47 results about "Cutaneous infections" patented technology

The invention discloses an application of a small molecule compound DK419 in preparation of a drug for resisting staphylococcus infection, and the CAS number of the small molecule compound DK419 is 2102672-22-8; the staphylococcus comprises at least one of staphylococcus aureus, staphylococcus epidermidis, staphylococcus hominis, staphylococcus capitis and staphylococcus haemolyticus. According to the technical scheme, the novel medical application of DK419 is disclosed, DK419 has the effects of inhibiting growth of staphylococcus and killing staphylococcus aureus, the antibacterial effect is better than that of first-line antibiotic vancomycin, and the bactericidal effect is equal to that of vancomycin; the DK419 has the effect of efficiently removing a biofilm; the DK419 can play a role in resisting staphylococcus aureus infection in an in-vivo skin infection model.

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

This invention provides an antimicrobial peptide spray, its preparation method, and its application in the prevention and treatment of peristomal skin infections. The spray comprises, by weight percentage, 0.05%-0.5% of a complex antimicrobial peptide, 0.1%-5% of a moisturizing and repairing film-forming matrix, 0.05%-0.2% of a buffer, 0.8%-1.2% of an isotonic regulator, 0.01%-0.5% of a stabilizer, and 0.005%-0.05% of a metal ion chelating agent, with the balance being water for injection. The complex antimicrobial peptide is composed of bovine lactoferrin antimicrobial peptide, sericin oligopeptide, and buckwheat-derived anti-inflammatory active peptide in a weight ratio of (3-5):(2-3):1. This spray possesses four core functions: broad-spectrum antibacterial activity, inhibition of bacterial biofilm, anti-inflammatory and soothing effects, and skin barrier repair. It is less likely to induce bacterial resistance, does not irritate damaged skin around the stoma, and can effectively prevent and treat peristomal skin infections.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

The invention discloses an anti-inflammatory bone-invigorating product containing eucommia ulmoides extract and a preparation process and application thereof, and relates to the technical field of anti-inflammatory product preparation, the anti-inflammatory bone-invigorating product is prepared from the following raw materials: calendula officinalis, chrysanthemum, fructus forsythiae, dandelion, eucommia ulmoides total glycoside extract, ampelopsis grossedentata extract, achyranthes bidentata extract, pholidota chinensis, eclipta alba, prebiotics, a binding agent, a diluent and an auxiliary agent. The medicinal properties of various herbal medicines and other effective components are combined, the texture, stability and usability of the plaster are guaranteed, meanwhile, the extracted eucommia ulmoides total glycoside can improve the inflammation inhibition effect, enhance the resistance of the plaster to bacteria and viruses and prevent skin infection, the permeability of the plaster is improved through the eucommia ulmoides total glycoside, and the treatment effect of the plaster is improved. The absorption of the skin on the medicine components is improved, so that comprehensive and effective anti-inflammatory and antibacterial protection is provided.

The invention discloses a medicinal moxa composition for preventing and treating atherosclerosis and suppurative bacterial infection co-disease. The medicinal moxa composition comprises coptis chinensis, radix rehmanniae, polygala tenuifolia, juncus effuses and moxa. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for effectively preventing and treating atherosclerosis and skin suppurative bacterial infection co-diseases through a multi-target synergistic effect. The medicinal moxa composition has the core effects of clearing away heart-fire, inducing diuresis for treating stranguria and promoting blood circulation to remove meridian obstruction, and forms a complete treatment system which uses cold and warm as well as treats both symptoms and root causes by purging fire for removing toxin through coptis chinensis, clearing heat and cooling blood through radix rehmanniae, soothing nerves and promoting intelligence through polygala, inducing diuresis and conducting heat downward movement through juncus effuses and combining moxa floss for warming and dredging meridians, eliminating cold to stop pain, resisting bacteria and diminishing inflammation. By inhibiting inflammatory factors, regulating epithelial cell proliferation and reaction to oxidative stress, regulating fluid shear force, atherosclerosis and Kaposi sarcoma-related herpesvirus infection-related pathways and other mechanisms, the medicinal folium artemisiae argyi composition realizes synergistic prevention and treatment of atherosclerosis and skin infection, and provides a basis for co-disease treatment.

The application discloses a HtsA-SLOdm fusion protein and application thereof in preparation of a group A streptococcus vaccine. The HtsA-SLOdm fusion protein is obtained by fusing and recombining a heme transport lipoprotein (HtsA) and a streptolysin protein containing a double-mutation site (SLOdm), can induce production of HtsA protein and SLOdm protein specific IgG antibodies in serum, has strong immunogenicity, can induce high-level IgG1 and IgG2a antibody titers, and the humoral immune response in inducing production of SLOdm protein specific IgG antibodies in serum is stronger than that of a single protein. In addition, the HtsA-SLOdm fusion protein can promote skin wound healing of mice, reduce bacterial content and inflammatory response at a skin infection site of the mice, accelerate wound healing, has almost no hemolytic activity, has high safety, and can be used for preparing a group A streptococcus vaccine.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and to methods for promoting healthy skin aging, treating skin disorders, treating cardiovascular disorders, treating renal disorders, treating angiogenesis disorders, such as cancer, treating tissue damage, such as non-cardiac tissue damage, treating progressive myocardial infarction, and treating various other disorders, such as complications resulting from diabetes with the compounds and compositions of the invention. Other disorders may include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infections, peripheral vascular disease, stroke, and the like.

The invention relates to the technical field of biological fermentation, and discloses a wormwood enzyme and a fermentation method thereof.The wormwood enzyme is prepared from, by mass, 0.5-1.5 parts of brown sugar, 2-4 parts of wormwood and 8-12 parts of purified water, S1, material pretreatment is conducted, specifically, the brown sugar is smashed till the particle size is smaller than or equal to 2 mm, and the wormwood is cut up after being cleaned; according to the wormwood enzyme disclosed by the invention, the brown sugar is firstly crushed, so that the brown sugar can be quickly dissolved, wormwood is cleaned and then cut up, so that the contact area with fermentation liquor can be increased, the growth and metabolism of beneficial microorganisms are facilitated under the conditions of shady, cool and dark places, the wormwood enzyme is fully fermented, and rich active ingredients are generated; the antibacterial components in the prepared wormwood enzyme can effectively inhibit bacterial reproduction, reduce the risk of skin infection, inhibit generation and release of inflammatory factors and relieve inflammatory reactions such as red and swollen skin and pain, and meanwhile, the wormwood enzyme can promote wound healing, stop bleeding and diminish inflammation and has an obvious treatment effect.

A Pharmaceutical composition for treating bacterial skin infections, burns and wounds is disclosed. It comprises an active ingredient, preferably Mupirocin, a biopolymer, preferably Chitosan, with molecular weight ranging from 250,000 Da to 600,000 Da, and a degree of deacetylation of not less than 80%, hydrolyzed Collagen, preferably of type I, with molecular weight ranging from 3 kDa to 6 kDa, and an ointment base comprising emulsifying agents, glycols and solubilizers. The invention has improved stability than the existing ointments, it heals skin and re-epithelializes faster than existing treatments thereby reducing hospitalisation period.

The present invention relates to methods of using cotinine to reduce negative effects of stress in cultured sea animals such as, for example, fish, krill, and crab. Examples of negative effects that can be reduced include, but are not limited to, duration of survival, weight loss, and skin infections. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present application relates to the technical field of pharmaceutical formulations, and particularly relates to a compound miconazole nitrate lotion and a preparation process thereof, which comprises the following raw materials in percentage by weight: miconazole nitrate 1.5-2.5%, amphiphilic polymer 5-6%, chlorhexidine gluconate 1.5-2.5%, casone 0.05-0.1%, benzoic acid 0.1-0.2%, surfactant 25-32%, PEG-120 methyl glucose dioleate 1-2%, citric acid monohydrate 0.3-0.4%, and sodium chloride 0.7-0.9%, and the rest is water. The compound miconazole nitrate lotion prepared by the present application has dual effects of anti-fungus and antibiosis, expands the scope of indications, enhances the overall antibacterial effect of the lotion, and is suitable for the treatment and prevention of various skin infections.

The invention discloses a traditional Chinese medicine external application composition for clearing away heat and toxic materials and relieving swelling and pain and a preparation method thereof. The composition takes rhubarb, golden cypress, notopterygium root, mirabilite and borneol as main components, all the components are compatible according to a specific proportion, and the composition has the effects of clearing away heat and toxic materials, relieving swelling and pain, eliminating dampness and astringing sores and promoting blood circulation to remove blood stasis. The preparation process comprises the steps of raw material pretreatment, mixing, preparation forming and the like, and stability and effectiveness of medicine components are ensured by controlling parameters such as crushing granularity, mixing time and heating temperature. The composition can be prepared into ointment, external application bags and other dosage forms, and is suitable for various diseases such as skin infection, traumatic inflammation, anorectal diseases, joint and muscle problems and the like. Clinical cases show that the composition is remarkable in curative effect and high in safety, avoids the adverse reaction of oral medicines, and has a good application prospect.

The defeatherer comprises a machine body and a defeathering head, the defeathering head comprises a fixed seat, a movable seat, a defeathering wheel assembly and an arc-shaped shaft, the movable seat is rotatably connected with the fixed seat, the arc-shaped shaft is connected with the defeathering wheel assembly in series, and the two ends of the arc-shaped shaft are connected with the movable seat and the fixed seat respectively; wherein an ozone generator is fixedly mounted on the fixed seat, and ozone generated by the ozone generator is blown to one side, which is gradually widened, of the dehairing wheel assembly. According to the defeatherer, ozone is generated through the ozone generator, the defeathering area is sterilized and disinfected through the strong oxidizing property of the ozone, bacterium breeding is effectively restrained, skin infection or discomfort is reduced, meanwhile, the hygiene, safety and use experience of equipment are improved, and the requirement of a user for efficient and healthy personal care equipment is met.

The present invention belongs to the field of microneedle patch preparations for transdermal drug delivery, specifically relating to a microneedle capable of loading a poorly water-soluble antibiotic, its preparation method, and its application. The microneedles of the present invention utilize gelatin methacrylate (GelMA) as a substrate. The poorly soluble antibiotic is encapsulated with bovine serum albumin and evenly distributed within the microneedles. The microneedles are obtained by preparing a GelMA solution, preparing BSA-encapsulated antibiotic nanoparticles, mixing the solutions, forming a microneedle mold, cross-linking and curing, and demolding and drying. The resulting microneedles exhibit excellent mechanical properties and biocompatibility. The microneedles of the present invention can locally deliver antibiotics and effectively treat localized skin infections. They offer advantages such as high drug stability, controlled release, and painless delivery. They can effectively penetrate the skin barrier, enhance drug bioavailability, mitigate the effects of the gastrointestinal environment on drug efficacy, and mitigate the "first-pass effect" in the liver, thereby improving patient compliance.

The present invention relates to a composition and use thereof directed towards treating various health ailments, such as skin and respiratory problems and various infections. More particularly, the present invention relates to a lime sulfur solution and use thereof, of varying percentages, directed towards improving vision and treating various skin problems and infections, such as toenail fungus, athlete's foot, jock itch, skin psoriasis, eczema, vaginal yeast infections, head or beard dandruff, respiratory infections, itching of the skin (particularly of the hands), acne (facial and / or body acne), poison ivy, insect bites, head and body lice, crabs, cuts, treating wounds infected by staff and / or MRSA (methicillin-resistant Staphylococcus aureus) bacteria, tongue thrush, ringworm, penis foreskin infections, skin tags, and is also directed towards treating various respiratory infections (such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, and Covid-19 infections). The present invention also relates to use of the aforementioned composition and solution as a disinfectant in gyms, spas, saunas, for professional athletes, or as a body and / or hair wash.

The utility model relates to the technical field of medical equipment, and provides an illumination control device for a photodynamic antibacterial product, which comprises a support plate and two square grooves symmetrically arranged on one side of the support plate. According to the illumination lamp, the first fastening screw rod and the second fastening screw rod are loosened by hands, limitation on the round block and the movable rod is relieved, at the moment, the movable rod can be pushed to drive the movable ring, the second rotating rod and the like to rotate by a proper angle, the movable rod slides towards one side along the interior of the movable ring, and the position of the illumination lamp is adjusted; the illumination lamp is fixed by rotating the first fastening screw rod and the second fastening screw rod reversely, and other illumination lamps can be adjusted similarly, so that the illumination lamp can be used for performing irradiation treatment on multiple skin infection areas of the patient and activating the photodynamic antibacterial product. Therefore, the number of equipment is reduced, and the use cost of the equipment is reduced.

The invention relates to the technical field of inorganic antibacterial materials, in particular to a preparation method and application of a novel spherical nano ZnO / CuO / Fe3O4 / Cu (at) Ag material. The core-shell type magnetic nano ZnO / CuO / Fe3O4 / Cu (at) Ag composite material is prepared according to the principle that Ag sol is loaded to ZnO / CuO / Fe3O4 / Cu and then the electron transfer efficiency of the material is improved by utilizing the characteristic that the oxidation-reduction potential of Ag is similar to that of Cu, so that the antibacterial efficiency of the composite material is improved, and the core-shell type magnetic nano ZnO / CuO / Fe3O4 / Cu (at) Ag composite material is prepared. In combination with the synergistic effect of multiple antibacterial components, the advantages that magnetic components are convenient to separate and recycle, electron transfer and ROS generation enhance bacteriostasis are achieved, escherichia coli and staphylococcus aureus are used as experimental strains to research the antibacterial activity of the antibacterial agent, and the toxicology of human cells and the healing promotion research of a rat skin infection model are researched.

Cosmetic composition in the form of an externally applicable preparation, selected from cream, ointment, lotion, gel or balm, characterized in that it contains crystal violet (methylrosanilium chloride) in a skin-compatible base.

The invention discloses a multiple detection kit for 29 children skin infection pathogens, and relates to the technical field of nucleic acid detection.The multiple detection kit comprises a reaction solution, an enzyme mixed solution, a positive reference substance and a negative reference substance, the reaction solution comprises a reaction premix solution, a primer pair and a fluorescent probe, and the reaction premix solution comprises 1 * PCR buffer, dNTP, dUTP and RNase free H2O; the enzyme mixed solution comprises 0.4 U / [mu] L of Taq DNA polymerase and 0.002 U / [mu] L of UDG enzyme; the positive reference substance contains target gene sequences and RP gene sequences of 29 pathogens. The specific primer pairs and the fluorescent probes for the 29 pathogens are combined, a single-tube PCR reaction system is combined, the function of synchronously detecting the 29 children skin infection pathogens through a single tube is achieved, the problems that according to a traditional detection method, multiple tubes are needed for respective detection, and operation is tedious are solved, and the detection efficiency is improved.

This invention relates to a composite hydrogel with hemostatic and antibacterial functions, its preparation method, and its application. The nanocomposite hydrogel is prepared by copolymerizing graphene oxide loaded with silver nanoparticles and chitosan grafted with dihydroporphyrin E6 during the preparation of thermosensitive poly(N-isopropylacrylamide) hydrogel. This composite hydrogel integrates multiple functions such as antibacterial, hemostatic, and cell proliferation and migration promotion. It possesses excellent thermosensitivity, injectability, swelling properties, tissue adhesion, and biodegradability. It achieves highly efficient antibacterial activity through photothermal-photodynamic synergy and multiple antibacterial components. Furthermore, it effectively controls bleeding by utilizing the sealing effect of the hydrogel and the hemostatic properties of chitosan, while simultaneously promoting fibroblast proliferation and migration. It plays a positive role in all stages of wound healing and is suitable for use as a dressing for infected skin wounds.

The invention relates to a disposable consumable structure of an oxygen injection instrument and the oxygen injection instrument, and belongs to the technical field of oxygen injection instruments, the consumable structure is composed of an atomizing nozzle and a liquid storage bottle, the structural design is optimized, the manufacturing cost is reduced, the consumable structure can be replaced as a disposable article, and the problems of blockage and residual pollution are solved. And the quick release design is optimized, so that the replacement process is convenient to operate, and the use experience is optimized. By designing the oxygen injection instrument matched with a disposable consumable use mode, the atomization effect is guaranteed, the problem of nozzle blockage is solved, and the skin infection risk caused by residual pollution is avoided.

The application discloses synthesis of a novel Schiff base gold (III) compound and antibacterial application thereof, and belongs to the technical field of medicine preparation; gold sodium aurothiomalate has significant antibacterial activity, but the Au-S bond thereof is easily broken by intracellular reducing thiol, and the gold sodium aurothiomalate is metabolized before reaching a target point to produce toxic side effects; based on the gold sodium aurothiomalate, developing a gold compound with stronger stability is one of strategies for overcoming drug-resistant bacteria; the Schiff base itself has antibacterial activity, and after being combined with gold (III) ions, the Schiff base can stabilize gold atoms and improve the activity of the gold atoms; in vitro antibacterial activity shows that Au6 and Au13 have significant antibacterial advantages on carbapenem and polymyxin-resistant Klebsiella pneumoniae, the minimum inhibitory concentration (MIC) is 10 micromoles, and the antibacterial activity is at least 16 times higher than that of the gold sodium aurothiomalate; in vivo antibacterial activity experiments prove that Au6 and Au13 can reduce mouse skin infection and promote wound healing, and can prolong the survival time of abdominal infection mice, and have important practical application value.

The application discloses a composition for treating stubborn skin infection, ulcer and inflammation and a preparation method and application thereof, and belongs to the technical field of functional compositions. The composition is prepared from components containing baicalin 1-5 parts, antibacterial alkaloids 0.5-3 parts, asiaticoside 2-6 parts, salvianolic acid B 3-8 parts, gallic acid 1-4 parts, white plant polysaccharide 5-10 parts, konjac glucomannan 3-10 parts, chitosan 3-5 parts, glycerol 8-20 parts, genipin 0.5-2 parts, calcium chloride 1-3 parts, laurazepam 1-3 parts and water 40-80 parts. The antibacterial alkaloids include berberine or phellodendrine. The application scientifically matches the above components based on deep understanding of the stubborn skin pathological mechanism, and the composition exhibits a significant synergistic effect in in-vitro antibacterial, antibiofilm and anti-inflammatory experiments. The preparation process is simple, the cost is low, and the application is suitable for industrial production.

This invention discloses a core-shell microneedle loaded with silver nanoparticles and growth factors, its preparation method, and its application, belonging to the field of biomedical technology. The core-shell microneedle includes a backing layer and an array of needle tips disposed on the backing layer; the needle tips in the needle tip array have a core-shell structure, with the shell layer of the needle tip loaded with protein-Ag2O2 composite nanoparticles and the core layer of the needle tip loaded with growth factors. The preparation method of the protein-Ag2O2 composite nanoparticles is as follows: a protein aqueous solution is mixed with a silver nitrate solution, and under alkaline conditions, it is reacted with a hydrogen peroxide solution to obtain the protein-Ag2O2 composite nanoparticles. The core-shell microneedles prepared by this invention, through hierarchical loading of silver peroxide nanoparticles and growth factors, respond to the microenvironment of infected skin wounds and perform programmed release, effectively preventing bacterial infection, promoting cell proliferation and angiogenesis, and driving tissue repair, effectively solving the problem of stagnant healing of infected wounds.

This invention relates to the field of materials science and technology, providing a live probiotic culture and delivery hydrogel scaffold, its preparation method, and its applications. The method provided by this invention is simple to operate and offers significant potential for application. The prepared hydrogel scaffold, when used in medical dressings for treating infected skin wounds, exhibits characteristics such as ultra-efficient polymerization, bioprintability, and injectability. It also demonstrates significant antibacterial and repair effects on infected skin wound models, achieving in-situ curing and sealing of the wound with only 1 second of UV irradiation. The method provided by this invention ensures excellent survival rates, controllable colonization efficiency, and sufficient biocompatibility of the probiotics embedded within the hydrogel scaffold. The antibacterial strategy of this invention significantly inhibits the colonization of pathogenic microorganisms, reshapes the composition of the host's symbiotic microbiota, and is microenvironmentally friendly.

The application discloses a water-absorbing low-swelling bacteriostatic hydrogel dressing and a preparation method and application thereof. The hydrogel dressing is prepared by taking chitosan, polyvinyl alcohol and oxidized chitosan as a skeleton and introducing natural extract berberine as a crosslinking agent and an antibacterial agent. The hydrogel dressing prepared by the method has good water absorption performance and low swelling performance. The hydrogel dressing can effectively manage wound exudates and provide stable interface protection for the wound. Meanwhile, the hydrogel has good anti-inflammatory, antioxidant, bacteriostatic and excellent biological safety. The hydrogel dressing can be applied to the treatment of skin infectious injury as a wound dressing, and has important significance in clinical production practice.

Compositions for preventing and treating bacterial infections include artificial sweeteners such as ace-k, saccharin and cyclamate. The compositions are particularly envisaged for topical administration for treating skin infections and for treating or preventing infections caused by Pseudomonas aeruginosa and / or Acinetobacter baumannii. Compositions including artificial sweeteners at sub-minimum inhibitory concentrations can also be used to disrupt virulence or increase the sensitivity of antibiotic-resistant bacteria to those antibiotics.

This invention relates to a traditional Chinese medicine composition and its preparation, comprising the following raw materials in parts by weight: rhubarb 18-30 parts, gardenia 18-30 parts, chuanxiong rhizome 9-16 parts, cinnamon twig 9-16 parts, safflower 1-10 parts, and frankincense 1-10 parts. This invention relates to the technical field of external preparations of traditional Chinese medicine. In the traditional Chinese medicine composition of this invention, rhubarb: clears heat and detoxifies, drains heat and promotes bowel movement, cools blood and detoxifies, removes blood stasis and unblocks meridians, has anti-inflammatory effects, and immunomodulatory effects; gardenia: clears heat and promotes diuresis, cools blood and detoxifies; chuanxiong rhizome: invigorates blood and promotes qi circulation, dispels wind and relieves pain; safflower: invigorates blood and unblocks meridians, disperses blood stasis and relieves pain; cinnamon twig: induces sweating and relieves muscle tension, warms and unblocks meridians, promotes qi circulation, calms the bladder and lowers qi, relieves joint pain, has antibacterial effects, anti-inflammatory and anti-allergic effects, dilates blood vessels, and promotes sweating. Frankincense: promotes blood circulation, relieves pain, reduces swelling and promotes tissue regeneration; when used together, these herbs target the core pathogenesis of traumatic swelling and pain (blood stasis), gouty arthritis (damp-heat stagnation), and skin infections (heat toxicity), achieving the treatment of three types of diseases with one ointment, filling a market gap.