A medicinal and edible composition and preparation process thereof

Abstract

The invention discloses a medicine-food combination and a preparation process, wherein the medicine-food combination is prepared from the following raw materials in parts by weight: 25-35 parts of yam, 10-15 parts of tremella, 5-10 parts of longan pulp, 5-10 parts of jujube, 10-15 parts of malt, 15-20 parts of atractylodes macrocephala, 10-15 parts of mulberry, 15-20 parts of lotus seeds, 10-15 parts of hemp seeds, 3-6 parts of tangerine peel, 10-15 parts of coix seeds, 15-20 parts of short-stemmed acanthopanax fruit, 5-10 parts of kaempferia galanga, and 9-18 parts of chicory. The raw materials of the invention synergize with each other, can be dissolved in a gastric acid environment to form mucus to protect the gastric mucosa, and have the effects of repairing mucosal damage, promoting gastrointestinal peristalsis, and anti-anxiety.

Description

Technical Field

[0001] The present invention relates to the field of health care products, and in particular to a medicine-food homologous composition and a preparation process thereof. Background Art

[0002] The pace of modern life is accelerating, and eating irregularly has become the norm. If things go on like this, gastrointestinal diseases will become more common. Problems such as weak stomach, loss of appetite, heartburn, poor digestion, and abdominal distension and pain frequently occur. While overdrawing the body, it is easy to generate anxiety, which in turn affects the quality of sleep.

[0003] At present, most of these symptoms are treated with Western medicine, supplemented by Chinese medicine. Long-term use can easily bring side effects and may also lead to drug dependence. As the saying goes, spleen and stomach diseases rely on treatment for 30% and care for 70%. Based on this, various dietary therapy products have appeared on the market, such as iron stick yam powder, eight treasure powder, etc. However, this type of dietary therapy products generally have the problem of slow effect, especially in improving anxiety. Summary of the invention

[0004] In order to solve the above problems, the present invention provides a medicine-food composition having the effects of nourishing the stomach, strengthening the stomach and improving anxiety, and a preparation process thereof.

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] A medicinal and edible composite material is prepared from yam, longan pulp, jujube, malt, atractylodes macrocephala, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax fruit, kaempferia galanga and chicory.

[0007] Furthermore, the medicine-food composition is prepared from the following raw materials in parts by weight:

[0008] 25-35 parts of yam, 10-15 parts of white fungus, 5-10 parts of longan pulp, 5-10 parts of jujube, 10-15 parts of malt, 15-20 parts of atractylodes, 10-15 parts of mulberry, 15-20 parts of lotus seeds, 10-15 parts of hemp seeds, 3-6 parts of tangerine peel, 10-15 parts of coix seeds, 15-20 parts of short-stemmed acanthopanax, 5-10 parts of galangal, and 9-18 parts of chicory.

[0009] Preferably, it is prepared from the following raw materials in parts by weight:

[0010] 25 parts of yam, 10 parts of white fungus, 5 parts of longan pulp, 5 parts of jujube, 10 parts of malt, 15 parts of atractylodes, 10 parts of mulberries, 15 parts of lotus seeds, 10 parts of hemp seeds, 3 parts of tangerine peel, 10 parts of coix seeds, 15 parts of short-stalked acanthopanax fruit, 5 parts of galangal, and 9 parts of chicory.

[0011] Preferably, it is prepared from the following raw materials in parts by weight:

[0012] 35 parts of yam, 15 parts of white fungus, 10 parts of longan pulp, 10 parts of jujube, 15 parts of malt, 20 parts of atractylodes, 15 parts of mulberries, 20 parts of lotus seeds, 15 parts of hemp seeds, 6 parts of tangerine peel, 15 parts of coix seeds, 20 parts of short-stalked acanthopanax fruit, 10 parts of galangal, and 18 parts of chicory.

[0013] Preferably, it is prepared from the following raw materials in parts by weight:

[0014] 30 parts of yam, 12.5 parts of white fungus, 7.5 parts of longan pulp, 7.5 parts of jujube, 12.5 parts of malt, 17.5 parts of atractylodes, 12.5 parts of mulberries, 17.5 parts of lotus seeds, 12.5 parts of hemp seeds, 4.5 parts of tangerine peel, 12.5 parts of coix seeds, 12.5 parts of short-stalked acanthopanax, 7.5 parts of galangal, and 13.5 parts of chicory.

[0015] The present invention also provides a process for preparing the above-mentioned medicine-food homologous composition, comprising the following steps:

[0016] S1, take the formula amount of Chinese yam, white fungus, longan meat, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stemmed Acanthopanax fruit, galangal, chicory, freeze solid, grind into powder, and obtain mixed powder;

[0017] S2. Place the obtained mixed powder in an enzymolysis tank, add appropriate amounts of purified water, cellulase and pectinase, and perform enzymolysis for 4 hours at a pH of 4.5-5.5, a temperature of 45°C, a substrate concentration of 3%, and an enzyme amount of 5000U / g. Then, use pepsin to perform enzymolysis for 3 hours at a pH of 1.5-2, a temperature of 37°C, a substrate concentration of 3%, and an enzyme amount of 5000U / g. Spray dry to obtain a composition. During the entire enzymolysis process, a high-voltage electrostatic field with a field strength of 30-60kV / m and a pulse frequency of 15-20Hz is applied.

[0018] Furthermore, in step S1, take a formula amount of yam, white fungus, longan pulp, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax, kaempferia galanga, and chicory, peel and / or remove the core and / or cut into pieces and / or remove the stems, wash, drain, and pack in ice cubes and freeze at -20°C.

[0019] Furthermore, in the step S1, after grinding, the powder is passed through a 50-mesh sieve.

[0020] Furthermore, in the step S2, the mass ratio of cellulase to pectinase is 3:2.

[0021] When the composition of the present invention is used, it is generally granulated by adding auxiliary materials, and the auxiliary materials can be sweeteners, fillers, etc.

[0022] The raw materials of the present invention synergize with each other and can be dissolved in a gastric acid environment to form mucus for protecting the gastric mucosa, and have the effects of repairing mucosal damage, promoting gastrointestinal peristalsis, and anti-anxiety. Among them, yam, combined with tremella, lotus seeds, coix seeds, etc., can be dissolved in a gastric acid environment to form mucus for protecting the gastric mucosa, thereby protecting the stomach wall, promoting gastric juice secretion, increasing appetite, and improving symptoms such as indigestion. The short-stalked Acanthopanax fruit has an immunomodulatory function, and can be combined with hemp seeds and kaempferia to effectively inhibit the growth of Helicobacter pylori, reduce gastric inflammation, and quickly relieve stomach pain. It cooperates with chicory, mulberries, and longan pulp to have a significant anti-anxiety effect and a mild sedative effect, thereby achieving a sleeping effect.

[0023] The present invention can significantly improve the precipitation rate of each effective component and thus improve the overall effect thereof by optimizing the preparation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments made with reference to the following drawings:

[0025] Figure 1 It is the average value of the ulcer index of each group in the embodiment of the present invention. DETAILED DESCRIPTION

[0026] The present invention is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the present invention, but are not intended to limit the present invention in any form. It should be noted that, for those of ordinary skill in the art, several variations and improvements may be made without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0027] Example 1

[0028] A medicinal and edible composition is prepared from the following raw materials in parts by weight:

[0029] 25 parts of yam, 10 parts of white fungus, 5 parts of longan pulp, 5 parts of jujube, 10 parts of malt, 15 parts of atractylodes, 10 parts of mulberries, 15 parts of lotus seeds, 10 parts of hemp seeds, 3 parts of tangerine peel, 10 parts of coix seeds, 15 parts of short-stalked acanthopanax fruit, 5 parts of galangal, and 9 parts of chicory.

[0030] The preparation comprises the following steps:

[0031] S1. Take the formulated amount of Chinese yam, white fungus, longan pulp, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax fruit, galangal, and chicory, peel and / or remove the core and / or cut into pieces and / or remove the stems, wash, drain, pack in ice cubes, freeze at -20°C, grind into powder, and pass through a 50-mesh sieve to obtain a mixed powder;

[0032] S2. The obtained mixed powder is placed in an enzymolysis tank, and appropriate amounts of purified water, cellulase and pectinase are added, wherein the mass ratio of cellulase to pectinase is 3:2, and enzymolysis is performed for 4 hours under the conditions of pH 4.5, temperature 45°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and then enzymolysis is performed for 3 hours with pepsin under the conditions of pH 1.5, temperature 37°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and spray-dried to obtain a composition; a high-voltage electrostatic field with a field strength of 30kV / m and a pulse frequency of 15Hz is applied during the entire enzymolysis process.

[0033] Example 2

[0034] A medicinal and edible composition is prepared from the following raw materials in parts by weight:

[0035] 35 parts of yam, 15 parts of white fungus, 10 parts of longan pulp, 10 parts of jujube, 15 parts of malt, 20 parts of atractylodes, 15 parts of mulberries, 20 parts of lotus seeds, 15 parts of hemp seeds, 6 parts of tangerine peel, 15 parts of coix seeds, 20 parts of short-stalked acanthopanax fruit, 10 parts of galangal, and 18 parts of chicory.

[0036] The preparation comprises the following steps:

[0037] S1. Take the formulated amount of Chinese yam, white fungus, longan pulp, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax fruit, galangal, and chicory, peel and / or remove the core and / or cut into pieces and / or remove the stems, wash, drain, pack in ice cubes, freeze at -20°C, grind into powder, and pass through a 50-mesh sieve to obtain a mixed powder;

[0038] S2. The obtained mixed powder is placed in an enzymolysis tank, and appropriate amounts of purified water, cellulase and pectinase are added, wherein the mass ratio of cellulase to pectinase is 3:2, and enzymolysis is performed for 4 hours under the conditions of pH 5.5, temperature 45°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and then enzymolysis is performed for 3 hours with pepsin under the conditions of pH 2, temperature 37°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and spray-dried to obtain a composition; a high-voltage electrostatic field with a field strength of 60kV / m and a pulse frequency of 20Hz is applied during the entire enzymolysis process.

[0039] Example 3

[0040] A medicinal and edible composition is prepared from the following raw materials in parts by weight:

[0041] 30 parts of yam, 12.5 parts of white fungus, 7.5 parts of longan pulp, 7.5 parts of jujube, 12.5 parts of malt, 17.5 parts of atractylodes, 12.5 parts of mulberries, 17.5 parts of lotus seeds, 12.5 parts of hemp seeds, 4.5 parts of tangerine peel, 12.5 parts of coix seeds, 12.5 parts of short-stalked acanthopanax, 7.5 parts of galangal, and 13.5 parts of chicory.

[0042] The preparation comprises the following steps:

[0043] S1. Take the formulated amount of Chinese yam, white fungus, longan pulp, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax fruit, galangal, and chicory, peel and / or remove the core and / or cut into pieces and / or remove the stems, wash, drain, pack in ice cubes, freeze at -20°C, grind into powder, and pass through a 50-mesh sieve to obtain a mixed powder;

[0044] S2. The obtained mixed powder is placed in an enzymolysis tank, and appropriate amounts of purified water, cellulase and pectinase are added, wherein the mass ratio of cellulase to pectinase is 3:2, and enzymolysis is performed for 4 hours under the conditions of pH 5, temperature 45°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and then enzymolysis is performed for 3 hours with pepsin under the conditions of pH 2, temperature 37°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and spray-dried to obtain a composition; a high-voltage electrostatic field with a field strength of 45kV / m and a pulse frequency of 17.5Hz is applied during the entire enzymolysis process.

[0045] Comparative Example 1

[0046] The Kaempferia galanga in Example 1 was replaced with Acanthopanax oleraceus, and the rest of the design was the same as in Example 1.

[0047] Comparative Example 2

[0048] The chicory in Example 2 was replaced with Acanthopanax sphenanthera, and the rest of the design was the same as in Example 2.

[0049] Comparative Example 3

[0050] The Acanthopanax acanthopanax in Example 3 was replaced with Chicory, and the rest of the design was the same as Example 3.

[0051] Comparative Example 4

[0052] S2. The obtained mixed powder is placed in an enzymolysis tank, and appropriate amounts of purified water, cellulase and pectinase are added, wherein the mass ratio of cellulase to pectinase is 3:2, and enzymolysis is performed for 4 hours at pH 5, temperature 45°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and then enzymolysis is performed for 3 hours with pepsin at pH 2, temperature 37°C, substrate concentration 3%, and enzyme addition amount 5000U / g, and spray-dried to obtain a composition.

[0053] The rest of the design is the same as in Example 3.

[0054] Comparative Example 5

[0055] S1, take the formula amount of Chinese yam, white fungus, longan pulp, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax fruit, galangal, chicory, peel and / or remove the core and / or cut into pieces and / or remove the stems, wash, drain, grind, pass through a 50-mesh sieve, and obtain a mixed powder;

[0056] The rest of the design is the same as in Example 3.

[0057] Elevated plus maze test

[0058] The elevated plus maze includes two mutually perpendicular open arms (30 cm long, 6 cm wide) and two closed arms (30 cm long, 6 cm wide), the upper part of the closed arms is open, and there is a 5 cm × 5 cm open part in the center. The maze is 50 cm above the ground. 100 ICR mice were taken, adaptively fed for one week, and randomly divided into 10 groups, each with 10 mice, namely blank control group (normal saline solution), diazepam group (5 mg / kg), Example 1 group (300 mg / kg), Example 2 group (300 mg / kg), Example 3 group (300 mg / kg), Comparative Example 1 group (300 mg / kg), Comparative Example 2 group (300 mg / kg), Comparative Example 3 group (300 mg / kg), Comparative Example 4 group (300 mg / kg), Comparative Example 5 group (300 mg / kg). The mice were given drugs by gavage for 14 days, once a day. 60 minutes after the last drug administration, the mice were placed in the central open part of the elevated plus maze, with their heads facing the closed arms. The DigBehv Animal Behavior Analysis System 2.0 automatically recorded the number of times the mice entered each arm and the length of stay within 5 minutes, namely the number of entries to the open arms (OE), the number of close arm entries (CE), the time to enter the open arms (OT), and the time to enter the closed arms (CT). The percentage of entries to the open arms to the total number of entries (OE%) and the percentage of time spent in the open arms to the total time in the arms (OT%) were used as indicators to show the anxiolytic effect. During the test, the mouse withdrew one foot from an arm, indicating the completion of the activity. After each test, the maze was wiped to remove feces before the next test.

[0059] Table 1 Elevated plus maze test ( n=10)

[0060]

[0061] As shown in Table 1, both the embodiment group and the comparative example group can significantly increase the percentage of the number of times mice enter the open arms in the elevated plus maze model experiment, and can significantly increase the percentage of the time mice stay in the open arms. The results show that the medicinal and edible compositions of the embodiment group and the comparative example group have good antianxiety effects. Compared with comparative example 1 group, comparative example 2 group and comparative example 3 group, the embodiment group can significantly increase the percentage of the number of times mice enter the open arms in the elevated plus maze model experiment, and can significantly increase the percentage of the time mice stay in the open arms. It can be seen that there is a synergistic relationship between short-stalked Acanthopanax, Kaempferia galanga and chicory. The combination of the three has a significant antianxiety effect and a mild sedative effect. Compared with comparative example 4 group and comparative example 5 group, the embodiment group can increase the percentage of the number of times mice enter the open arms in the elevated plus maze model experiment, and can increase the percentage of the time mice stay in the open arms. It can be seen that the process of the present invention can significantly improve the precipitation rate of each effective ingredient, thereby improving its overall effect.

[0062] Gastric mucosal repair ability experiment

[0063] 90 Wistar rats were selected, half male and half female, weighing 190-230g. They were fasted for 24 hours before the experiment and given water to drink. The abdominal cavity was opened under ether anesthesia, and a glass tube with an inner diameter of 5mm and a length of 30mm was placed vertically on the serosal surface of the gastric body. 0.2mL of glacial acetic acid was added to the lumen. After 1.5 minutes, a cotton swab was used to dip out the glacial acetic acid, and the surgical incision was sutured. After surgery, the rats resumed their normal diet. After 24 hours, the rats were randomly divided into: experimental group 1 (300 mg / kg), experimental group 2 (300 mg / kg), experimental group 3 (300 mg / kg), control group 1 (300 mg / kg), control group 2 (300 mg / kg), control group 3 (300 mg / kg), control group 4 (300 mg / kg), control group 5 (300 mg / kg) and model control group ((physiological saline solution), 10 rats in each group, free access to ordinary food and drinking water, oral gavage once in the morning and evening every day, for 14 consecutive days. Two hours after the last oral gavage, the rat stomach was dissected out, fixed with 10% formaldehyde for 10 minutes, and then the stomach was cut open along the greater curvature of the stomach and flattened on glass. The longest diameter and the shortest diameter of the ulcer site were measured, and the average of the longest diameter and the shortest diameter was used as the ulcer index. The results are shown in Table 2.

[0064] Table 2 Ulcer index of each group

[0065]

[0066] According to the data in Table 2, it can be concluded that the average ulcer index of the model group is 8.94mm, the average ulcer index of the experimental group 1 is 3.6mm, the average ulcer index of the experimental group 2 is 3.45mm, the average ulcer index of the experimental group 3 is 3.44mm, the average ulcer index of the control group 1 is 5.23mm, the average ulcer index of the control group 2 is 5.55mm, the average ulcer index of the control group 3 is 4.9mm, the average ulcer index of the control group 4 is 4.33mm, and the average ulcer index of the control group 5 is 3.9mm. By comparing the above-mentioned average ulcer index, it can be concluded that the experimental groups 1-3 all have good effects of repairing gastric ulcers, and the control groups 1-5 also have certain effects of repairing gastric ulcers, but the effects are not as good as the experimental groups 1-3, and the main reason for the correction is the synergistic enhancement between the components and the differences in the preparation process. It can be seen that the medicine-food homologous composition of the present invention has the effect of repairing mucosal damage.

[0067] When the composition of the present invention is used, it is generally granulated by adding auxiliary materials, and the auxiliary materials can be sweeteners, fillers, etc.

[0068] The above describes the specific embodiments of the present invention. It should be understood that the present invention is not limited to the above specific embodiments, and those skilled in the art may make various modifications or variations within the scope of the claims, which do not affect the essence of the present invention.

Claims

1. A medicine-food composition, characterized in that: Prepared from the following raw materials in parts by weight: 25-35 parts of Chinese yam, 10-15 parts of white fungus, 5-10 parts of longan pulp, 5-10 parts of jujube, 10-15 parts of malt, 15-20 parts of white atractylodes, 10-15 parts of mulberry, 15-20 parts of lotus seeds, 10-15 parts of hemp seeds, 3-6 parts of tangerine peel, 10-15 parts of coix seeds, 15-20 parts of short-stemmed acanthopanax fruit, 5-10 parts of galangal, and 9-18 parts of chicory; The preparation comprises the following steps: S1, take the formula amount of Chinese yam, white fungus, longan meat, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stemmed Acanthopanax fruit, galangal, chicory, freeze solid, grind into powder, and obtain mixed powder; S2. Place the obtained mixed powder in an enzymolysis tank, add appropriate amounts of purified water, cellulase and pectinase, and perform enzymolysis for 4 h at pH 4.5-5.5, temperature 45°C, substrate concentration 3%, and enzyme addition amount 5000 U / g. Then, use pepsin to perform enzymolysis for 3 h at pH 1.5-2, temperature 37°C, substrate concentration 3%, and enzyme addition amount 5000 U / g. Spray dry to obtain a composite. During the entire enzymolysis process, a high-voltage electrostatic field with a field strength of 30-60 kV / m and a pulse frequency of 15-20 Hz is applied.

2. The medicine-food composition according to claim 1, characterized in that: Prepared from the following raw materials in parts by weight: 25 parts of yam, 10 parts of white fungus, 5 parts of longan pulp, 5 parts of jujube, 10 parts of malt, 15 parts of atractylodes, 10 parts of mulberries, 15 parts of lotus seeds, 10 parts of hemp seeds, 3 parts of tangerine peel, 10 parts of coix seeds, 15 parts of short-stalked acanthopanax fruit, 5 parts of galangal, and 9 parts of chicory.

3. The medicine-food composition according to claim 1, characterized in that: Prepared from the following raw materials in parts by weight: 35 parts of yam, 15 parts of white fungus, 10 parts of longan pulp, 10 parts of jujube, 15 parts of malt, 20 parts of atractylodes, 15 parts of mulberries, 20 parts of lotus seeds, 15 parts of hemp seeds, 6 parts of tangerine peel, 15 parts of coix seeds, 20 parts of short-stalked acanthopanax fruit, 10 parts of galangal, and 18 parts of chicory.

4. A medicine-food composition, characterized in that: Prepared from the following raw materials in parts by weight: 30 parts of yam, 12.5 parts of white fungus, 7.5 parts of longan pulp, 7.5 parts of jujube, 12.5 parts of malt, 17.5 parts of atractylodes, 12.5 parts of mulberry, 17.5 parts of lotus seeds, 12.5 parts of hemp seeds, 4.5 parts of tangerine peel, 12.5 parts of coix seeds, 12.5 parts of short-stemmed acanthopanax fruit, 7.5 parts of galangal, and 13.5 parts of chicory; The preparation comprises the following steps: S1, take the formula amount of Chinese yam, white fungus, longan meat, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stemmed Acanthopanax fruit, galangal, chicory, freeze solid, grind into powder, and obtain mixed powder; S2. Place the obtained mixed powder in an enzymolysis tank, add appropriate amounts of purified water, cellulase and pectinase, and perform enzymolysis for 4 h at pH 4.5-5.5, temperature 45°C, substrate concentration 3%, and enzyme addition amount 5000 U / g. Then, use pepsin to perform enzymolysis for 3 h at pH 1.5-2, temperature 37°C, substrate concentration 3%, and enzyme addition amount 5000 U / g. Spray dry to obtain a composite. During the entire enzymolysis process, a high-voltage electrostatic field with a field strength of 30-60 kV / m and a pulse frequency of 15-20 Hz is applied.

5. The medicine-food composition according to claim 1, characterized in that: In the step S1, take the formulated amount of yam, white fungus, longan pulp, jujube, malt, atractylodes, mulberry, lotus seed, hemp seed, tangerine peel, coix seed, short-stalked acanthopanax, kaempferia galanga, and chicory, peel and / or remove the core and / or cut into pieces and / or remove the stems, wash, drain, pack in ice cubes, and freeze at -20°C.

6. The medicine-food composition according to claim 1, characterized in that: In the step S1, after grinding, the powder is passed through a 50-mesh sieve.

7. The medicine-food composition according to claim 1, characterized in that: In the step S2, the mass ratio of cellulase to pectinase is 3:2.

Images