L-tryptophan has the efficacy of improving or treating oocyte maturation disorders and improving ovarian reserve function.

The invention discloses a soothing and repairing skin care composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The skin care composition is prepared from the following components in parts by mass: 3 to 7 parts of herba centellae extract, 0.5 to 1 part of radix scutellariae extract, 2 to 4 parts of rhizoma polygoni cuspidati extract, 1 to 3 parts of radix gentianae extract and 15 to 20 parts of rhizoma atractylodis macrocephalae extract. Wherein the rhizoma atractylodis macrocephalae root extract is prepared by adopting a compound fermentation process of rhodotorula glutinis, lactobacillus brewer and lactobacillus paracasei, and active ingredients are richer. Through the synergistic effect of multiple components, the composition can significantly inhibit secretion of inflammatory factors IL-6 and activity of hyaluronidase and promote HaCaT cell migration, has excellent soothing, anti-inflammatory and repairing effects, and can effectively improve the problems of skin sensitivity, dryness and barrier injury.

The invention belongs to the technical field of biomedicine, and particularly relates to a preparation method and application of baicalein supramolecular nanobelts.The baicalein supramolecular nanobelt for relieving intestinal injury of crisp tilapia mossambica is prepared according to the following steps that baicalein and dimethyl sulfoxide are mixed, then water is added for stirring, then centrifugal cleaning and dialysis are conducted with purified water, and the baicalein supramolecular nanobeltssambica is obtained; and freezing and drying to obtain the baicalein supermolecule nanobelt. The water solubility and bioavailability of the baicalein supramolecular nanobelt are remarkably improved, the crisp meat quality of tilapia can be kept, and intestinal inflammation can be relieved.

This invention discloses a polyacid-based mild acne-removing composition, its preparation method, and its application, belonging to the field of acne treatment preparation technology. By mass percentage, the polyacid-based mild acne-removing composition comprises 1%–10% bee venom peptide, 0.25%–5% microcapsules containing polydeoxyribonucleotides, 0.2%–1.5% soothing active ingredients, 0.5%–3% biosaccharide gum-1, 0.2%–2% biosaccharide gum-2, 0.05%–0.5% astragalus gum, 0.1%–1% pH buffering compound, 2%–10% acid mixture, and 3%–20% alcohol mixture, with the balance being water. This acne-removing composition achieved a low-irritation user experience with a high-concentration polyacid formula in subjects with sensitive, mild to moderate facial acne, effectively improving the problems of poor tolerance and limited applicability of traditional acid-based acne products for sensitive skin, significantly broadening the applicable skin types and application scenarios for high-efficacy acid-based acne products, and balancing effective acne removal with safety suitable for sensitive skin.

The invention provides a polishing method for reducing the surface roughness of diamond, and the polishing method comprises the following steps: polishing a diamond material by adopting a reactive ion etching method, the radio frequency power of the reactive ion etching method is 10-1000 W, the etching time is 1-50 min, and the adopted gas comprises one or a combination of more of Ar, O2, Cl2, BCl3, SF6, CF4 and CHF3. According to the polishing method provided by the invention, the surface smoothness of the diamond can rapidly reach the sub-nanometer level, the defects such as subsurface damage and machining stress of the diamond can be eliminated, and the surface quality of the diamond is improved.

The invention relates to the technical field of nutritious sports food, and discloses cashew nut and sea cucumber peptide exercise recovery powder and a method, the cashew nut and sea cucumber peptide exercise recovery powder comprises the following components by mass: 40%-55% of a composite peptide composition, 25%-35% of a rapid energy supply matrix, 5%-10% of an anti-inflammatory active component, and 10%-15% of a synergistic auxiliary agent, the composite peptide composition is formed by compounding a cashew nut extract and sea cucumber peptide according to a mass ratio of (4-6): (3-5), the molecular weight distribution of the cashew nut extract is 200-800Da, the purity of the cashew nut extract is greater than or equal to 92%, the molecular weight distribution of the sea cucumber peptide is 300-1000Da, the purity of the sea cucumber peptide is greater than or equal to 90%, the rapid energy supply matrix is formed by compounding maltodextrin and fructo-oligosaccharide according to a mass ratio of (3-4): 1, and the anti-inflammatory active component comprises curcumin microcapsules and resveratrol. Through the specific compounding design of the cashew nut extract and the sea cucumber peptide, in combination with precise molecular weight control, advantage complementation of amino acid composition is achieved, and the gastrointestinal tract absorption efficiency of nutritional ingredients is remarkably improved in cooperation with a targeted slow release technology of curcumin microcapsules.

The invention belongs to the technical field of biomedical materials, and particularly relates to a full-implantable muscle defect electrical stimulation biological piezoelectric system and a preparation method and application thereof, and the electrical stimulation biological piezoelectric system comprises a piezoelectric nano generator and conductive hydrogel; the piezoelectric nano generator comprises a chitosan-polyvinyl alcohol composite biological piezoelectric film; the conductive hydrogel is obtained by performing ultraviolet radiation on an aqueous solution containing methacrylated silk fibroin, carbon nanotubes soaked in a dopamine solution and a photoinitiator. The device has the characteristics of biological compatibility and good accelerated self-healing, and is expected to promote the development of a symbiotic electrical stimulation treatment device without a battery and a circuit.

This invention belongs to the field of feed additive technology, specifically relating to a microalgae compound feed additive for alleviating weaning stress in calves and its preparation method. The microalgae compound feed additive comprises the following raw materials in parts by weight: 5-10 parts microalgae powder, 2-6 parts unsaturated fatty acid / modified montmorillonite complex, 0.7-1.2 parts probiotics, and 0.3-0.5 parts walnut shell extract. This microalgae compound feed additive can improve the fragile intestinal barrier function and immunity of weaned calves, enhance their growth performance, and thus improve breeding efficiency.

The utility model is suitable for the technical field of fireproof door hot pressing, and provides a fireproof door hot pressing device which comprises supporting frames, a conveying belt arranged between the supporting frames and a fixing frame arranged on the supporting frames. A group of hydraulic cylinders are symmetrically arranged on the fixing frame; the tail ends of piston rods of the two hydraulic cylinders are connected with the same hot pressing plate, a set of lead screw sliding tables are symmetrically arranged on the top side of the fixing frame, and the movable ends of the two lead screw sliding tables are connected with the same assembly frame. The same pressing roller is rotationally matched between the assembly frames; according to the device, real-time monitoring and uniform control of the temperature in the hot-pressing process are realized through the sectional structure and the infrared temperature measurement channels between the adjacent sections, and the accuracy and the stability of hot-pressing operation are ensured, so that the product quality is ensured; and meanwhile, due to the synergistic effect of the pressing roller and the hot pressing plate, the problem of uneven pressing of a single hot pressing plate is avoided, and the hot pressing stability and the product quality are further improved.

The invention belongs to the technical field of medicine, and particularly relates to application of strictosamide in preparation of a medicine for treating periodontitis, strictosamide is extracted and separated from a nauclea officinalis medicinal material, a periodontitis animal model is constructed, strictosamide is adopted to conduct intervention treatment on the model, and the periodontitis treatment effect is improved. Periodontium is taken to be subjected to TRAP staining, Micro-CT detection and HE staining detection respectively, and it is proved that the strictosamide can specifically regulate and control activation of osteoclasts, pathological alveolar bone resorption caused by periodontitis is effectively inhibited, alveolar bone loss is reduced, meanwhile, damage to the periodontium can be remarkably relieved, bone repair is promoted, and the treatment effect is good. And the disease progress of periodontitis is fundamentally blocked. The experimental result has clinical significance, and a new scheme is provided for clinical treatment of periodontitis.

The invention discloses a preparation method for synthesizing a high-temperature-resistant viscous material. The high-temperature-resistant viscous material is mainly composed of a poly (oxazolidinone) derivative (POL), an AB type hydrophilic-hydrophobic block copolymer, a nano reinforcement, microcapsules and the like. The preparation method comprises the following steps: ultrasonically dispersing the POL, the copolymer and the nano reinforcement in NMP, adding the microcapsule to prepare a pre-glue solution, carrying out argon plasma treatment on a base material, then coating, and carrying out stepped curing to trigger cyclization. The material has excellent high-temperature tolerance and self-repairing capability, is suitable for bonding metal or ceramic structures in extreme environments such as aerospace, nuclear power and the like, and can realize long-term stable bonding and self-repairing in a range of 200-400 DEG C.

The invention relates to the technical field of MOS (Metal Oxide Semiconductor) semiconductors, and discloses a voltage-withstanding MOSFET (Metal Oxide Semiconductor Field Effect Transistor) device for high-load shutdown of a robot dog and a preparation method thereof, the voltage-withstanding MOSFET device comprises a plurality of parallel MOS cells, and each MOS cell comprises a drain electrode, a semiconductor epitaxial layer, a source electrode and a grid electrode; the semiconductor epitaxial layer comprises an N substrate layer, an N drift layer, a P + layer, an N well layer and a P well layer, and a lightly doped N layer is arranged in the middle of the N drift layer of each MOS cell; laterally symmetrical L-type P-layers with inclined tops and arc-shaped opposite side tops are introduced to the two sides of an N drift layer, and in cooperation with the middle buffering effect of a lightly doped N layer, local electric field concentration at the edge of the N drift layer in a traditional device can be accurately dispersed; the arc-shaped and L-shaped contours defined by the photoetching process can effectively guide the electric field to be uniformly distributed, so that the breakdown risk caused by too strong local electric field is avoided.

A method for removing a low-dielectric-constant material layer includes: providing a wafer to be cleaned, the surface of which has a low-dielectric-constant material layer; dry etching the wafer using oxygen plasma to reduce the methyl content in the low-dielectric-constant material layer; performing a first isotropic etching on the wafer for a first duration using an etching solution of a first concentration; and performing a second isotropic etching on the wafer for a second duration using the etching solution of a second concentration; wherein the second concentration is less than the first concentration, and the second duration is less than the first duration. This method can quickly and effectively remove the low-dielectric-constant material layer from the wafer surface and significantly reduce the number of particles on the cleaned wafer surface, making the wafer suitable for reuse, thereby improving efficiency and reducing costs.

The application provides a drug-loaded nanoparticle Cor@PDA-PEG@CD11b and a preparation method and application thereof, the preparation method comprises the following steps: S1, mixing cordycepin solution and PDA aqueous solution, so that the cordycepin and the PDA form a complex Cor@PDA through π-π stacking effect; S2, the obtained complex Cor@PDA is modified by PEG to prepare a complex Cor@PDA@PEG; S3, the obtained Cor@PDA@PEG is dispersed in a buffer solution, and an anti-CD11b antibody is added; after reacting for 24h, centrifugation, washing, collecting the precipitate, and drying, the Cor@PDA-PEG@CD11b is obtained. The drug-loaded nanoparticle Cor@PDA-PEG@CD11b prepared by the application provides a new idea and direction for the treatment of sepsis-related lung injury; through the characteristics of the PDA nanoparticles, the cordycepin is released in a controlled manner, and the problem that the cordycepin is rapidly oxidized and inactivated after entering the body is avoided, the bioavailability is improved, the specific antibodies on the surface of immune cells and the physiological characteristics are utilized, the immune cells are quickly and chemotactically recruited to the inflammatory injury site in the early stage of acute inflammation, the drug is quickly and accurately targeted, and the sepsis lung injury is reduced.

This invention, entitled "Application of 6-Methylcoumarin in the Preparation of Products for Treating Intestinal Diseases and Improving the Intestinal Barrier," belongs to the fields of biomedical technology and food. The technical problem to be solved is the poor safety, side effects, and drug resistance of existing IBD clinical drugs. The key technical solutions are the application of 6-methylcoumarin in the preparation of products that improve intestinal barrier function, its application as a treatment for intestinal barrier repair drugs, and its application as a treatment for intestinal barrier-related intestinal diseases.

The present disclosure relates to a hair-protecting, damaged hair-repairing, or hair-strengthening composition, more specifically, the composition can include: (i) a peptide including one or more sequence units consisting of Xaa-Yaa-Zaa (each of the Xaa, Yaa, and Zaa is independently selected from the group consisting of C (cysteine), K (lysine), W (tryptophan), V (valine), L (leucine), and F (phenylalanine), the Xaa, Yaa, and Zaa are not the same as each other, wherein, when the Xaa and Yaa are C and K, respectively, the Zaa is not L); (ii) a peptide derivative having a fatty acid or an organic acid bound to an N-terminus of the peptide, or (iii) at least 3 kinds of amino acids selected from the group consisting of C, K, W, V, L, and F.

The application discloses a kind of image processing technical field's based on cube projection format's double generator panorama image repair method, to solve the problem of image repair in prior art will have artifact, distortion and over-smoothing etc., it includes obtaining panorama image to be repaired, and its format is converted into cube map projection format;The front, rear, left and right four faces of panorama image to be repaired are spliced, and the rectangular image to be repaired is obtained;The rectangular image to be repaired is repaired using four-face generator, and the reconstructed rectangular image is obtained;The reconstructed rectangular image is spliced with upper and lower two faces according to channel, and the multi-channel image to be repaired is obtained;The image to be repaired is repaired using six-face generator, and the reconstructed panorama image is obtained;The format of reconstructed panorama image is converted into equirectangular projection format, which is the panorama image after repair.The application can ensure that the content of repair area is reasonable, and reduce the phenomenon of artifact, distortion and over-smoothing in repair area.

The embodiment of the invention provides a back contact battery and a preparation method thereof, and a photovoltaic module, and belongs to the field of solar cells, the battery comprises a silicon substrate (1), the back surface is provided with a first region (A), a second region (B) and a spacer region (C), the adjacent first region (A) and second region (B) are separated by the spacer region (C), at least part of the surface of the first region (A) is a textured surface and comprises a plurality of pyramid structures (2), the pyramid structure (2) comprises a transition face (21) and a plurality of side faces (22), and the tops of the side faces (22) are connected through the transition face (21). An emitter (3) having a first conductivity type, provided on the back surface of the silicon substrate (1) and located in the first region (A); the carrier collection layer has a second conductivity type opposite to the first conductivity type, is arranged on the back surface of the silicon substrate (1) and is positioned in the second region (B); and a first electrode (13) in ohmic contact with the emitter (3) at the textured surface. The back contact battery has excellent electrical properties.

This invention discloses a self-healing rubber magnet and its preparation method. The preparation method includes: S1, weighing the following components in parts by weight: 100 parts rubber matrix; 150-400 parts magnetic powder; 10-45 parts self-healing agent; 2-5 parts vulcanizing agent; 1-2 parts vulcanization auxiliaries; 1-6 parts coupling agent; 0.5-2 parts antioxidant; mixing and drying the magnetic powder and coupling agent to obtain surface-modified magnetic powder; S2, plasticizing the rubber matrix, then adding the self-healing agent and antioxidant and mixing to obtain a rubber mixture, wherein the self-healing agent is selected from polysulfide rubber containing dynamic disulfide bonds, a composite of natural rubber grafts containing carboxyl groups and ZnO, or polyether thiourea glycol; S3, adding the modified magnetic powder to the rubber mixture and mixing, then adding the vulcanizing agent and vulcanization auxiliaries and continuing to mix to obtain a compound; S4, vulcanizing and molding the compound. This rubber magnet maintains high magnetic properties while possessing a highly efficient self-healing function.