The invention relates to building material engineering, and aims at providing a preparing method of nano-modified high permeability resistant concrete. The preparing method comprises the steps of conducting dry stirring on cement, sand, gravel, fly ash, blast-furnace slag powder and silica fume, and mixing the mixture evenly; mixing a nanometer additive, a water reducing agent and water which accounts for half the weight evenly, and adding the nanometer additive, the water reducing agent and the water which accounts for half the weight into the mixture for stirring; then adding the water which accounts for the other half the weight and continuing to conducting mixing; conducting discharging, and putting the new mixture into molds; conducting maintenance according to a conventional maintenance mode after removing the molds to obtain the nano-modified high permeability resistant concrete. According to the preparing method of the nano-modified high permeability resistant concrete, the limitation of the influence of a single mineral component on the performance of the concrete is solved, through the combination of the multifunctional composition, the effect of function superposition and synergy is achieved, the composite multifunctional composition can effectively optimize the concrete structure grain composition, and by optimizing the internal pore structure of the concrete, the aim of improving the permeability resistance is achieved. The grain composition optimization is conducted on the concrete structure by utilizing the nanometer additive, the high activity and the microcrystal nuclear effect of nano-particles are given full play to at the same time, and the permeability resistance of the concrete structure is improved.