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Drug-delivery absorbable hemostatic sponge and method for preparing same

A hemostatic sponge and drug technology, applied in absorbent pads, medical science, bandages, etc., can solve the problems of application limitations, poor tissue adhesion, virus infection, etc., and achieve great economic and social benefits

Inactive Publication Date: 2009-12-02
深圳市朗天文化创意有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic materials reported at present mainly include powders (zeolite, collagen powder and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose and fibrin glue, etc., and they have certain weak points respectively: gelatin and Collagen has poor tissue adhesion, and the hemostatic function of both depends on sufficient platelets and coagulation factors, so the application is limited; fibrin glue is derived from blood, which may cause viral infection; porous zeolite and potato starch absorb The water in the blood will release a lot of heat, causing wound inflammation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1 gram of deacetylation is 40% chitosan (molecular weight is between 20,000-300,000) dissolved in 100ml 0.2% (v / v) acetic acid solution, and 0.1 gram of drug tranexamic acid is added to obtain chitosan and drug acetic acid solution A; add solution A droplet into emulsifier 10% paraffin solution B, stir at room temperature for 10 minutes at high speed, then add 5 grams of cross-linking agent tripolyphosphate, and continue stirring at room temperature for 10 minutes to obtain the drug-loaded shell Polycan microspheres; 1 gram of drug-loaded chitosan microspheres is placed in 20ml 2% (mass volume fraction) human collagen solution and stirred at room temperature for 10 min, placed in a rectangular mold, the collagen containing drug microspheres is freeze-dried and By Co 60 The desired hemostatic sponge was obtained after irradiating and sterilizing.

Embodiment 2

[0026] 1 gram of deacetylation is 60% chitosan (molecular weight is between 20,000-300,000) dissolved in 100ml 1% (v / v) acetic acid solution, and 0.1 gram of drug tranexamic acid is added to obtain chitosan and the acetic acid solution A of the drug; add the solution A droplet into the emulsifier 20% paraffin solution B, stir at room temperature for 10 minutes at high speed, add 0.5 g of cross-linking agent tripolyphosphate, and continue stirring at room temperature for 100 minutes to obtain the drug-loaded shell Polycan microspheres; place 0.1 gram of drug-loaded chitosan microspheres in 20ml 2% (mass volume fraction) human-like collagen solution and stir at room temperature for 10 min, place them in a rectangular mold, and freeze-dry the collagen containing drug microspheres And by Co 60 The desired hemostatic sponge was obtained after irradiating and sterilizing.

Embodiment 3

[0028] 1 gram of deacetylation is 80% chitosan (molecular weight is between 20,000-300,000) dissolved in 100ml 2% (v / v) acetic acid solution, and 0.1 gram of drug tranexamic acid is added to obtain chitosan and the acetic acid solution A of the drug; add the solution A droplet into the emulsifier 5% paraffin solution B, stir at room temperature for 10 minutes at high speed, then add 10 grams of cross-linking agent tripolyphosphate, and continue stirring at room temperature for 10 minutes to obtain the drug-loaded shell Polycan microspheres; 1 gram of drug-loaded chitosan microspheres is placed in 20ml 1% (mass volume fraction) human collagen solution and stirred at room temperature for 10 min, placed in a rectangular mold, the collagen containing drug microspheres is freeze-dried and By Co 60 The desired hemostatic sponge was obtained after irradiating and sterilizing.

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PUM

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Abstract

The invention discloses a drug-delivery absorbable hemostatic sponge, which belongs to the technical field of novel hemostatic materials and comprises drug-loaded chitosan microsphere and collagen protein, wherein the drug-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The weight ratios of the medicinal grade chitosan to the medicinal grade tranexamic acid are (0.01-100):1 respectively. The invention also discloses a method for preparing the drug-delivery absorbable hemostatic sponge. By selecting collagen with good hemostatic function and biocompatibility as the main hemostatic substrate, compounding the drug-delivery chitosan microsphere and the medicinal grade tranexamic acid, and making use of the special properties of the chitosan including hemostatic function and drug-delivery function, a novel hemostatic sponge with rapid hemostasis and lasting and steady drug delivery in a period of time can be prepared, and has considerable economic and social benefits.

Description

technical field [0001] The invention belongs to the technical field of novel hemostatic materials, and in particular relates to a drug slow-release absorbable hemostatic sponge with simple preparation, good biocompatibility, remarkable effect and the function of main drug treatment and a preparation method thereof. Background technique [0002] In the first aid treatment of sudden accidents and trauma hemostasis during surgery, it is very important for patients to effectively and quickly stop bleeding locally. The hemostatic materials reported at present mainly include powders (zeolite, collagen powder and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose and fibrin glue, etc., and they have certain weak points respectively: gelatin and Collagen has poor tissue adhesion, and the hemostatic function of both depends on sufficient platelets and coagulation factors, so the application is limited; fibrin glue is derived from blood, w...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/20A61L15/44
Inventor 甘少磊王万霞
Owner 深圳市朗天文化创意有限公司
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