31 results about "Abdominal Infection" patented technology

The invention discloses application of N4-hydroxycytidine and a derivative thereof in preparation of a medicine for treating cat abdominal infection. The test result shows that the N4-hydroxycytidine and the derivative thereof have a very small toxic effect on normal cat cells, have an obvious inhibiting effect on cat coronavirus (FCoV), and can obviously reduce the virus titer of the virus in the cells. Therefore, the N4-hydroxycytidine and the derivative thereof can be used for preparing a feline coronavirus inhibitor for treating feline infectious peritonitis, and are good in curative effect and high in safety.

The invention discloses a peritoneal drainage flushing device based on multi-dimensional parameter monitoring and a negative pressure regulation and control system, and belongs to the technical field of peritoneal drainage. The peritoneal drainage flushing device and negative pressure regulation and control system based on multi-dimensional parameter monitoring comprises a device support, a multi-channel rotary valve and two negative pressure pumps, a flow guide pipe and a backflow pipe are arranged between the two negative pressure pumps and the multi-channel rotary valve, and pipeline detection modules are installed on the flow guide pipe and the backflow pipe. The peritoneal drainage device solves the problems that an existing peritoneal drainage device is not ideal in treatment effect and affects the treatment effect when a drainage tube is blocked, early intervention is carried out by adjusting a negative pressure pump, a multi-channel rotary valve and a three-way electromagnetic valve, targeted treatment is automatically triggered at the early stage of complications through continuous and multi-dimensional monitoring, and the treatment effect is effectively improved. The tube blocking rate, the abdominal infection rate and the abdominal hypertension syndrome occurrence rate are remarkably reduced, the pain of a patient is relieved, the recovery time is shortened, and personalized and self-adaptive adjustment is carried out according to the physical state of the patient.

The invention relates to application of dronedarone hydrochloride in preparation of a polymyxin synergist. A checkerboard method-minimum inhibitory concentration test, a growth curve test and a sterilization curve test prove that dronedarone hydrochloride and colistin have a good in-vitro synergistic antibacterial effect; an isothermal titration calorimetry test confirms that dronedarone hydrochloride can play a synergistic antibacterial role by combining cardiolipin and phosphatidyl glycerol. Meanwhile, a mouse ExPEC drug-resistant strain abdominal cavity infection model shows that the dronedarone hydrochloride can remarkably enhance the in-vivo treatment effect of the colistin. Compared with drug research and development of unknown active compounds, the dronedarone hydrochloride as a marketed drug can effectively accelerate the research and development process of new drugs and reduce the risk of drug research and development failure, which is of great significance in prolonging the antibacterial activity of existing antibiotics and solving the problem of bacterial drug resistance.

The invention discloses a lipidosome composite hydrogel microsphere for repairing damaged intestinal mucosa and a preparation method thereof, LHMs (at) 4-OI is composed of hyaluronic acid modified targeted drug-loaded lipidosome, sodium alginate, hydrochloric acid treated sucralfate and a CaCl cross-linking agent, and rapid gel forming is carried out under the voltage of 11.0 KV through an electrospray technology. The microspheres have pH responsiveness and gastric juice digestion resistance, CD44 receptor targeting is achieved through hyaluronic acid modification, sodium alginate and Ca form an egg box structure to provide a three-dimensional network, and sucralfate enhances adhesion to isolate harmful substances. The preparation method comprises the steps of preparation of the drug-loaded liposome by a film hydration method, hyaluronic acid modification and electrospray crosslinking, is simple to operate and low in cost, and can be used for large-scale production. The microspheres can effectively load an anti-inflammatory drug 4-OI, inhibit expression of inflammatory factors and promote self-repair of damaged intestinal mucosa, and have wide application prospects in the fields of abdominal infection, inflammatory bowel diseases, colorectal cancer and the like.

The invention relates to the technical field of medicine feeding for enema, in particular to an enterocoelia medicine feeding device capable of preventing abdominal cavity infection, which comprises a supporting plate and a pressing plate arranged on the supporting plate, a connecting column is fixedly mounted on the pressing plate, a liquid medicine plate is fixedly mounted on the connecting column, and a medicine bag is fixedly mounted on the liquid medicine plate; a liquid outlet plate is fixedly connected to the medicine bag, and a guide pipe is rotationally installed on the liquid outlet plate. An anti-fouling sleeve is fixedly mounted on one surface of the supporting plate, and an anal plug is connected to the anti-fouling sleeve; a pushing structure is arranged on the supporting plate, when the pressing plate is driven by external force to get close to the supporting plate, the pushing structure can drive the guide pipe to slide, and the guide pipe rotates in the sliding process; the supporting plate is further provided with a medicine feeding structure, and when the pushing structure acts, the medicine feeding structure can be driven to act so as to drive the liquid outlet plate to be close to the medicine liquid plate, so that the medicine bag is driven to contract, and the medicine liquid is discharged.

The invention discloses a protection device for reducing the abdominal cavity infection rate, and relates to the technical field of medical protection instruments.The protection device for reducing the abdominal cavity infection rate comprises a protection belt, and a sealing ring gasket is installed on the surface of one end of a plurality of reset springs. Therefore, the connecting support ring pushes the sealing ring pad, the sealing ring pad is tightly attached to an outlet of the drainage tube and the outer side of a surgical wound, invasion of microorganisms such as external bacteria and viruses is prevented, the infection risk is reduced, the stability and effectiveness of a drainage system are kept, and the sealing effect is enhanced through tight attachment of the sealing ring pad. The stability of the whole drainage tube fixing device is improved, when a patient moves or moves, the sealing ring pad can effectively prevent the drainage tube from falling off or shifting due to external force, continuous and effective operation of a drainage system is guaranteed, and complications and discomfort caused by falling off or shifting of the drainage tube are reduced.

The invention provides an antibacterial active peptide YC18 and antibacterial application, and belongs to the technical field of biological medicine. The invention provides an antibacterial peptide. The amino acid sequence of the antibacterial peptide is as shown in SEQ ID No. 1. The active polypeptide YC18 has different degrees of antibacterial activity to various bacteria, especially has MIC of 6.25 mu g / ml to staphylococcus aureus and methicillin-resistant staphylococcus aureus, and is good in antibacterial effect and high in sterilization speed. The active polypeptide YC18 has the capacity of inhibiting and removing a biofilm, is low in hemolytic activity and free of cytotoxicity, does not easily generate drug resistance in the use process, has an obvious protection effect on an abdominal cavity infection model, and has the potential of being applied as an anti-infection drug.

This invention provides a reusable ascites drainage device, comprising: a drainage seat, a drainage tube, a negative pressure assembly, and a collection container; one end of the drainage tube is connected to the drainage seat, and the negative pressure assembly and the collection container are both connected to the other end of the drainage tube; the negative pressure assembly is used to generate negative pressure within the drainage tube, allowing ascites fluid from the drainage seat to enter the drainage tube; the collection container is used to collect the ascites fluid draining from the drainage tube; the drainage seat includes an annular shell, one end of which is provided with a self-sealing soft body for sealing; one end of the drainage tube is connected to a puncture needle, which is inserted into and penetrates the self-sealing soft body into the annular shell. This embodiment reduces tissue damage from repeated punctures, improves patient comfort, enhances the precise control of negative pressure within the drainage tube, protects tissues near the drainage seat from damage, and reduces the risk of abdominal infection.

The present invention discloses a system and method for early warning evaluation of abdominal infection after gastric cancer surgery, which belongs to the technical field of gastric cancer surgery infection, including an information collection module for obtaining the clinical manifestations, pathogenesis characteristics and infection factors of historical infection cases, and also includes obtaining the time of completion of the patient's operation and the time of confirming the infection of the patient, and calculating the time difference from the completion of the operation to the confirmation of the infection, and obtaining the weight of the time difference from the time difference of the historical infection case, and a data management module for grouping the different clinical manifestations and pathogenesis characteristics of the historical infection case. The present invention is based on the observation of the condition, with nurses as the leading factor, to construct an early warning evaluation tool for abdominal infection with high specificity and strong sensitivity, which can identify the precursors of infection early, provide a reliable basis for medical diagnosis, make decision interventions early, shorten the healing time and hospitalization time of patients with anastomotic fistula, reduce the unplanned transfer rate and mortality rate to the ICU, and improve the clinical outcome of patients.

The application belongs to the field of pharmaceutical chemistry and medicine, and relates to a cephalosporin compound and its use in preparing antibacterial drugs. Specifically disclosed are the use of a cephalosporin compound, or a pharmaceutically acceptable salt thereof, or a medicine composition taking the cephalosporin compound as an effective active ingredient in preparing a medicine for preventing and treating gram-negative drug-resistant bacterial infections. The compound can irreversibly covalently bind to metal beta-lactamase, inhibit the hydrolysis of beta-lactam antibiotics, effectively reduce the minimum inhibitory concentration (MIC) value and the blood bacterial load of gram-negative drug-resistant bacteria in a mouse with abdominal infection, and can be combined with beta-lactam antibiotics such as meropenem to prepare a compound preparation for treating diseases such as infections caused by gram-negative drug-resistant bacteria.

The invention discloses an antibacterial peptide derived from an animal metagenome as well as a preparation method and application of the antibacterial peptide. Specifically, the amino acid sequence of the antibacterial polypeptide is as shown in any one of SEQ ID NO.1-55. The antibacterial polypeptide provided by the invention has a novel amino acid sequence, and in-vitro experiments prove that the antibacterial polypeptide has inhibitory activity on common pathogenic bacteria such as escherichia coli, salmonella, staphylococcus aureus or streptococcus. According to the invention, evaluation on multiple aspects such as minimum inhibitory concentration, biological safety (namely cytotoxicity and hemolysis effect on mammalian cells) and the like is carried out, and a mouse acute abdominal cavity infection model is established to verify the antibacterial activity of the antibacterial polypeptide in vivo. Results show that the antibacterial polypeptide shows high antibacterial activity in vitro and still keeps certain antibacterial activity in in-vivo experiments, and the survival rate of mice with acute abdominal infection can be increased.

The invention discloses a targeted B cell epitope peptide monoclonal antibody as well as a preparation method and application thereof, five B cell epitope peptide positive hybridoma cell strains: 2G6H3, 6F11B7, 6F11E4, 4H9D8 and 4H9B7 are successfully screened by utilizing a hybridoma cell technology, and the monoclonal antibody is purified. The five monoclonal antibodies can recognize B cell epitope peptide, rEm.P29 and P29 protein in natural antigen, and 6F11B7, 6F11E4 and 2G6H3 which are high in specificity and affinity are selected for evaluating the curative effect of an abdominal cavity infected animal model. The results show that the monoclonal antibody can significantly inhibit the growth of echinococcus multilocularis in mice, has a curative effect higher than that of a clinical drug albendazole, does not have side effects such as liver and kidney function impairment caused by chemotherapeutic drugs, and does not affect other organs. The invention has treatment potential and treatment safety, and provides a brand new treatment strategy for clinically treating the alveolar echinococcosis.

The invention relates to the technical field of ascites concentration and reinfusion, in particular to an ascites concentration and reinfusion system which is characterized in that a soft pigtail drainage catheter is reserved after left and right abdominal cavity puncture to create an abdominal cavity drainage channel, an abdominal cavity outer port is sealed by a heparin cap after ascites concentration and reinfusion is finished, and when subsequent ascites concentration and reinfusion needs to be carried out on the next day, the heparin cap is used for sealing the abdominal cavity outer port. The closed ascites concentration and feedback pipeline can be formed again only by twisting down the heparin cap with the closed port and connecting the extracorporeal circulation blood path of the blood purification device, the hollow fiber dialyzer and the blood perfusion machine, and the second time, the third time or more times of ascites concentration and feedback are carried out. Therefore, repeated abdominal cavity puncture for multiple times of ascites concentration and reinfusion can be avoided, the pain of a patient and the risk of abdominal cavity infection caused in the puncture process are avoided, and the operation time and cost are saved.

The utility model discloses an abdominal cavity drainage tube, which belongs to the technical field of medical instruments and is characterized in that one end of a tail seat is communicated with one end of a drainage outer tube, the other end of the drainage outer tube penetrates through a fixing cap to be communicated with one end of a drainage inner tube, a negative pressure cavity head is sleeved outside the drainage inner tube, one end of the negative pressure cavity head is in threaded connection with the fixing cap, and the other end of the negative pressure cavity head is inserted into one end of a three-way cavity head; the other end of the three-way cavity head is connected with one end of the drainage tube, one end of the dosing outer tube penetrates through the cavity head on one side of the three-way cavity head and extends into the drainage tube to be communicated with the dosing inner tube, the other end of the dosing outer tube is connected with the dosing connector, the drainage tube is arranged on the outer side of the drainage inner tube in a sleeving mode, and the other end of the drainage tube is connected with the guide head. A developing line is arranged on the drainage tube in the axial direction, and the flushing mechanism is connected with the cavity head on the other side of the three-way cavity head. The utility model integrates the functions of drainage, flushing and dosing, can clean in time to prevent blockage, and avoids the problem that the abdominal cavity of a patient is infected due to the pollution of the abdominal cavity drainage tube.

The invention belongs to the technical field of medicines, and particularly relates to a composition for diagnosing sepsis and a medicine for preventive treatment of sepsis, by detecting the content of tryptophan and the composition of 32 metabolites of tryptophan of a patient infected with sepsis in the abdominal cavity, the composition is divided into seven combinations, the invention relates to a method for diagnosing / predicting sepsis by using at least one of tryptophan, a combination of 32 tryptophan metabolites, a combination of tryptophan-Indole / AhR pathway metabolites, a combination of tryptophan-5-HT pathway metabolites, a combination of tryptophan-Kynin / IDO1 pathway metabolites, a combination of differential metabolites in plasma and a combination of differential metabolites in excrement. And tryptophan is applied to the mice infected with sepsis in the abdominal cavity for prevention and treatment, so that early diagnosis and treatment of sepsis are realized, and the survival rate of the mice infected with sepsis is remarkably improved.

The present invention discloses an anti-slip, anti-leak, anti-backflow, fixing and protective device for endoscope, comprising a support cylinder, the outside of the support cylinder is provided with a shrinkable and expandable arc-shaped support, the inside of the support cylinder is provided with a shrinkable and expandable endoscope fixing part, and the two ends of the inside of the support cylinder are provided with elastic sealing parts, and the middle part of the elastic sealing part is provided for the endoscope to pass through and is closely matched with the endoscope. The anti-slip, anti-leak, anti-backflow, fixing and protective device for endoscope of the present invention can prevent the endoscope from being dislodged from the intestine due to the peristalsis of the gastrointestinal tract, ensure the operation efficiency, and also avoid the risk of suffocation caused by the backflow of gastric contents in the digestive tract into the airway, and also avoid the serious abdominal infection caused by the gastrointestinal contents flowing into the outside of the gastrointestinal cavity from the defect of the gastrointestinal wall, which endangers the life safety of the patient, and ensures the smooth progress of the operation.

The application discloses synthesis of a novel Schiff base gold (III) compound and antibacterial application thereof, and belongs to the technical field of medicine preparation; gold sodium aurothiomalate has significant antibacterial activity, but the Au-S bond thereof is easily broken by intracellular reducing thiol, and the gold sodium aurothiomalate is metabolized before reaching a target point to produce toxic side effects; based on the gold sodium aurothiomalate, developing a gold compound with stronger stability is one of strategies for overcoming drug-resistant bacteria; the Schiff base itself has antibacterial activity, and after being combined with gold (III) ions, the Schiff base can stabilize gold atoms and improve the activity of the gold atoms; in vitro antibacterial activity shows that Au6 and Au13 have significant antibacterial advantages on carbapenem and polymyxin-resistant Klebsiella pneumoniae, the minimum inhibitory concentration (MIC) is 10 micromoles, and the antibacterial activity is at least 16 times higher than that of the gold sodium aurothiomalate; in vivo antibacterial activity experiments prove that Au6 and Au13 can reduce mouse skin infection and promote wound healing, and can prolong the survival time of abdominal infection mice, and have important practical application value.

The invention discloses synthesis and antibacterial application of a novel Schiff base gold (III) compound, and belongs to the technical field of medicine preparation. Golden nofen has remarkable antibacterial activity, but an Au-S bond of the gold nofen is easily damaged by reducing thiol in cells and is metabolized before reaching a target spot to generate toxic and side effects, and development of a gold compound with higher stability based on the gold nofen is one of strategies for overcoming drug-resistant bacteria; schiff base has antibacterial activity and can stabilize gold atoms and improve the activity of the gold atoms after being combined with gold (III) ions; in-vitro antibacterial activity shows that Au6 and Au13 have remarkable antibacterial advantages on carbapenems and polymyxin-resistant klebsiella pneumoniae, the minimum inhibitory concentration (MIC) is 10 mu M, and the antibacterial activity of Au6 and Au13 is improved by at least 16 times compared with that of Jinnofen; in-vivo antibacterial activity experiments prove that Au6 and Au13 can reduce mouse skin infection, promote wound healing and prolong the survival time of mice with abdominal infection, and have important practical application value.

The utility model discloses a sleeve type drainage tube fixing device which comprises a sleeve body, the two ends of the sleeve body are constraint ends, and after a drainage tube enters the sleeve body, the sleeve body is temporarily clamped on the drainage tube through the constraint ends. The drainage device is simple in structure and convenient to operate, the drainage tube placed in the drainage device can be continuously tightened through the tightening cap and the valve piece, the purpose of fixing and protecting the drainage tube is achieved, and the situation that a tube cavity is twisted and folded due to the change of the body position of a patient, the gravity action of the drainage device and the like is reduced; meanwhile, the joint of the inner tube and the outer tube and the exposed part of the inner tube are also protected, and secondary infection caused by hospital sexual infection to a patient is avoided.

The invention relates to a multi-factor analysis-based postoperation bleeding risk early warning and evaluation method and system for pancreaticoduodenectomy, and belongs to the technical field of data analysis. The method comprises the steps of obtaining the age and gender of a patient, presetting an age threshold value, dividing the age according to the age threshold value to obtain age group data, obtaining physiological data, and calculating a pancreatic fistula estimated value through a pancreatic fistula prediction model according to the physiological data and the age group data; obtaining abdominal cavity physiological data, and calculating to obtain an abdominal cavity infection estimated value through the abdominal cavity infection prediction model according to the abdominal cavity physiological data; and obtaining early warning physiological data, and according to the early warning physiological data, the pancreatic fistula estimation value, the abdominal cavity infection estimation value and the gender, performing calculation through the bleeding risk early warning evaluation model to obtain bleeding estimation grade data. The hemorrhage risk early warning evaluation after the pancreaticoduodenectomy based on multi-factor analysis is realized.

The utility model relates to the technical field of drainage tubes, and discloses a circulating stamping drainage tube which comprises a first drainage tube, a second drainage tube is arranged on one side of the first drainage tube, one end of the first drainage tube is communicated with one end of the second drainage tube through a connecting line, and a first sealing piece and a second sealing piece are arranged in an inner cavity of one end of the first drainage tube. According to the technical scheme, the first drainage tube can be placed in front of pancreatic-intestinal anastomosis, the second drainage tube is placed in rear of pancreatic-intestinal anastomosis, and the two drainage tubes are led out of the body through the upper left abdomen, so that the problem that an open structure enables the outside to be communicated with the inside of the abdominal cavity, and abdominal cavity infection is easily caused is solved; the sealing performance of the injector can be guaranteed, the injector can further conveniently and completely push air pressure or water pressure into the first drainage tube, so that pus or necrotic floccules blocked in the drainage tube are removed, pancreatic fistula seepage around a pancreatic-intestinal anastomotic stoma is fully and circularly drained, and the working effect of the drainage tube is further guaranteed.

The utility model relates to the technical field of puncture drainage, in particular to an anti-blocking abdominal cavity puncture drainage device. The problem that an existing drainage tube is blocked by impurities in the working process and cannot work normally is solved. Comprising a supporting pipe, the upper side of the supporting pipe is fixedly connected with a connecting shell, the interior of the supporting pipe is slidably connected with a drainage pipe, a pressure detector is arranged in the drainage pipe, one side of the supporting pipe is fixedly connected with a mounting shell, the lower side of the supporting pipe is fixedly connected with an impact pipe, and a water supply assembly is arranged in the mounting shell; the water supply assembly is used for supplying water into the impact pipe. According to the utility model, water sprayed from the impact holes in the impact tube impacts the water absorption holes, so that impurities blocked in the water absorption holes are cleaned, the normal work of the drainage tube is ensured, the abdominal cavity puncture drainage work is smoothly carried out, meanwhile, the abdominal cavity is prevented from becoming a hotbed for bacterial reproduction, and the risk of abdominal cavity infection is reduced.

The excrement receiving device for the intestinal obstruction operation comprises a collecting bag and a threaded drainage tube, and the collecting bag is connected with one end of the drainage tube and used for storing excrement of a human body. An air bag is arranged outside the other end of the drainage tube and is connected to a control valve; the anti-bacterial drainage tube further comprises an anti-bacterial layer, the anti-bacterial layer is attached to the periphery of a preset area of the drainage tube, the preset area is located below the air bag, and a round protective pad is arranged below the anti-bacterial layer. According to the utility model, the intestine is well connected with the drainage tube, the other end of the drainage tube is connected with the collection bag, the collection bag is communicated with the drainage tube below, the protection bag is wrapped outside the drainage tube, and then excrement in the intestine is discharged to the collection bag until the excrement is completely discharged. After the drainage tube is exhausted, the drainage tube is completely stuffed into the protection bag, the protection bag stuffed with the drainage tube is completely toured, and the protection bag is thrown into a garbage can after the touring is tightened, so that the abdominal cavity infection and the incision infection can be effectively reduced, and the environmental pollution caused by stinky odor in an operation room is also reduced.

The invention discloses a classification method and a classification device for abdominal cavity infectious effusion. The classification method comprises the following steps: segmenting a plurality of non-enhanced CT images by using a pre-trained segmentation model; for each liquid accumulation region, applying a morphological dilation operation of a first size to produce a first lesion surrounding region, and performing a morphological dilation operation of a second size to produce a second lesion surrounding region; extracting a quantitative morphological feature, a 3D radiomics feature, a plurality of focus surrounding features, a plurality of local pathological features and a plurality of global context features; selecting a plurality of target features, and calculating a radiomics score of each non-enhanced CT image; inputting the radiomics score and the clinical parameters into a logistic regression model for training to obtain a trained logistic regression model; and using the trained logistic regression model to classify non-enhanced CT images to be classified. According to the method, the classification of the infectious hydrops in the abdominal cavity can be quickly and accurately realized at low cost.

The utility model relates to an abdominal cavity drainage device with a flushing pipeline, which is characterized in that a drainage tube body (0) of the device is of a sandwich structure and consists of an outer tube (001), an inner tube (002) and a water injection cavity (102). The water injection inlet pipe (101) is communicated with the water injection cavity (102), the water injection notch (103) and the drainage notch (203) are respectively communicated with the water injection cavity (102) and the inner pipe (002), and the drainage outlet pipe (201) is connected with the inner pipe (002) and is connected with a liquid collection assembly containing a liquid collection bottle (303) and the like. During working, flushing liquid flushes the sinus tract through the water injection cavity (102), percolate flows into the inner tube (002) and then enters the liquid collecting assembly, and the flow intercepting clamp (302) can control flow of drainage liquid. Compared with the prior art, blood clots, necrotic tissues and pus in the sinus tract can be effectively removed, the risk of abdominal cavity infection caused by blockage of the drainage tube is greatly reduced, and good conditions are created for wound healing.

The invention relates to a drainage tube based on abdominal infection control. The drainage tube comprises a drainage tube body, a sleeve and a flushing tube. A connecting piece is arranged at the connecting end, and a drainage hole and a connecting cap are arranged at the inserting end. The front end of the drainage tube is sleeved with the sleeve, the connecting end is provided with a connecting block, the inserting end is conical, the side wall of the inserting end is provided with a plurality of through holes, and the diameters of the through holes are enlarged from outside to inside. The water outlet is located at the top end of the inserting end, and the water inlet end is located at the bottom end of the connecting block. Integration of flushing, drainage and dosing is achieved through the flushing tube and the infusion tube, blockage is prevented through the design of the through holes, the sleeve is provided with scale marks, the sizes of the drainage tube and the sleeve are optimized, and the drainage tube is suitable for different patients. The drainage tube effectively controls infection, improves drainage efficiency, promotes rehabilitation of a patient, reduces the use intensity of antibiotics (DDD) to a certain extent, and reduces the proportion of unplanned return to an operating room.

The invention belongs to the technical field of biological medicines, and particularly relates to application of an antibacterial peptide KP5 in preparation of a medicine for treating carbapenem-resistant acinetobacter baumannii infection. The invention finds that the antibacterial peptide KP5 with the amino acid sequence shown as SEQ ID NO: 1 has obvious inhibitory activity on carbapenem-resistant acinetobacter baumannii for the first time, so that a brand new effective treatment means can be provided for clinically treating infection (especially acute abdominal infection) caused by drug-resistant bacteria. Moreover, the invention further finds that the antibacterial peptide KP5 and the acinetobacter baumannii infection resisting drug sulbactam can generate a synergistic effect when being used together under a specific concentration, and the synergistic effect can obviously enhance the antibacterial effect on carbapenem-resistant acinetobacter baumannii; an important basis is provided for optimizing a treatment scheme for resisting carbapenem acinetobacter baumannii infection.

The invention discloses a percutaneous puncture abdominal war trauma early-stage multifunctional first-aid kit which comprises a Trocar puncture assembly, a double sleeve, an outer connector, a flushing assembly, a liquid collecting bottle and a negative pressure pump, and the Trocar puncture assembly is used for puncturing the abdominal cavity of a patient; the double sleeve is matched with the Trocar puncture assembly, and the double sleeve is guided to be placed into an abdominal cavity infection part through the Trocar puncture assembly; the outer joint is mounted at the opening end of the double sleeve; the flushing assembly is connected with the outer connector through a flushing pipe and used for injecting normal saline into the double sleeves. The top of the liquid collecting bottle is connected with the outer connector through the drainage tube and used for being matched with the double sleeves to drain thick fester and necrotic tissue in the abdominal cavity of a patient and centralize the thick fester and the necrotic tissue in the liquid collecting bottle. The air inlet end of the negative pressure pump is connected with the top of the liquid collecting bottle through an air suction pipe and used for pumping air so that negative pressure can be formed in the space in the liquid collecting bottle. The side holes in the side faces of the drainage channels in the double sleeves cooperate with continuous negative pressure, and viscous pus and necrotic tissue can be effectively discharged.

Alcohol-associated liver disease, particularly alcohol-associated hepatitis, constitutes a significant global health burden with high mortality rates. Imbalances in the gut microbiota are important for the progression of alcohol-associated liver disease, a condition classified as non-infectious. Disclosed herein are methods of treating or ameliorating a symptom of alcohol-associated hepatitis and methods of reducing or preventing mortality associated with alcohol-associated hepatitis. Also disclosed herein are methods of treating or ameliorating a symptom of sepsis, urinary tract infection, pneumonia, intra-abdominal infections, and / or endocarditis. Further disclosed are methods of determining responsiveness of a subject to treatment with the small molecule inhibitor C7, methods of identifying a subject for a clinical trial for treatment for alcohol-associated hepatitis and methods of screening for candidate compounds for treating alcohol-associated hepatitis.

The application provides an abdominal cavity flushing and draining device, which comprises a draining tube, a flushing tube, a plug-in seat, an elastic sealing part, and the flushing tube is plugged into the inner cavity of the draining tube; the plug-in seat is arranged on the draining tube and is provided with a plug-in hole for inserting the flushing tube; the elastic sealing part is sleeved at the connection part of the draining tube and the flushing tube, one end of the elastic sealing part is in sealing connection with the plug-in seat, and the other end of the elastic sealing part is in sealing connection with the peripheral wall of the flushing tube; since the elastic sealing part is wrapped outside the flushing tube, the elastic sealing part blocks dust and bacteria in the outside world during the pulling process of the flushing tube, and the risk of abdominal cavity infection of a patient is reduced.