The invention discloses a citrus powder composition capable of neutralizing the effect of alcoholic drinks and protecting the liver, and a preparation method of the citrus powder composition, and belongs to the field of food processing. The citrus powder composition capable of neutralizing the effect of alcoholic drinks and protecting the liver is prepared from the following raw materials of citrus powder, radix puerariae powder, carrot powder and traditional Chinese medicine powder, and is prepared through the following steps of preparing the traditional Chinese medicine powder, performing blending, performing steaming, performing drying, performing crushing, performing packaging and the like. The citrus powder composition capable of neutralizing the effect of alcoholic drinks and protecting the liver disclosed by the invention has the following characteristics that compared with a conventional medicine capable of neutralizing the effect of alcoholic drinks, the citrus powder composition capable of neutralizing the effect of alcoholic drinks and protecting the liver can neutralize the effect of alcoholic drinks and can also complement nutrient substances desired by human bodies at the same time, besides, the citrus powder composition capable of neutralizing the effect of alcoholic drinks and protecting the liver is powdery, so that the citrus powder composition capable of neutralizing the effect of alcoholic drinks and protecting the liver is good in solubility, absorption by the human bodies is facilitated, and the efficacy of neutralizing the effect of alcoholic drinks can be faster to achieve; the added traditional Chinese medicine powder has the efficacies of promoting the circulation of qi, promoting diuresis, regulating the function of the stomach, neutralizing the effect of alcoholic drinks, protecting the liver, relieving vomiting, preventing gastrointestinal mucosas from absorbing alcohol, reducing alcohol concentration in blood, alleviating burning sensation of the stomach and the like, so that the gastrointestinal mucosas are protected; and in addition, the whole preparation process is free from additives, safe and free from side effects.