21results about How to "Good injectability" patented technology

The invention relates to injectable cross-linked collagen gel and a preparation method thereof. Two crosslinking strategies of self-crosslinking and crosslinking agent crosslinking are fused together for the first time, and two types of amido bonds, namely amido bonds of a collagen-collagen structure (A) and amido bonds of a collagen-fatty amine-collagen structure (B), are respectively constructed through two crosslinking paths, namely catalysis of collagen polypeptide self-crosslinking and catalysis of fatty amine crosslinking, so that a hard / soft dual crosslinking network is obtained. The relative proportion of the structure A and the structure B in the final product is adjusted through a proper cross-linking process, so that the strength and the stability of the final product are adjusted and controlled, and the use requirements of different injection parts can be met.

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses sequential slow-release temperature-sensitive hydrogel and a preparation method and application thereof.The preparation method comprises the following steps that a blood sample is subjected to programmed centrifugation, and a gel layer of leukocyte-rich platelet-rich fibrin L-PRF and a gel layer of improved platelet-rich fibrin A-PRF are obtained respectively; and the gel layer is cut into pieces, pre-frozen, freeze-dried, ground and sieved, so that L-PRF freeze-dried powder and A-PRF freeze-dried powder are obtained respectively, and the methacrylic acid gelatin microspheres entrapped with the L-PRF freeze-dried powder are prepared. The microspheres and A-PRF freeze-dried powder are loaded into a temperature-sensitive hydrogel system composed of chitosan, polygalacturonic acid and sodium beta-glycerophosphate, so that the growth factors can be effectively entrapped in the hydrogel structure, and continuous release is realized; the system has good mechanical strength and structural stability, the retention time of the material in vivo is prolonged, and stable three-dimensional network support is provided.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The application discloses a kind of nanocomposite hydrogel for treating osteoarthritis and its preparation method and application, the nanocomposite hydrogel includes cerium dioxide nanoparticles, the cerium dioxide nanoparticles are modified with hyaluronic acid;Ergothioneine is loaded on hyaluronic acid modified cerium dioxide nanoparticles to form nanocomposite EGT-CeO2@HA;And temperature-sensitive hydrogel carrier, the nanocomposite EGT-CeO2@HA is uniformly dispersed in the temperature-sensitive hydrogel carrier.This composite hydrogel can activate ATF4-dependent pro-survival autophagy pathway, reduce cartilage cell inflammatory damage, and improve cartilage degeneration.

The invention discloses a nano composite hydrogel based on phase engineering 1T-MoSe2 as well as a preparation method and application of the nano composite hydrogel. The nano composite hydrogel comprises a temperature-sensitive hydrogel matrix, and the < 1 > T-MoSe2 nanosheets are dispersed in the hydrogel matrix. The hydrogel loaded with the 1T-MoSe2 nanosheets is used for preparing the medicine or dressing for treating the diabetic chronic wounds, the dressing can generate a large amount of ROS and generate the photothermal effect under the combined stimulation of exogenous ultrasound (US) and near-infrared light (NIR), and the hydrogel has efficient photothermal response and ROS generation capacity and can be used for preparing the medicine or dressing for treating the diabetic chronic wounds. Low-concentration hydrogen peroxide can be catalyzed to generate a large amount of hydroxyl radicals (. OH), and the broad-spectrum sterilization effect on various bacteria is achieved in combination with the photothermal effect; when no exogenous stimulation exists, inherent SOD and CAT-like enzyme activity is shown, excessive active oxygen is removed, the oxidative stress state of the wound surface is effectively relieved, polarization of macrophages to M2 anti-inflammatory phenotypes is promoted, and control over the inflammatory state is achieved.

This invention belongs to the field of biomedical materials and relates to a method for preparing a multi-dynamically bonded hydrogel based on polysaccharides from the traditional Chinese medicine *Solanum nigrum* and its application. *Solanum nigrum* is initially extracted and precipitated with alcohol to obtain crude polysaccharides. The polysaccharides are then deproteinized using the Sevag method to obtain a crude polysaccharide solution. After dialysis and freeze-drying, crude polysaccharide is obtained. The crude product is separated and purified to obtain homogeneous polysaccharides. The homogeneous polysaccharide solution is reacted with sodium periodate solution in the dark, followed by dialysis, purification, and freeze-drying to obtain oxidized *Solanum nigrum* polysaccharide OBY. OBY is dissolved in boric acid solution to obtain solution A. Carboxymethyl chitosan is dissolved in polyvinyl alcohol solution to obtain solution B. After the solutions A and B have fully reacted, they are placed in a mold to obtain a multi-dynamically bonded hydrogel based on *Solanum nigrum* polysaccharides. This hydrogel can be applied to the preparation of drugs for chronic wound repair, providing a novel material system and application strategy for developing new wound dressings with excellent physicochemical properties, intelligent response characteristics, and active repair functions.

This invention discloses a baicalin-matrine self-assembled injectable hydrogel and its preparation method, belonging to the field of medicinal chemistry. The above-mentioned self-assembled injectable hydrogel is composed of baicalin and matrine in a molar ratio of 2.5-6:1. The preparation steps are as follows: (1) Dissolve baicalin and matrine in a solvent to obtain a reaction solution, then add alkali solution until baicalin is completely dissolved, and finally heat and stir, and then cool; (2) Adjust the pH of the product obtained in step (1) to 3.5-5.5 with a strong acid solution to form a gel. This invention uses natural small molecule compounds to self-assemble and form an injectable hydrogel, which can exert its specificity, has the advantages of low toxicity and good biocompatibility, not only achieving the sustained release effect of bioactive ingredients, but also self-assembling into nanoparticles during the release process, which can not only improve drug solubility, but also enhance the therapeutic effect of the drug.

The invention discloses mussel-imitating bacteria responsive injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel is formed by compounding a mussel-imitating viscous hydrogel bracket and a bacterial response agent, the viscous hydrogel scaffold is QCS-EC (Quaternized Chitosan) and is formed by non-covalent binding of QCS (Quaternized Chitosan) and EGCG (Epigallocatechin Gallate); the bacterial response agent is a supramolecular nano cross-linked compound TEBox-B12, and is formed by self-assembly of box-shaped quaternized pyridine heterocyclic organic salt molecules TEBox and salt containing suprachaotropic liquid anions B12H12-through hydrogen bonds and electrostatic interaction. The hydrogel disclosed by the invention has NIR-II photo-thermal and photodynamic antibacterial treatment functions, and can be used for efficiently killing bacteria in deep tissues; the hydrogel also has high adhesion, good biocompatibility and injectability, is strong in convenience and applicability, can provide a good healing environment for wounds, promotes fibroblast proliferation and migration, accelerates wound tissue regeneration and healing processes, and reduces scar formation.

This invention relates to a mildly photothermal-releasing, injectable, self-healing hydrogel dressing for wound healing after oral cancer surgery. The hydrogel dressing is prepared by loading NO donor-loaded nanoparticles into a thermosensitive ABA triblock copolymer. This hydrogel dressing possesses thermosensitivity, injectability, self-healing properties, mild photothermal antibacterial activity, controlled NO release, blood compatibility, and biocompatibility. It can promote tissue regeneration, angiogenesis, and cell migration in postoperative wounds after oral cancer surgery, making it an ideal material for postoperative wound management in oral cancer patients.

The invention discloses injectable photocuring hydrogel for bone tissue repair and a preparation method and application thereof.The method comprises the steps that at the room temperature, SA, HA, AAm, MBA, Hmpp and Acc-NHS are added into deionized water to be dissolved, and a precursor solution is obtained; under the condition of high-speed mechanical stirring, dropwise adding a CaCl2 aqueous solution into the precursor solution, and continuously stirring, so that a sodium alginate chain segment and calcium ions are subjected to ionic cross-linking, and injectable ionic cross-linking hydrogel with the shear thinning characteristic is obtained; and adding HAp into the injectable ionic crosslinking hydrogel under the condition of keeping high-speed mechanical stirring, and continuously stirring to obtain the injectable photocuring hydrogel with the bone repair function. The hydrogel disclosed by the invention has excellent injectable performance, controllable light curing conversion capability, relatively high mechanical strength, wet interface adhesion performance and bone repair potential, and is expected to be used as a minimally invasive implantable medical device for repairing bone tissue injury.

This invention relates to the field of medical materials technology, specifically to recombinant humanized collagen composite microspheres, their preparation method, and applications. This invention provides a preparation method that requires no chemical reagents and involves extremely simple steps. The method employs a purely physical process of "ultrasonic dispersion + liquid nitrogen rapid freezing + freeze-drying," which simplifies the operation process, lowers equipment requirements, and reduces production error-tolerant costs, thereby achieving efficient preparation and stable mass production of composite microspheres. These composite microspheres have broad application prospects in soft tissue repair, especially in minimally invasive cosmetic procedures and complex wound filling.

The invention provides a composition for filling as well as a preparation method and application thereof. The composition comprises gel particles and an aqueous medium hyaluronate solution, the gel particles comprise silk fibroin, hyaluronic acid or a salt thereof, and a cross-linking agent, and the gel particles comprise a porous three-dimensional body; the mass ratio of the silk fibroin to the hyaluronic acid or the salt thereof to the cross-linking agent is (0.1-10): (1-20): 1.

The present application relates to the field of coal seam grouting hole sealing, in particular to a hole sealing device, comprising a grouting pipe and two hole sealing bags, the hole sealing bags are annular, the hole sealing bags are sleeved on the extraction pipe and bonded with the extraction pipe, the grouting pipe penetrates the hole sealing bags, and the two hole sealing bags are connected through the grouting pipe, the hole sealing bags are sealed with the grouting pipe through a clamp, and the right end of the grouting pipe is plugged with a plug; a blasting valve is installed on the grouting pipe between the two hole sealing bags, a one-way valve is also installed on the grouting pipe, and the one-way valve is located in the hole sealing bag. When the technical scheme is adopted, the hole sealing effect is improved.

This invention relates to a reversible drug-loaded hydrogel with multi-stimulus responsiveness, its preparation method, and its applications, belonging to the field of biomedical technology. The invention involves sequentially modifying a carboxylated polysaccharide with phenylboronic acid and thiolation to obtain thiolized phenylboronic acid polysaccharide. This thiolized polysaccharide is then fully cross-linked with a healing-promoting drug and a prepared thiolized graphene in an alkaline buffer solution to obtain a reversible drug-loaded hydrogel with multi-stimulus responsiveness. The reversible drug-loaded hydrogel provided by this invention can undergo reversible structural changes or performance responses under external stimuli such as pH, reduction, and photothermal stimulation, thereby achieving good injectability, self-healing properties, and controlled drug release. Furthermore, the reversible drug-loaded hydrogel provided by this invention exhibits good biocompatibility and hydrophilicity, which is beneficial for enhancing the application potential of the hydrogel in the biomedical field, particularly in wound dressings and wound repair.

This invention discloses a nano-modified composite grouting material suitable for deep, high-temperature geothermal environments and its preparation method, belonging to the field of geotechnical engineering technology. The raw materials for preparing this composite material include: cement, fly ash, cellulose nanofibers, Pluronic F-127 dispersant, calcium formate, tannic acid, borax, defoamer, and water; wherein the mass ratio of tannic acid, calcium formate, and borax is (0.15-0.25):(1.1-1.4):(0.1-0.2). This invention, through the compounding of specific admixtures, effectively overcomes the defects of traditional grouting materials, such as rapid setting at high temperatures and poor rheological properties. The resulting composite material exhibits low viscosity, long pumpability, and high early strength in high-temperature environments, significantly improving the reinforcement effect on deep, high-temperature rock masses and providing a high-performance, high-reliability grouting solution for deep underground engineering.

The application provides a spatiotemporal sequential regulation photothermal injectable hydrogel and a preparation method and application thereof, and belongs to the technical field of biological medicine. The hydrogel is composed of quaternized methacrylated chitosan, benzaldehyde-terminated polyethylene glycol, a photoinitiator and polydopamine-modified nano-hydroxyapatite, and forms a double-network crosslinked structure through a Schiff base reaction and a blue light-induced radical polymerization. The hydrogel has good injectability, mechanical properties and biocompatibility. Under near-infrared light irradiation, spatiotemporal sequential treatment can be realized by regulating the light power in stages: high-power irradiation produces high temperature to rapidly kill bacteria, and low-power irradiation produces mild photothermal stimulation to promote osteogenesis and angiogenesis. The hydrogel has the functions of antibiosis, osteogenesis promotion and angiogenesis promotion, and can be used for precise repair of infected bone defects, and has a wide clinical application prospect.

This invention relates to the field of injectable hydrogel dressings, specifically disclosing a porous microsphere-reinforced injectable in-situ molded hydrogel dressing and its preparation method. The dressing includes a porous microsphere component and a photocrosslinkable hydrogel matrix component. The porous microsphere component serves as a reinforcing filler dispersed within the photocrosslinkable hydrogel matrix component. A precursor solution of the photocrosslinkable hydrogel matrix component permeates into the pores of the porous microsphere component, forming a mechanically anchored structure after in-situ photocrosslinking and curing. It also includes a natural antibacterial and healing-promoting component, fenugreek oil, with a mass fraction of 3%-8%. The porous microsphere component has a compressive modulus of 150-300 kPa, and its modulus retention rate is not less than 89% after 10 compression cycles. This design balances the convenience of injectability with reliable mechanical support, endowing the hydrogel with sustained healing-promoting activity.

This invention discloses a CH@SHP099-NPs composite hydrogel, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the technical challenge of achieving long-term, safe, and precise metabolic intervention with SHP2, this invention constructs a hydrogel system composed of chondroitin sulfate and hyaluronic acid. This system can retain SHP099-loaded nanoparticles within the joint cavity, forming a long-acting intrasynovial drug library, thereby continuously inhibiting the SHP2-AMPK signaling axis. The CH@SHP099-NPs composite hydrogel prepared in this invention can effectively reprogram the metabolic state of macrophages, reduce glycolysis flux, restore synovial immune metabolic homeostasis, and significantly improve synovial inflammation, chondrocyte activity, and cartilage structural integrity in vivo. This invention proposes a mechanism-guided local delivery metabolic intervention strategy, which is expected to provide a new interventional approach for the treatment of osteoarthritis.

The invention discloses a chitosan-beta-glycerophosphoric acid temperature-sensitive material and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations and nano delivery, the chitosan-beta-glycerophosphoric acid temperature-sensitive material is formed by combining amino groups of chitosan and phosphate groups of beta-glycerophosphoric acid through hydrogen bond interaction, the invention relates to a copper-doped Prussian blue composite temperature-sensitive hydrogel, which is composed of copper-doped Prussian blue light thermocatalytic nanoparticles loaded with tripterine and a chitosan-beta-glycerophosphoric acid temperature-sensitive material. The composite temperature-sensitive hydrogel is in a liquid state under a low-temperature condition, and can be quickly subjected to sol-gel conversion at a physiological temperature, so that in-situ gelling is realized. The prepared composite hydrogel has good injectability and biocompatibility, copper-doped Prussian blue shows photo-thermal performance under irradiation of near-infrared light, and copper ions can participate in catalytic reaction to generate reactive oxygen species, so that the copper-doped Prussian blue and the chemotherapy effect of the tripterine are cooperated to enhance the tumor treatment effect.

The invention belongs to the technical field of biomedical engineering materials, and discloses a nano composite hydrogel for diabetic bone repair and a preparation method thereof.The preparation method comprises the steps that oxidized hyaluronic acid is prepared and modified through phenylboronic acid to obtain OHA-PBA; then preparing a halloysite nanotube loaded with bulbus lilii glycoside B; and finally, uniformly mixing an OHA-PBA aqueous solution with the RB-HNT powder, adding a polyvinyl alcohol aqueous solution, and constructing a dynamic cross-linked network through reversible borate bonds formed by phenylboronic acid and hydroxyl groups and hydrogen bonds formed by the hydroxyl groups on the surface of the RB-HNT and the polymer. The nano-composite hydrogel disclosed by the invention has diabetes pathology microenvironment responsiveness, can be controllably degraded under high glucose, ROS or acidic conditions, slowly releases RB and silicon ions, and synergistically exerts antioxidant, anti-inflammatory and osteogenesis promoting effects; meanwhile, excellent injectability and self-healing ability are achieved, the material can be attached to irregular bone defect parts, and minimally invasive drug delivery is achieved.

The application belongs to the technical field of biomedical materials, and particularly relates to a high-efficiency crosslinking agent of recombinant collagen, a crosslinked recombinant collagen hydrogel and application, and particularly provides a new use of cationic tetra(hydroxymethyl)phosphonium chloride (THPC) as a crosslinking agent in crosslinking of a recombinant collagen hydrogel, wherein the amino acid sequence of the recombinant collagen is shown as SEQ ID No. 1, the method for crosslinking the recombinant collagen hydrogel by THPC, and the prepared hydrogel has high biocompatibility, good mechanical properties and injectability, and significantly enhanced anti-enzymatic hydrolysis capacity; the method is simple, convenient and easy to operate, and can be applied to the fields of implant agents, artificial skin, hemostatic sponges, stent materials, medical devices and the like, and has a wide application prospect.