15 results about "Double emulsion" patented technology

This invention discloses a method for preparing hydrophilic drug nanoliposomes based on microfluidic-low-shear coupling double emulsion and the hydrophilic drug nanoliposomes prepared according to the following method: (1) Prepare aqueous solutions of hydrophilic drugs and chloroform solutions of soybean lecithin respectively; (2) Add the chloroform solution of soybean lecithin to the chamber as the oil phase, and inject the aqueous solution of hydrophilic drugs into the oil phase in the low-shear stirring field through a microtube under low-speed stirring and shearing, and collect the W / O pre-emulsion sample; (3) Use the W / O pre-emulsion sample as the dispersed phase, and inject it into the external aqueous phase in the same way as in step (2), and emulsify it under low-speed stirring and shearing to form a W / O / W double emulsion; (4) Remove the chloroform by vacuum evaporation of the W / O / W double emulsion to obtain hydrophilic drug nanoliposomes. The prepared Ganoderma lucidum polysaccharide nanoliposomes have a particle size controlled at 200-300 nm, a polydispersity index of about 0.2, and an encapsulation efficiency of more than 70%, which is more than twice that of the traditional thin film hydration method. It solves the technical problem of low encapsulation efficiency of water-soluble macromolecular Ganoderma lucidum polysaccharides.

The application belongs to the field of food functional factor processing, and particularly relates to a water-in-oil-in-water composite emulsion embedding lactoferrin, a preparation method and application. The W1 / O / W2 double emulsion system is constructed by a two-step method, and the leakage and inactivation risks of lactoferrin and VD3 in the preparation, storage and processing processes are effectively reduced through the double barrier effect of the oil phase film and the outer water phase film. Under the optimized sodium caseinate and gellan gum compounding conditions, the encapsulation rate of lactoferrin can be up to 82.52%, which proves that the structure has obvious advantages in improving the loading efficiency of active substances, and can significantly improve the encapsulation rate and structural stability of lactoferrin. The water-in-oil-in-water composite emulsion system prepared by the application can significantly improve the retention rate of lactoferrin in the digestion process, enhance the tolerance of lactoferrin to the gastrointestinal environment, and then enhance the arrival rate of lactoferrin in the intestinal tract, thereby improving the overall bioavailability.

This invention belongs to the field of fire extinguishing materials and their preparation technology, and provides a fire extinguishing microcapsule and its microfluidic controllable preparation method. The preparation method is characterized by the following steps: (1) preparing fluids of each phase, (2) preparing a dual emulsion using a microfluidic device, (3) collecting and sealing the dual emulsion in a collection container, controlling the axis of the collection container to be horizontal, and controlling the collection container to rotate around its axis for 1 to 15 minutes, applying light to solidify the outer shell of the dual emulsion droplets while maintaining the rotation of the collection container, cleaning, and drying to obtain the final product. The fire extinguishing microcapsule prepared by this method consists of an outer shell and a liquid fluorine-containing fire extinguishing agent encapsulated within the outer shell. The outer shell of the fire extinguishing microcapsule has a uniform thickness, and the eccentricity between the outer shell and the core is less than 0.1. The method of this invention can achieve precise customization of fire extinguishing microcapsules according to the differentiated fire characteristics of different application scenarios, and can improve the concentricity between the core and the outer shell of existing fire extinguishing microcapsules.

Systems and methods for measuring osmotic pressure are described. In many embodiments, double emulsion droplets can be used as osmotic pressure sensors to measure local osmotic pressure. The double emulsion droplets can measure osmotic pressure in living cells and / or tissues.

A probiotic microsphere with in-situ proliferation, its preparation method and application. The microsphere is prepared by a two-step Pickering double emulsion method, encapsulating probiotics and panax notoginseng saponins, and then mixed with sodium alginate and cross-linked by calcium ions. The structure significantly improves the survival rate of probiotics in simulated gastric juice, intestinal juice, heat treatment and antibiotic environment, and maintains high viable cell count during long-term storage. Co-encapsulated PNS and double emulsion stabilizer natural polysaccharide-protein nanocomposite can promote the proliferation of probiotics in-situ, increase their activity. In addition, the microsphere can effectively promote the colonization and proliferation of probiotics in the intestinal tract, enhance the oral bioavailability of bioactive ingredients, and is suitable for functional food, feed, biological medicine field, especially as 3D printing special medical food for dysphagia population and prevention and treatment of intestinal inflammatory diseases.

The application provides a method for preparing hollow non-spherical micro-nanoparticles based on a coaxial micro-reactor, and belongs to the field of droplet microfluidics and polymer materials. A three-channel coaxial micro-reactor is designed to generate a water-in-oil-in-water (W / O / W) double emulsion. The innermost phase is an alkaline electrolyte aqueous solution, the intermediate oil phase is a polymer solution, and the outermost phase is a surfactant aqueous solution. With the volatilization of the intermediate phase solvent, the double emulsion droplets form hollow non-spherical micro-nanoparticles. The double emulsion is placed in a collection liquid with different electrolyte concentrations, water molecules in the collection liquid penetrate into the innermost phase under the action of osmotic pressure, increase the size of the inner droplets of the double emulsion, and then change the morphology of the outer droplets, so that the non-spherical structure required is presented, and the size of the hollow micro-nanoparticles is controllable. The coaxial micro-channel reactor used in the application adopts a flow focusing structure, which is used for controllable generation of double emulsion to prepare multi-chamber hollow non-spherical micro-nanoparticles.

This invention discloses a method for preparing a dual-emulsion sustained-release agent for remediating petroleum-contaminated groundwater, belonging to the field of petroleum pollution control. The method includes preparing a nutrient matrix, preparing a dual-emulsion nutrient sustained-release agent, and preparing an outer shell structure. The specific steps for preparing the dual-emulsion nutrient sustained-release agent are as follows: Step 1, obtaining an inner aqueous phase W1; Step 2, obtaining an experimental oil phase O; Step 3, stirring to form a W1 / O type emulsion; Step 4, obtaining an outer aqueous phase W2; Step 5, obtaining the dual-emulsion nutrient sustained-release agent. The specific steps for preparing the outer shell structure are as follows: Step 1, heating to form a gelling agent; Step 2, the ratio of the gelling agent to W1 / O / W2 is 5:1; Step 3, water bath heating; Step 4, solution separation; Step 5, obtaining a boric acid solution; Step 6, forming spherical structures in the solution; Step 7, obtaining the dual-emulsion sustained-release agent. Beneficial effects: It can efficiently degrade petroleum hydrocarbons in groundwater, improving the petroleum hydrocarbon degradation effect by more than 40%.

This invention belongs to the field of cosmetic technology, specifically relating to an anti-aging composition containing nanospheres and its preparation method, as well as its application in skincare products. The method employs a double emulsion solvent evaporation method to prepare nanospheres. Soybean lecithin and polylactic acid-glycolic acid copolymer are dissolved in an organic solvent as the oil phase. Superoxide dismutase, collagenase, trehalose, and bovine serum albumin are dissolved in phosphate buffer as the inner aqueous phase. After emulsification to form a primary emulsion, it is added to an outer aqueous phase containing polyvinyl alcohol and homogenized to form a double emulsion. After solidification, centrifugation, and washing, the nanospheres are obtained. The resulting composition exhibits good enzyme protection and skin permeability, effectively scavenging free radicals and inhibiting collagen degradation, showing broad application prospects in the skincare field. This invention features a simple process, uses commercially available raw materials, and is suitable for large-scale production.

The application relates to the field of inorganic materials, in particular to a kind of antimony trioxide and its preparation method and application, organic antimony precursor is added to O / W / O type double Pickering emulsion, after reaction at 30-50 DEG C, the solid is collected by centrifugation, and after acid washing and water washing, drying can be carried out, the antimony trioxide prepared in the application has a hollow structure, and has a wide application prospect in high-performance energy storage devices such as secondary batteries, and has important economic value.

The present disclosure relates to a modular, multi-fluidic, multi-nozzle system. The system may incorporate a hub having a first and second internal fluid reservoirs for holding first and second fluids. The hub has recess in flow communication with each of the first and second internal fluid reservoirs. A fluid droplet generation chip is removably secured in the recess and has first and second flow paths in communication with the first and second internal fluid reservoirs, and an opening forming an ejection port. The fluid droplet generation chip receives streams of the first and second fluids and releases the two streams simultaneously through the ejection port. In this manner double emulsion fluid droplets are created in which a quantity of the first fluid is fully encapsulated within a quantity of the second fluid.

This invention discloses a triptolide sustained-release injection, its preparation method, and its application, belonging to the field of pharmaceutical technology. The sustained-release injection is composed of triptolide-polylactic acid-glycolic acid copolymer nanoparticles and hyaluronic acid hydrogel. The triptolide-polylactic acid-glycolic acid copolymer nanoparticles are prepared by a double emulsion-solvent evaporation method, with an encapsulation efficiency of 60.58±0.91% and a drug loading of 1.16±0.13%. The nanoparticles are further encapsulated in the hyaluronic acid hydrogel to form a composite formulation with good injectability. This invention also provides a method for establishing a collagen-induced arthritis (CIA) model in mice. By administering the drug via local intra-articular injection, a dual sustained-release effect is achieved, significantly reducing the systemic toxicity of triptolide, alleviating paw swelling, improving knee joint pathological changes, regulating serum inflammatory factor levels, and reducing liver and spleen damage in the model mice. This triptolide sustained-release injection has broad prospects for application in the preparation of drugs for treating rheumatoid arthritis.

The application relates to a kind of thermal irreversible double emulsion gel simulation fat and its preparation method and application, belong to the technical field of plant-based food processing.To solve the technical problems such as low taste simulation degree, poor texture stability and difficult to realize multi-layer structure fusion of existing plant-based imitation fatty pork belly, the present application uses plant protein, composite hydrophilic colloid (plant source galactomannan colloid and microbial source anionic polysaccharide colloid), calcium salt, dextran colloid, emulsifier, vegetable oil and water as raw materials, through primary emulsion preparation, complete outer water phase construction, double emulsion construction, gelation and maturation process, a simulation fat with double emulsion gel structure and thermal irreversibility, excellent texture and stability is prepared.The simulation fat is used as a fat component, combined with a plant lean meat component and a biomimetic meat skin component through a specific adhesive and a multi-layer composite process, a three-layer plant-based imitation five-pork-belly product with a lean meat layer-fat layer-meat skin layer can be prepared.

This invention belongs to the field of daily chemical product technology, and particularly relates to a scalp oil-control composition containing tea polyphenols, its preparation method, and its application. The composition comprises the following components in weight percentages: 10-50% plant oil, 0.01-15% water-in-oil emulsifier, 0.01-15% oil-in-water emulsifier, 0.001-5% modified tea polyphenol nanoparticles, and the balance being water. This invention uses a water-in-oil emulsion as the base form, with modified tea polyphenol nanoparticles as the internal phase, effectively improving the stability of tea polyphenols; simultaneously, the addition of an oil-in-water emulsifier modifies the emulsion, forming a water-in-oil-in-water (W / O / W) double emulsion structure to solve the problem of poor solubility in water-in-oil emulsions. Furthermore, through the synergistic effect between the components, this invention can effectively regulate the scalp's oil-water balance, achieving excellent scalp oil control; it also possesses good moisturizing effects, combining the advantages of oil control and gentle care.

The application discloses a preparation method of high-load dried orange peel essence slow-release microcapsules. The method comprises the following steps: firstly, dissolving composite wall material raw materials in water to obtain an aqueous phase; secondly, mixing dried orange peel essence, vegetable oil and an emulsifier to obtain an oil phase; thirdly, dropping the oil phase into the aqueous phase to form an oil-in-water (W / O) primary emulsion, which is a core liquid; fourthly, dropping the core liquid into an outer oil phase containing a surfactant to emulsify and form a water-in-oil-in-water (W / O / W) double emulsion; fifthly, adding a forming agent solution and performing ionic crosslinking to form gel microcapsules wrapping oil droplets of the essence; and finally, separating, washing and drying to obtain the high-load dried orange peel essence slow-release microcapsules. The composite wall material raw materials are a combination of sodium alginate and pectin. The application realizes the concentration of the essence in the emulsion droplets and the physical isolation of the composite wall material raw materials through a W / O / W double emulsion template, and combines the rapid ionic gelation of the composite wall material raw materials, so that the loading rate of the essence is increased to more than 60%, which is much higher than the loading rate level of a traditional interfacial polymerization method (6.4%) and a conventional emulsion polymerization method (21.8%).

Disclosed in the present invention is a method for incubating self-assembled organic material crystals based on double emulsion droplets. W / O / W double emulsion droplets having uniform size are prepared by means of a microfluidic chip. During the preparation process of the double emulsion droplets, a self-assembled organic material solution is used as an internal aqueous phase solution, an intermediate oil phase solution is a water-insoluble solution, and a solution containing a relatively high salt concentration serves as an external aqueous phase solution to perform encapsulation of the self-assembled organic material solution, thereby preventing the self-assembled organic material from being released into the external aqueous phase solution. The double emulsion droplets loaded with the self-assembled organic material solution are incubated. By means of the concentration difference between the external aqueous phase solution and the internal aqueous phase solution, under the influence of osmotic pressure, water molecules in the internal aqueous phase solution migrate to the external aqueous phase, and thus the concentration of the self-assembled organic material in the double emulsion droplets also increases accordingly, thereby promoting the growth of self-assembled organic material crystals. Finally, the self-assembled organic material crystals having uniform size are obtained inside the double emulsion droplets, and each double emulsion droplet contains a single self-assembled organic material crystal.