49 results about "Gastrointestinal wall" patented technology

The present invention involves new interventional methods and devices for reconfiguring a portion of the gastrointestinal tract. The procedures are generally performed laparoscopically and may generally be described as laparoscopic plication gastroplasty (LPG) in which, after obtaining abdominal access, spaced apart sites on a gastric wall are engaged, approximated and fastened to create one or more tissue folds forming one or more plications projecting into the gastrointestinal space. The serosal tissue may optionally be treated during the procedure to promote the formation of a strong serosa-to-serosa bond that ensures the long-term stability of the tissue plication. These procedures are preferably carried out entirely extragastrically (i.e. without penetrating through the gastrointestinal wall), thereby minimizing the risks of serious complications.

The present invention involves new interventional methods and devices for reducing gastric volume, and thereby treating obesity. The procedures are generally performed laparoscopically and may generally be described as laparoscopic plication gastroplasty (LPG) in which, after obtaining abdominal access, spaced apart sites on a gastric wall are engaged and approximated to create one or more tissue folds that are then secured by placing one or more tissue fasteners to produce one or more plications projecting into the gastrointestinal space. The serosal tissue may optionally be treated during the procedure to promote the formation of a strong serosa-to-serosa bond that ensures the long-term stability of the tissue plication. These procedures are preferably carried out entirely extragastrically (i.e. without penetrating through the gastrointestinal wall), thereby minimizing the risks of serious complications. Minimally invasive devices for approximating and fastening soft tissues are disclosed that enable these new interventional methods to be carried out safely, efficiently and quickly. Methods for reversing the procedure are also disclosed.

Devices and methods are provided for ablational treatment of regions of the digestive tract in post-bariatric surgery patients who fail to achieve or maintain the desired weight loss. Bariatric procedures include Roux-en-Y gastric bypass, biliopancreatic diversion, and sleeve gastrectomy. These procedures reconstruct gastrointestinal tract features, creating pouches, stoma, and tubes that restrict and/or divert the digestive flow. Post-surgical dilation of altered structures is common and diminishes their bariatric effectiveness. Ablation of compromised structures can reduce their size and compliance, restoring bariatric effectiveness. Ablation, as provided the invention, starts at the mucosa and penetrates deeper into the gastrointestinal wall in a controlled manner. Control may also be provided by a fractional ablation that ablates some tissue within a target region and leaves a portion substantially unaffected. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.

Devices and methods for applying gastrointestinal stimulation include implanting a stimulation device including a body with at least one expandable portion and a bridging portion and at least one stimulation member in the gastrointestinal tract. The at least one stimulation member includes one or more energy delivery members, one or more sensors, or a combination of both. The body maintains the device within the gastrointestinal space, and preferentially within the pyloric portion of the patient's stomach, and prevents passage of the device from the gastrointestinal space, but is not rigidly anchored or affixed to the gastrointestinal wall tissue.

Devices and methods are provided for ablating areas of the gastrointestinal tract affected with certain benign, pre-cancerous, or early cancerous lesions that originate within the epithelium and are limited to the mucosal layer of the gastrointestinal tract wall. Examples of such lesions include benign conditions such as cervical inlet patch (ectopic gastric mucosa in the upper esophagus), as well as pre-cancerous and cancerous conditions such as intestinal metaplasia/intra-epithelial neoplasia/early cancer of the stomach, squamous intra-epithelial neoplasia and early cancer of the esophagus, oral and pharyngeal leukoplakia, flat colonic polyps, anal intra-epithelial neoplasia (AIN), and early cancers of the anal canal. Ablation, as provided the invention, commences at the epithelial layer of the gastrointestinal wall and penetrates deeper into the gastrointestinal wall in a controlled manner to achieve a successful patient outcome, the latter of which is defined generally as eradication of the targeted lesion, and/or a change in the targeted lesion to prevent or forestall patient morbidity. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.

Systems and methods are disclosed for the inversion of gastro intestinal diverticula and repair of associated intestinal wall tissue by means of endoscopy through a natural orifice such as the mouth or anus without making incisions in the abdominal wall or opening the peritoneal cavity.

A system for controlling the running track of a capsule endoscope comprises a plurality of electromagnetic coils, an electromagnet power supply system, a microprocessor and a handle control system. The handle control system is electrically connected with the electromagnet power supply system through the microprocessor, the electromagnet power supply system is electrically connected with the electromagnetic coils, the handle control system is pushed in a handheld manner to generate coordinate information, the coordinate information is converted into current amplitude values related to the corresponding electromagnetic coils, the current amplitude values are outputted to the corresponding electromagnetic coils so that the electromagnetic coils generate magnetic field attraction consistent with handle thrust, the running track of the capsule endoscope with a magnet in human intestines and stomach is controlled and adjusted in real time, gastrointestinal walls in a specific direction are shot, and more clear and accurate images are acquired. The invention further provides a method for controlling the running track.

The invention discloses a capsule for gastrointestinal color ultrasound contrast and belongs to the field of traditional Chinese medicines. The capsule provided by the invention comprises the following active components in parts by weight: 45-60 parts of Poria cocos, 40-55 parts of Bletilla, 35-50 parts of concha haliotidis, 30-48 parts of radix curcumae, 28-45 parts of Codonopsis pilosula, 25-40 parts of Mangnolia officinalis, 22-36 parts of talcum powder, 18-30 parts of oyster, 15-25 parts of immature bitter orange, 12-22 parts of Fritillaria thun-bergli, 8-18 parts of cuttlebone and 4-10 parts of cornu cervi degelatinatum. The capsule provided by the invention is novel in formula, excellently prepared, remarkable in strong echo spots and clear in display of gastrointestinal wall layers and meanwhile has the treatment effect on gastrointestinal diseases, and also has the functions of stopping blooding and omitting, inhibiting acid and detoxifies, slowing down adverse effect caused by color ultrasound contrast, and the resistance to drugs is reduce, so that the capsule is suitable for clinical application.

The invention belongs to the technical field of medicines, and particularly discloses a self-microemulsion preparation of axitinib. The prepared preparation is a self-microemulsion composition and comprises the following components in percentage by mass: 0.1-10% of axitinib, 5-70% of oil phase, 10-90% of a surfactant and 0-50% of a cosurfactant. The dissolution rate and the mixing uniformity of the prepared axitinib preparation meet the requirements, the axitinib preparation is spontaneously dispersed in gastrointestinal fluid under gastrointestinal peristalsis after being orally taken to form O/W type nanoemulsion, and drug molecules are wrapped in a carrier, so that the particle size of the drug molecules is correspondingly increased, the membrane permeation mode is changed after the nanoemulsion is in contact with small intestine epidermal cells, original passive diffusion transport is changed into endocytosis transport, and stimulation of the nanoemulsion to gastrointestinal tracts is reduced through active cytosis or endocytosis absorption, so that stimulation caused by too high local concentration of the medicines and long-time contact with the gastrointestinal walls is reduced, and side effects of the gastrointestinal tracts of the medicines can be reduced.

The invention belongs to the technical field of medicines, and discloses a self-microemulsion composition of a tyrosine kinase inhibitor. The self-microemulsion composition comprises the following components: 0.1-40% of the tyrosine kinase inhibitor and 60-99.9% of a carrier, wherein the carrier comprises an oil phase, a surfactant and a cosurfactant; and the self-microemulsion composition spontaneously forms a microemulsion with a particle size of less than 50 nm when encountering an aqueous medium. The dissolution rate and the mixing uniformity of the prepared tyrosine kinase inhibitor meetthe requirements, the tyrosine kinase inhibitor is spontaneously dispersed in gastrointestinal fluid under gastrointestinal peristalsis after oral administration to form an O/W type nanoemulsion, drugmolecules are wrapped in the carrier, and the particle size of the drug molecules is correspondingly increased, so that the membrane permeation mode is changed after the nanoemulsion makes contact with small intestine epidermal cells, original passive diffusion transport is changed into endocytosis transport, and stimulation of the nanoemulsion to gastrointestinal tracts is reduced through activecytosis or endocytosis absorption, so that irritation caused by too high local concentration of drugs and long-time contact with gastrointestinal walls is reduced, and side effects of the drugs on the gastrointestinal tracts can be reduced.

The invention provides a separable capsule for detecting a disease marker in gastric fluid and acquiring a real image of the stomach. The separable capsule comprises a main cabin, an auxiliary cabin I and an auxiliary cabin II, wherein the main cabin comprises a wireless emission module, a micro battery, a power control module and a signal acquisition and control circuit; the auxiliary cabin I comprises an image acquisition image or a gastric fluid detection sensor; the auxiliary cabin II comprises an image acquisition circuit or a gastric fluid detection sensor; each image acquisition circuit comprises an LED lamp group, a CMOS sensor and a micro controller; the auxiliary cabin I and the auxiliary cabin II are connected and fixed with the main cabin through degradable fixing rings; after the degradable fixing rings are degraded, the auxiliary cabin I and the auxiliary cabin II are separated from the main cabin. The separable capsule provided by the invention can take a picture of a gastrointestinal wall and can also detect various disease markers; after the detection is completed, the two auxiliary cabins of the capsule are separated from the main cabin, so that the total size of the capsule is decreased, and the risk that the capsule cannot be discharged after entering a human body is effectively reduced.

The invention discloses a method for preparing a cellulose gastrointestinal ultrasound angiography agent. Ethyl cellulose microspheres are firstly prepared; then a silicon oil defoamer is prepared; finally, the ethyl cellulose microspheres with a grain diameter of 20 microns and the silicon oil defoamer are mixed according to mass proportion of 1 to 100; thus the cellulose gastrointestinal ultrasound angiography agent is obtained. Due to the ability of eliminating gastrointestinal gases, the silicon oil defoamer can effectively eliminate artifacts caused by the interference of gases; evenness of a development image is determined by the grain diameter and the distribution of the ethyl cellulose microspheres; when the grain diameter is 20 microns and the distribution of the granularity is even, the ultrasound development effect is the best. The angiography agent of the invention not only ensures clear display of the structure of gastrointestinal wall, but helps to clearly distinguish surrounding organs and is expected to be used in clinical examination of gastrointestinal power.

The invention provides a system for controlling capsule endoscope motion. The system comprises an electromagnet power supply system and an electromagnetic coil. A power supply and a waveform control module are arranged in the electromagnet power supply system, and the electromagnet power supply system is electrically connected with the electromagnetic coil. When a human body swallowing a capsule endoscope with a magnet enters a magnetic field generated by the electrified electromagnetic coil, the waveform control module of the electromagnet power supply system provides current with waveforms changing according to a certain frequency for the electromagnetic coil, strength of the magnetic field alternately changes, and the capsule endoscope with the magnet is attached to the gastrointestinal inner wall under attraction of the magnetic field. The magnetic field with the alternately changing strength leads the capsule endoscope to move transversely and horizontally close to the gastrointestinal wall constantly so as to meticulously shoot all positions of the gastrointestinal wall to obtain clear image data, retention of the capsule endoscope caused by the fact that the capsule endoscope is attached to and embedded into the gastrointestinal concave wall due to too large attraction force is avoided, and accuracy and controllability of image shooting in the stomachs is further improved.

The invention relates to a pharmaceutic preparation for treating stomach cancer and an application thereof. The pharmaceutic preparation comprises the following components: poria cocos, piper cubeba, amomum tsao-ko, herba eupatorii, fructus terminaliae billericae, codonopsis pilosula, astragalus membranaceus, orchis, hawthorn fruit, black bean peel, concha arcae, gorgon euryale seed, liquorice, fructus forsythia, cyrtomium fortunei, dandelion, radix isatidis and halloysitum rubrum. The pharmaceutic preparation is more reasonable in medicinal materials on the basis of the stomach cancer treatment theory, and balanced in yin and yang; the medicinal materials are matched to improve the blood circulation, make the pharmaceutical effect and function be more comprehensive and treat both the symptoms and root causes, so that the pharmaceutic preparation has the effects of replenishing qi to invigorate the spleen and promoting qi circulation to relieve pain; through the coordination of the medicinal materials, the pharmaceutic preparation has the effects of eliminating cold to stop pain, soothing the liver to regulate the flow of vital energy, warming to strengthen the middle warmer, and nourishing and harmonizing the stomach, and can be used for rapidly eliminating the stomach pain, powerfully inhibiting the tumor growth, nourishing the gastrointestinal wall and thoroughly curing the stomach cancer.

The invention provides a method for adjusting the position and pose of a robot by utilizing feedback force information. The method comprises the steps that if force sensing points are distributed in the circumferential direction of a capsule, the relative positions of a guiding magnet and the capsule robot are adjusted; and if the force sensing points are distributed in the axial direction of thecapsule, the relative positions and relative poses of the guiding magnet and the capsule robot are adjusted. According to the method, by adjusting the position and pose of the capsule robot, the capsule can keep the magnetic interaction action damage to the gastrointestinal wall cannot be caused, and the provided method has important clinical application value.

The invention discloses a capsule-like gas contrast agent for gastrointestinal CT and an application method thereof. According to the invention, a gas production agent and dimethicone powder (in a weight ratio of 4: 1) are mixed and then sealed in three enteric capsule shells with different wall thicknesses to prepare three contrast agent capsules with different wall thicknesses. The capsule-like gas contrast agent is capable of producing gas in gastrointestinal cavities and eliminating bubbles in intestinal mucus. In use, a capsule with a thickest wall is orally taken at first; then a capsule with a medium-thickness wall is orally taken in 15 min; a capsule with a thinnest wall is orally taken in another 15 min; and then gastrointestinal CT scanning is carried out in 15 min. Plain CT scanning may be carried out immediately after the capsule-like gas contrast agent is taken. The capsule-like gas contrast agent utilizes the characteristic of high contrast between the gastrointestinal wall and gas, so a low dosage of the capsule-like gas contrast agent can be used for CT scanning without influence on image diagnosis quality. The capsule-like gas contrast agent has the clinical application value of improvement of accuracy of CT images in displaying of gastrointestinal lesions and reduction in radiation harm of CT inspection to the stomach and intestine.

The invention discloses a disposable endoscope set and an endoscope device. The disposable endoscope set is characterized in that an elastic sleeve is sleeved outside an image acquisition module and asteering control module of the disposable endoscope set; a film tube is tightly sleeved on the outer sides of the image acquisition module, the steering control module and the elastic sleeve; the endoscope device comprises the disposable endoscope set and an operation module detachably connected to the rear end of the disposable endoscope set. The disposable endoscope group is discarded after being used, the infection problem caused by repeated use is avoided, the operation module which does not invade human body can be repeatedly used, through the high bendability of the elastic sleeve, theelasticity of telescopic deformation and the high bendability of a membrane tube, the disposable endoscope set has the bending deformation capacity with a large bending angle on the whole, pushing andpressing on the intestinal wall can be effectively reduced, and damage to the gastrointestinal wall of the human body is reduced.

A method of delivering and recovering a curved needle includes a step of inserting a first needle holder into abdominal cavity, a step of inserting a second needle holder holding a curved needle into gastrointestinal tract, a step of penetrating gastrointestinal wall with the curved needle to protrude the curved needle to the abdominal cavity, a step of removing the curved needle from the gastrointestinal wall and delivering the curved needle and the suture thread to the abdominal cavity, a suture step of suturing tissues in the abdominal cavity, a step of protruding the curved needle to the gastrointestinal tract, a step of removing the curved needle from the gastrointestinal wall and returning the curved needle from the abdominal cavity to the gastrointestinal tract, and a step of taking out the curved needle from the gastrointestinal tract to outside of body to recover the curved needle.

The invention discloses a traditional Chinese medicine formula for treating chronic gastritis and a preparation method thereof. The traditional Chinese medicine formula is prepared from the following raw materials by weight: 40g to 50g of polished round-grained rice, 4g to 9g of radix aconiti carmichaeli, 3g to 7g of neocheiropteris palmatopedata rhizome, 6g to 10g of tea leaves, 5g to 9g of Sichuan filbert fruit, 2g to 5g of lasia spinosa rhizome, 3g to 8g of Chinese toon leaves, 7g to 11g of fructus oryzae germinatus, 6g to 9g of flos eriocauli, 2g to 7g of herba euphorbiae humifusae, 3g to 6g of flos caryophyllata essence, 1g to 4g of root of Chinese chives, 3g to 6g of fructus crataegi, 2g to 5g of pyrus pashia fruit, 7g to 11g of common bombax root, and 800g to 1000g of water. The preparation method comprises the following steps of cleaning and soaking the polished round-grained rice, adding water into the other herbal medicines, boiling by fire, adding the soaked polished round-grained rice into the boiled medicine liquid, and boiling into porridge. The traditional Chinese medicine formula has the advantages that the traditional Chinese medicine formula is used for treating the chronic gastritis; more than ten types of natural herbal medicines are utilized and are boiled into the medicine food by eleven steps; while the mucous membrane is restored and the natural protection of gastrointestinal wall is formed, the effects of nourishing internal organs, promoting Qi of stomach and intestine, enhancing power of stomach and intestine, and promoting digestion are realized; when the toxin dirt in the stomach is cleaned, the internal environment of the stomach and intestine is re-established, the reasonable excretion of gastric gland is wholly regulated, the excessive excretion of gastric acid is avoided, the normal pH (potential of hydrogen) value in a stomach cavity under the condition of not using western medicines is maintained, the strong acid environment of the survival environment of helicobacter pylori is destroyed, and the infection is avoided.