50 results about "Compounds drug" patented technology

The invention provides a system and method utilizing, among other things, fluorescence spectroscopy in the ultraviolet portion of the electromagnetic spectrum to determine chemical species and concentrations. The basic measuring system includes optics, a spectrograph, a detector, and an energy source (“head” components), along with a computer and control electronics and power source capable of generating and detecting unique fluorescence signatures for individual and unique mixtures of chemical substances including, for example, prescribed and/or compounded medications, alcohol products, food types, synthetic drugs, narcotics, perfumes, liquids, and the like.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament/factors continuously and stably in a certain time, along with great economic and social benefits.

The invention relates to a composite medicament stent for inhibiting cardiovascular restenosis and a preparation method. The stent is prepared by performing laser cutting on a metal tube; the surface of the stent is corroded by electrochemical acid solution so as to form nanopores; the surface of a main body is coated with a nondegradable bioactive coating with thickness of 10 to 50 microns; a degradable biocompatible polymer medicament coating with thickness of 10 to 100 microns are coated outside the nondegradable bioactive coating; the nondegradable bioactive coating is prepared by mixing a nondegradable biocompatible high polymer, active biological components, an organic solvent and the like to form solution and spraying and drying the solution and the like; and the medicament coating is prepared by mixing a degradable biocompatible high polymer, anti-restenosis medicament ingredients, an organic solvent and the like to form solution and spraying and drying the solution and the like. The composite medicament stent has the characteristics of slow medicament release and capability of effectively reducing restenosis and thrombosis at the later stage of stent implantation.

The invention discloses a drug-delivery absorbable hemostatic sponge, which belongs to the technical field of novel hemostatic materials and comprises drug-loaded chitosan microsphere and collagen protein, wherein the drug-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The weight ratios of the medicinal grade chitosan to the medicinal grade tranexamic acid are (0.01-100):1 respectively. The invention also discloses a method for preparing the drug-delivery absorbable hemostatic sponge. By selecting collagen with good hemostatic function and biocompatibility as the main hemostatic substrate, compounding the drug-delivery chitosan microsphere and the medicinal grade tranexamic acid, and making use of the special properties of the chitosan including hemostatic function and drug-delivery function, a novel hemostatic sponge with rapid hemostasis and lasting and steady drug delivery in a period of time can be prepared, and has considerable economic and social benefits.

The invention discloses a diastole bar apron sodium antibiotics and preparing craft, which is characterized by the following: allocating with mass ratio as 100-400 antibiotics, 100-400 diastole bar apron sodium, 10-300 liposome and 10-300 polyvinyl pyrrolidon; keeping the drug-effect of common diastole bar apron sodium antibiotics compound; prolonging nullifying half-decay time of the antibiotics; adding antioxidant into composite drug; increasing stability of the drug. This invention can prolongs the effective time of the drug.

The invention discloses a biocompatible nano composite drug carrier with a synergistic anti-tumor effect, a drug with a synergistic anti-tumor effect, and preparation methods of the biocompatible nano composite drug carrier and the drug. The biocompatible nano composite drug carrier provided by the invention comprises a core, a connecting layer coating the core and a shell layer coating the connecting layer, wherein the core is provided with degradable porous inorganic nano particles already absorbing anti-cancer drugs; the connecting layer is formed by polyelectrolyte; the shell layer is alternately assembled by protein and polyelectrolyte layer by layer; and the protein is selected from one tumor necrosis factor superfamily member. The invention has the advantages that by utilizing a layer-by-layer assembly technology, a great quantity of protein/polysaccharide nano composite drug carriers with core-shell structures can be prepared simply and conveniently; and the nano composite drug carrier can be used for wrapping and releasing water-soluble drugs, so that the cost is effectively reduced and scale production is easy to realize.

The invention provides a compound preparation containing diphosphonic acid compound and vitamin clathrate and a preparation method thereof, and belongs to the technology field of medicines. The compound preparation comprises (wt%) diphosphonic acid compound 5-50 and vitamin D 0.005-0.5, wherein the vitamin D is prepared into clathrate derivative with cyclodextrin, and the weight ratio of vitamin D to clathrate derivative is 1:(100-2,000). The invention provides a simple and practical preparation method for a compound preparation containing alendronate and vitamin D with the improved solubility and stability of vitamin D. The inventive compound preparation has definite therapeutic effect and good safety; and has improved solubility and stability of vitamin D due to clathration of vitamin D with cyclodextrin or derivative thereof, thereby being helpful for controlling content uniformity in case of low dose preparation production and reducing the loss vitamin D raw material during batch charging.

The invention relates to a ternary nano composite drug, a preparation method thereof, and an application of the drug in preparation of a pharmaceutical composition for treating tumors. The ternary nano composite drug comprises a core carrier, an active pharmaceutical ingredient, and a stabilizing agent which is used to cover the core carrier and the active pharmaceutical ingredient. The core carrier comprises a first nano particle, which can generate active free radicals by supersonic wave excitation, a composite nano particle having medicinal imaging signals on the basis of the first nano particle, or a combination of the first nano particle and the composite nano particle. The pharmaceutical ingredient is loaded on the core carrier. The stabilizing agent comprises hydrophilic polymer, liposome with hydroxyl groups or carboxylic groups on the surface, bovine serum albumin nano particles, human serum albumin nano particles, or combination thereof. The invention also relates to an application of a binary nano composite drug in preparation of a pharmaceutical composition which can be used to cure tumors through supersonic wave excitation. The tumor target treatment can be realized through the synergetic cooperation between supersonic wave treatment and chemotherapy.

The invention discloses a making method of drug coating on the elution rack, which comprises the following steps: dissolving vitamin A acid drug and polymer in the organic solvent to obtain the coating liquid of vitamin A acid; coating the liquid on the predisposed metal rack surface; evaporating solvent; obtaining the buried vitamin A acid coating; dissolving estrogen drug and polymer in the organic solvent to obtain estrogen coating liquid; coating on the surface of estrogen coating liquid; evaporating; obtaining the product; or dissolving vitamin A acid, estrogen drug and polymer in the organic solvent to obtain the composition of drug and polymer; coating on the predisposed metal rack surface; evaporating; burying in the drug coating of vitamin A acid and estrogen.

Kits for allowing pharmacist to easily compound medications are provided. The kits include a mixing container, a first active ingredient and an inactive ingredient. It is further provided that methods of mixing compounds. Some kits include coloring agents that aid in the establishment proper mixing. Other kits include colored labels located on the ingredients.

The invention belongs to a compound medicine administration method in the field of medical equipment. According to the compound medicine administration method, various liquid medicines are enabled to be packaged inside a capsule, the capsule is put into a needle cylinder, a pushing plug is installed in the needle cylinder, a pushing plate is installed inside the pushing plug, the pushing plate is fixed by a bolt, a pull ring is connected with one end of the bolt, a spring is installed between the pushing plate and the bottom of the pushing plug; a needle head is installed on the bottom of the needle cylinder, a hollow portion of the needle is a needle passage, one end of the needle head is inserted into the needle cylinder to serve as an inner needle head, the other end of the needle head servers as an injection needle head; a needle passage of the inner needle head is in a straight-through shape, or in a cross shape, or in a T shape; when medicines are administrated, the bolt is pulled out through the pull ring; under the function of the spring, the capsule is pressed by the pushing plate, the inner needle head is enabled to penetrate all capsules in sequence, and the liquid medicines flow into subcutaneous tissues or muscle. The compound medicine administration method is capable of completing multi-medicine injection processes at one time, ration is accurate, instruments are convenient to carry, operation is simple, the problem of mixing of a plurality of emergency treatment medicines is effectively resolved, and the compound medicine administration method is especially suitable for occasions of self-saving and mutual saving of wounded people.

The invention discloses a composite nano-drug constructed by nanoparticles coupled with pharmaceutical ingredients as well as a preparation method and an application of the composite nano-drug, and belongs to the technical field of composite drugs. The method for preparing the nano-drug comprises the following operations: modifying amino on the surfaces of nanoparticles which contain hydroxy in the surfaces, and activating biological or small-molecular drugs containing hydroxy; and then conducting a conjugate coupling reaction on the nanoparticles and the drugs, so that a plurality of chemicalbonds are constructed, combining the plurality of chemical bonds so as to prepare the nano-drug. Based upon researches, it is indicated that an anti-cancer effect can be greatly improved on the basisof a synergistic effect between active ingredients of natural drugs (such as taxol, ginsenoside and other traditional Chinese medicines) and a nano-material, and meanwhile, key and breakthrough points can be also provided for researching and producing efficient anti-cancer nano-drugs which are low or free from toxic and side effects and have targeting and autonomous targeting performances.

A method of producing solid composite lipid/drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid/drug nanoparticles suspended or dispersed in the liquid.

The invention discloses a copper telluride nanocomposite drug particle for thermal chemotherapy and a construction method thereof. Hydrophobic drugs; the surface of nanocomposite drug particles is modified with amphiphilic molecules. The copper telluride nanoparticles coated with oleic acid of the present invention can not only be used as a material for photothermal therapy of tumors, and can effectively kill cancer cells at a lower laser intensity and lower concentration; but also can be used as a drug carrier, thereby realizing The synergistic treatment of thermal chemotherapy can effectively improve the efficiency of tumor treatment; therefore, copper telluride nanoparticles have broad application prospects in drug delivery and tumor treatment.

The invention relates to a preparation method of an L-DOPA (levodopa) modified organic-inorganic composite medicine slow release stent coating. The L-DOPA modified organic-inorganic composite medicine slow release stent coating is prepared by the steps of hydrolyzing tetraethyl orthosilicate which is a precursor liquid of SiO2, polycondensing and mixing with polyethylene glycol (PEG) and medicine, wherein L-DOPA is added to be used as a coating modifying agent and the coating is prepared by adopting a pull method. The coating can realize slow release of loaded medicine while ensuring better bonding with a metal stent, and effectively avoids burst release.

The invention discloses a nano antitumor medicament prepared by compounding water-soluble polymer poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA) with isoplyacid having antitumor performance and a preparation method thereof. The method comprises the following steps of: preparing isoplyacid aqueous solution and macromoleclar polymer aqueous solution with certain concentration; and uniformly mixing the two kinds of solution to obtain the macromoleclar polymer-isoplyacid nano compound antitumor medicament. By the nano antitumor medicament, the ordered assembly of the polymer PGEA serving as a medicinal carrier with a bioactivity function and isoplyacid anions with antitumor medicinal value is realized for the first time, and the compound medicament has a nano order of magnitude. The compound medicament has a simple preparation process, high maneuverability and an economic, clean and pollution-free process.

The invention discloses an asiaticoside-based compound medicine for treating depression and belongs to the technical field of medical treatment. The compound medicine comprises asiaticoside and borneol. Compared with a medicine in which asiaticoside of the same dose is used alone, the compound medicine disclosed by the invention is higher in curative effect, and has the characteristics of fast effectiveness and obvious effect. In order to overcome the defects of antidepressant drugs in clinical application, particularly the defects such as great side effects and high treatment cost when the drugs are taken for a long time, the invention provides a pharmaceutical composition which is fast in effectiveness, low in price and small in side effects. According to combined application of asiaticoside and the traditional Chinese medicine borneol, a better treatment effect can be achieved compared with that of single use of asiaticoside. The experiments prove that the pharmaceutical composition can enhance the treatment effect of the medicine and reduce the actual dosage of the asiaticoside, so that the treatment cost is greatly reduced.

The invention discloses a composite medicament taking cyclopeptide RGD-modified graphene quantum dots as a carrier, and a preparation method and the application thereof. The composite medicament takesthe cyclopeptide RGD-modified graphene quantum dots as the carrier; the carrier is loaded with a medicament and a photosensitizer. According to the composite medicament disclosed by the invention, the targeting ability is effectively improved through cyclopeptide RGD; a photothermal effect is achieved through the graphene quantum dots; a photodynamic effect is achieved through the photosensitizer; a chemotherapeutic effect is achieved through an anti-cancer medicament; the purpose of treating cancer synergistically through thermal therapy, phototherapy and chemotherapy is achieved; the composite medicament has an inhibiting effect on a plurality of tumours. The composite medicament lays a foundation for synergistic treatment of active targeting, the thermal therapy, the phototherapy and the chemotherapy, and provides a new thought for multi-path synergistic treatment of the cancer.