Self-crosslinked hydroformylated bacterial cellulose functional porous nano-material and preparation method thereof

Abstract

The invention relates to a self-crosslinked hydroformylated bacterial cellulose porous nano-material and a preparation method thereof. The material comprises bacterial cellulose, polysaccharides or polypeptides, an antibacterial agent and a foaming agent. The preparation method comprises the following steps: dissolving the polysaccharides or polypeptides, stirring the polysaccharides or polypeptides to form a solution, adding a certain amount of dispersed hydroformylated bacterial cellulose, a certain amount of the antibacterial agent (or antibacterial sol) and a certain amount of the foaming agent to the solution, stirring all above materials to make bubbles uniformly exist in the obtained mixed solution, pouring the mixed solution to a die, quenching the above sample, placing the quenched sample in a vacuum lyophilizer, and carrying out vacuum drying to prepare the self-crosslinked degradable polysaccharide or polypeptide composite hydroformylated bacterial cellulose functional porous nano-material. The material has the inherent good mechanical performances of a porous material, also as the advantages of good biocompatibility, fast dry state wetting rate, good attachment to skins, and good antibacterial function, and can be used as various medical wound repairing materials, multifunctional wound dressings and novel tissue engineering scaffolds.

Description

technical field [0001] The present invention relates to a self-crosslinking degradable formaldehyde nano-bacteria cellulose functional porous material applied in many fields such as medical hemostasis, biological antibacterial, wound repair, tissue engineering porous scaffold, etc., especially relates to a biocompatible, permeable The invention discloses a functional porous material of aldehydized nano-bacteria cellulose with good mechanical strength through self-crosslinking, rapid local hemostasis and antibacterial, reducing wound infection rate, degradable and good skin adhesion, and a preparation method thereof. Background technique [0002] Porous material is a microporous material with solid medium as material and countless pores inside the matrix, and it can also be regarded as a composite material with gas as filler. In recent years, as wound dressings, wound repair materials, and scaffold materials for cells to carry out life activities in tissue engineering, their ...

AI Technical Summary

Problems solved by technology

The products produced by these processes all use cross-linking agents to improve the mechanical properties of polysaccharide porous materials, but the cross-linking agent residues have certain toxicity to the human body, and they cannot have good performance without foaming into porous materials.

There is also a patent that discloses a bacterial cellulose / chitosan composite sponge dressing. The bacterial cellulose strips are mixed with chitosan solution, and the porous material made has poor performance due to no chemical crosslinking reaction. ; In addition, the bacterial cellulose strips are mixed with chitosan solution, the bacterial cellulose is not uniformly dispersed, and the prepared porous material has defects, and the performance of different parts is quite different

[0005] In the patent documents published above involving polysaccharides, polypeptides or bacterial cellulose porous materials, the moisture absorption, hemostasis, and antibacterial properties of porous materials need to be improved; cross-linking agents are used, and their residues are toxic to the human body; the permeability, Poor skin adhesion, easy to fall off

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