51 results about "Compounds drug" patented technology

The invention provides a system and method utilizing, among other things, fluorescence spectroscopy in the ultraviolet portion of the electromagnetic spectrum to determine chemical species and concentrations. The basic measuring system includes optics, a spectrograph, a detector, and an energy source (“head” components), along with a computer and control electronics and power source capable of generating and detecting unique fluorescence signatures for individual and unique mixtures of chemical substances including, for example, prescribed and / or compounded medications, alcohol products, food types, synthetic drugs, narcotics, perfumes, liquids, and the like.

The invention provides a system and method utilizing, among other things, fluorescence spectroscopy in the ultraviolet portion of the electromagnetic spectrum to determine chemical species and concentrations. The basic measuring system includes optics, a spectrograph, a detector, and an energy source (“head” components), along with a computer and control electronics and power source capable of generating and detecting unique fluorescence signatures for individual and unique mixtures of chemical substances including, for example, prescribed and / or compounded medications, alcohol products, food types, synthetic drugs, narcotics, perfumes, liquids, and the like.

The invention relates to a composite drug stent and a preparation method thereof. The stent includes a stent body and active drugs; wherein, the stent body is a perforated medical material with good biocompatibility, which can be made by optionally using stainless steel, cobalt-based alloy, titanium alloy, nickel-titanium alloy, or polylactic acid bio-polymer material; the active drugs include special endothelial progenitor cell antibody drug and anti-smooth muscle cell proliferation drug. The internal surface of the perforated stent body is fixedly provided with the special endothelial cell antibody drug, while the external surface of the perforated stent body is coated with the anti-smooth muscle cell proliferation drug. The preparation method includes as follows: (1) pretreating the surface of the stent body; (2) making holes; (3) post-treating the surface of the stent body; (4) dispensing medicines; (5) coating the external surface; (6) fixing the internal surface; (7) drying at low temperature. The preparation method can selectively absorb endothelial progenitor cells and facilitate in repairing endodermis, and can effectively inhibit the proliferation and migration of vascular smooth muscle cells, persistently and effectively reduce the newborn endangium, effectively prevent the stent from narrowing, and avoid the risk of tardive thrombosis.

The invention discloses an emulsion multi-dimensional rapid preparation microfluidic device, and discloses a compound medicine microcarrier with a core-shell structure, and applications thereof. The compound medicine microcarrier with the core-shell structure is characterized by being prepared through taking W / O / W or O / W / O double emulsion as templates by adopting a microfluidic method, a core and a shell are respectively made of two degradable polymer materials with biocompatibility and are respectively hydrophilic and hydrophobic. The hydrophilic part can be loaded with various hydrophilic medicines, the hydrophobic part can be loaded with various hydrophobic medicines; along with the degradation of the core-shell material, the hydrophilic and hydrophobic drugs loaded internally can be sustainably released, and the purpose that the hydrophilic and hydrophobic medicines are simultaneously delivered and synergically slow-released can be achieved. In addition, the release rate of the medicine can be controlled by controlling the thickness of the shell layer. The microcapsule with the core-shell structure has the characteristics that the preparation method is low in cost, easy to operate and convenient to produce on large scale, and the like, the prepared medicine microcarrier has good biocompatibility, is high in medicine encapsulation rate, and good in controllability.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament / factors continuously and stably in a certain time, along with great economic and social benefits.

The invention relates to a composite medicament stent for inhibiting cardiovascular restenosis and a preparation method. The stent is prepared by performing laser cutting on a metal tube; the surface of the stent is corroded by electrochemical acid solution so as to form nanopores; the surface of a main body is coated with a nondegradable bioactive coating with thickness of 10 to 50 microns; a degradable biocompatible polymer medicament coating with thickness of 10 to 100 microns are coated outside the nondegradable bioactive coating; the nondegradable bioactive coating is prepared by mixing a nondegradable biocompatible high polymer, active biological components, an organic solvent and the like to form solution and spraying and drying the solution and the like; and the medicament coating is prepared by mixing a degradable biocompatible high polymer, anti-restenosis medicament ingredients, an organic solvent and the like to form solution and spraying and drying the solution and the like. The composite medicament stent has the characteristics of slow medicament release and capability of effectively reducing restenosis and thrombosis at the later stage of stent implantation.

The invention discloses a drug-delivery absorbable hemostatic sponge, which belongs to the technical field of novel hemostatic materials and comprises drug-loaded chitosan microsphere and collagen protein, wherein the drug-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The weight ratios of the medicinal grade chitosan to the medicinal grade tranexamic acid are (0.01-100):1 respectively. The invention also discloses a method for preparing the drug-delivery absorbable hemostatic sponge. By selecting collagen with good hemostatic function and biocompatibility as the main hemostatic substrate, compounding the drug-delivery chitosan microsphere and the medicinal grade tranexamic acid, and making use of the special properties of the chitosan including hemostatic function and drug-delivery function, a novel hemostatic sponge with rapid hemostasis and lasting and steady drug delivery in a period of time can be prepared, and has considerable economic and social benefits.

The invention provides a medical sodium alginate gel microsphere and a preparation method and application of the medical sodium alginate gel microsphere. The medical sodium alginate gel microsphere consists of a composite medicine carrier and a water-insoluble medicine; the medicine is coated with the composite medicine carrier; and the composite medicine carrier is an ion crosslinking agent-sodium alginate-divalent metal ion, wherein the ion crosslinking agent is 4-aminomethylbenzoic acid or tranexamic acid. The preparation method comprises the following steps of: (1) mixing ion crosslinking agent aqueous solution with divalent metal ion solution in the same volume to obtain composite solidifying liquid; (2) dispersing medicine powder or an agent into sodium alginate aqueous solution; uniformly mixing; dropwise adding the mixture into the composite solidifying liquid obtained in step (1) through a high-voltage static droplet generating device or a syringe needle, so that the mixture drops are solidified into spheres; and (3) dehydrating gel microspheres which are washed with the distilled water; and drying at normal temperature. The medical sodium alginate gel microsphere can be used for treating tuberculosis, endocrine disease and tumor, and also can be used for treating local acute hemorrhage and chronic errhysis.

The invention discloses a diastole bar apron sodium antibiotics and preparing craft, which is characterized by the following: allocating with mass ratio as 100-400 antibiotics, 100-400 diastole bar apron sodium, 10-300 liposome and 10-300 polyvinyl pyrrolidon; keeping the drug-effect of common diastole bar apron sodium antibiotics compound; prolonging nullifying half-decay time of the antibiotics; adding antioxidant into composite drug; increasing stability of the drug. This invention can prolongs the effective time of the drug.

The invention discloses a biocompatible nano composite drug carrier with a synergistic anti-tumor effect, a drug with a synergistic anti-tumor effect, and preparation methods of the biocompatible nano composite drug carrier and the drug. The biocompatible nano composite drug carrier provided by the invention comprises a core, a connecting layer coating the core and a shell layer coating the connecting layer, wherein the core is provided with degradable porous inorganic nano particles already absorbing anti-cancer drugs; the connecting layer is formed by polyelectrolyte; the shell layer is alternately assembled by protein and polyelectrolyte layer by layer; and the protein is selected from one tumor necrosis factor superfamily member. The invention has the advantages that by utilizing a layer-by-layer assembly technology, a great quantity of protein / polysaccharide nano composite drug carriers with core-shell structures can be prepared simply and conveniently; and the nano composite drug carrier can be used for wrapping and releasing water-soluble drugs, so that the cost is effectively reduced and scale production is easy to realize.

The invention provides a compound preparation containing diphosphonic acid compound and vitamin clathrate and a preparation method thereof, and belongs to the technology field of medicines. The compound preparation comprises (wt%) diphosphonic acid compound 5-50 and vitamin D 0.005-0.5, wherein the vitamin D is prepared into clathrate derivative with cyclodextrin, and the weight ratio of vitamin D to clathrate derivative is 1:(100-2,000). The invention provides a simple and practical preparation method for a compound preparation containing alendronate and vitamin D with the improved solubility and stability of vitamin D. The inventive compound preparation has definite therapeutic effect and good safety; and has improved solubility and stability of vitamin D due to clathration of vitamin D with cyclodextrin or derivative thereof, thereby being helpful for controlling content uniformity in case of low dose preparation production and reducing the loss vitamin D raw material during batch charging.

The invention provides compositions and methods for the convenient compounding of pharmaceuticals. Single and multiple unit of use kits are provided which contain all the necessary components required for preparing a compounded pharmaceutical. The kits of the invention include a first container having a first active agent and a second container having at least one second inactive agent. The kits of the invention are also useful for compounding veterinary pharmaceuticals.

The invention relates to a ternary nano composite drug, a preparation method thereof, and an application of the drug in preparation of a pharmaceutical composition for treating tumors. The ternary nano composite drug comprises a core carrier, an active pharmaceutical ingredient, and a stabilizing agent which is used to cover the core carrier and the active pharmaceutical ingredient. The core carrier comprises a first nano particle, which can generate active free radicals by supersonic wave excitation, a composite nano particle having medicinal imaging signals on the basis of the first nano particle, or a combination of the first nano particle and the composite nano particle. The pharmaceutical ingredient is loaded on the core carrier. The stabilizing agent comprises hydrophilic polymer, liposome with hydroxyl groups or carboxylic groups on the surface, bovine serum albumin nano particles, human serum albumin nano particles, or combination thereof. The invention also relates to an application of a binary nano composite drug in preparation of a pharmaceutical composition which can be used to cure tumors through supersonic wave excitation. The tumor target treatment can be realized through the synergetic cooperation between supersonic wave treatment and chemotherapy.

The invention provides compositions and methods for the convenient compounding of pharmaceuticals. Single and multiple unit of use kits are provided which contain all the necessary components required for preparing a compounded pharmaceutical. The kits of the invention include a first container having a first active agent and a second container having at least one second inactive agent. The kits of the invention are also useful for compounding veterinary pharmaceuticals.

The invention discloses a making method of drug coating on the elution rack, which comprises the following steps: dissolving vitamin A acid drug and polymer in the organic solvent to obtain the coating liquid of vitamin A acid; coating the liquid on the predisposed metal rack surface; evaporating solvent; obtaining the buried vitamin A acid coating; dissolving estrogen drug and polymer in the organic solvent to obtain estrogen coating liquid; coating on the surface of estrogen coating liquid; evaporating; obtaining the product; or dissolving vitamin A acid, estrogen drug and polymer in the organic solvent to obtain the composition of drug and polymer; coating on the predisposed metal rack surface; evaporating; burying in the drug coating of vitamin A acid and estrogen.

The invention relates to a polyacrylic acid-calcium phosphate composite nano-drug carrier and a preparing method and application thereof. The preparing method includes the following steps: (1) a microcosmic salt aqueous solution is rapidly poured into a calcium source aqueous solution, ammonium hydroxide is added to adjust the pH value, even stirring is carried out, and centrifugation washing is carried out after a reaction is carried out to obtain sediment; and (2) the sediment obtained in the step (1) is dispersed into deionized water again, polyacrylic acid is added, and stable polyacrylic acid-calcium phosphate composite nanoparticle suspension liquid is obtained through ultrasonic dispersion. The polyacrylic acid-calcium phosphate composite nano-drug carrier has the beneficial effects that the process is simple, raw materials are easy to obtain, the production process is environment-friendly and safe, the preparing period is short, and the overall process can be completed within one hour. The polyacrylic acid-calcium phosphate composite nano-drug carrier is good in biocompatibility, safe and free of toxic and side effects. Loading and slow releasing of a medicine can be achieved, the toxic and side effects caused by short-time high-concentration medicines can be avoided, and the using rate of the medicines can be improved.

Kits for allowing pharmacist to easily compound medications are provided. The kits include a mixing container, a first active ingredient and an inactive ingredient. It is further provided that methods of mixing compounds. Some kits include coloring agents that aid in the establishment proper mixing. Other kits include colored labels located on the ingredients.

The invention belongs to a compound medicine administration method in the field of medical equipment. According to the compound medicine administration method, various liquid medicines are enabled to be packaged inside a capsule, the capsule is put into a needle cylinder, a pushing plug is installed in the needle cylinder, a pushing plate is installed inside the pushing plug, the pushing plate is fixed by a bolt, a pull ring is connected with one end of the bolt, a spring is installed between the pushing plate and the bottom of the pushing plug; a needle head is installed on the bottom of the needle cylinder, a hollow portion of the needle is a needle passage, one end of the needle head is inserted into the needle cylinder to serve as an inner needle head, the other end of the needle head servers as an injection needle head; a needle passage of the inner needle head is in a straight-through shape, or in a cross shape, or in a T shape; when medicines are administrated, the bolt is pulled out through the pull ring; under the function of the spring, the capsule is pressed by the pushing plate, the inner needle head is enabled to penetrate all capsules in sequence, and the liquid medicines flow into subcutaneous tissues or muscle. The compound medicine administration method is capable of completing multi-medicine injection processes at one time, ration is accurate, instruments are convenient to carry, operation is simple, the problem of mixing of a plurality of emergency treatment medicines is effectively resolved, and the compound medicine administration method is especially suitable for occasions of self-saving and mutual saving of wounded people.

The invention discloses a composite nano-drug constructed by nanoparticles coupled with pharmaceutical ingredients as well as a preparation method and an application of the composite nano-drug, and belongs to the technical field of composite drugs. The method for preparing the nano-drug comprises the following operations: modifying amino on the surfaces of nanoparticles which contain hydroxy in the surfaces, and activating biological or small-molecular drugs containing hydroxy; and then conducting a conjugate coupling reaction on the nanoparticles and the drugs, so that a plurality of chemicalbonds are constructed, combining the plurality of chemical bonds so as to prepare the nano-drug. Based upon researches, it is indicated that an anti-cancer effect can be greatly improved on the basisof a synergistic effect between active ingredients of natural drugs (such as taxol, ginsenoside and other traditional Chinese medicines) and a nano-material, and meanwhile, key and breakthrough points can be also provided for researching and producing efficient anti-cancer nano-drugs which are low or free from toxic and side effects and have targeting and autonomous targeting performances.

A method of producing solid composite lipid / drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid / drug nanoparticles suspended or dispersed in the liquid.

The present invention relates to the field of medicine technology. The in-vivo self-degradable epitradural adhesion prevention and its composite medicine slow-releasing biological film are prepared with chitin and polylactic acid and serves to prevent adhesion, and the medicines in the composite film, such as nutrient medicine, chemotherapeutic drug and antiphlogistic are locally slow-released. The biological film can be degraded and absorbed with in the body.

The invention provides compositions and methods for the convenient compounding of pharmaceuticals. Single and multiple unit of use kits are provided which contain all the necessary components required for preparing a compounded pharmaceutical. The kits of the invention include a first container having a first active agent and a second container having at least one second inactive agent. The kits of the invention are also useful for compounding veterinary pharmaceuticals.

The present embodiments may relate to topically delivered compounded medications for the treatment of scar tissue, skin disorders, and / or other ailments. In one aspect, a transdermal cream or gel may provide for the effective administration of multiple medications simultaneously. Preferably, a silicone-based gel may be provided as a base composition and may have a non-zero percentage of silicone or silicone variant. The silicone-based gel may comprise cyclopentasiloxane, polysilicone-11, dimethicone, and C30-45 alkyl cetearyl dimethicone crosspolymer, and include several active ingredients, such as glucocorticoids, antihistamines, and nerve depressants. The silicone-based gel may include a combination of fluticasone, loratadine, and gabapentin. The concentrations of fluticasone and loratadine may be relatively low, while that of gabapentin moderately high. The silicone-based gel may also have one or more local anesthetics, such as prilocaine and / or lidocaine. The silicone-based gel may include additional active ingredients, such as NSAIDs, anticonvulsants, antidepressants, muscle relaxants, and / or other active ingredients.

The invention discloses a copper telluride nanocomposite drug particle for thermal chemotherapy and a construction method thereof. Hydrophobic drugs; the surface of nanocomposite drug particles is modified with amphiphilic molecules. The copper telluride nanoparticles coated with oleic acid of the present invention can not only be used as a material for photothermal therapy of tumors, and can effectively kill cancer cells at a lower laser intensity and lower concentration; but also can be used as a drug carrier, thereby realizing The synergistic treatment of thermal chemotherapy can effectively improve the efficiency of tumor treatment; therefore, copper telluride nanoparticles have broad application prospects in drug delivery and tumor treatment.

The invention relates to a preparation method of an L-DOPA (levodopa) modified organic-inorganic composite medicine slow release stent coating. The L-DOPA modified organic-inorganic composite medicine slow release stent coating is prepared by the steps of hydrolyzing tetraethyl orthosilicate which is a precursor liquid of SiO2, polycondensing and mixing with polyethylene glycol (PEG) and medicine, wherein L-DOPA is added to be used as a coating modifying agent and the coating is prepared by adopting a pull method. The coating can realize slow release of loaded medicine while ensuring better bonding with a metal stent, and effectively avoids burst release.

The invention discloses a nano antitumor medicament prepared by compounding water-soluble polymer poly (2-hydroxyl-3-(2-hydroxyethylamino) propyl methacrylate) (PGEA) with isoplyacid having antitumor performance and a preparation method thereof. The method comprises the following steps of: preparing isoplyacid aqueous solution and macromoleclar polymer aqueous solution with certain concentration; and uniformly mixing the two kinds of solution to obtain the macromoleclar polymer-isoplyacid nano compound antitumor medicament. By the nano antitumor medicament, the ordered assembly of the polymer PGEA serving as a medicinal carrier with a bioactivity function and isoplyacid anions with antitumor medicinal value is realized for the first time, and the compound medicament has a nano order of magnitude. The compound medicament has a simple preparation process, high maneuverability and an economic, clean and pollution-free process.

A method of producing solid composite lipid / drug nanoparticles that includes the steps of: (1) dissolving a lipid and a drug in a suitable organic solvent to form a solution; (2) emulsifying the solution in a liquid to form an emulsion having a discontinuous phase of micelles comprising the organic solvent, the drug and the lipid, and a continuous phase comprising the liquid; and (3) contacting the emulsion with a supercritical fluid under conditions suitable to keep the supercritical fluid in a supercritical state, whereby the supercritical fluid extracts the organic solvent from the micelles, causing them to precipitate as organic-solvent free solid composite lipid / drug nanoparticles suspended or dispersed in the liquid.

The invention discloses a composite drug carrier based on metal nanoparticles and microgel and an application thereof. The composite drug carrier is formed by precious metal nanoparticles and attachedthermal response polymer gel microspheres skeleton, and the attached thermal response polymer gel microspheres skeleton is the skeleton formed by poly (N-isopropyl acrylamide)PNIPAM microspheres; andthe precious metal nanoparticles are gold nanospheres. The carrier is used on drug release and combined photo-thermal treatment; The nano gold is used for coating invasive microgel to change the surface chemistry of the microgel, a composite drug-loaded system is constructed, the nano gold has good biological compatibility and efficient thermal responsiveness, can achieve drug thermal response controlled release, has combined photo-thermal treatment effect, and achieves a drug combined treatment purpose.

The invention discloses an asiaticoside-based compound medicine for treating depression and belongs to the technical field of medical treatment. The compound medicine comprises asiaticoside and borneol. Compared with a medicine in which asiaticoside of the same dose is used alone, the compound medicine disclosed by the invention is higher in curative effect, and has the characteristics of fast effectiveness and obvious effect. In order to overcome the defects of antidepressant drugs in clinical application, particularly the defects such as great side effects and high treatment cost when the drugs are taken for a long time, the invention provides a pharmaceutical composition which is fast in effectiveness, low in price and small in side effects. According to combined application of asiaticoside and the traditional Chinese medicine borneol, a better treatment effect can be achieved compared with that of single use of asiaticoside. The experiments prove that the pharmaceutical composition can enhance the treatment effect of the medicine and reduce the actual dosage of the asiaticoside, so that the treatment cost is greatly reduced.