23 results about "Arteriovenous malformation" patented technology

The invention discloses a brain arteriovenous malformation vascular structure lumped model simulation method and system, and the method comprises the steps: obtaining the three-dimensional image data of a preset region of the head of a human body, and recognizing a brain arteriovenous malformation vascular mass region in the three-dimensional image data; constructing a blood vessel three-dimensional structure model, and acquiring three-dimensional space coordinate data of each voxel in the cerebral arteriovenous malformation vascular cluster region in the model; calibrating an inlet and an outlet of the blood vessel three-dimensional structure model and corresponding pressure set values and / or flow velocity set values; extracting a plurality of skeleton points of the blood vessel based on the blood vessel three-dimensional structure model to obtain a microscopic blood vessel network; based on the three-dimensional space coordinate data, the length and the average diameter of each blood vessel in the microscopic blood vessel network are obtained, and the flow resistance of the blood vessels is calculated; based on the pressure set value and the flow velocity set value of the blood vessel three-dimensional structure model and the flow resistance of each blood vessel, the blood flow velocity and pressure distribution data of each blood vessel are calculated through a lumped parameter model, and the hemodynamic characteristics of the cerebral arteriovenous malformation blood vessel are obtained.

The invention provides a quinoline compound as well as a preparation method and application thereof, the quinoline compound comprises at least one of chemical formulas shown as a formula I, # imgabs0 #, R1, R3 and R4 independently comprise H, halogen, an oxygen-containing group, a nitrogen-containing group, a phosphorus-containing group, a sulfur-containing group or a carbon-containing unsaturated bond, and R1, R3 and R4 independently comprise H, halogen, an oxygen-containing group, a nitrogen-containing group, a phosphorus-containing group, a sulfur-containing group or a carbon-containing unsaturated bond; r2 comprises alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl which contain or do not contain substituent groups. According to the quinoline compound and the pharmaceutically acceptable salt thereof, the generation of cerebral arteriovenous malformation can be inhibited from the gene level, and the generation of drug resistance is avoided; and the tumor inhibition effect is excellent.

A detachable tip sheathed balloon microcatheter is provided for delivering an embolic agent to a target location for the embolization of an arteriovenous malformation (AVM). The detachable tip sheathed balloon microcatheter including a balloon microcatheter including a first shaft and an inflatable balloon that is coupled to a distal end portion of the first shaft; and a detachable tip assembly that is configured to be detachably coupled to the first shaft of the balloon microcatheter. The detachable tip assembly includes a protective balloon sheath that is coupled to a proximal end portion of the second shaft, wherein when the detachable tip assembly is coupled to the balloon microcatheter, the protective balloon sheath surrounds at least a portion of the inflatable balloon.

The invention relates to an implant for the treatment of arteriovenous malformations, in particular aneurysms, in which the implant can be brought into a target site in the vasculature of a patient in a compressed state by means of a microcatheter, and the implant is imparted with a second structure by means of which it assumes an expanded state when released from the microcatheter, wherein the implant is releasably connected to the insertion aid via a separation site, and wherein the implant in the expanded state has a body having a proximal section and a distal section wherein the proximal section and the distal section have a dome-shaped configuration wherein the convex side of the dome of the proximal section is in a proximal direction and the convex side of the dome of the distal section is in a distal direction. The convex side of the dome of the proximal section faces in the distal direction, and wherein the proximal section and the distal section are connected to each other by a plurality of connecting struts. Alternatively, the implant may have the shape of a closed tulip head. The implant according to the invention can effectively adapt to the shape of a corresponding aneurysm.

The invention relates to an implant (1) for the treatment of arteriovenous malformations, in particular aneurysms (2), wherein the implant (1) can be introduced in a compressed state to a destination in the blood vessel system of a patient by means of a microcatheter (3) and a secondary structure is imprinted on the implant (1) by means of which it assumes an expanded state upon release from the microcatheter (3), wherein the implant (1) is detachably connected to an insertion aid (5) via a release point (4) and, in the expanded state, has a base body (6) which is constructed from struts (16), wherein the struts (16) are at least partially connected to one another at intersection points, so that spaces (11) are formed between the struts (16), wherein, in the expanded state, the struts (16) extend radially outwards at the proximal end of the base body (6) and, further along, axially in a distal direction and radially inwards.such that a bulging of the base body (6) results, wherein the base body (6) has a zone at its distal end where the struts (16) are not connected to each other. The implant (1) according to the invention is able to adapt well to the shape of the respective aneurysm (2).

The invention discloses a three-dimensional cerebral arteriovenous malformation blood vessel morphology complexity calculation method and device, and the method comprises the steps: obtaining image data of cerebral arteriovenous malformation blood vessels in a preset region of a brain, extracting a lesion blood vessel structure in the image data based on a threshold segmentation algorithm, and carrying out the image segmentation and synthesis processing, obtaining a three-dimensional blood vessel model of cerebral arteriovenous malformation blood vessels; based on the three-dimensional blood vessel model, multi-term fractal analysis calculation of cerebral arteriovenous malformation blood vessels is carried out, and multi-scale fractal feature values are obtained; and based on the multi-scale fractal feature value, calculating the morphological complexity of the cerebral arteriovenous malformed blood vessel. A set of systematic quantitative parameter system is constructed through fractal analysis, the morphological characteristics of AVM lesions and the complexity of vascular construction of the AVM lesions can be accurately reflected, the lesion characteristics can be conveniently and rapidly evaluated, and the limitation of relying on subjective judgment in the past is avoided.

The invention discloses an application of a small molecule medicine PLX4032 in preparation of a medicine for treating cerebral arteriovenous malformation diseases, the small molecule medicine PLX4032 can inhibit excessive activation of a BrafV600E mutant protein Braf-MEK1 signal channel, so that the kinase activity of the BrafV600E mutant protein is reduced, the expression of the BrafV600E mutant protein in the cerebral arteriovenous malformation diseases is avoided, and the cerebral arteriovenous malformation diseases can be treated by using the small molecule medicine PLX4032 to treat the cerebral arteriovenous malformation diseases. Pathological cells can be directly targeted, and the treatment effect is good.

The invention provides a device and a method for evaluating the curative effect of arteriovenous malformation. The device comprises a light source, a photoelectric detector, an optical circulator, a detection device, a micro-control unit and terminal equipment, the light source is connected with the optical circulator through a first optical fiber, and the photoelectric detector is connected with the optical circulator through a second optical fiber; the optical circulator is connected with the detection device through a third optical fiber; the photoelectric detector is connected with the micro-control unit, and the micro-control unit is connected with the terminal equipment; skin surface micro-vibration changes are collected through a high-sensitivity diaphragm structure, and dynamic and objective evaluation of the curative effect is achieved in combination with frequency domain and time domain analysis methods.

The invention relates to an implant (1) for treating arteriovenous malformations, in particular aneurysms (2), wherein the implant (1) can be brought to a target site in the patient's vascular system in a compressed state via a microcatheter (3), and the implant (1) is given a second structure by which it adopts an expanded state when released from the microcatheter (3), wherein the implant (1) is detachably connected to an insertion aid (5) via a detachment site (4), and wherein the implant (1) in the expanded state has a body (6), the body (6) having a proximal section (7) and a distal section (8), wherein the proximal section (7) and the distal section (8) have a dome-shaped configuration, wherein the convex side of the dome of the proximal section (7) faces in the proximal direction and the convex side of the dome of the distal section (8) faces in the distal direction, and wherein the proximal section (7) and the distal section (8) are connected to each other by a plurality of connecting struts (9). Alternatively, the implant (1) can have the shape of a closed tulip flower head. The implant (1) according to the invention can effectively adapt to the shape of a corresponding aneurysm (2).

This invention discloses the application of the small molecule drug PLX4032 in the preparation of a drug for the treatment of cerebral arteriovenous malformation. The small molecule drug PLX4032 of this invention can inhibit Braf... V600E Overactivation of the mutant protein Braf-MEK1 signaling pathway, thereby reducing Braf V600E The mutant protein's kinase activity, thereby preventing Braf from occurring in arteriovenous malformations of the brain. V600E The expression of mutant proteins can directly target diseased cells, resulting in good therapeutic effects.

This invention discloses an AI-powered intelligent embolization assistance system for arteriovenous malformations of the brain and spinal cord. By integrating an AI-powered intelligent embolization assistance subsystem and an image-guided platform, it matches 3D-DSA angiography images with internally stored hydrodynamic models of different embolization materials to obtain a three-dimensional vascular architecture map of the lesion and surrounding vessels. Through AI calculation, it completes virtual path planning, simulating the embolization path, three-dimensional course, and embolization range. Based on this, it provides real-time navigation of the microcatheter during EVT, intelligently following its path. After the procedure, it re-acquires 3D-DSA angiography images, performs multimodal image fusion, and assesses the embolization status, the three-dimensional relationship with surrounding structures, and potential related complications. This system enables preoperative planning and simulation of the interventional embolization path and range, and real-time navigation, tracking, and assessment of the lesion during the procedure, effectively improving the efficacy of EVT.

The invention relates to a single-component medical composition in the form of a hydrogel comprising silicate nanoparticles, water, a hydrogel-forming synthetic polymer, and one or more bio-based proteins and / or polymers. Such a composition can be used as a flexible replacement for coil implants in the treatment of aneurysms, tumors, or arteriovenous malformations, and due to its extensive biodegradability and better tolerability, it avoids long-term anticoagulation therapy. The present invention further relates to devices filled with such a composition, and to kits containing such compositions or devices as one component and a medical device, in particular in the form of a stent, as a further component.

The application provides an arteriovenous malformation curative effect evaluation device and method, which comprises a light source, a photodetector, an optical circulator, a detection device, a micro control unit and a terminal device; the light source is connected with the optical circulator through a first optical fiber, and the photodetector is connected with the optical circulator through a second optical fiber; the optical circulator is connected with the detection device through a third optical fiber; the photodetector is connected with the micro control unit, and the micro control unit is connected with the terminal device; the high-sensitivity diaphragm structure is used to collect the micro vibration changes of the skin surface, and the frequency domain and time domain analysis methods are combined to realize dynamic and objective evaluation of curative effect.

A method of processing image data for automated segmentation of an arteriovenous malformation includes obtaining a graph representation, combining nodes of the graph representation, determining a node or combined node with a highest number of direct connections to the node or combined node as the origin node, and combining nodes connected directly to the origin node. The method includes combining, with the origin node, a branching node connected to the origin node if it fulfills: the branching node is connected directly to precisely three nodes, and the branching node is connected directly or indirectly to a further branching node that is connected directly to at least four nodes. The indirect connection includes one or more nodes that are each connected directly to precisely two nodes. The method includes carrying out the method again, beginning with the combining of the nodes, if nodes are combined with the origin node.

The invention discloses a composite magnetic photo-thermal microsphere. The composite magnetic photo-thermal microsphere comprises a macromolecular polymeric material grafted with an amino group, a magnetic material and a photo-thermal preparation, the high-molecular polymeric material grafted with the amino group has positive electricity; the photo-thermal preparation has electronegativity, and the photo-thermal preparation is loaded on a macromolecular polymeric material grafted with amino groups through electrostatic adsorption. The composite magnetic photo-thermal microsphere provided by the invention has photo-thermal and magnetic control multifunctional modes, has a more stable three-dimensional network structure with higher charge content, remarkably improves the strong adsorption function on targeted drugs, markers and the like, can realize accurate targeted embolism, and has a good application prospect. The device can be used as an efficient interventional therapy machine for radiotherapy or minimally invasive surgery, and is applied to clinical intravascular treatment of tumors, arteriovenous malformation or local inflammation.

The invention discloses a cerebral arteriovenous malformation interventional embolism postoperation reserved tube cutting device which comprises a support and an extrusion block. An extrusion block is slidably connected into the bracket; an extrusion groove is formed in the upper end of the stent, a cut-off groove is formed in the lower end of the stent and slidably connected with the microcatheter, and an extrusion slope is arranged at the joint; an extrusion block is arranged on one side of the extrusion groove, and inclined grooves are formed in two sides of the upper end; the upper end of one side of the extrusion block is provided with a sliding block, and the lower end of the extrusion block is provided with an extrusion spring which is fixedly connected with one side of the extrusion groove; the sliding block is slidably connected with the support and penetrates through the support to be provided with an extrusion block. The micro-catheter can be linearly inserted by extruding inclined plane connection, so that the insertion resistance caused by the inclined plane is avoided.

The present invention provides a method and device for grading arteriovenous malformations based on time-enhanced radiomics. First, a neural network is used to detect blood vessels in the DSA images of patients, and the frame numbers at which the blood vessels start and end to appear are recorded; the frame numbers at which the blood vessels start and end to appear are divided by the DSA sampling frame rate to obtain the time points at which the detected blood vessels start and end to appear, and time features are obtained through calculation; since multiple frames of DSA images can be synthesized into a minimum intensity map by taking the minimum pixel value of each pixel point on the time axis, a corresponding minimum intensity map is synthesized for the DSA images corresponding to the time features, and the time features are used for weighting to obtain a time-enhanced minimum intensity map; time-enhanced radiomics features are obtained by calculating the time-enhanced minimum intensity map, and a prediction model for grading arteriovenous malformations is constructed by means of machine learning. This method and device can accurately and simply evaluate the high and low grades of arteriovenous malformations.

The invention relates to a one-component medical composition in the form of a hydrogel which comprises silicate nanoparticles, water, a hydrogel-forming synthetic polymer and one or more bio-based proteins and / or polymers. Such a composition can be used as a flexible substitute for coil implants in the treatment of aneurysms, tumours or arteriovenous malformations, and due to its extensive biodegradability and improved tolerability, makes long-term anticoagulation therapy unnecessary. The present invention also relates to devices filled with such a composition, and kits which contain such compositions or devices as one component and a medical device, in particular in the form of a stent, as another component.

In particular, the invention relates to a vascular occlusion apparatus for the treatment of diseases such as fistulas, distal end perforations, LIMA side branches, tumors, arteriovenous malformations, etc., which allows the closure of vessel ends and vessel walls and vessel ruptures that allow blood flow in the pathological vascular structure, which allows the unwanted blood flow to be stopped by positioning it in the desired position within the vessel, and does not require the use of a different apparatus for positioning.

Provided herein are methods for the treatment and prevention of vascular lesions arising from RASA1 and / or EPHB4 mutations and associated with capillary malformation-arteriovenous malformation (CM-AVM).

A detachable tip sheathed balloon microcatheter is provided for delivering an embolic agent to a target location for the embolization of an arteriovenous malformation (AVM). The detachable tip sheathed balloon microcatheter including a balloon microcatheter including a first shaft and an inflatable balloon that is coupled to a distal end portion of the first shaft; and a detachable tip assembly that is configured to be detachably coupled to the first shaft of the balloon microcatheter. The detachable tip assembly includes a protective balloon sheath that is coupled to a proximal end portion of the second shaft, wherein when the detachable tip assembly is coupled to the balloon microcatheter, the protective balloon sheath surrounds at least a portion of the inflatable balloon.