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Preparation method of inorganic/organic multi-drug controlled release composite nano fiber scaffold

A technology of composite nanofibers and controlled drug release, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of good stability, improved therapeutic effect and short preparation time.

Inactive Publication Date: 2014-04-30
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these patents only use a single nanofiber to carry a drug, and there are few reports of three or more drug sustained release systems

Method used

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  • Preparation method of inorganic/organic multi-drug controlled release composite nano fiber scaffold
  • Preparation method of inorganic/organic multi-drug controlled release composite nano fiber scaffold
  • Preparation method of inorganic/organic multi-drug controlled release composite nano fiber scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mesoporous silica / hydroxyapatite / polylactic acid composite nanofibrous scaffold loaded with doxorubicin, hydroxycamptothecin, and paclitaxel for cancer therapy.

[0032] (1) Prepare mesoporous silica nanoparticles and load doxorubicin on them;

[0033] (2) Prepare hydroxyapatite and load hydroxycamptothecin on it;

[0034] (3) Prepare 10ml of polylactic acid-hexafluoroisopropanol solution with a mass-volume ratio of 1:10, and add the third drug, paclitaxel, at 1% polylactic acid mass;

[0035] (4) Add the drug-loaded nanoparticles prepared in steps (1) and (2) to the solution prepared in step (3) respectively, wherein the amount of doxorubicin-loaded mesoporous silica is 15% relative to that of polylactic acid. %, the amount of hydroxycamptothecin hydroxyapatite added is 15% relative to the mass of polylactic acid.

[0036](5) Draw up the solution with a syringe, adjust the voltage to 18kV, the advancing speed to 3ml / h, the receiving distance to 15cm, the temperature ...

Embodiment 2

[0038] Liposome / mesoporous silica / gelatin composite nanofibrous scaffold loaded with plasmid DNA, dexamethasone, and sphingosine-1-phosphate for bone tissue repair.

[0039] (1) Liposomes were prepared by thin film method, and plasmid DNA was loaded on them;

[0040] (2) Prepare mesoporous silica nanoparticles and load them with sphingosine-1-phosphate;

[0041] (3) Prepare 10ml of an aqueous solution of fish gelatin with a mass-volume ratio of 9:10, and add another drug, dexamethasone, to the solution at a mass-volume ratio of 5% of the fish gelatin;

[0042] (4) Add the drug-loaded nanobodies prepared in steps (1) and (2) to the solution prepared in step (3) respectively, wherein 10% of the liposome loaded with plasmid DNA relative to the mass of gelatin is added, and The amount of mesoporous silicon loaded with sphingosine-1-phosphate is 10% relative to the mass of gelatin;

[0043] (5) Draw up the mixed liquid in (4) with a syringe, adjust the voltage to 14kV, the advanc...

Embodiment 3

[0046] Poly(lactic-co-glycolic acid) nanospheres / mesoporous silicon / silk fibroin composite nanofiber scaffold loaded with vitamin A, vitamin C and vitamin E for skin repair.

[0047] (1) PLAG nanospheres were prepared by double emulsion method and loaded with vitamin A;

[0048] (2) Prepare mesoporous silica nanoparticles and load vitamin E on them;

[0049] (3) Prepare 10ml of 20% silk fibroin aqueous solution by mass volume percentage, and add drug vitamin C to the solution according to 5% silk fibroin mass;

[0050] (4) Add the drug-loaded nanoparticles prepared in steps (1) and (2) respectively to the solution prepared in step (3), wherein, adding vitamin A-loaded poly(lactic-co-glycolic acid) nanospheres relative to silk fibroin 5% of the mass of silk fibroin, add vitamin E mesoporous silicon loaded with respect to 10% of the mass of silk fibroin;

[0051] (5) Draw the mixed liquid in (4) with a syringe, adjust the voltage to 15kV, push the speed to 0.3ml / h, receive dis...

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Abstract

The invention relates to a preparation method of inorganic / organic multi-drug controlled release composite nano fiber scaffold, which includes the steps of preparing drug loading nanoparticle with particle size of 5-500 nm, preparing mixed solution of high molecular polymer and drug, adding multiple drug loading nanoparticles into the polymer solution, ultrasonically stirring, and carrying out electrostatic spinning to obtain inorganic / organic multi-drug controlled release composite nano fiber scaffold with diameter of 50-800 nm. The preparation method provided by the invention has the advantages of mild reaction conditions, simple operation, and easy experimental apparatus, and is in favor or large-scale production; the obtained multi-drug controlled release composite nano fiber scaffold has good stability and good biocompatibility and biodegradability, and can be stored for a long period of time, and the degradation product is non-toxic. The inorganic / organic multi-drug controlled release composite nano fiber scaffold can be widely applied in the fields of tissue engineering, biomedical engineering, drug therapy and the like.

Description

technical field [0001] The invention belongs to the field of multi-drug controlled-release composite nanofiber stents, in particular to a method for preparing an inorganic / organic multi-drug controlled-release composite nanofiber stent. Background technique [0002] With the advancement of science and technology, the development of pharmacy has entered a new era. In order to better control the dosage of drugs, improve the utilization rate of drugs, reduce the side effects of drugs, effectively treat diseases and alleviate the pain of patients, various pharmaceutical preparations are developing in the direction of stable storage and controlled release. In the drug controlled release system, in addition to the drug itself, the drug carrier also plays an important role. The forms of the drug controlled release carrier mainly include nanoparticles and nanofibers. A new type of drug controlled release carrier can be prepared by adding drugs, bioactive factors, etc. into the inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/24A61L27/12A61L27/02A61L27/18A61L27/22A61L27/60A61K47/34A61K47/04D04H1/4382D04H1/728A61K31/704A61K31/4745A61K31/337
Inventor 何创龙冯炜陈梦霞仇可新聂伟
Owner DONGHUA UNIV
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