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Method for preparing high molecular micro nanometer capsule

A micro-nano, polymer technology, applied in the direction of microsphere preparation, microcapsule preparation, microcapsules, etc., can solve the problem of carrying a variety of water-soluble drugs or oil-soluble drugs, and the difficulty of realizing water-soluble drugs and oil-soluble drugs. drug compatibility issues

Inactive Publication Date: 2007-10-17
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many ways to combine micro-nanocapsules and drugs, but the common problem is that it is difficult to realize the compatibility of water-soluble drugs and oil-soluble drugs, and it is difficult to carry a variety of different water-soluble drugs or oil-soluble drugs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Measure 4 mg of ibuprofen, and disperse it evenly in 20 mL of chloroform; take 0.1 g of poly-L-lactic acid with a molecular weight of 210,000, dissolve it in the above oil-soluble drug solution to form a polymer solution, and prepare 40 mL of 0. The polyvinyl alcohol aqueous solution of 1% (mass percentage) is standby;

[0031] Inject 0.5mL of double distilled water into the above polymer solution, stir at a stirring speed of 6000rpm for 0.5min to make a water-oil emulsion; then inject the above water-oil emulsion into the prepared aqueous solution of polyvinyl alcohol, stir at 300rpm Stir at a high speed for 1 min to make a water-oil-water double emulsion;

[0032] Prepare 60 mL of 0.5% (volume percent) isopropanol aqueous solution, inject the above-mentioned water-oil-water double emulsion into the prepared isopropanol aqueous solution, and continue stirring at a stirring speed of 2000 rpm for 8 hours to obtain a suspension of solidified microcapsules , centrifuging ...

Embodiment 2

[0035] Take 200mg of ciprofloxacin and disperse it evenly in 20mL of chloroform; take 5g of poly-L-lactic acid with a molecular weight of 210,000 and dissolve it in the above oil-soluble drug solution to form a polymer solution and prepare 40mL of 0.1% (mass percent) polyvinyl alcohol aqueous solution for subsequent use;

[0036] Inject 0.5mL of double distilled water into the above polymer solution, stir at a stirring speed of 6000rpm for 0.5min to make a water-oil emulsion; then inject the above water-oil emulsion into the prepared aqueous solution of polyvinyl alcohol, stir at 300rpm Stir at a high speed for 1 min to make a water-oil-water double emulsion;

[0037] Prepare 60 mL of 0.5% (volume percent) isopropanol aqueous solution, inject the above-mentioned water-oil-water double emulsion into the prepared isopropanol aqueous solution, and continue stirring at a stirring speed of 2000 rpm for 8 hours to obtain a suspension of solidified microcapsules , centrifuging the sus...

Embodiment 3

[0040] Measure 4mg of ibuprofen, and disperse it evenly in 20mL of dichloromethane; take 0.1g of polyorthoester with a molecular weight of 50,000, dissolve it in the above-mentioned oil-soluble drug solution to form a polymer solution, and prepare 200mL1 .0% (mass percentage) hydroxyethyl cellulose aqueous solution, 1mL 0.2mg / mL amino acid aqueous solution for later use;

[0041] Inject 1mL of 0.2mg / mL amino acid aqueous solution into the above polymer solution, stir at a stirring speed of 10000rpm for 1min to make a water-oil emulsion; then inject the above water-oil emulsion into the prepared hydroxyethyl cellulose aqueous solution, Stir for 3 minutes at a stirring speed of 1000rpm to make a water-oil-water double emulsion;

[0042] Prepare 220mL of 30% (volume percent) ethanol aqueous solution, inject the above-mentioned water-oil-water double emulsion into the prepared ethanol aqueous solution, and continue stirring at a stirring speed of 500rpm for 2h to obtain a suspensi...

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Abstract

The invention relates to a preparation method of macromolecule micro / nano-capsules in the field of macromolecule functional material, which has the following steps: firstly, to prepare a water soluble medical solution and an oil soluble medical solution; to dissolve the macromolecule material into the oil soluble medical solution to form a polymer solution; after that, to inject the water soluble medical solution into the polymer solution to make a water-oil latex; to inject the latex into stabilizer solution to get water-oil-water dual latex; then to inject the dual latex into the curing agent solution to get a suspension of curing microcapsules; to centrifuge the suspension to get the microcapsules, which is washed and cooling dried to get a dry powder put into the sealing container; and lastly to get the micro / nano-capsules after vacuumizing, charging to standard atmospheric pressure at moment and sealed conserving. The grain size of micro / nano-capsules is nm degree to micron degree, and can be used in the regular ultrasonic radiography and molecule imaging. The invention realizes the compatibility of water soluble and oil soluble medicines, and has the effect of controlled release.

Description

technical field [0001] The invention relates to a preparation method in the technical field of polymer materials, in particular to a preparation method of polymer micro-nano capsules. Background technique [0002] Drug microencapsulation products have been widely used as an important dosage form. The main purposes of drug microencapsulation include: ① Covering the bad smell and taste of drugs; ② Improving the stability of drugs; ③ Preventing the loss of drugs in the stomach. ④ Make liquid drugs solid for application and storage; ⑤ Favor the compatibility of compound drugs; ⑥ Make drugs have slow or controlled release properties; Encapsulation of cells or biologically active substances. The microcapsules of drugs have been developed from initial external use to oral administration and even intravenous injection. As a new type of drug carrier, micro-nanocapsule ultrasound contrast agents can not only enhance ultrasound imaging, but also have potential targeted therapeutic ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61K9/50
Inventor 孙康窦红静陆蓉
Owner SHANGHAI JIAO TONG UNIV
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