1390results about How to "Repair damage" patented technology

The invention relates to self-healing polyurethane resin containing disulfide bond and a preparation method thereof. The polyurethane resin comprises, by weight parts, 10-30 parts of polyether or polyester polyol, 3-20 parts of polyisocyanates, 1-10 parts of chain extender containing the disulfide bond, 0.001-1 part of organic tin or tertiary amine catalyst and 50-80 parts of organic solvent. The method for preparing the self-healing polyurethane resin containing the disulfide bond comprises the steps of weighing raw materials, stirring, heating and performing dehydration for the polyether or polyester polyol under vacuum conditions, lowering the temperature to 85 DEG C or below, adding the polyisocyanates and the organic tin or tertiary amine catalyst, reacting, lowering the temperature to 50 DEG C or below, adding the organic solvent and the chain extender containing the disulfide bond, reacting and performing vacuum defoamation to obtain the self-healing polyurethane resin. The self-healing polyurethane resin heals by itself under the heating or ultraviolet (UV) light conditions, the required conditions are mild, the healing speed is high, the effect is good, the preparation method is simple and easy to control, and raw materials are goods of commercialized production and are cheap and easy to obtain.

An object is to provide a method for manufacturing an SOI substrate provided with a single crystal semiconductor layer which can be used practically even when a substrate having a low heat resistant temperature, such as a glass substrate or the like, is used. Another object is to manufacture a highly reliable semiconductor device using such an SOI substrate. An SOI substrate having a single crystal semiconductor layer which is transferred from a single crystal semiconductor substrate to a supporting substrate, and an entire region of which is melted by laser light irradiation to cause re-single-crystallization is used. Accordingly, the single crystal semiconductor layer has reduced crystal defects, high crystallinity and high planarity.

Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.

The invention provides an officinal health-care solid electronic aerosolization liquid, mainly comprising the following components by weight percent: 35-45% of propylene glycol, 30-35% of medicament, 10-15.0% of deionized water, 3-3.5% of tobacco leaf extract solution, 3-3.5% of tobacco flavour, 2-3.0% of excipient, 0.2-1.0% of calcium pectate and 0.3-0.8% of curing agent. The invention also provides a preparation method of the officinal health-care solid electronic aerosolizatioon liquid. The invention contains multiple officinal components having treating function on lungs, thus having treating function on symptoms such as dryness and itch of the throat and irritable cough which are caused by smoking, chronic pharyngitis and dryness of mouth and nose, thirst and dry cough, less sputum or distressed cough caused by the fact that sputum is glued; meanwhile the invention is solid, thus the stability of storing and use is improved, production and transportation are more convenient and flexible, and fragrance can be remained to be more complete.

A dual-layer bag catheter is composed of two ball layers and three cavities. Its internal bag layer is used for expanding blood vessel. Its external bag layer made of unique millipore film is used for delivering the therapeutic genes or medicine to the wall of blood vessel or target organ.

A composition of porous material and gel for preparing artificial bone is prepared from collagen and porous material chosen from alpha-tricalcium phosphate/hydroxy apatite, beta-tricalcium phosphate/hydroxy apatite-coral, calcium phosphate/hydroxy apatite, calcium carbonatel tricalcium phosphate, etc.

A method to form a monolithic 3D device including: processing a first layer including first mono-crystal transistors; transferring a second mono-crystal layer on top of the first layer including first mono-crystal transistors by using ion-cut layer transfer; and repairing the damage caused by the ion-cut by using optical annealing.

An auxiliary push bumper for a motor vehicle which is clamped to the original bumper by brackets attached to bumper guards on such push bumper. The push bumper is made of a plurality of bumper sections made of extruded aluminum whose ends are releaseably attached to the bumper guards for easy repair of the push bumper by replacement of a damaged bumper section. In one embodiment the push bumper includes a center section formed of an extruded aluminum u-shaped channel with an diagonal stiffening plate inserted into such channel. The center section is fastened at its opposite ends to a pair of bumper guards which may each be formed of a metal loop and a metal reinforcing plate attached to such loop and to the ends of the center section. A pair of curved side sections of the bumper are fastened at their inner end to the bumper guard plates and fastened at their outer end to the frame of the vehicle. A pair of side lights may be mounted on the bumper guards to transmit light beams from the sides of the vehicle. A second pair of front lights may be mounted on the center section of the bumper to project light beams from the front of the vehicle.

In a method for manufacturing a high-quality GaN-based semiconductor layer on a substrate of different material, an AlN nucleation layer is grown on a substrate, a GaN buffer layer is grown on the AlN nucleation layer, and the substrate annealed. The AlN nucleation layer is formed to have a thickness greater than a critical radius of a nucleus of AlN crystal and less than a critical resilient thickness of AlN, and the GaN buffer layer is formed to have a thickness greater than a critical radius of a nucleus of GaN crystal and less than a critical resilient thickness of GaN. Annealing time is greater than L²/D_Ga where L indicates a diffusion distance of Ga, and D_Ga indicates a diffusion coefficient of Ga in the AlN nucleation layer.

The invention discloses a self-repairing polyurethane coating and a preparation method thereof. The polyurethane coating comprises the following raw materials in parts by mass: 15-20 parts of polyisocyanates, 40-60 parts of hydrophilic polyester polyol or polyether polyol, 2-3 parts of a chain extender and 7-15 parts of methylcystein. The preparation method comprises the following steps: preparing a hydrophilic polyurethane prepolymer from hydrophilic polyester polyol or polyether polyol and the chain extender, and reacting the isocyanate group in the hydrophilic polyurethane prepolymer with methylcystein, so as to obtain a polyurethane material of which the tail end or the main chain contains 2-urea-4-pyrimidone units; spraying or coating the polyurethane material on the surface of a substrate, thereby obtaining the self-repairing polyurethane coating. The self-repairing of the self-repairing polyurethane coating disclosed by the invention can be completed without external repairing agent or requirements of special environment, the coating is good in transparency, high in strength, good in filming property, simple in process and low in cost, and the function of repeated repairing in same positions can be achieved.

Provided is a method of culturing a successor cell from a precursor cell comprising co-culturing a precursor cell such as, without limitation, a human embryonic stem cell or a neuronal stem cell with an adult mesenchymal stem cell. In one embodiment, the adult mesenchymal stem cell is derived from adipose tissue. Also provided is a composition comprising mesenchymal stem cells in a growth matrix biologically-compatible with the cells. In another embodiment, a method of regenerating tissue is provided comprising introducing into a patient a cell growth niche comprising either or both of mesenchymal stem cells and neuronal stem cell or successor cell in a growth matrix biologically-compatible with the cells. In another embodiment, a method of regenerating tissue is provided comprising introducing into a patient a cell growth niche comprising matrix, cells and slow release polymer beads containing growth factors.

An apparatus and method for repairing the juncture or intersection of a first conduit and a second conduit is disclosed. The apparatus includes a main body for transporting and positioning a repair material impregnated with at heat curable resin system or matrix. An inflation device carried within the main body positions and compresses the repair material against the intersection. This includes a portion of the interior of the second conduit and flange portion in the first conduit. The inflation device includes conductive fibers that are electrically conductively heated to effect curing of the resin in the repair material.

The invention discloses a human umbilical cord mesenchymal stem cell (HUMSC) anti-hepatic fibrosis injection and a preparation method thereof. The injection is composed of 10%-50% of human albumin stock solution, 49.5%-89.5% of acetated Ringer's solution and 0.5% of heparin calcium, wherein, the concentration of the human albumin stock solution is 10%, and 1ml of the injection contains 6*10<5>-7*10<5> HUMSCs. The preparation method comprises the following steps: providing an MSC preserving fluid and pre-cooling the MSC preserving fluid for later use, wherein, the MSC preserving fluid comprises the human albumin stock solution, the Acetated Ringer's solution and the heparin calcium; providing the HUMSCs and adding the HUMSCs to the MSC preserving fluid; and adjusting the number of the HUMSCs added to the MSC preserving fluid to be 6*10<5>-7*10<5> HUMSCs/ml by means of re-suspending. The injection provided by the invention has the advantages of obvious curative effect and high stability, and is convenient in storage and transport and safe in use, thus being capable of bringing gospel to patients with hepatic fibrosis.

The present invention relates to an oral formulation comprising a hyaluronic acid-phospholipid complex, and to use of a hyaluronic acid-phospholipid complex for the manufacture of a joint function-improving and protecting agent for oral administration which can alleviate the arthritic symptoms in patients with arthritic conditions, increase the concentration of hyaluronic acid in synovial fluid, improve the lubrication of joints, as well as maintain and enhance the normal functions of joints.

Method for regulating hair growth, comprising the steps of applying a composition to keratinous tissue comprising the hair in need of regulation, said composition comprising at least one PARP-1 inhibiting compound; and delivering energy to the keratinous tissue by means of an energy delivery device.

The invention discloses a vibration disturbance resistant crack leaking stoppage and reinforcement method applied to underground works. The method comprises the steps as follows: the surface of a crack is cleaned, and holes are drilled with a drilling tool crosswise along two sides of the crack and purged and washed clean; grouting nipples are mounted in the drilled holes and screwed tightly, epoxy resin grout is poured into the grouting nipples, and pouring is repeated several times for grout supplement and is stopped until the pouring pressure change is gentle; the exposed grouting nipples are removed when the fact that epoxy resin is completely cured is confirmed after pouring, and the overflow cured grout is cleaned; a V-shaped groove is opened along the crack and is cleaned, coated with an interfacial agent and filled with a sealing adhesive, surfaces of two sides of the crack are cleaned, and then an acrylic acid resin elastic coating is painted. With the adoption of the processing manner, damage to a waterproof layer due to drilling can be restored, the problems of water channeling and damage to the waterproof layer can also be effectively solved, and the problem of crack leakage is effectively solved.

A repair and strengthening system for a reinforced concrete structure has a ribbed steel plate, and a filler. The ribbed steel plate is disposed facing a strengthened area with a predetermined space therebetween. The strengthened area is an area to be strengthened in a structure surface that is a surface of a reinforced concrete structure. The filler is injected in the space between the structure surface and the ribbed steel plate. Ribs are formed on the ribbed steel plate by hot rolling. The ribs protrude from a steel-plate front face that is a side of the ribbed steel plate facing the structure surface.

The invention discloses a low-cost sintered neodymium boron magnet, which comprises components including, by weight percentage, 5.0-6.5% of Pr (praseodymium), 20-28% of Nd (neodymium), 3-5% of Ho (holmium), 1.0-1.1% of boron, 0.4-0.8% of Al (aluminum), 0.1-0.2 % of Zr (zirconium), 0.4-0.6% of Nb (niobium), 0.12-0.17% of Cu (copper), 0.03-0.08% of Ga (gallium), 0.4-1.0% of Co (carbon monoxide) andthe balance iron. The production method includes: pretreatment of raw materials, ingot casting and smelting, hydrogen decrepitation and pulverization, magnetic field orienting and forming, isostatic processing, sintering, ageing and detecting. In the low-cost sintered neodymium boron magnet, high-cost dysprosium of rare metal is substituted by low-cost holmium of rare metal, so that production cost of products is reduced without affecting magnetic performances of the sintered neodymium boron magnet. Furthermore, the production method is simple in operation, excellent ingot casting structure can be obtained by ingot casting and smelting process, and the high-performance sintered neodymium iron boron magnet can be obtained.

The Rho family GTPases regulates axon growth and regeneration. Inactivation of Rho with C3, a toxin from Clostridium botulinum, can stimulate regeneration and sprouting of injured axons. The present invention provides novel chimeric C3-like Rho antagonists. These new antagonists are a significant improvement over C3 compounds because they are 3-4 orders of magnitude more potent to stimulate axon growth on inhibitory substrates than recombinant C3. The invention further provides evidence that these compounds promote repair when applied to the injured mammalian central nervous system.

The invention discloses a compound growth factor collagen sustained-release carrier material for promoting repair of various traumas in oral and maxillofacial regions and a method for preparing the same. In order to overcome the defect of poor curative effect existing in the conventional medicaments for treating the traumas of various tissues such as an oral cavity and a face, a bioactive collagen sustained-release material is prepared by combining collagen modified by liposome, chitosan, glycosaminoglycan and the like with one or more of a basic fibroblast growth factor (bFGF), a platelet derived growth factor (PDGF-BB), a vascular endothelial growth factor (VEGF) and a keratinocyte growth factor (KGF). The bioactive collagen sustained-release material is characterized in that: each gram of bioactive collagen sustained-release material contains not less than 10ng of growth factors, and the bioactive collagen sustained-release material has the obvious effect of treating various facial tissue traumas such as tooth extraction wound, oral ulcer, facial nerve injury, mandibular defect and the like. The collagen sustained-release carrier material can continuously release an effective amount of the growth factors to the wound for a long time, fully exert the inducing effect of the growth factors and obviously shorten the time for wound healing so as to fulfill the aim of treatment.

The invention relates to a method for preparing tissue engineering cornea. Amniotic epithelial stem cells and mesenchymal stem cells are adopted as seed cells; after in-vitro induced differentiation, the seed cells are planted on both surfaces of a natural acellular corneal stroma; and the tissue engineering cornea is formed by in-vitro organ culture. A scaffold used in the method overcomes the difficulty of large immunological rejection of a xenogenic corneal stroma and reserves the structure (capable of restoring the transparence of the cornea) and main components (comprising growth factorscapable of promoting the cornea to grow, proliferate and differentiate) of the natural cornea. Compared with a product in the prior art, the cornea has the advantages of low cost, convenient operation, wide source and easy storage; and the tissue engineering cornea containing living cells has certain elasticity and tenacity, easy change of shape size and thickness and extremely low immunogenicity, avoids complications caused by non-corneal materials, can be reformed by receptor cells after being implanted into a body, can be quickly integrated with an organism for realizing transparency, and is suitable for restoring cornea damage caused by various reasons.

As described below, the present invention features methods for reprogramming somatic cells and related therapeutic compositions and methods.