352results about How to "Good injectability" patented technology

Injectable bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.

Bone cement mixing and delivery device and methods are disclosed. The device includes a first tube / barrel (e.g., a syringe barrel) containing a bone cement powder and a second tube / barrel that can be filled with or that contains a liquid; the first and second tubes / barrels can be fluidly connected end-to-end such that there is fluid communication between the tubes / barrels. Also disclosed are methods of preparing the device for use, methods for forming a bone cement using the device, and methods and device design to extend the shelf life of the device.

Disclosed are pumpable-fluid compositions and methods for establishing hydraulic isolation in cemented subterranean wells. The fluid compositions comprise solids-free solutions of water-soluble polymers. Upon entering voids and cracks in the cement sheath and contacting the set-cement surfaces, the fluid gels and forms a seal that prevents further leakage.

The invention relates to an injectable temperature sensitive gel used for filling and repairing damaged tissues. The gel is characterized in that: medical-grade hyaluronic acid and chitosan are used as gel raw materials; the gel swelling ratio is 2-500; and a temperature sensitive temperature is 32-37 DEG C. The gel provided by the invention has the advantages that the injection temperature sensitive gel has physical and chemical properties of a general gel, also has injectable and temperature sensitive properties and a good fluidity at a room temperature and is easy for injection; the formability in organisms is good and the degradation is slow so that the general gel can not be compared; a cross-linking agent is not used for the gel so that harms of the cross-linking agent to a human body are avoided; a gel system can prolong a persistence time of the gel in a body, and also can continuously stimulate the body to produce reactions so that the tissue in-situ regeneration and repair is promoted and the filling quality is increased; and the gel simultaneously has the advantages of reducing bacterial invansion, anticoagulation and low allergic reaction and the like.

The invention discloses a preparation method for an injectable poly(L-lactic acid) microsphere. The preparation method comprises the following steps: (1) preparing an organic solution of poly(L-lacticacid); (2) preparing an aqueous solution of sodium carboxymethylcellulose / mannitol; (3) adding the organic solution of poly(L-lactic acid) into the aqueous solution of sodium carboxymethylcellulose / mannitol drop by drop, carrying out uniform mixing, and then removing an organic solvent in the mixed solution; and (4) lyophilizing the solution obtained in the step (3) so as to obtain the injectablepoly(L-lactic acid) microsphere. According to the preparation method of the invention, a mixed solvent of sodium carboxymethylcellulose and mannitol is used as a stabilizer; when the freeze-dried mixture is redissolved, the poly(L-lactic acid) microsphere can be uniformly dispersed in the solution, and good injectable effect is obtained; and the preparation method of the invention is simple in process steps and suitable for mass preparation and industrial application.

The invention discloses a high-performance superfine cement based grouting material for microfissuring and silty fine sand soil grouting treatment, and application of the grouting material. The grouting material comprises the following ingredients in parts by weight: 50-79 parts of Portland cement clinker, 19-48 parts of an auxiliary cementing material and 2-7 parts of desulfurized gypsum, whereinthe auxiliary cementing material comprises the following ingredients in parts by weight: 25-57 parts of mineral slag, 8-21 parts of steel slag, 18-36 parts of pulverized fuel ash, 6-12 parts of limestone flour, 1-8 parts of silica fume and 2.5-12.8 parts of a high-performance composite regulator; the high-performance composite regulator comprises the following ingredients in parts by weight: 5-16parts of sodium hydroxide, 4-12 parts of sodium silicate, 4-14 parts of potassium metaaluminate, 12-21 parts of calcium chloride, 11-18 parts of lithium chloride, 4-12 parts of triethanolamine, 21-27parts of alum, 18-29 parts of aluminum sulfate, 0.2-1.5 parts of hydroxypropyl methyl cellulose, 0.1-3.0 parts of viscous polymer, 0-0.8 parts of polypropylene fiber and 0.5-3.0 parts of a superplasticizer; and the viscous polymer is an acrylic ester polymer or an ethylene-vinyl acetate copolymer.

The invention discloses injectable self-sealing gel applicable to drug loading and releasing and a preparation method and application thereof. Macromolecular microgel particles with surface charge are used herein, and colloidal gel is obtained by self-assembly through static mutual action of the particles. Since static actions in the microgel are physically crosslinked and are reversible; the colloidal gel of the invention has good injectability and self-healing property, no chemical crosslinking reaction needs to be introduced during injection and curing, the gel is different from chemical macromolecules and is free of small-molecular crosslinking agents, and the gel is good in biocompatibility, degradable and absorbable, free of toxic and side effects and good in safety and is possibly applicable widely to the field of biomedicine.

The invention discloses a nanometer colloid particle-assembled high-strength self-repairing injectable composite colloid gel material and a preparation method and application thereof. According to the preparation method, two-phase colloid particles with opposite electric charges are uniformly blended in an alkaline or acidic environment, an acidifying agent or alkalizing agent is added to induce the pH of the solution to recover the neutrality, electrostatic self-assembly among the two-phase colloid particles is initiated, and a uniformly-dispersed composite gel network is formed, wherein the gel is high in mechanical strength and wide in regulation and control range, the elasticity modulus of the gel can be regulated and controlled within the range of 10 Pa-100 kPa, and the self-repairing efficiency of the gel is higher than or equal to 100%. The silicon dioxide-gelatin composite colloid gel which has both the high mechanical strength and the self-repairing performance is finally and successfully prepared, and it is verified that the composite gel still can quickly recover the mechanical strength after being broken by shear force many times; in addition, the composite gel has the excellent injectable property and plasticity and can be used for an in-vitro cell culture matrix material by serving as an injectable biological material.

The invention relates to a microorganism slab grouting device and a microorganism slab grouting method used for reinforcing a liquefiable foundation. The device comprises a grouting panel, a pipeline switching device, an extended panel and grouting pipes. The grouting method comprises the following steps: a. vertically ramming microorganism slab grouting devices arranged in I and II forms into a to-be-reinforced stratum; b. carrying out butt joint on one ends of the first and second grouting pipes with first and second slurry passages in the microorganism slab grouting devices, connecting the other end of the first grouting pipe with a valve, a grouting pump and urease-producing microorganism bacterial liquid storage pond in sequence, and connecting the other end of the second grouting pipe with the valve, the grouting pump and a cementing solution storage pond in sequence; and c. opening the valve and the slurry injection pump to grout for the stratum, wherein the microorganism slab grouting devices are lifted uniformly during grouting, and after grouting is completed, all microorganism slab grouting devices in the field are pulled out and stand for 12h, and finally, underground water is pumped out for sewage treatment. Compared with the prior art, the microorganism slab grouting device and method can simplify the procedures, shorten the duration and eliminate the problem of size effect.

The invention discloses an efficient superfine cement based composite grouting material for grouting treatment of a water-rich sand layer, a preparation process and application. The efficient superfine cement based composite grouting material is prepared from the following components in parts by weight: 40 to 80 parts of portland cement clinker, 10 to 45 parts of coal ash, 5 to 30 parts of superfine slag micro powder, 2 to 6.5 parts of desulphurization gypsum, 1 to 10 parts of silica fume, 0.51 to 2.10 parts of first mixed composite modifier, 0.4 to 2.4 parts of second mixed composite modifierand 5.5 to 8.9 parts of third mixed composite modifier; the coal ash is prepared from the following components in parts by weight: 50 to 100 parts of high-calcium coal ash and 0 to 50 parts of low-calcium coal ash; the first mixed composite modifier is prepared from the following components in parts by weight: 96 to 99 parts of super plasticizer and 1 to 4 parts of hydroxypropyl methyl cellulose;the second mixed composite modifier is prepared from the following components in parts by weight: 20 to 32 parts of sodium hydroxide, 21 to 28 parts of sodium carbonate, 18 to 32 parts of sodium sulfate and 18 to 36 parts of sodium metaaluminate; the third mixed composite modifier is prepared from the following components in parts by weight: 12 to 25 parts of calcium chloride, 8 to 21 parts of lithium chloride, 10 to 23 parts of triethanolamine and 32 to 68 parts of sulphoaluminate cement clinker.

Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and / or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation.

The invention discloses a product used for forming calcium magnesium injectable bone cement, comprising solid phase powder obtained by uniformly mixing composite phosphoric acid calcium salt and magnesium phosphate powder as well as curing solution obtained by dissolving dextrin and hydrophosphate in water. The invention also discloses a calcium magnesium injectable bone cement and preparation method and application thereof. The curing solution and solid phase powder in the product are uniformly mixed and blended into paste, thus obtaining water phase high efficiency scattering-resistant rapid curing bone cement capable of being injected with calcium magnesium and injectable product used for preparing bone tissue wound repairing. The invention is low in cost of raw materials, preparation method is simple, the obtained calcium magnesium injectable bone cement has strong scattering-resistance and rapid curing speed.

The invention belongs to the technical field of medical polymer materials and in particular relates to X ray developing thermotropic hydrogel and a preparation method thereof. The X ray developing thermotropic hydrogel comprises an iodine-containing amphiphilic block copolymer and a solvent, wherein the iodine-containing amphiphilic block copolymer is obtained by bonding an iodine-containing micromolecule and an amphiphilic block copolymer by virtue of a covalent bond, and thermotropic gelatinization phase transformation can be carried out on a water system of the X ray developing thermotropic hydrogel along with temperature increase. The thermotropic hydrogel can be implanted under the skin and implanted into an abdominal cavity, an articular cavity and other specific parts of a human body in a mode of injection, and in situ formed hydrogel has good X ray developing performance, clear positioning and long-term tracing observation can be carried out on the hydrogel by adopting an X ray radiography technique. The thermotropic hydrogel also can serve as a medicine controlled release carrier, a tissue repairing support, a blood vascular embolization agent, a tissue marker and the like and can be used for realizing integration of diagnosis and treatment.

The invention provides a moldable bone repairing material for bone repairing. The material is prepared from the following raw materials in parts by weight: 20-90 parts of alpha-calcium sulfate hemihydrate and hydroxyapatite, 20-40 parts of bioactive mineral powder, 10-80 parts of autologous bone powder particles or DBM (demineralized bone matrix) particles, and hydrogel, wherein the ratio of hydrogel to the total usage of the raw materials is 1:0.5-1:15, the hydrogel is optimally PEO-PPO-PEO (polyoxyethylene-polyoxypropylene-polyoxyethylene) segmented copolymer solution. The prepared moldable bone repairing material for bone repairing is applicable to in-situ curing after wound injection and in-vitro quick curing for bone repairing, wherein all components are proved to be degradable materials with excellent biocompatibility.

The invention relates to composite bone cement for repairing bone tissues and a preparation method thereof. The bone cement is prepared from the following components in percentage by mass: 90-99.9 percent of calcium sulfate / calcium phosphate composite and 0.1-10 percent of additives. The method comprises the following steps: uniformly mixing raw materials, drying in an oven at 70 DEG C, grinding, and performing a crystal transformation reaction in a high-pressure kettle at a temperature of 120-200 DEG C and a pressure of 0.1-1MPa for 3-8 hours; after reaction, drying in an oven at 80-100 DEG C for 12 hours, and uniformly grinding to obtain bone cement powder; and weighing the bone cement powder, adding the powder into a liquid in a powder-liquid mass ratio of (1-3):1, uniformly stirring, and curing to obtain the bone cement. The prepared bone cement has the advantages of high tensile strength, good injection performance, good water scattering resistance, controllable degradation and the like, has excellent biological activity, compatibility and safety, and is used for fixing multiple bone fractures and filling bone defects.

The invention provides a premixed calcium silicate based root canal filling material with suspension stability as well as a preparation method and an application thereof. At least one calcium silicate compound is used as a main phase, and at least a second phase for improving solidification performance, at least one nonaqueous phase solvent which can be mixed with water, at least one suspension stabilizing agent and at least one radiopaque material are added in order to prepare the root canal filling material with excellent injectable performance. An inorganic dispersant with suspension stabilizing effect is added into the premixed type calcium silicate based root canal filling material system, based on reservation of excellent biological compatibility, biological activity, marginal sealability, and the like of the calcium silicate material, layering, deposition or flocculation of the premixed system are effectively prevented, long-term dispersion stability of the premixed paste is improved, and the material can be used as a filling material for dental pulp capping, root canal therapy, and other dental restoration fields.

The invention discloses a polymethyl methacrylate (PMMA) compound bone cement precursor which comprises solid phase powder and solidification liquid, wherein the solid phase powder comprises strontium borate bioglass, polymethyl methacrylate powder and a polymerization initiator, the solidification liquid comprises methyl methacrylate and a polymerization activator, and the mass of the solid phase powder is 50 to 80 percent of the mass sum of the solid phase powder and the solidification liquid. The invention also provides a preparation method of polymethyl methacrylate compound bone cement, the compound bone cement combines the performance of the strontium borate bioglass and pure PMMA bone cement, has excellent biological activity, biological degradability, biological compatibility as well as mechanical strength matched with bones, so as to achieve a good effect on prompting bone reconstruction; the invention also provides an application of the strontium borate bioglass / polymethyl methacrylate compound bone cement.

The invention discloses injectable intelligent response hydrogel and a preparation method and application thereof and solves the problems that traditional hydrogel cannot achieve self-repairing afterbeing broken and is poor in adhesive capacity to original tissue in the prior art. The structure of the injectable intelligent response hydrogel is as shown in formula I. The preparation method includes: allowing an aldehyde group modified natural material or synthetic polymer to have Schiff base reaction with a hydrazide natural material or synthetic polymer with a disulfide bond to prepare the injectable intelligent response hydrogel. The injectable intelligent response hydrogel can be used as a drug carrier or / and a biological material. The injectable intelligent response hydrogel is scientific in design, simple to operate, good in injectability and biocompatibility and degradable, has certain adhesive capacity to original tissue, has self-healing performance, pH sensitivity and redox property and is an ideal drug carrier and biological repairing material.

The invention belongs to the fields of high polymer materials and mechanical instruments and relates to a hydrogel composition for gastrointestinal submucosal injection and an application of the hydrogel composition. The hydrogel composition provided by the invention is composed of a mixture, a solvent and a color indicator, wherein the mixture is composed of two or more segmented copolymers; water is taken as a main body by the solvent; a water solution of the hydrogel composition has thermotropic gelatinization property; a polymer mixture can be dissolved in water at a room temperature or a low temperature to form a low-viscosity solution; the water solution of the mixture can be subjected to reversible sol-gel transition along with temperature rise. The hydrogel composition material provided by the invention can be applied to preparation of the composition material for endoscopic submucosal dissection and is capable of reducing complications such as perforation and bleeding in an ESD operation when applied to ESD; the operation safety is improved; the operation difficulty is reduced; the time required for finishing operation is shortened; and convenience is provided for ESD diagnosis and treatment of cancers such as colon cancer and rectal cancer.

The invention discloses a quick-setting early-strength geopolymer grouting material and a preparation method of same. The grouting material includes, by mass, 40-100 parts of a framework material, 0-20 parts of a doping framework material, 5-10 parts of an alkali activator, and 0.5-10 parts of a chemical additive. The grouting material has good durability, excellent groutability and short maintenance time, and is simple in preparation method.

The invention relates to doped black phosphorus quantum dot thermal treatment syringeability bone cement as well as the preparation and the application thereof. A self-cured component is mixed with a heating nano material so as to obtain a modified bone cement solid-phase powder, wherein an alpha-tricalcium phosphate material functions as coating and carrying, and PLGA (Plgapoly Lactic-Co-Glycolic Acid) / black phosphorus quantum dots function as heating; by taking sodium phosphate as a main body and phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifiers, preparing a neutral bone cement curing liquid so as to improve the syringeability of a formula; mixing the bone cement solid-phase powder with the curing liquid, so as to obtain a cured product. A main component, namely, hydroxyapatite, of the cured product, can be increased, and the PLGA and a black phosphorus material have very good degradation properties inside biological bodies. The doped black phosphorus quantum dot thermal treatment syringeability bone cement has the advantages of being simple and convenient in preparation method, simple in raw material and applicable to large-scale production.

The invention provides a compound betamethasone suspension injection, which is a compound preparation composed of low-solubility betamethasone dipropionate and high-solubility betamethasone sodium phosphate. Long-lasting, it can be used for the treatment of musculoskeletal and cartilage tissue diseases, allergic diseases, skin diseases, collagen diseases, tumors and other clinical diseases.

The invention provides a pre-mixed calcium silicate / magnesium phosphate double-phase composite self-solidification root canal filling material and a preparation method and application thereof. Magnesium phosphate bone cement powder and at least one calcium silicate compound serve as the main phase, and at least one nonaqueous phase solvent capable of being mixed and dissolved with water and at least one injection-resistance material are added to prepare the root canal filling material with the excellent injectable performance. According to the pre-mixed calcium silicate / magnesium phosphate double-phase composite self-solidification root canal filling material and the preparation method and application thereof, the advantages of magnesium phosphate and calcium silicate materials are combined, so that the solidification time is short, the biological activity is good, and the marginal seal and anti-microbial characteristics are good; and meanwhile clinical application is convenient, and the root canal filling material can serve as the filling material for the field of dental department restoration such as pulp-capping and root canal therapy.

The invention provides an injecting paste material for underground structure water plugging and a preparation method thereof and belongs to the field of material science. The injecting paste material comprises the following raw materials in parts by weight: 200-600 parts of Portland cement, 600-900 parts of ultra-fine slag powder, 550-650 parts of water, 10-30 parts of sodium silicate, 5-10 parts of high efficiency slushing agent and 0.5-2 parts of cellulose ether. The water glass (sodium silicate) and Portland cement serve as an activator of the ultra-fine slag powder, the water amount of the injecting paste material is reduced by using the high efficiency slushing agent, the cellulose ether serves as a water-retaining agent, a thixotropic agent and a thickening agent of the injecting paste material, the superfine cement is replaced by employing the Portland cement and the ultra-fine slag powder, various materials can be mixed and stirred on site, the Portland cement, the ultra-fine slag powder and the cellulose ether are uniformly mixed and packaged in advance and are transported to the site and are uniformly mixed and stirred with water, water glass and high efficiency slushing agent, various requirements of the injecting paste are met, and the amount of the ultra-fine cement is reduced.

The invention discloses a synthesis method of in-situ-enhanced thermosensitive polymer. The synthesis method includes the following steps of homopolymerizing double-bond functional monomer or copolymerizing the double-bond functional monomer, carbonic ester, lactone and lactide on the conditions of hydroxy-containing initiators and amine catalysts, wherein the homopolymerization or copolymerization reaction temperature ranges from 50 DEG C to 80 DEG C, and reaction time ranges from 1 to 4 hours. The hydrogel is in a liquid state at low temperature while is in a gel state at physiological temperature, and can be injected with bioactive molecules and biological signals conveniently and is endowed with special bioactivity. Besides, the hydrogel can be degradable gradually at the physiological environment.

The invention provides a composite superfine cement grout slurry and a preparation method thereof. The slurry is prepared by conducting ball milling on a matrix component and an additive component to obtain an ultrafine composite grouting material and mixing the water and cement according to a ratio of 0.5-0.8. The matrix consists of ordinary silicate cement, fly ash, slag and water; and the additive component comprises a grinding agent, an activator, a composite superplasticizer, an expansive agent and a retarder. The composite superfine cement grout slurry contains the following components by weight: 10% of slag, 0.8%-1.2% of composite superplasticizer, 5%-10% of expansive agent and 0.1%-0.6 of the retarder. The composite superfine cement grouting slurry provided by the invention has high fluidity and high bonding strength, and good impermeability and volume stability, and can significantly improve groutability and reinforce performance of subtle fracture of rocks if applied.

The present invention relates to a dynamic imine bond polysaccharide polymer-based injectable hydrogel and a preparation method and an application thereof. The dynamic imine bond polysaccharide polymer-based injectable hydrogel comprises the following raw material components in weight percentages: 5-18% of a component A: oxidized sodium alginate, 0.1-20% of a component B: a mixture of one or two of water-soluble chitosan and 3,3'-dithiobis(propanohydrazide), and the balanced solvent. The materials are prepared into an even solution according to the ratio. Compared with the prior art, "Schiff base", amide bonds and other dynamic imine bonds are used to realize cross-linking and can form a gel under mild conditions of human body temperature and acid and alkali, and no biotoxic initiators areneeded. The hydrogel is fast in gel-forming speed and injectable after forming. The hydrogel is mild in the preparation conditions, and excellent in compression properties, biocompatibility and injectability, and has broad application prospects in the field of cartilage repair.

The invention provides a coal mine underground reservoir and a multi-layer grouting anti-seepage reinforcement method for a reservoir dam and belongs to the field of coal mine underground construction. According to the multi-layer grouting anti-seepage reinforcement method, the area of the underground reservoir and the location of the coal pillar dam are determined and set through the volume; two side tunnels and withdrawal tunnels of the underground reservoir are drilled, concrete grout and silica sol are sequentially sprayed on the tunnel walls, and concrete and silica sol spray layers are formed; a plurality of shallow grouting holes are constructed in the sides, near the coal pillar dam, of the two side tunnels and the withdraw tunnels and the holes are sealed for grouting, and then a plurality of deep grouting holes are constructed and sealed for grouting; and finally, an artificial water retaining dam is constructed for sealing the tunnels, and accordingly the closed coal mine underground reservoir is formed. The multi-layer grouting anti-seepage reinforcement method has the double effects of reinforcement and sealing on the coal pillar of the coal mine underground reservoir; and nano-scale, inorganic, green and efficient materials are selected, the anti-seepage safety of the coal pillar dam can be ensured, and the coal mine underground reservoir is made durable and stable.

The present invention provides a tire puncture sealant including a rubber latex and 1,3-propanediol, which has a reduced viscosity at low temperatures, has better injectability at low temperatures, and is also excellent in storage stability, initial sealing performance, and seal retention performance.

The invention belongs to the field of biomedical polymer materials, and specifically relates to a thermally induced hydrogel containing selenium or tellurium, and a preparation method and applications thereof. The thermally induced hydrogel is composed of an amphiphilic block copolymer containing selenium or tellurium and a solvent; thermally induced gelatinization phase transformation of a water system of the amphiphilic block copolymer and the solvent can be realized with temperature increasing so as to realize spontaneous formation of a physical hydrogel, wherein the amphiphilic block copolymer containing selenium or tellurium is obtained via covalent bonding of small molecules containing selenium or tellurium with an amphiphilic block copolymer. Long-acting platinum drug gel sustained-release preparations can be obtained via coordination of the thermally induced hydrogel with platinum drugs. The long-acting platinum drug gel sustained-release preparations are capable of prolonging and adjusting release behavior of the loaded platinum antitumor drugs. Drug administration of the long-acting platinum drug gel sustained-release preparations in tumor, around tumor, or in tumor cavity can be realized via injection; in situ formation of gel is realized at body temperature, and the platinum drugs loaded via coordination bonds can be released from the gel slowly, so that administration frequency is reduced, and drug whole body toxicity is reduced. The long-acting platinum drug gel sustained-release preparations can be applied to tumor treatment at different periods.