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Temperature sensing nano gel system for blood vessel embolism material

A technology of nanogel and blood vessel embolization, applied in the field of biomedical engineering

Active Publication Date: 2007-03-07
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, poly-N-isopropylacrylamide nanogels have not been reported as vascular embolization materials for interventional therapy.

Method used

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  • Temperature sensing nano gel system for blood vessel embolism material
  • Temperature sensing nano gel system for blood vessel embolism material
  • Temperature sensing nano gel system for blood vessel embolism material

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] Preparation of thermosensitive nanogels:

[0030] According to the ratio of monomer ratio (A:B) of 80~99:1~20, weigh two kinds of comonomers, dissolve them in a certain volume of water, make the concentration of monomers 0.1~0.2mol / L, add 0.2-10% cross-linking agent based on total moles of monomers, anionic surfactant is used as emulsifier, and emulsifier concentration is 0.5-5mmo / L. The emulsifier is preferably sodium dodecyl sulfate (SDS). After passing nitrogen for 30 minutes under magnetic stirring, add a water-soluble free radical initiator, the reaction temperature is 20-90 ° C, and the reaction uses N 2 Gas protection, the reaction time is 4 ~ 24h. The nanogel dispersion obtained by the reaction is dialyzed, freeze-dried, and stored in a desiccator for future use. The concentration of the initiator used in the above process is 1-5 mmol / L, and the initiator can be potassium persulfate (KPS), ammonium persulfate-tetramethylethylenediamine or potassium persulfate...

Embodiment 1

[0040] 2.263g NIPAAm (20mmol), 0.014g AAm (0.2mmol), 0.031g MBAAm (0.2mmol) and 0.030g SDS were added to a 250mL three-necked flask equipped with a reflux condenser and a gas guiding device, and a 171.3mL ultra- Pure water was dissolved under magnetic stirring. First pass high-purity nitrogen into the above reaction system for 30 minutes, then heat to 70°C, and add 0.0452g KPS to initiate the polymerization reaction. in N 2 In the atmosphere, react at 70±1°C for 4.5 hours. A white cloudy nanogel suspension was obtained. The nanogel suspension was dialyzed in ultrapure water for two weeks, 5 mL was reserved for testing, and the rest was freeze-dried to collect the freeze-dried powder.

[0041] Determination of the average particle size of the nanogel particles: use a Nano-ZS 90 laser particle size analyzer (Malvern, UK) to measure, the light source is a helium-neon laser (λ=633nm), and the detection angle is 90°. The test sample is nanogel dialysate diluted with ultrapure w...

Embodiment 2

[0043] Add 1.488g NIPAAm (13mmol), 0.182g N-n-propylacrylamide (NNPAAm) (1.6mmol), 0.176g MBAAm (1.09mmol) and 0.030g SDS to a 250mL container equipped with a reflux condenser and a gas guide In a three-necked bottle, dissolve with 125mL ultrapure water under magnetic stirring. First, high-purity nitrogen was introduced into the above reaction system for 30 minutes, and then 0.050 g of ammonium persulfate and 100 μL of tetramethylethylenediamine were added to initiate the polymerization reaction. in N 2 In the atmosphere, the reaction was carried out at room temperature for 24 hours. A nanogel suspension is obtained. The nanogel suspension was dialyzed in ultrapure water for two weeks, 5 mL was reserved for testing, and the rest was freeze-dried to collect the freeze-dried powder.

[0044] Determination of the average particle size of the nanogel particles: use a Nano-ZS 90 laser particle size analyzer (Malvern, UK) to measure, the light source is a helium-neon laser (λ=633...

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Abstract

The invention relates to a vessel plug material used in intervene treatment. Wherein, said material is temperature-sensitive nanometer gel system based on polymer N-isopropyl acrylamide (PNIPAAm), which comprises polymer N-isopropyl acrylamide nanometer gel and dispersed medium, while the gel mass percentages is 3-20% and the particle diameter of temperature-sensitive nanometer gel is 50-1000nm. The inventive temperature-sensitive nanometer gel system also can contain developer, soluble antineoplastic. The invention can control the polymer monomer kinds and ratios, the crosslinker amount and the density of temperature-sensitive nanometer gel, to control the sol-gel transformation temperature of said system, and the inventive product has better external flow property and high sol-gel transformation speed, to be used to treat vessel plug, etc.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a new type of vascular embolism material for interventional therapy-thermosensitive nano gel system. Background technique [0002] Embolization therapy refers to the selective intubation of thrombogenic agents to occlude the corresponding blood vessels to achieve therapeutic purposes. There are a variety of interventional vascular embolization materials. Mainly divided into granular embolic materials such as gelatin, albumin, bletilla striata, and polyvinyl alcohol; liquid embolic materials such as absolute ethanol, lipiodol, etc.; large embolic materials such as coils, detachable balloons, etc.; magnetic embolic materials such as glucose Glycan magnetic composite microspheres and radioembolic materials, etc. (Sheng Xizhong et al., Journal of Medical Imaging. 2004, 14(10): 852; Li Shipu et al., Bio-Orthopedic Materials and Clinical Research. 2005, 12(2): 46). Each of the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/16
Inventor 王芹杨祥良杨亚江刘卫郑传胜张志伟赵彦兵冯敢生徐辉碧
Owner HUAZHONG UNIV OF SCI & TECH
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