107results about How to "Gelation time is short" patented technology

The invention discloses a bi-component quick haemostatic gel and an application thereof. The gel is composed of natural aldehyde polysaccharide solution in mass concentration of 1-20% and amino modified natural biomacromolecule solution in mass concentration of 1-20% at volume ratio of 1:(0.1-1). According to the invention, the stickiness of the gel can be increased and the gelling time can be reduced in the manner of increasing the aldehyde content in the natural polysaccharide and the concentration of the natural aldehyde polysaccharide solution; the gelling time can be reduced in the manner of increasing the grafting volume of amino group in the amino modified natural biomacromolecule solution and the concentration of the amino modified natural biomacromolecule solution. According to the invention, the modified biomacromolecule and the natural biomacromolecule are adopted, so that the biological safety is high; the use method is simple; the bi-component quick haemostatic gel can be applied to the medical haemostatic field and can form the gel for stopping bleeding within 10-600 seconds.

A process for preparing natural gel of magnesium aluminium silicate from bentonite, attapulgite, bentone, etc includes such steps as pulverizing, preparing slurry, adding pour depressor, stirring, dynamic centrifugal separation, adding inorganic salt containing one-valence metal ions, stirring, pre-activating, adding organic salt containing at least Na ions, stirring for modifying, and post-treating.

The invention relates to a photoinduced nitroso crosslinked hydrogel material and a preparation method and application thereof. The preparation method comprises the following steps of dissolving a macromolecular derivative which is modified by an o-nitrobenzyl photo trigger in a component A into a biocompatible medium, so as to obtain a solution A; uniformly mixing the solution A, or adding a solution B containing a component B, so as to obtain a hydrogel precursor solution; under the condition of using light source to radiate the hydrogel precursor solution, enabling the o-nitrobenzyl photo trigger in the component A to produce nitroso groups through photo-inducing, and enabling the nitroso group to generate dimerization crosslinking by self to form the hydrogel, or generate addition crosslinking with nucleophile or electrophile in the component B to form the hydrogel. The invention also provides a kit for preparing the hydrogel, and application of the hydrogel in tissue engineering,regeneration medicines, 3D (three-dimensional) printing or cell, protein or drug carriers. The photoinduced nitroso crosslinked hydrogel material has the advantages that the hydrogel precursor solution can be sprayed or smeared onto the surface of the tissue, so as to realize the in-situ gelling under the condition of light radiation; the photoinduced nitroso crosslinked hydrogel material is especially suitable for the post-operation wound sealing and the tissue liquid leakage blockage.

The invention relates to a vessel plug material used in intervene treatment. Wherein, said material is temperature-sensitive nanometer gel system based on polymer N-isopropyl acrylamide (PNIPAAm), which comprises polymer N-isopropyl acrylamide nanometer gel and dispersed medium, while the gel mass percentages is 3-20% and the particle diameter of temperature-sensitive nanometer gel is 50-1000nm. The inventive temperature-sensitive nanometer gel system also can contain developer, soluble antineoplastic. The invention can control the polymer monomer kinds and ratios, the crosslinker amount and the density of temperature-sensitive nanometer gel, to control the sol-gel transformation temperature of said system, and the inventive product has better external flow property and high sol-gel transformation speed, to be used to treat vessel plug, etc.

The invention discloses a preparation method of nano meso-porous silicon composite hydrogel with a controlled release function. The preparation method includes the steps that micromolecular medicine is loaded in meso-porous silicon nano-particles; an oxidized hyaluronic acid and carboxymethyl chitosan solution is prepared, and the medicine-carrying nano-particles are added into the hyaluronic acid solution to be ultrasonically treated and then stirred to be uniform; a medicine-carrying nano composite hydrogel carrier is prepared. The prepared nano composite hydrogel has good mechanical performance, biocompatibility, biodegradability and medicine slow release effects, and has potential of being applied to the fields of tissue engineering and biological medicine treatment. In addition, the preparation method of the nano composite hydrogel is simple, cost is low, and large-scale production can be achieved.

The invention discloses a chitosan-based hydrogel, and a preparation method and application thereof. The chitosan-based hydrogel is prepared with chitosan or a derivative thereof as a raw material bygrafting an ortho-phenyl dihydroxyl group compound onto the main chain of the raw material and then performing cross-linking via a cross-linking agent. The preparation method for the hydrogel comprises the following steps: firstly grafting an ortho-phenyl dihydroxy group onto chitosan or the derivative thereof to allow a product to have wet adhesion; and then, performing a cross-linking reaction to form the hydrogel material with sufficient mechanical strength and viscoelasticity. The hydrogel material has wet adhesion, hemostasis and wound healing promotion functions, and has good applicationprospects in tissue engineering and skin repairing.

The invention discloses amphipathic polysaccharide derivative/poloxamer thermo-sensitive type in-situ hydrogel and a preparation method thereof. The thermo-sensitive type in-situ hydrogel is prepared in the mode that amphipathic polysaccharide series derivatives, poloxamer polymer and hydrophobic drugs interact to form stable in-situ hydrogel, the gelatinization temperature of the thermo-sensitive type in-situ hydrogel ranges from 34 DEG C to 37 DEG C, and the gelatinization time for forming the in-situ hydrogel at the gelatinization temperature ranges from one to three minutes. The poloxamer polymer is the mixture of poloxamer 407 and any one kind of poloxamer of other types. Compared with common amphipathic/poloxamer in-situ hydrogel, the in-situ hydrogel is higher in stability and longer in drug sustained release time, parenteral drug delivery and improving of drug bioavailability are made possible, and the in-situ hydrogel can be applied to mucous membrane drug delivery, transdermal drug delivery and parenteral drug delivery systems; the preparation method of the mphipathic polysaccharide derivative/poloxamer thermo-sensitive type in-situ hydrogel is convenient to operate, simple in process and cheap in needed equipment and raw material.

The invention discloses a preparation method of hydrogel based on polyphenol-silver nano-enzyme with a plasma effect. The preparation method comprises the following steps: 1, adding a phenolic hydroxyl group-containing compound into an aqueous silver ion solution to form a mixed solution A, wherein the molar ratio of silver ions to the phenolic hydroxyl group-containing compound in the mixed solution A is (87-118):1; 2, adding a double-bond compound solution with the mass concentration of 15-45% into the mixed solution A obtained in step 1, and fully and uniformly stirring to form a mixed solution B, wherein the volume ratio of the acrylic acid solution to the mixed solution A is (15-30%):1; and 3, adding an initiator into the mixed solution B obtained in step 2, uniformly mixing, and carrying out self-polymerization to obtain the required hydrogel. Only the initiator, a monomer containing double bonds, specific metal ions and the organic matter containing the phenolic hydroxyl groupsare self-polymerized into the gel, and other auxiliary conditions are not needed; and the hydrogel has the advantages of short gelatinizing time, excellent mechanical properties, extremely strong adhesion property, good conductivity and certain antibacterial property.

The invention discloses an ammonia-free gel. The ammonia-free gel is rapidly prepared by adding, by weight, 10 to 20 parts of water and 2 parts of sodium silicate into 1 part of a powder agent, and is used for fire prevention. The powder agent is composed of following ingredients, by weight, 30% of sodium bicarbonate, 20% of magnesium sulfate, 40% of copper sulphate, 5% of cellulose, 3% of bentonite, and 2% of a thickening agent. The thickening agent is a cellulose thickening agent; and reaction is carried out at normal temperature. It is confirmed by experiment research and cost analysis that, compared with conventional gel in the market, a preparation method of the ammonia-free gel is simple; gelation time is shorter; raw materials are easily available; water retaining rate is high; the ammonia-free gel is friendly to the environment, is nontoxic, is harmless, is odorless, possesses no corrosivity, and improved fire resistance and heat stability, and can be commonly used for coal mine fire extinguishing.

The invention relates to a medicinal injectable anti-adhesive gel and a preparation method thereof. The gel is prepared from a crosslinking agent and natural polymer or synthesized polymer in a mass ratio of (0.01-1):1. The preparation method comprises the following steps: respectively preparing phosphate buffer solutions of macromolecular polymer and crosslinking agent; filling two injection syringes of a two-way injection device; extruding the two-way injection device to mix the two solutions in a needle and form gel; and injecting the natural or synthesized polymer solution with an anti-adhesive effect and the crosslinking agent to the wound position by virtue of the two-way injection device, quickly filling gaps around nerves or tendons and other tissues, and in-situ forming flexible gel in a short time. The gel is not influenced by positions, can endure stress of peripheral tissues and does not have pressure effect. Since the gel is crosslinked by the crosslinking agent, the gel has a relatively long degradation time, is capable of completely preventing the operating wound from adhering in the chronic inflammation period, and can be finally degraded or absorbed in the body. The medicinal injectable anti-adhesive gel can be widely applied.

The invention relates to a preparation method of POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel. The preparation method comprises the following steps: carrying out Michael addition reaction on 4-arm-PEG-MAL and POSS-SH to obtain a POSS-PEG pre-polymer; taking a matrix metalloproteinase substrate peptide as a cross-linking agent, carrying out the Michael addition reaction on the matrix metalloproteinase substrate peptide and the POSS-PEG pre-polymer and crossly linking to form gel, so as to obtain the POSS-PEG hybrid hydrogel. The POSS-PEG hybrid hydrogel provided by the invention has good mechanical strength and the mechanical strength of the POSS-PEG hybrid hydrogel can be finely regulated and controlled through changing the molecular weight of the 4-arm-PEG-MAL and the mol ratio of the POSS-SH to the 4-arm-PEG-MAL; meanwhile, the POSS-PEG hybrid hydrogel can be prepared in a triethanolamine with low concentration and gel formation time is short; the damages or loss on seed cells or medicines loaded on the POSS-PEG hybrid hydrogel can be reduced as much as possible under the condition that basic physicochemical properties are ensured.

The invention relates to a zirconium sol, a preparation method and applications thereof, wherein the zirconium sol has a corrosion rate of not more than 1 g/m<2>.h, the pH value of 2.5-4, and the viscosity of more than 1000 mPa.s. The preparation method comprises: carrying out first contact on a zirconium-containing salt and an alkali solution, wherein a molar ratio of Zr to OH<-> is 1:1-2; carrying out second contact on the first contact mixture and an acid, wherein a molar ratio of Zr to H<+> is 1:1-3, and preferably the temperature of the first contact is 20-30 DEG C higher than the temperature of the second contact; and carrying out third contact on the second contact mixture and an acid, wherein a molar ratio of Zr to H<+> is 1:1-3. According to the present invention, the zirconium sol is used for preparing catalytic cracking catalysts, can improve the sphericity of the catalyst, and can improve the hydrocarbon oil cracking reaction effect of the catalyst.

The invention provides albumin hydrogel. The albumin hydrogel is prepared by mixing albumin, a cross-linking agent and a solvent, the cross-linking agent comprises a repeating unit having a structureof formula (I) and an end group having a structure of formula (II). The invention develops the albumin hydrogel which is rapid in crosslinking, low in gelatinization concentrating and free of biotoxicity, and the albumin hydrogel is applied to the fields of cell culture, tissue engineering and drug delivery. Besides, as a good paclitaxel topical treatment drug carrier, the albumin hydrogel overcomes the defect of poor paclitaxel solubility, polyoxyethylene castor oil with biotoxicity is not introduced, and compared with a systemic preparation, the albumin hydrogel has the advantages that the administration frequency is effectively reduced, the drug concentration at a tumor is increased, and the systemic toxicity is reduced. Nanoparticles wrapping paclitaxel are used as gel forming components of the gel, so that uniform distribution of the paclitaxel in the gel can be realized, and stable and continuous release is realized.

A ceramics catalyst surface active coating in the catalyst technical field and its preparation method. The coating has following components in mass ratio: 6.62-33.11% of pseudo-boehmite, 0-26.49% of gamma-alumina and 0.33-1.96% of additive and the balance of water. The produced active alumina coating has small deposition loss, has uniform coating and stable physical and chemical properties. The obtained coating has low shedding rate of less than 1.55%.

The invention relates to the field of cell culture, in particular relates to letilla striata polysaccharide hydrogel, a culture medium and application thereof as well as a method of inducing differentiation of umbilical cord mesenchymal stem cells (hUC-MSCs) to corneal epithelial cells. The method comprises the steps of sulfating letilla striata polysaccharide and then crosslinking with Epsilon-polylysine carrying polyfunctional groups to prepare the polysaccharide hydrogel. The letilla striata polysaccharide hydrogel is of a semi-transparent membrane, has good porosities, and is suitable for the growth and the differentiation of cells. The experiment shows that by taking the letilla striata polysaccharide hydrogel provided by the invention as a scaffold, after the hUC-MSCs and amniotic epithelial cells are subjected to co-culture for 7 days, the differentiation rate of the hUC-MSCs can be up to 31.96%. The differentiation rate (p is less than 0.01) is obviously superior to that of a contrasting example which does not adopt the hydrogel scaffold. In addition, the hydrogel provided by the invention can promote the cells to grow vigorously, and shorten the induction time.

The invention discloses a method for using a Pickering emulsion method for producing GelMA macropore hydrogel and application. The method comprises the steps of dissolving GelMA and PEG-4SH in PBS buffer liquid, and stirring a mixture; adding MgO nano-particles after fully dissolving the GelMA and the PEG-4SH, stirring a mixture, and conducting ultrasonic treatment on the mixture; adding dodecaneand a photoinitiator, and using a high-speed homogenizer for intensively stirring a mixture to obtain stable Pickering emulsion; and making the emulsion subjected to UV illumination to form gel, and obtaining the GelMA macropore hydrogel by using ethyl alcohol and water for full wash dialysis. The produced GelMA macropore hydrogel has the advantage of the macropore structure, can promote transportation of nutrient substances, discharging of metabolic products and cell communication, entraps a component containing Mg, has effect of promoting adhesion and proliferation of bone marrow mesenchymalstem cells and promoting osteogenic differentiation, has excellent biocompatibility, can be used as a bone tissue engineering scaffold with excellent performance, and has large clinical application potential in the field of bone repair.

The invention belongs to the technical field of ceramic synthesis and provides a method for preparing a strontium lanthanum manganate/copper calcium titanate composite magnetoelectric ceramic materialby virtue of a sol-gel method. The method comprises the steps of respectively preparing lanthanum strontium manganite (LSMO) precursor powder, copper calcium titanate and CCTO precursor powder by virtue of the sol-gel method, mixing the LSMO precursor powder with the CCTO precursor powder, adding an adhesive, uniformly mixing, pressing to form a ceramic blank, and sintering a ceramic blank, so asto obtain a strontium lanthanum manganate/copper calcium titanate (LSMO-CCTO) composite magnetoelectric ceramic sample. The method has the beneficial effects that the raw materials are low in cost; components in the reaction process are controllable, and an impure phase is avoided; the gelling time is short; a preparation process is simple, and the dielectric property and magnetism of the ceramicsample have very strong regularity; a ceramic wafer is high in density and grain uniformity; and the process is simple and easy for industrial production, the prepared ceramic sample is high in density and grain uniformity and excellent in magnetoelectric performance.

The invention belongs to the technical field of petrochemical engineering, and particularly relates to an anhydrous fracturing fluid suitable for shale gas and a preparation method of the anhydrous fracturing fluid. The anhydrous fracturing fluid suitable for shale gas is prepared from the following raw materials in percentage by mass: 0.5-2% of a crosslinking agent, 2-6% of a complex iron activator and the balance of a low carbon hydrocarbon; in a pressure vessel with a pressure of 0.8-3.0 MPa, the crosslinking agent is added into the low carbon hydrocarbon to be uniformly mixed, the complex iron activator is added to be stirred for 2-5 min, so that the anhydrous fracturing fluid suitable for shale gas is obtained; and the low carbon hydrocarbon is one or a mixture of more of propane, butane, n-hexane, n-heptane and kerosene. The anhydrous fracturing fluid suitable for shale gas easily flows back, has a good sand-carrying property, does not harm reservoirs, and can satisfy the needs of fracturing reconstruction of shale oil and gas and strong water-sensitive compact oil and gas reservoirs. A synthetic method is simple, and the content of an effective component dialkyl phosphate in a product is high, thereby facilitating the industrialization production of the anhydrous fracturing fluid.

The invention discloses a preparation method of injectable aquagel based on a polyaspartic acid derivative. The method comprises the following steps of: undergoing a thermal polycondensation reaction by taking L-aspartic acid as a raw material, taking phosphoric acid as a catalyst and taking a mixed solvent of sulfolane and 1,3,5-trimethylbenzene as a reaction solvent to obtain polysuccinimide, and undergoing a ring-opening reaction by attacking with a hydrazine hydrate serving as a nucleophilic reagent to obtain a polyaspartamide hydrate; making 3-aminopropylene glycol and ethanol amine undergo a ring-opening reaction with polysuccinimide in sequence to obtain poly-3-amino-1,2-propylene glycol-modified poly(2-hydroxyethyl asparagine), and adding sodium periodate for undergoing an oxidation reaction to prepare formyl-modified poly(2-hydroxyethyl asparagine); and dissolving two prepared products into a phosphoric acid buffer solution respectively, and mixing the two solutions to formedaquagel. The preparation method disclosed by the invention has the advantages of easiness for implementing, low manufacturing cost and short gel forming time; and the injectable aquagel can be widelyapplied to medicament carriers and tissue engineering bracket materials.

The invention provides a simple mixing preparation method with which a gel form of chitosan/graphene oxide/beta-isodium glycerophosphate thermosensitive hydrogel can be formed under a temperature below 37 DEG C. Through rheological tests, the influences of chitosan concentration, beta-isodium glycerophosphate concentration and graphene oxide concentration upon chitosan hydrogel gelling temperature and time are researched. As a result, the chitosan concentration, beta-isodium glycerophosphate concentration and graphene oxide concentration are negatively correlated to chitosan thermosensitive hydrogel gelling temperature and time.