Compound medicine microcarrier with core-shell structure

Abstract

The invention discloses an emulsion multi-dimensional rapid preparation microfluidic device, and discloses a compound medicine microcarrier with a core-shell structure, and applications thereof. The compound medicine microcarrier with the core-shell structure is characterized by being prepared through taking W / O / W or O / W / O double emulsion as templates by adopting a microfluidic method, a core and a shell are respectively made of two degradable polymer materials with biocompatibility and are respectively hydrophilic and hydrophobic. The hydrophilic part can be loaded with various hydrophilic medicines, the hydrophobic part can be loaded with various hydrophobic medicines; along with the degradation of the core-shell material, the hydrophilic and hydrophobic drugs loaded internally can be sustainably released, and the purpose that the hydrophilic and hydrophobic medicines are simultaneously delivered and synergically slow-released can be achieved. In addition, the release rate of the medicine can be controlled by controlling the thickness of the shell layer. The microcapsule with the core-shell structure has the characteristics that the preparation method is low in cost, easy to operate and convenient to produce on large scale, and the like, the prepared medicine microcarrier has good biocompatibility, is high in medicine encapsulation rate, and good in controllability.

Description

technical field [0001] The invention belongs to the field of biological materials. It specifically relates to a composite drug microcarrier with a core-shell structure and its preparation method and application. The microcarrier can be used to simultaneously transport hydrophilic and hydrophobic drugs, and provides a new type of material for synergistic sustained-release drug delivery. Background technique [0002] The drug concentration in the human body by the general administration method can only be maintained for a short period of time, and the blood drug concentration must be maintained by frequent administration, which causes the drug concentration in the tissue to fluctuate greatly, which may cause side effects and patient compliance. Low. The drug release involved in the field of biology uses a certain matrix material as a carrier, embeds specific drug components, and releases it continuously to patients in a specific form and at a controlled rate. have a crucial ...

AI Technical Summary

Problems solved by technology

[0003] There are various methods for preparing microcarriers. Traditional methods include phase separation, spray drying, emulsification solvent evaporation, mechanical stirring, etc. However, the microcarriers prepared by these methods have large size distribution, non-uniform particle size, and monodisperse Due to the violent collision between microspheres caused by mechanical stirring, the microspheres break and the encapsulated drug is lost, resulting in poor drug encapsulation efficiency; in addition, because the traditional microcarriers are hollow microspheres or microspheres encapsulated with liquid, Once the outer shell is degraded, it will cause a burst release of the internal drug, and the sustained release effect is greatly limited

The co-delivery of multiple drugs, especially the co-delivery of hydrophilic and hydrophobic drugs is difficult to achieve

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