36 results about "Abdominal Infection" patented technology

The invention relates to a cefonicid sodium hydrate and a preparation method and application thereof. The cefonicid sodium hydrate has better storage stability and is applicable to preparation of the medicaments for treating or preventing such diseases caused by gram positive or negative sensitive bacteria as respiratory system infection, hepatobiliary system infection, five sense infection, urinary tract infection, abdominal infection, pelvic infection, sepsis, skin soft tissue infection, bone and joint infections, annexitis, intrauterine infection, parametritis, meningitis, gonorrhea and the like of human or animals.

The invention relates to the technical field of medicine, and discloses cefaclor composition particles and a preparation method thereof. The cefaclor composition particles disclosed by the invention are prepared from the following raw materials in parts by weight: 250 parts of cefaclor, 8 parts of bromhexine hydrochloride, 1,490 parts of sucrose, 20 parts of acesulfame, 2.5 parts of essence and 250 parts of sorbitol. The cefaclor composition particles disclosed by the invention comprise sorbitol which can be taken as a medicament dispersing agent for enhancing the medicament solubility and can be used for enhancing the antibacterial action of cefaclor. As proved by a test, the cefaclor composition particles disclosed by the invention have enhanced antibacterial action and high stability and can be widely applied to treatment of bacterial infection diseases such as respiratory tract infection, bone and joint infection, pelvic infection, abdominal infection and the like.

The invention relates to a gel material for preventing intestinal adhesion, which is used for preventing peritoneal adhesion after operation. Hyaluronic acid crosslinking preparations for isolating damaged wounds can cause severe adverse reactions during application, such as abdominal pain, abdominal infection, and intestinal adhesion, and even reoperation is performed due to adverse reactions for some patients; the hyaluronic acid crosslinking preparations also have a dissociation phenomenon in the body, and the isolation effect is reduced. The gel material for preventing intestinal adhesion of the invention is a gel system formed by polyacrylamide, a hydrotalcite colloid material, iron ion crosslinked hyaluronic acid gel liquid, 2-deoxy-D-glucose (2-DG) with anti-inflammation and pain-relieving efficacy, tramadol hydrochloride, and acetaminophen. After operation, the gel material is coated directly on a wound; crosslinking effect is generated with fibrin blood clots on the wound; thus the gel material is firmly adhered to the wound; good isolation effect is reached. The medicinal components with anti-inflammation pain-relieving efficacy are directly applied to the wound; and inflammation caused by singly application of hyaluronic acid isolating substances is alleviated.

The invention discloses a modified peach pit flatus-smoothing oral liquid used for operative complications and a preparation method thereof. Bulk drugs for the oral liquid comprise, by weight, 3 to 15 parts of processed monkshood, 4 to 20 parts of quick fried ginger, 3 to 15 parts of peach seed, 3 to 15 parts of rhubarb root and rhizome, 5 to 15 parts of cassia twig, 5 to 15 parts of honey-fried licorice root and 2 to 8 parts of saltcake. The modified peach pit flatus-smoothing oral liquid provided by the invention has the advantages of a simple formula, a wide application scope, effects of antioxidation, adjustment and improvement of immunity of a human body, stopping of bleeding, antiphlogosis, lung diffusing, stasis removal, blood nourishing, intestine moistening, stagnation dredging and bowel relaxing and prevention and treatment effects on postoperative complications like postoperative adhesive intestinal obstruction, postoperative uroschesis, postoperative abdominal infection and postoperative abdominal incision fat liquefaction.

The invention discloses a multiplex fluorescent PCR kit for detecting abdominal bacterial infection. The kit comprises a PCR buffer solution, MgCL2, dNTPs, Taq enzyme, primer probe mixed liquid and apositive quality control, wherein the primer probe mixed liquid comprises a primer group and a probe group. The detection method comprises the following steps: adding nucleic acid extracts into a fluorescent PCR reaction tube respectively; adding the PCR buffer solution, MgCL2, dNTPs, Taq enzyme and the primer probe mixed liquid; covering the fluorescent PCR reaction tube with a tube cover; performing fluorescent PCR detection; and performing fluorescent PCR amplification cycle, and interpreting the result. By integrating the advantages of direct detection as well as the characteristics of real-time fluorescent quantitative PCR technology, the kit and method disclosed by the invention can realize quick, accurate and high-sensitivity detection and identification of 10 common abdominal infection bacteria.

The invention relates to a cefonicid sodium hydrate and a preparation method and application thereof. The cefonicid sodium hydrate has better storage stability and is applicable to preparation of the medicaments for treating or preventing such diseases caused by gram positive or negative sensitive bacteria as respiratory system infection, hepatobiliary system infection, five sense infection, urinary tract infection, abdominal infection, pelvic infection, sepsis, skin soft tissue infection, bone and joint infections, annexitis, intrauterine infection, parametritis, meningitis, gonorrhea and the like of human or animals.

The invention relates to a lomefloxacin aspartate hydrate and the preparation, as well as the usage. The lomefloxacin aspartate hydrate of the invention (the molecular formula is C17H19F2N3O3.C4H7NO4.nH2O, n is equal to 0.5 to 2.5), the lomefloxacin aspartate hydrate of the invention is the fluoroquinolone antibacterial agent used for human or animal respiratory infection, genitourinary infection, gastrointestinal tract bacterial infection, abdominal infection, bile duct infection, typhoid and other infections, bone and joint infection, skin soft tissue infection, sepsis and other systemic infection, other infections, such as paranasal sinusitis, otitis media, blepharitis and so on which are caused by Gram positive or negative bacteria and sensitive bacteria, the invention has the advantages of stable existence, easy storage and transportation and convenient preparation of the pharmaceutical preparations.

The invention relates to intrusion type inverted titanium clips. The intrusion type inverted titanium clips comprise inverted titanium clips, wherein the inverted titanium clips are M-shaped; the middle V-shaped part of the inverted titanium clips is a release section, the two sides of the inverted titanium clips are clamping sections; two ends of the clamping sections are bended inward; and the each end is provided with at least one sawtooth for meshing. The invention also discloses a use method of the inverted titanium clips. The intrusion type inverted titanium clips can realize multilevel, multiple-degree-of-freedom and free release, effectively close the outer wall of an orifice puncture hole and solve the problems of the bleeding and fistula of the puncture hole after the operation so as to avoid abdominal infection, septicemia and the like caused by gastric fistula, intestinal fistula and the like. When closed, the inverted titanium clips of the invention are shaped like a reverse triangle and can basically intrude orifice issue, and the outside of the orifice is smooth, thus the damage of the visceral organ outside the orifice can be prevented. The intrusion type inverted titanium clips are convenient, fast and reliable to use, has good clamping performance, is characterized by good clamping property and toughness and no displacement after clamping, and overcomes the current bottleneck that the outer wall of the orifice can not be closed.

The invention discloses a peritoneal dialysis device. The device comprises an ultraviolet sterilization module. The ultraviolet sterilization module is configured to emit ultraviolet lights towards an infusion connector assembly for carrying out peritoneal dialysis on patients, and to sterilize at least part of the infusion connector assembly. The peritoneal dialysis device is capable of effectively sterilizing the infusion connector assembly and maintaining the hygiene of the peritoneal dialysis for a long period of time, thereby reducing or avoiding the occurrence of abdominal infection of the patients.

The invention discloses an infection prevention device in choledocholithotomy. The infection prevention device in choledocholithotomy comprises a main rod, a clamping mechanism and a leakage-proof cover; the main rod is a hollow circular rod; the clamping mechanism is arranged at one end of the main rod rotatably and coaxially; the front end of the clamping mechanism can stretch into a bile duct from the incision of the bile duct, clamp the edge of the incision of the bile duct, and form a sealing state with the edge of the incision; one end of the leakage-proof cover is connected outside theclamping mechanism, and covers the main rod therein; the other end of the leakage-proof cover is a free end; and an operation hole communicated with the inner wall of the leakage-proof cover is formedat the bottom of the free end. In a stone taking surgery, the infection prevention device in choledocholithotomy in the invention can effectively prevent liquid, such as bile, from turbulently flowing from the incision; and thus, the abdominal infection rate is reduced.

The invention discloses a VX2 rabbit liver transplantation tumor model. A construction method of the VX2 rabbit liver transplantation tumor model comprises the steps as follows: firstly, an anesthetic for intramuscular injection is prepared, the concentration of the anesthetic is 3% pentobarbital sodium, and the dosage is 1 mL / kg; then the VX2 tumor block for intramuscular injection is processed into a tumor block with the size of 1*1*1 mm<3>, the tumor block is inoculated into the body of a young rabbit in the anesthetic state for tumor formation, and the tumor formation parts are rabbit thigh muscle parts on the two sides of the young rabbit; and finally, separated VX2 tumor tissue is rapidly stored in PBS (Phosphate Buffer Solution) at 4 DEG C, muscular tissues around the tumor are removed by using a cell operation table, the tumor block is cut into 1*1*1 mm<3>, and the tumor block is transplanted into the liver of a healthy adult rabbit for planting. The VX2 rabbit liver transplantation tumor model is high in tumor formation rate, a formed tumor is a single tumor generally, the probability of abdominal cavity implantation metastasis and abdominal cavity infection is low, and follow-up experimental research is facilitated.

The invention discloses a multi-functional forceps for laparoscopic appendectomy, which mainly comprises a clamping jaw, a connecting rod and a handle portion. A screw thread is arranged in the clamping jaw, the friction force can be increased to clamp an appendix tightly, and the operation is finished; jaw teeth are connected with the high-frequency electric knife host through a wire harness in the connecting rod, and can electrically cut or be electrically connected with the root of the appendix; after the jaws are combined, the sealing performance is good, and after the appendix is separated from the appendix residue end, the appendix is taken out by an laparoscope sleeve directly through the multi-functional forceps for laparoscopic appendectomy, so that the pollutants in the appendixcan be prevented from leaking into the abdominal cavity, and the risk of abdominal infection is reduced; the length of an jaw head is fixed and the jaw head is the medical insulating material, and thelength of the appendix residue end is suitable , and the cecal wall of the ileocecus is protected from being damaged by an electric knife; The clamping jaw is provided with two layers, the outer layer is made of a medical insulating material, the inner layer is made of a conductive material, and other organs cannot be damaged by mistake during operation.

A medical peritoneal dialysis machine, the invention is characterized in that it innovatively designs a medical instrument capable of preventing abdominal infection (peritoneal dialysis-associated peritonitis) caused by environmental pollution. The invention can be used for peritoneal dialysis operations in medical institutions at all levels and home dialysis operations for peritoneal dialysis patients. Ultraviolet rays in the 254nm and 185nm bands are used as disinfection and sterilization media, and the principle of the two bands of ultraviolet light is exerted. The invention consists of a peritoneal dialysis liquid numerical control heating and constant temperature system, a disinfection and sterilization system, an infusion operating system, a peritoneal dialysis liquid pre-use inspection system, a peritoneal dialysis user's self-safety protection system, and a mobile system when changing application places.

The invention discloses an application of PA4608 protein as a target in preparing antibacterial drugs. By constructing a PA4608 (mapZ) site mutant strain mapz_R13A and a mapZ whole gene knockout mutant and by utilizing a nematode-quick killing infection model, a scratch cell model and a mouse abdominal infection model for study, the invention first puts forwards that the c-di-GMP binding site of PA4608 protein plays an important regulatory role in pseudomonas aeruginosa infection process, puts forwards that the site is a key site for the pathogenicity of the pseudomonas aeruginosa, and furtherputs forwards a new target, namely a c-di-GMP receptor PA4608 used for preventing and / or treating the pseudomonas aeruginosa. The invention provides an important theoretical basis for the developmentof new antibacterial drugs, especially for the design of new antibacterial drugs based on c-di-GMP receptor induction mechanism, provides an important theoretical reference for the prevention and clinical treatment of pseudomonas aeruginosa infection, and has important practical significance.

The invention relates to application of 20(S)-ginsenoside Rh2 in preparation of drugs enhancing antibacterial action of 4-quinolones. The invention discloses that 20(S)-ginsenoside Rh2 can improve the therapeutic effect of ciprofloxacin on a mouse abdominal infection model, and can reduce the minimal inhibitory concentration (MIC) of ciprofloxacin in staphylococcus aureus ATCC 29213, 4 staphylococcus aureus clinical strains, and pseudomonas aeruginosa ATCC 27853. On a staphylococcus aureus invaded THP-1 macrophage model, 20(S)-ginsenoside Rh2 can enhance the intracellular antibacterial action of levofloxacin. Therefore, 20(S)-ginsenoside Rh2 is expected to be used for preparing a synergist of quinolone antibiotics, and can be developed into assistant drugs of anti-infective therapy.

The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor and antibiotic agents to treat, pre-emptively treat or prevent infectious peritonitis or intra-abdominal infection and reduce the occurrence of local peritonitis or intra-abdominal abscess resulting therefrom by the intraperitoneal administration of the compositions.

The present invention is directed to co-therapy and methods for the treatment of bacterial infections due to A. baumannii, such as pneumonia, blood stream infections, wound infections, urinary tract infection and intra-abdominal infections.

The invention discloses conditioning paste for treating cat abdominal infection and a preparation method of the conditioning paste. The conditioning paste is prepared from the following components: Chinese herbaceous peony, raw liquorice, codonopsis pilosula, bighead atractylodes rhizome, pericarpium citri reticulatae, cortex moutan, salvia miltiorrhiza, red paeony root, radix bupleuri, patrinia, selfheal, dandelion, Chinese waxgourd seed, honeysuckle, radix stemonae and ginger. The feline infectious peritonitis is a chronic, progressive and lethal infectious disease caused by feline infectious peritonitis virus, has the main characteristics of peritonitis, accumulation of a large amount of ascites and high fatality rate, and has the external symptoms of stomachache, nausea and vomiting, fever, unclear recognition and the like. According to the invention, the Chinese herbaceous peony and the raw licorice are used as monarch drugs for nourishing liver, relieving spasm and pain, clearing heat and detoxifying. Codonopsis pilosula, atractylodes macrocephala koidz and pericarpium citri reticulatae are adopted to promote transportation and transformation of spleen and stomach of pets and enhance autoimmunity, radix stemonae and ginger are adopted to kill insects and bacteria, and the death rate of infected cats on the abdomen is reduced by adopting prevention and conditioning principles.

The invention discloses an emergency treatment device for war wound abdominal wall defects. The emergency treatment device comprises an anti-adhesion film, a suction tube, a filling layer and an air bag layer, wherein one side of the anti-adhesion film is provided with the filling layer; one side, which is far away from the anti-adhesion film, of the filling layer is provided with the air bag layer; the outer wall of one end of the suction tube is provided with a plurality of suction holes and extends into the filling layer; and the other end of the suction tube extends out of the filling layer. Due to utilization of the anti-adhesion film loaded with antibiotics, abdominal visceral organs can be isolated from contact with external air to avoid abdominal infection, and in addition, the abdominal visceral organs, especially the intestinal canals, can be protected from adhesion, even damage and the like. Since the suction tube is placed in the sponge part of the filling layer, suction can be carried out to lead out seepage or oozing liquid, and through negative pressure suction, a wound surface is prevented from being overlarge. After the latticed air bag layer on the outmost layer is inflated, the air bag layer can perform a function of pressurized binding and bleeding stopping, the traumatic condition of a wounded person can be prevented from getting worse during wartime and after the war, and a protecting and cushioning function is performed for the abdominal visceral organs or the intestinal canals.

The invention relates to the field of drug formulas, in particular to a traditional Chinese medicine enema liquid for the prevention and the treatment of chronic severe hepatitis with abdominal infection. Raw materials of dried rehmannia root, rhubarb, bitter orange, officinal magnolia bark and dandelion are prepared into the enema liquid by immersing, decocting and filtering. The enema liquid is characterized in that the weight parts of the raw materials are: 20 to 40 parts of dried rehmannia root, 10 to 20 parts of rhubarb, 10 to 20 parts of bitter orange, 10 to 20 parts of officinal magnolia bark and 10 to 20 parts of dandelion. The formula of the enema liquid has significant effects of clearing heat, removing toxicity, nourishing yin, promoting production of fluid, cooling blood, stopping bleeding, clearing hollow viscera, eliminating blood stasis, eliminating carbuncles and reducing stagnation. A patient has no toxicity or side effects after the application, the enema liquid is applicable to the prevention and the treatment of the chronic severe hepatitis with abdominal infection, and the cure and recovery rate is higher.

The invention relates to a rectum anastomotic stoma protection device and an operation method, and the rectum anastomotic stoma protection device is characterized in that the rectum anastomotic stoma protection device comprises a drainage main pipe, an enteral fixator, a perfusion head, a drainage sleeve film, an in-vitro drainage pipeline, an in-vitro fixing clamp, a collection container, a perfusion pipeline, an inflation pipeline and a negative pressure pipeline, the enteral fixator is installed on outer wall of the drainage main pipe, and the drainage main pipe is provided with a drainage cavity, a perfusion cavity, an inflation cavity and a negative pressure cavity, the upper end of the perfusion cavity is connected with the perfusion head, the lower end of the perfusion cavity is connected with the perfusion pipeline, the upper end of the inflation cavity is of a closed structure, the lower end of the inflation cavity is connected with the inflation pipeline, the upper end of the negative pressure cavity is provided with a negative pressure side hole, the negative pressure side hole is communicated with the outer cavity of the intestinal fixator, and the lower end of the negative pressure cavity is connected with the negative pressure pipeline, the drainage sleeve membrane is connected with the lower end of the drainage cavity, the outer end of the drainage sleeve film is connected with an in-vitro drainage pipeline, and the other end of the in-vitro drainage pipeline is connected with a collection container. The invention has the advantages that the anastomotic stoma can be effectively isolated, patient abdominal cavity infection caused by excrement contacting with the surgical anastomotic stoma is avoided, bypass and secondary reduction surgery are not needed, and the pain of a patient is relieved.

The invention discloses a balloon sheathing canal for common bile duct exploration. The balloon sheathing canal comprises a sheathing canal body, wherein the sheathing canal body comprises a first canal body and a second canal body; the first canal body is perpendicular to the second canal body in position; the first canal body is communicated with the second canal body through a bent pipe; the first tube body is longer than the second tube body; a first balloon and a second balloon are arranged at the end, close to the bent pipe, of the first tube body; a gap is formed between the first balloon and the second balloon; and a protruding part is arranged on the side, close to the second balloon, of the first balloon. According to the balloon sheathing canal, an incision can be blocked from the two sides of the incision, and abdominal infection and intraperitoneal abscess caused by the fact a large amount of infectious bile, broken stone, bile mud and choledochoscope flushing fluid flow into the abdominal cavity through the incision in the common bile duct exploration process can be prevented.

The invention discloses application of piperine to the preparation of drugs for preventing and treating septicemia. Piperine can strongly enhance the leucine-induced activation of mTORC1. Piperine can prevent bacterial abdominal infection and further prevent septicemia, and can also enhance the functions of macrophages, including bacterial phagocytosis and TNF-alpha and IL-6 secretion capability, to prevent bacterial infection induced macrophage apoptosis. Therefore, piperine or the combination of piperine, leucine and glutamine can enhance the mTORC1 activity of bodies and be used for treating bacterial infections and septicemia.