58results about How to "Good injectability" patented technology

The invention discloses an in-situ injectable bone repair adhesive material with a double-sequence osteogenesis promoting function as well as a preparation method and application of the in-situ injectable bone repair adhesive material. The preparation method comprises the following steps: 1) sequentially carrying out dual chemical grafting modification on hyaluronic acid by using methacrylic anhydride and dopamine hydrochloride to obtain a DA-HAMA biomacromolecule with UV curing and adhesion functions; (2) preparing a Ca < 2 + > physical cross-linked sodium alginate microsphere material loaded with an osteogenesis promoting drug by using a micro-fluidic system; and (3) preparing a DA-HAMA solution under dark and heating conditions, adding the vascular promoting factors and the drug-loaded microspheres when the DA-HAMA solution is cooled to room temperature, uniformly mixing, and carrying out centrifugal defoaming and irradiation sterilization to obtain the in-situ injectable bone repair adhesive material. The bone repair adhesive material has the functions of being degradable, injectable, capable of being adhered in a wet state, promoting blood vessels and promoting bone formation, and a brand new strategy is provided for bone defect repair.

The invention discloses injectable hydrogel for eye drug sustained release and a preparation method and application thereof.The method comprises the steps that a NaIO4 solution is dropwise added into a hyaluronic acid solution, after the reaction is conducted in a dark place at the room temperature, ethylene glycol is added for continuous reaction, and formylated hyaluronic acid is prepared; the preparation method comprises the following steps: adding adipic dihydrazide into a carboxymethyl cellulose solution, uniformly stirring at room temperature, adding 1-hydroxybenzotriazole and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and stirring to react, so as to prepare aminated carboxymethyl cellulose; and mixing the PBS solution of aminated carboxymethyl cellulose with the PBS solution of formylated hyaluronic acid, uniformly stirring, adding a to-be-carried drug and a FeCl3 solution, and carrying out a reaction to prepare the injectable hydrogel for sustained release of the eye drug. The hydrogel is convenient to use and high in gelation rate, effectively realizes controllable release of drugs, and has a wide application prospect in the field of biological medicines.

The invention belongs to the technical field of geotechnical engineering, and particularly relates to a nanocarbon reinforced superfine cement-based blocking material as well as a preparation method and application thereof. The superfine cement-based blocking material prepared by the invention is prepared by uniformly mixing 45-50 parts of cement, 0.5-2.5 parts of a solid waste sintered active material, 0-0.05 part of a water reducing agent, 0.015-0.1 part of carbon nanotubes, 0.5-2.5 parts of a 1% solution of carbon quantum dots and 45-50 parts of water. The material has relatively low porosity and is not dispersed; the high groutability is achieved, and the material can permeate into tiny holes; and it is guaranteed that the material has high strength, the crushed rock bonding and reinforcing strength is high, and the material has wide application prospects.

The invention discloses a bone cement composite material with collapse resistance and a preparation method thereof, and belongs to the technical field of biomedical materials. The composite material comprises a solid phase part and a liquid phase part, the liquid phase part and the solid phase part are mixed according to the liquid-solid ratio of 0.35 mL / g to 0.6 mL / g; the solid phase part is composed of calcium sulfate powder and calcium phosphate powder, and the mass ratio of the calcium sulfate powder to the calcium phosphate powder is 85: 15; the liquid phase part is selected from carboxymethyl chitosan or a combination of carboxymethyl chitosan and sodium alginate. The bone cement composite material prepared by the preparation method disclosed by the invention has good biocompatibility; due to a gel network formed by carboxymethyl chitosan and sodium alginate, the compressive strength of the bone cement is remarkably improved, and the collapse resistance and injectable performance are excellent; meanwhile, the bone cement composite material promotes the attachment and proliferation of osteoblasts, and can induce osteogenic differentiation in vitro.

The invention provides a composite hydrogel based on chitosan and an acellular matrix. The composite hydrogel comprises methacrylic acid chitosan and a methacrylic acid modified acellular matrix, the prepared composite hydrogel has good injectability, good degradability and relatively high mechanical properties, and can regulate the aggregation of the bone marrow mesenchymal stem cells (BMSCs), and the bone marrow mesenchymal stem cell composite hydrogel has a remarkable effect of repairing transparent cartilage by transplanting a cartilage defect model.

The invention belongs to the technical field of biological medicine, and particularly relates to peptide slow-release temperature-sensitive hydrogel as well as a composition, a preparation method and application thereof. The composition consists of a hydrogel monomer polymer and biological peptide, wherein the biological peptide is Leucokinin VIII, and the biological peptide is Leucokinin VIII The hydrogel monomer polymer is prepared by mixing and heating polyethylene glycol, lactide and stannous zincate. The preparation method of the peptide slow-release temperature-sensitive hydrogel comprises the following steps: mixing polyethylene glycol, lactide and stannous zincate, and carrying out heating and stirring reaction to prepare a hydrogel monomer polymer; and then mixing the hydrogel monomer polymer with the Leucokinin VIII, so as to obtain the peptide slow-release temperature-sensitive hydrogel. The peptide sustained-release temperature-sensitive hydrogel has the advantages of excellent temperature-sensitive characteristic, injectability, drug sustained-release performance, biocompatibility and biological safety.

A preparation method of antibacterial hydrogel with enhanced antioxidant activity and NIR / pH double responsiveness comprises the following steps: firstly, preparing hollow copper sulfide nanoparticles, then dispersing the hollow copper sulfide nanoparticles into a chitosan solution to prepare the chitosan solution containing the hollow copper sulfide nanoparticles, and then adding the hollow copper sulfide nanoparticles into the chitosan solution to prepare the antibacterial hydrogel with enhanced antioxidant activity and NIR / pH double responsiveness. And sequentially adding a cross-linking agent epigallocatechin gallate (EGCG) solution and a 3-formyl phenylboronic acid solution (3-FPBA), and carrying out cross-linking, so as to obtain the antibacterial hydrogel with enhanced antioxidant activity and NIR / pH double responsiveness. The hydrogel is used for wound dressings in biomedical engineering materials. The preparation method is simple, the preparation process is green and safe, higher solid-like performance is shown, meanwhile, excellent injectability is kept, and great advantages can be achieved in the bacterial wound infection healing process.

The invention belongs to the technical field of medical materials, and particularly relates to high-strength dual-network self-healing hydrogel as well as a composition, a preparation method and application thereof. The composition for preparing the high-strength dual-network self-healing hydrogel comprises a composition A for constructing a first network system of the hydrogel and a composition B for constructing a second network system of the hydrogel, wherein the composition A comprises modified chitosan and modified hyaluronic acid, and the composition B comprises polyvinyl alcohol and sodium tetraborate; the volume ratio of the polyvinyl alcohol to the modified chitosan to the modified hyaluronic acid is (5-7): (5-7): 1; the concentration of the modified chitosan is 2-4 wt%, the concentration of the modified hyaluronic acid is 8-12 wt%, and the concentration of the polyvinyl alcohol is 18-22 wt%. The high-strength dual-network self-healing hydrogel prepared on the basis of the composition has relatively high mechanical performance and excellent self-healing performance, and also has excellent resilience performance, swelling performance, shape memory and ionic conduction behavior.

The invention discloses temperature-sensitive antibacterial hydrogel based on ultra-small-particle-size copper nanoparticles and a preparation method of the temperature-sensitive antibacterial hydrogel, and relates to the technical field of biomedical materials. The preparation method of the temperature-sensitive antibacterial hydrogel comprises the step of uniformly mixing the gel matrix, the stabilizer, the pH buffer solution and the ultra-small-particle-size copper nanoparticles to prepare the temperature-sensitive antibacterial hydrogel. The preparation method of the copper nanoparticles with the ultra-small particle size comprises the following steps that lactoferrin is dissolved in water, copper sulfate pentahydrate is added, an alkali solution is added to adjust the pH of the solution to be 8-14, then a reducing agent is added for a reaction, dialysis and drying treatment are conducted, and the copper nanoparticles with the ultra-small particle size are obtained. The hydrogel has good injectability, can release the copper nanoparticles under specific conditions and rapidly sterilize, in addition, the hydrogel is convenient to synthesize and simple to operate, has good biocompatibility, shows relatively low cytotoxicity to cells, and has relatively great application potential in the process of treating skin wound infection.

The invention relates to a preparation method of cell-loaded silk fibroin hydrogel fibers and fibers, the preparation method of the cell-loaded silk fibroin hydrogel fibers comprises the following steps: mixing a silk fibroin solution with a riboflavin solution to obtain a mixed solution, adding a hydrogen peroxide solution into the mixed solution to obtain a precursor solution, and carrying out ultrasonic treatment on the precursor solution to obtain the cell-loaded silk fibroin hydrogel fibers. Adding stem cells into the precursor solution, and then carrying out photocuring reaction under the irradiation of an ultraviolet lamp to prepare the hydrogel fiber. The fiber is obtained through the preparation method. According to the preparation method of the cell-loaded silk fibroin hydrogel fiber and the fiber, the gel forming time is greatly shortened, efficient and uniform loading of cells is achieved, the survival rate of the cells is increased, no organic reagent residues exist in the preparation process, operation is easy, the technological process is short, and the method is suitable for industrial production. The prepared fiber is free of biotoxicity, excellent in mechanical property, good in light transmission and good in biocompatibility, and has certain potential and application prospects in the biomedical field.

The present invention discloses a low-viscosity and high-strength cement-based grouting material and a preparation method thereof. The grouting material comprises the following components: 300-600 parts of a cementitious material having volcanic ash properties, 0.2-0.6 parts of a micro-nano coagulant, a water reducer of 0.25-2% of the mass of the cementitious material, and a water-cement ratio of 0.4-0.8. The cementitious material having volcanic ash properties comprises silicate cement and modified microbeads. The preparation method comprises the following steps: uniformly mixing the cementitious material having volcanic ash properties and the micro-nano coagulant. Then, a mixed solution formed by the water reducer and water is added, and the mixture is uniformly stirred to obtain the cement-based grouting material. The present invention reduces the water-cement ratio of cement slurry and ensures the strength of cement stone, while reducing the viscosity of cement slurry and improving injectability.

The invention belongs to the technical field of biomedical materials, and particularly relates to an agarose gel implant with good injection performance. The preparation method comprises the following steps: dissolving agarose in a buffer solution at 90-120 DEG C to obtain a clear and transparent solution, cooling to 40-55 DEG C, adding alkali and a chemical cross-linking agent, stirring to react for 2-5 minutes, standing to react for 4-24 hours at 5-35 DEG C, and dialyzing and homogenizing to obtain the chemical cross-linked agarose hydrogel implant. Compared with agarose hydrogel formed by self-aggregation physical action, the agarose gel implant has better injection performance, and the injection chirality of an injection person and the comfort of an injected person are improved.

The invention relates to injectable cross-linked collagen gel and a preparation method thereof. Two crosslinking strategies of self-crosslinking and crosslinking agent crosslinking are fused together for the first time, and two types of amido bonds, namely amido bonds of a collagen-collagen structure (A) and amido bonds of a collagen-fatty amine-collagen structure (B), are respectively constructed through two crosslinking paths, namely catalysis of collagen polypeptide self-crosslinking and catalysis of fatty amine crosslinking, so that a hard / soft dual crosslinking network is obtained. The relative proportion of the structure A and the structure B in the final product is adjusted through a proper cross-linking process, so that the strength and the stability of the final product are adjusted and controlled, and the use requirements of different injection parts can be met.

The present invention discloses a drilling recyclable microseismic sensor installation method, comprising the following steps: S1: making a sensor installation base and a hole protection steel pipe; S2: drilling a hole in the rock mass of the monitoring area; S3: assembling the microseismic sensor, the installation base, and the hole protection steel pipe and placing them in the borehole; S4: sealing the borehole and grouting; S5: connecting a collector and performing microseismic monitoring; S6: recovering the microseismic sensor. The present invention aims at the problems of high ground stress, soft and broken rock mass, and large mining impact in underground engineering, realizes the protection, recovery and recycling of microseismic sensors, and improves the coupling effect of drilling installation of microseismic sensors and the quality of signal acquisition.

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses sequential slow-release temperature-sensitive hydrogel and a preparation method and application thereof.The preparation method comprises the following steps that a blood sample is subjected to programmed centrifugation, and a gel layer of leukocyte-rich platelet-rich fibrin L-PRF and a gel layer of improved platelet-rich fibrin A-PRF are obtained respectively; and the gel layer is cut into pieces, pre-frozen, freeze-dried, ground and sieved, so that L-PRF freeze-dried powder and A-PRF freeze-dried powder are obtained respectively, and the methacrylic acid gelatin microspheres entrapped with the L-PRF freeze-dried powder are prepared. The microspheres and A-PRF freeze-dried powder are loaded into a temperature-sensitive hydrogel system composed of chitosan, polygalacturonic acid and sodium beta-glycerophosphate, so that the growth factors can be effectively entrapped in the hydrogel structure, and continuous release is realized; the system has good mechanical strength and structural stability, the retention time of the material in vivo is prolonged, and stable three-dimensional network support is provided.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The application discloses a kind of nanocomposite hydrogel for treating osteoarthritis and its preparation method and application, the nanocomposite hydrogel includes cerium dioxide nanoparticles, the cerium dioxide nanoparticles are modified with hyaluronic acid;Ergothioneine is loaded on hyaluronic acid modified cerium dioxide nanoparticles to form nanocomposite EGT-CeO2@HA;And temperature-sensitive hydrogel carrier, the nanocomposite EGT-CeO2@HA is uniformly dispersed in the temperature-sensitive hydrogel carrier.This composite hydrogel can activate ATF4-dependent pro-survival autophagy pathway, reduce cartilage cell inflammatory damage, and improve cartilage degeneration.

The present invention belongs to the technical field of biomedical materials, and specifically relates to a hyaluronic acid-tripeptide molecule electrostatic co-assembly injectable hydrogel and a preparation method thereof. The hydrogel is composed of hyaluronic acid with a negatively charged molecular chain, a tripeptide molecule with a positively charged molecule, and a buffer, wherein the tripeptide molecule is a phenylalanine-tyrosine-lysine sequence, and has shear thinning, rapid self-repair, mechanical stability and good biocompatibility, and has a good application prospect in the biomedical field.

The invention discloses a nano composite hydrogel based on phase engineering 1T-MoSe2 as well as a preparation method and application of the nano composite hydrogel. The nano composite hydrogel comprises a temperature-sensitive hydrogel matrix, and the < 1 > T-MoSe2 nanosheets are dispersed in the hydrogel matrix. The hydrogel loaded with the 1T-MoSe2 nanosheets is used for preparing the medicine or dressing for treating the diabetic chronic wounds, the dressing can generate a large amount of ROS and generate the photothermal effect under the combined stimulation of exogenous ultrasound (US) and near-infrared light (NIR), and the hydrogel has efficient photothermal response and ROS generation capacity and can be used for preparing the medicine or dressing for treating the diabetic chronic wounds. Low-concentration hydrogen peroxide can be catalyzed to generate a large amount of hydroxyl radicals (. OH), and the broad-spectrum sterilization effect on various bacteria is achieved in combination with the photothermal effect; when no exogenous stimulation exists, inherent SOD and CAT-like enzyme activity is shown, excessive active oxygen is removed, the oxidative stress state of the wound surface is effectively relieved, polarization of macrophages to M2 anti-inflammatory phenotypes is promoted, and control over the inflammatory state is achieved.

This invention belongs to the field of biomedical materials and relates to a method for preparing a multi-dynamically bonded hydrogel based on polysaccharides from the traditional Chinese medicine *Solanum nigrum* and its application. *Solanum nigrum* is initially extracted and precipitated with alcohol to obtain crude polysaccharides. The polysaccharides are then deproteinized using the Sevag method to obtain a crude polysaccharide solution. After dialysis and freeze-drying, crude polysaccharide is obtained. The crude product is separated and purified to obtain homogeneous polysaccharides. The homogeneous polysaccharide solution is reacted with sodium periodate solution in the dark, followed by dialysis, purification, and freeze-drying to obtain oxidized *Solanum nigrum* polysaccharide OBY. OBY is dissolved in boric acid solution to obtain solution A. Carboxymethyl chitosan is dissolved in polyvinyl alcohol solution to obtain solution B. After the solutions A and B have fully reacted, they are placed in a mold to obtain a multi-dynamically bonded hydrogel based on *Solanum nigrum* polysaccharides. This hydrogel can be applied to the preparation of drugs for chronic wound repair, providing a novel material system and application strategy for developing new wound dressings with excellent physicochemical properties, intelligent response characteristics, and active repair functions.

This invention discloses a baicalin-matrine self-assembled injectable hydrogel and its preparation method, belonging to the field of medicinal chemistry. The above-mentioned self-assembled injectable hydrogel is composed of baicalin and matrine in a molar ratio of 2.5-6:1. The preparation steps are as follows: (1) Dissolve baicalin and matrine in a solvent to obtain a reaction solution, then add alkali solution until baicalin is completely dissolved, and finally heat and stir, and then cool; (2) Adjust the pH of the product obtained in step (1) to 3.5-5.5 with a strong acid solution to form a gel. This invention uses natural small molecule compounds to self-assemble and form an injectable hydrogel, which can exert its specificity, has the advantages of low toxicity and good biocompatibility, not only achieving the sustained release effect of bioactive ingredients, but also self-assembling into nanoparticles during the release process, which can not only improve drug solubility, but also enhance the therapeutic effect of the drug.

The invention discloses mussel-imitating bacteria responsive injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The hydrogel is formed by compounding a mussel-imitating viscous hydrogel bracket and a bacterial response agent, the viscous hydrogel scaffold is QCS-EC (Quaternized Chitosan) and is formed by non-covalent binding of QCS (Quaternized Chitosan) and EGCG (Epigallocatechin Gallate); the bacterial response agent is a supramolecular nano cross-linked compound TEBox-B12, and is formed by self-assembly of box-shaped quaternized pyridine heterocyclic organic salt molecules TEBox and salt containing suprachaotropic liquid anions B12H12-through hydrogen bonds and electrostatic interaction. The hydrogel disclosed by the invention has NIR-II photo-thermal and photodynamic antibacterial treatment functions, and can be used for efficiently killing bacteria in deep tissues; the hydrogel also has high adhesion, good biocompatibility and injectability, is strong in convenience and applicability, can provide a good healing environment for wounds, promotes fibroblast proliferation and migration, accelerates wound tissue regeneration and healing processes, and reduces scar formation.

This invention relates to a mildly photothermal-releasing, injectable, self-healing hydrogel dressing for wound healing after oral cancer surgery. The hydrogel dressing is prepared by loading NO donor-loaded nanoparticles into a thermosensitive ABA triblock copolymer. This hydrogel dressing possesses thermosensitivity, injectability, self-healing properties, mild photothermal antibacterial activity, controlled NO release, blood compatibility, and biocompatibility. It can promote tissue regeneration, angiogenesis, and cell migration in postoperative wounds after oral cancer surgery, making it an ideal material for postoperative wound management in oral cancer patients.

The invention discloses injectable photocuring hydrogel for bone tissue repair and a preparation method and application thereof.The method comprises the steps that at the room temperature, SA, HA, AAm, MBA, Hmpp and Acc-NHS are added into deionized water to be dissolved, and a precursor solution is obtained; under the condition of high-speed mechanical stirring, dropwise adding a CaCl2 aqueous solution into the precursor solution, and continuously stirring, so that a sodium alginate chain segment and calcium ions are subjected to ionic cross-linking, and injectable ionic cross-linking hydrogel with the shear thinning characteristic is obtained; and adding HAp into the injectable ionic crosslinking hydrogel under the condition of keeping high-speed mechanical stirring, and continuously stirring to obtain the injectable photocuring hydrogel with the bone repair function. The hydrogel disclosed by the invention has excellent injectable performance, controllable light curing conversion capability, relatively high mechanical strength, wet interface adhesion performance and bone repair potential, and is expected to be used as a minimally invasive implantable medical device for repairing bone tissue injury.

The invention relates to the technical field of liquid metal functional composite materials, in particular to liquid metal foam composite ink for 3D structure printing and a preparation method and application thereof.The method comprises the following steps that (1) a proper amount of liquid metal is taken to be mixed with inorganic filler through mechanical force, and a liquid metal composite material is obtained; and (2) the liquid metal composite material obtained in the step (1) is subjected to vacuum treatment, and the liquid metal foam composite ink is obtained.According to the preparation method, addition of additives such as water, an expansion substance, a foaming agent and a framework material is not needed, complex reaction processes and equipment needed by additional auxiliary forming technologies including freezing assistance, light curing, sintering and pouring are not needed, and the preparation process is simple. The novel liquid metal foam composite ink which is low in filler content, high in injectability and high in strength can be simply, rapidly and massively prepared, a high-precision and uniform 3D structure can be printed, and the novel liquid metal foam composite ink can be applied to the fields of biological medicine, aerospace, electronics, thermal interfaces and the like.

The invention provides injectable composite gel as well as a preparation method and application thereof. The composite gel comprises a gel carrier and active microspheres which are suspended and dispersed in the gel carrier; wherein the gel carrier comprises a methacrylated hyaluronic acid gel, and the methacrylated hyaluronic acid gel is obtained by cross-linking methacrylated hyaluronic acid; the active microspheres comprise polylactic acid microspheres. The composite gel disclosed by the invention is simple in component, does not contain other components such as a chemical cross-linking agent, an auxiliary suspending agent and a surfactant, and has good injectability and heat resistance, and after moist heat sterilization, microspheres are basically maintained to be spherical, have an excellent dispersion effect in a gel carrier, do not have the conditions of deformation, precipitation and the like, and can be kept stable for a long time without sedimentation.

This invention relates to the field of medical materials technology, specifically to recombinant humanized collagen composite microspheres, their preparation method, and applications. This invention provides a preparation method that requires no chemical reagents and involves extremely simple steps. The method employs a purely physical process of "ultrasonic dispersion + liquid nitrogen rapid freezing + freeze-drying," which simplifies the operation process, lowers equipment requirements, and reduces production error-tolerant costs, thereby achieving efficient preparation and stable mass production of composite microspheres. These composite microspheres have broad application prospects in soft tissue repair, especially in minimally invasive cosmetic procedures and complex wound filling.

The invention provides a composition for filling as well as a preparation method and application thereof. The composition comprises gel particles and an aqueous medium hyaluronate solution, the gel particles comprise silk fibroin, hyaluronic acid or a salt thereof, and a cross-linking agent, and the gel particles comprise a porous three-dimensional body; the mass ratio of the silk fibroin to the hyaluronic acid or the salt thereof to the cross-linking agent is (0.1-10): (1-20): 1.

The present application relates to the field of coal seam grouting hole sealing, in particular to a hole sealing device, comprising a grouting pipe and two hole sealing bags, the hole sealing bags are annular, the hole sealing bags are sleeved on the extraction pipe and bonded with the extraction pipe, the grouting pipe penetrates the hole sealing bags, and the two hole sealing bags are connected through the grouting pipe, the hole sealing bags are sealed with the grouting pipe through a clamp, and the right end of the grouting pipe is plugged with a plug; a blasting valve is installed on the grouting pipe between the two hole sealing bags, a one-way valve is also installed on the grouting pipe, and the one-way valve is located in the hole sealing bag. When the technical scheme is adopted, the hole sealing effect is improved.

This invention relates to a reversible drug-loaded hydrogel with multi-stimulus responsiveness, its preparation method, and its applications, belonging to the field of biomedical technology. The invention involves sequentially modifying a carboxylated polysaccharide with phenylboronic acid and thiolation to obtain thiolized phenylboronic acid polysaccharide. This thiolized polysaccharide is then fully cross-linked with a healing-promoting drug and a prepared thiolized graphene in an alkaline buffer solution to obtain a reversible drug-loaded hydrogel with multi-stimulus responsiveness. The reversible drug-loaded hydrogel provided by this invention can undergo reversible structural changes or performance responses under external stimuli such as pH, reduction, and photothermal stimulation, thereby achieving good injectability, self-healing properties, and controlled drug release. Furthermore, the reversible drug-loaded hydrogel provided by this invention exhibits good biocompatibility and hydrophilicity, which is beneficial for enhancing the application potential of the hydrogel in the biomedical field, particularly in wound dressings and wound repair.