Traditional Chinese medicinal powder and preparation method thereof

A technology for traditional Chinese medicine powder and traditional Chinese medicinal materials, which is applied in the directions of pharmaceutical formulations, powder delivery, and medical preparations containing active ingredients, etc. Increases hydrophilicity and reduces fishy odor

Active Publication Date: 2012-07-04
四川厚德医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For active or toxic drug powders, uneven mixing will have serious consequences
[0012] How to avoid defects such as uneven drug components and easy loss of some special components caused by the random agglomeration of the physical properties of the powder after ultrafine pulverization after the single raw material or compound drug is prepared into powder, so that the drug (or compound drug) After the drug) is prepared into a powder, the composition of the drug (particle) remains consistent on the microscopic level, so as to ensure that the quality of the powder is stable and controllable. The processing and preparation technology of traditional Chinese medicine powder has become an important proposition

Method used

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  • Traditional Chinese medicinal powder and preparation method thereof
  • Traditional Chinese medicinal powder and preparation method thereof
  • Traditional Chinese medicinal powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1 The basic procedure of Chinese medicine powder particle design of the present invention

[0067] The basic process of traditional Chinese medicine particle design includes: (1) pretreatment of medicinal materials; (2) determination of powder parameters; (3) formulation of design procedures and screening of structural models; (4) control of process parameters; (5) establishment of evaluation models.

[0068] Pretreatment of medicinal materials: The medicinal materials must be fully dried before being pulverized. Generally, it is best to control the water content within the range of 3-5%. The prescribed medicinal materials are separately crushed into coarse powder (80-100 mesh) for later use.

[0069] Determination of powder parameters: determination of particle size distribution, shape, specific surface area, moisture absorption rate, critical relative humidity, wettability, angle of repose, bulk density, void ratio, compression degree, dissolution rate, fib...

Embodiment 2

[0073] Example 2 Study on the Influence of Pretreatment of Chinese Medicinal Materials on Particle Forming in the Preparation of Chinese Medicinal Powder of the Present Invention

[0074] (1) The particle size variation of Indigo Naturalis granules, Indigo Naturalis coarse powder, and Indigo Naturalis fine powder at different time points

[0075] Take Qingdai granules (raw materials provided by the company), Qingdai coarse powder (between No. 1 sieve and No. 2 sieve), and Qingdai fine powder (between No. 7 sieve and No. 9 sieve), and control the moisture content at about 3%. Study the change rule of the material fineness at different crushing time points for the above three samples under the same feeding amount and the same crushing conditions. The initial feeding is 700g, and samples are taken at 3, 6, 9, 12, 15, and 17 minutes respectively, each sampling volume is about 5g, and the change of particle size distribution is measured by the Malvern laser particle size diffractom...

Embodiment 3

[0088] Embodiment 3 solves the oxidation loss of the anthraquinone components in rhubarb in Liaoyuan Qili powder during storage

[0089] Liaoyuan Qilisan was first recorded in the sixth volume of "Ministry of Health's Drug Standard Traditional Chinese Medicine Prescriptions" in 1992, and it was added and subtracted from the classic prescription Qilisan. This product can be taken orally and can be used externally, and can be widely used for bruises, redness, swelling and pain caused by internal stagnation of blood stasis, and has good market potential. However, due to the ultrafine grinding, the anthraquinone components in the rhubarb medicinal material are directly exposed to the air, the specific surface area is large, and the contact area with oxygen is large, so it is easy to be oxidized and lost, resulting in a decrease in drug efficacy. Therefore, Chinese medicine particle design technology is used to wrap rhubarb powder containing anthraquinones in the inner layer to iso...

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Abstract

The invention relates to a traditional Chinese medicinal powder. The traditional Chinese medicinal powder comprises the following traditional Chinese medicinal herbs in part by weight: 0.5-1 part of medicinal framework material, a medicinal core material which is 1-5 times of the medicinal framework material, and 0-30 parts of compound medicinal material, wherein the medicinal framework material and the compound medicinal material are medicinal materials which contain fiber as a prescription raw material or have stable physical and chemical properties and stability, low moisture absorption, small irritation; and the medicinal core material is the medicinal material which contains volatile, easily-oxidized and unstable traditional Chinese medicinal active components, or is easy to absorb moisture and irritant to oral mucous membrane or gastrointestinal mucous membrane or is poor in taste and color. The traditional Chinese medicinal powder can change the physical properties of medicinal particles and can reduce the loss of easily-oxidized components and the volatility of volatile components; the moisture absorption of the medicinal powder can be improved; the hydrophilicity (wettability) of the medicinal powder can be increased; the mixing uniformity of multiple materials can be improved; the irritation of the medicine to the oral mucous membrane or the gastrointestinal mucous membrane, and the stench of the medicine can be reduced; and the mouthfeel and the color of the medicine can be improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine powder and a preparation method thereof. It belongs to the field of medicine. Background technique [0002] In the application of traditional Chinese medicine, some single or compound medicines need to be powdered into medicine due to the characteristics of the medicine itself and the characteristics of the disease to be treated. This kind of medicine powder has a sharp increase in the surface area per unit volume (or weight) of the medicine because of its small particles. Its physical and chemical properties change, which affects the process of crushing, sieving, mixing, sedimentation, filtration, drying and other processes of drugs in production, as well as the molding and production of various dosage forms. In addition, the basic characteristics of the micropowder (such as particle size and surface area) also directly affect the release and efficacy of the drug. [0003] Micropowder is also c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/14
Inventor 王达宾杨明杨胜郭治平张定堃
Owner 四川厚德医药科技有限公司
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