77 results about "Cutaneous infections" patented technology

The invention discloses an application of a small molecule compound DK419 in preparation of a drug for resisting staphylococcus infection, and the CAS number of the small molecule compound DK419 is 2102672-22-8; the staphylococcus comprises at least one of staphylococcus aureus, staphylococcus epidermidis, staphylococcus hominis, staphylococcus capitis and staphylococcus haemolyticus. According to the technical scheme, the novel medical application of DK419 is disclosed, DK419 has the effects of inhibiting growth of staphylococcus and killing staphylococcus aureus, the antibacterial effect is better than that of first-line antibiotic vancomycin, and the bactericidal effect is equal to that of vancomycin; the DK419 has the effect of efficiently removing a biofilm; the DK419 can play a role in resisting staphylococcus aureus infection in an in-vivo skin infection model.

The invention provides an application of schizophyllan as a human beta-defensin-2 accelerant. According to the application, the effect of inducing human beta-defensin-2 (hBD-2) expression of the schizophyllan is found for the first time, and the schizophyllan can effectively stimulate an antimicrobial defense system on the surface of a human body to restore the stability of a natural internal environment, so that the schizophyllan is used for improving natural defense on the surface of the human body or improving microbiome balance on the surface of the human body; the active effects on prevention and / or reduction of skin infection, skin sensitivity, skin barrier damage and skin microecological disorder, prevention and improvement of pox muscles and the like are achieved, and the application field of the substance is widened.

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

This invention provides an antimicrobial peptide spray, its preparation method, and its application in the prevention and treatment of peristomal skin infections. The spray comprises, by weight percentage, 0.05%-0.5% of a complex antimicrobial peptide, 0.1%-5% of a moisturizing and repairing film-forming matrix, 0.05%-0.2% of a buffer, 0.8%-1.2% of an isotonic regulator, 0.01%-0.5% of a stabilizer, and 0.005%-0.05% of a metal ion chelating agent, with the balance being water for injection. The complex antimicrobial peptide is composed of bovine lactoferrin antimicrobial peptide, sericin oligopeptide, and buckwheat-derived anti-inflammatory active peptide in a weight ratio of (3-5):(2-3):1. This spray possesses four core functions: broad-spectrum antibacterial activity, inhibition of bacterial biofilm, anti-inflammatory and soothing effects, and skin barrier repair. It is less likely to induce bacterial resistance, does not irritate damaged skin around the stoma, and can effectively prevent and treat peristomal skin infections.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

The invention discloses an anti-inflammatory bone-invigorating product containing eucommia ulmoides extract and a preparation process and application thereof, and relates to the technical field of anti-inflammatory product preparation, the anti-inflammatory bone-invigorating product is prepared from the following raw materials: calendula officinalis, chrysanthemum, fructus forsythiae, dandelion, eucommia ulmoides total glycoside extract, ampelopsis grossedentata extract, achyranthes bidentata extract, pholidota chinensis, eclipta alba, prebiotics, a binding agent, a diluent and an auxiliary agent. The medicinal properties of various herbal medicines and other effective components are combined, the texture, stability and usability of the plaster are guaranteed, meanwhile, the extracted eucommia ulmoides total glycoside can improve the inflammation inhibition effect, enhance the resistance of the plaster to bacteria and viruses and prevent skin infection, the permeability of the plaster is improved through the eucommia ulmoides total glycoside, and the treatment effect of the plaster is improved. The absorption of the skin on the medicine components is improved, so that comprehensive and effective anti-inflammatory and antibacterial protection is provided.

The bellyband comprises a bellyband body, a detachable liquid suction bag is arranged on the inner side face of the bellyband body, and a liquid suction hole is formed in the middle of the inner side face of the liquid suction bag. A detachable umbilical hernia protection area and a puncture protection area are arranged on the inner side face of the bellyband body or the liquid suction bag. And the functions of absorbing ascites, conveniently improving the wearing comfort, reducing skin infection, protecting umbilical hernia, protecting abdominal cavity puncture and abdominal cavity drainage bags and the like can be provided.

The invention discloses a medicinal moxa composition for preventing and treating atherosclerosis and suppurative bacterial infection co-disease. The medicinal moxa composition comprises coptis chinensis, radix rehmanniae, polygala tenuifolia, juncus effuses and moxa. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for effectively preventing and treating atherosclerosis and skin suppurative bacterial infection co-diseases through a multi-target synergistic effect. The medicinal moxa composition has the core effects of clearing away heart-fire, inducing diuresis for treating stranguria and promoting blood circulation to remove meridian obstruction, and forms a complete treatment system which uses cold and warm as well as treats both symptoms and root causes by purging fire for removing toxin through coptis chinensis, clearing heat and cooling blood through radix rehmanniae, soothing nerves and promoting intelligence through polygala, inducing diuresis and conducting heat downward movement through juncus effuses and combining moxa floss for warming and dredging meridians, eliminating cold to stop pain, resisting bacteria and diminishing inflammation. By inhibiting inflammatory factors, regulating epithelial cell proliferation and reaction to oxidative stress, regulating fluid shear force, atherosclerosis and Kaposi sarcoma-related herpesvirus infection-related pathways and other mechanisms, the medicinal folium artemisiae argyi composition realizes synergistic prevention and treatment of atherosclerosis and skin infection, and provides a basis for co-disease treatment.

Disclosed are compositions for competitive inhibition of pathogens against pathogenic infections comprising (a) Bacillus coagulans; (b) Bacillus subtilis; (c) citric acid; and (d) gallic acid including any combinations thereof. The compositions disclosed in this invention is capable to treat and prevent pathogenic infections of the genital organs as well as suitable for treatment and prevention of dermal infections. A method of preventing recurrence of the infections by way of supporting the growth of inherent natural doderlein microbial populations due to application of the compositions of the present invention are also disclosed. Further, use of the compositions of the present invention obviates the need of prior specific diagnosis of the infections due to its broad-spectrum activity against multiple bacterial and fungal pathogens.

The application discloses a HtsA-SLOdm fusion protein and application thereof in preparation of a group A streptococcus vaccine. The HtsA-SLOdm fusion protein is obtained by fusing and recombining a heme transport lipoprotein (HtsA) and a streptolysin protein containing a double-mutation site (SLOdm), can induce production of HtsA protein and SLOdm protein specific IgG antibodies in serum, has strong immunogenicity, can induce high-level IgG1 and IgG2a antibody titers, and the humoral immune response in inducing production of SLOdm protein specific IgG antibodies in serum is stronger than that of a single protein. In addition, the HtsA-SLOdm fusion protein can promote skin wound healing of mice, reduce bacterial content and inflammatory response at a skin infection site of the mice, accelerate wound healing, has almost no hemolytic activity, has high safety, and can be used for preparing a group A streptococcus vaccine.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and to methods for promoting healthy skin aging, treating skin disorders, treating cardiovascular disorders, treating renal disorders, treating angiogenesis disorders, such as cancer, treating tissue damage, such as non-cardiac tissue damage, treating progressive myocardial infarction, and treating various other disorders, such as complications resulting from diabetes with the compounds and compositions of the invention. Other disorders may include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infections, peripheral vascular disease, stroke, and the like.

The invention discloses sports equipment for arm muscle exercise and a using method thereof.The sports equipment comprises a herdsman stool body and a mounting frame arranged on the herdsman stool body, and a first training pad is fixedly mounted on the upper portion of one side of the mounting frame; a second training pad is fixedly mounted above the other side of the mounting frame through a hinge in a rotating manner; the guide rail is fixedly arranged below the mounting frame, a training pad cleaning mechanism is installed above the guide rail in a transmission mode, and a guide rail sliding seat is arranged at the lower end of the training pad cleaning mechanism, so that cleaning of the training pad in a working mode of wiping, alcohol spraying and blow-drying is achieved, and the cleanliness of the training pad is improved; meanwhile, the protective sleeve can be arranged on the upper surface of the training pad in a sleeving mode, the effect of isolating stains and bacteria is achieved, and therefore the problem that after an existing herdsman stool in a gymnasium is used, sweat stains and bacteria are left on the surface of the stool, and the skin infection risk is increased when the stool is directly used without being clean is effectively avoided.

The invention provides a zigzag / Bluetooth / WIFI-based intelligent urine and excrement early warning device and method, and the device comprises a paper diaper body, and is characterized in that a graphene sensor is arranged in the paper diaper body, and comprises a detection strip which extends to the front and rear edges of the paper diaper; intelligent information acquisition hardware which is correspondingly and electrically connected with the graphene sensor is clamped at the front edge of the paper diaper body, and the intelligent information acquisition hardware is connected to a cloud operation monitoring platform through a Zigbee / Bluetooth / WIFI module, so that the problems of signal transmission distance limitation and stability are solved; meanwhile, health data such as excrement and urine, body position, body temperature, heart rate, urine volume, uric acid, urine sugar and urine protein can be accurately recognized, so that nursing personnel or family members of a user are timely reminded to replace paper diapers, inconvenience caused by long-time wet discomfort and frequent examination is reduced, the skin infection risk is reduced, the comfort level and life quality of the user are improved, and the service life of the user is prolonged. Meanwhile, the physical health condition of the user is known in time.

The present invention relates to a four-arm antimicrobial peptide rich in imidazole groups, wherein the four-arm antimicrobial peptide is composed of four identical polypeptide side chains with 8-12 amino acid residues and three interconnected lysine residues, respectively connected to form amino groups, and terminated with amino groups; each polypeptide side chain is composed of histidine residues, or is composed of histidine residues and one selected from lysine residues or arginine residues. The four-arm antimicrobial peptide of the present invention not only exhibits narrow-spectrum antimicrobial activity to Pseudomonas aeruginosa (P.aeruginosa), but can also be used as a synergistic adjuvant of antibiotics, and more effectively treats skin infections caused by P.aeruginosa without damaging normal human skin microbial flora. At the same time, it has high safety, low hemolytic side effects, and is not easy to develop drug resistance, and has great clinical application potential.

The invention relates to the technical field of biological fermentation, and discloses a wormwood enzyme and a fermentation method thereof.The wormwood enzyme is prepared from, by mass, 0.5-1.5 parts of brown sugar, 2-4 parts of wormwood and 8-12 parts of purified water, S1, material pretreatment is conducted, specifically, the brown sugar is smashed till the particle size is smaller than or equal to 2 mm, and the wormwood is cut up after being cleaned; according to the wormwood enzyme disclosed by the invention, the brown sugar is firstly crushed, so that the brown sugar can be quickly dissolved, wormwood is cleaned and then cut up, so that the contact area with fermentation liquor can be increased, the growth and metabolism of beneficial microorganisms are facilitated under the conditions of shady, cool and dark places, the wormwood enzyme is fully fermented, and rich active ingredients are generated; the antibacterial components in the prepared wormwood enzyme can effectively inhibit bacterial reproduction, reduce the risk of skin infection, inhibit generation and release of inflammatory factors and relieve inflammatory reactions such as red and swollen skin and pain, and meanwhile, the wormwood enzyme can promote wound healing, stop bleeding and diminish inflammation and has an obvious treatment effect.

A Pharmaceutical composition for treating bacterial skin infections, burns and wounds is disclosed. It comprises an active ingredient, preferably Mupirocin, a biopolymer, preferably Chitosan, with molecular weight ranging from 250,000 Da to 600,000 Da, and a degree of deacetylation of not less than 80%, hydrolyzed Collagen, preferably of type I, with molecular weight ranging from 3 kDa to 6 kDa, and an ointment base comprising emulsifying agents, glycols and solubilizers. The invention has improved stability than the existing ointments, it heals skin and re-epithelializes faster than existing treatments thereby reducing hospitalisation period.

The present invention relates to methods of using cotinine to reduce negative effects of stress in cultured sea animals such as, for example, fish, krill, and crab. Examples of negative effects that can be reduced include, but are not limited to, duration of survival, weight loss, and skin infections. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

The present application relates to the technical field of pharmaceutical formulations, and particularly relates to a compound miconazole nitrate lotion and a preparation process thereof, which comprises the following raw materials in percentage by weight: miconazole nitrate 1.5-2.5%, amphiphilic polymer 5-6%, chlorhexidine gluconate 1.5-2.5%, casone 0.05-0.1%, benzoic acid 0.1-0.2%, surfactant 25-32%, PEG-120 methyl glucose dioleate 1-2%, citric acid monohydrate 0.3-0.4%, and sodium chloride 0.7-0.9%, and the rest is water. The compound miconazole nitrate lotion prepared by the present application has dual effects of anti-fungus and antibiosis, expands the scope of indications, enhances the overall antibacterial effect of the lotion, and is suitable for the treatment and prevention of various skin infections.

The present invention relates to a liquid antibody formulation comprising an antibody, preferably dupilumab, L-arginine at a concentration of from 150 to 300 mM, a surfactant, and optionally a buffer, wherein the pH of the liquid antibody formulation is from 5.0 to 7.0. The invention further relates to a method for the preparation thereof and use of the liquid antibody formulation in the treatment, prevention or amelioration of any disease or disorder associated with IL-4 activity, including diseases or disorders mediated by activation of IL-4RC, such as atopic dermatitis (AD), e.g. moderate to severe atopic dermatitis, atopic eczema, asthma, e.g. moderate to severe eosinophilic or oral steroid dependent asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), chronic rhinosinusitis without nasal polyps (CRsNP), eosinophilic esophagitis (EoE), prurigo nodularis (PN), skin infections, chronic obstructive pulmonary disease (COPD), chronic spontaneous urticaria (CSU), chronic inducible cold urticaria (CINDU), allergic fungal rhinosinusitis (AFRS).

The invention discloses a traditional Chinese medicine external application composition for clearing away heat and toxic materials and relieving swelling and pain and a preparation method thereof. The composition takes rhubarb, golden cypress, notopterygium root, mirabilite and borneol as main components, all the components are compatible according to a specific proportion, and the composition has the effects of clearing away heat and toxic materials, relieving swelling and pain, eliminating dampness and astringing sores and promoting blood circulation to remove blood stasis. The preparation process comprises the steps of raw material pretreatment, mixing, preparation forming and the like, and stability and effectiveness of medicine components are ensured by controlling parameters such as crushing granularity, mixing time and heating temperature. The composition can be prepared into ointment, external application bags and other dosage forms, and is suitable for various diseases such as skin infection, traumatic inflammation, anorectal diseases, joint and muscle problems and the like. Clinical cases show that the composition is remarkable in curative effect and high in safety, avoids the adverse reaction of oral medicines, and has a good application prospect.

To provide an inhibitor of aldose reductase.SOLUTION: There are a new compound and its pharmaceutical composition, and various treatments of other disorders such as a method for promoting health aging of skin, treatment of dermopathy, treatment of cardiovascular disorder, treatment of nephropathy, treatment of angiogenic disorder such as cancer, treatment of tissue damage such as non-heat tissue damage, treatment of progressive myocardial infarction, treatment of ischemia damage, and treatment of complications caused by diabetes, which use the compound and the composition. The other damages are not limited to above, and can include atherosclerosis, cardiomyopathy, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, skin infectious disease, peripheral vascular disease, cerebral stroke, galactose blood disease, asthma, and PMM2-CDG.SELECTED DRAWING: None

The defeatherer comprises a machine body and a defeathering head, the defeathering head comprises a fixed seat, a movable seat, a defeathering wheel assembly and an arc-shaped shaft, the movable seat is rotatably connected with the fixed seat, the arc-shaped shaft is connected with the defeathering wheel assembly in series, and the two ends of the arc-shaped shaft are connected with the movable seat and the fixed seat respectively; wherein an ozone generator is fixedly mounted on the fixed seat, and ozone generated by the ozone generator is blown to one side, which is gradually widened, of the dehairing wheel assembly. According to the defeatherer, ozone is generated through the ozone generator, the defeathering area is sterilized and disinfected through the strong oxidizing property of the ozone, bacterium breeding is effectively restrained, skin infection or discomfort is reduced, meanwhile, the hygiene, safety and use experience of equipment are improved, and the requirement of a user for efficient and healthy personal care equipment is met.

The invention belongs to the field of transdermal drug delivery microneedle patch preparations, and particularly relates to a microneedle capable of loading antibiotics insoluble in water as well as a preparation method and application of the microneedle. According to the microneedle, methylacryloylated gelatin (GelMA) serves as a base material, insoluble antibiotics are wrapped by bovine serum albumin and evenly distributed in the microneedle, and the microneedle is obtained through the steps of preparing a GelMA solution, preparing antibiotic nano-particles wrapped by the BSA, mixing the solution, forming a microneedle mold, conducting cross-linking solidification, conducting demolding and drying and the like. And the microneedle with good mechanical property and biocompatibility is obtained. The microneedle can locally deliver antibiotics and effectively treat local skin infection. The invention has the advantages of high drug stability, controllable release, painless delivery and the like, and can effectively break through the skin barrier, improve the bioavailability of the drug, avoid the influence of the gastrointestinal environment on the drug effect and the'first pass effect 'of the liver, and improve the compliance of patients.

The present invention belongs to the field of microneedle patch preparations for transdermal drug delivery, specifically relating to a microneedle capable of loading a poorly water-soluble antibiotic, its preparation method, and its application. The microneedles of the present invention utilize gelatin methacrylate (GelMA) as a substrate. The poorly soluble antibiotic is encapsulated with bovine serum albumin and evenly distributed within the microneedles. The microneedles are obtained by preparing a GelMA solution, preparing BSA-encapsulated antibiotic nanoparticles, mixing the solutions, forming a microneedle mold, cross-linking and curing, and demolding and drying. The resulting microneedles exhibit excellent mechanical properties and biocompatibility. The microneedles of the present invention can locally deliver antibiotics and effectively treat localized skin infections. They offer advantages such as high drug stability, controlled release, and painless delivery. They can effectively penetrate the skin barrier, enhance drug bioavailability, mitigate the effects of the gastrointestinal environment on drug efficacy, and mitigate the "first-pass effect" in the liver, thereby improving patient compliance.

The present application relates to the fields of ozone medicine and hydrogen medicine and their interactive applications, and specifically discloses an oxidation and antioxidant medical system. The oxidation and antioxidant medical system includes ozone and hydrogen-rich hemodialysis treatment water generation and supply equipment, oxidation and antioxidant saline generation equipment, oxidation and antioxidant intestinal flora reconstruction and fecal bacteria transplantation equipment, oxidation and antioxidant gynecological treatment equipment, oxidation and antioxidant burn and scald infiltration treatment equipment, and oxidation and antioxidant hemodialysis treatment equipment. The system generates ozone dialysis water and hydrogen-rich dialysis water by electrolyzing dialysis water in a dedicated electrolytic cell, and further configures it into ozone and hydrogen-rich dialysis saline. It can be applied to intestinal flora for intestinal flora reconstruction and fecal bacteria transplantation, and is applied to the treatment of gynecological diseases and infiltration rehabilitation treatment of patients with burns and scalds, cleaning treatment of difficult-to-heal tissues, treatment of gangrene, treatment of oral inflammation, and treatment of skin infections and skin diseases caused by fungi and bacteria.

The present invention relates to a composition and use thereof directed towards treating various health ailments, such as skin and respiratory problems and various infections. More particularly, the present invention relates to a lime sulfur solution and use thereof, of varying percentages, directed towards improving vision and treating various skin problems and infections, such as toenail fungus, athlete's foot, jock itch, skin psoriasis, eczema, vaginal yeast infections, head or beard dandruff, respiratory infections, itching of the skin (particularly of the hands), acne (facial and / or body acne), poison ivy, insect bites, head and body lice, crabs, cuts, treating wounds infected by staff and / or MRSA (methicillin-resistant Staphylococcus aureus) bacteria, tongue thrush, ringworm, penis foreskin infections, skin tags, and is also directed towards treating various respiratory infections (such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, and Covid-19 infections). The present invention also relates to use of the aforementioned composition and solution as a disinfectant in gyms, spas, saunas, for professional athletes, or as a body and / or hair wash.

The utility model relates to the technical field of medical equipment, and provides an illumination control device for a photodynamic antibacterial product, which comprises a support plate and two square grooves symmetrically arranged on one side of the support plate. According to the illumination lamp, the first fastening screw rod and the second fastening screw rod are loosened by hands, limitation on the round block and the movable rod is relieved, at the moment, the movable rod can be pushed to drive the movable ring, the second rotating rod and the like to rotate by a proper angle, the movable rod slides towards one side along the interior of the movable ring, and the position of the illumination lamp is adjusted; the illumination lamp is fixed by rotating the first fastening screw rod and the second fastening screw rod reversely, and other illumination lamps can be adjusted similarly, so that the illumination lamp can be used for performing irradiation treatment on multiple skin infection areas of the patient and activating the photodynamic antibacterial product. Therefore, the number of equipment is reduced, and the use cost of the equipment is reduced.

The invention provides application of pyrrolimidazole in development of a CrtN enzyme inhibitor, and a CrtN enzyme activity test, a growth curve, pigment yield determination, a hydrogen peroxide killing test, a whole blood killing test and a mouse skin scald infection test prove that pyrrolimidazole can inhibit the activity of the CrtN enzyme, reduce the anti-oxidation removal capability of staphylococcus aureus and inhibit the growth of the CrtN enzyme. The protection effect of a staphylococcus aureus skin infection model is improved. Therefore, as a potential staphylococcus aureus pigment synthesis inhibitor, the depyrrolimidazole can reduce the oxidative stress resistance of staphylococcus aureus by inhibiting the activity of the CrtN enzyme, and has important significance for clinically developing safe and effective antioxidant adjuvants.

The invention relates to the technical field of inorganic antibacterial materials, in particular to a preparation method and application of a novel spherical nano ZnO / CuO / Fe3O4 / Cu (at) Ag material. The core-shell type magnetic nano ZnO / CuO / Fe3O4 / Cu (at) Ag composite material is prepared according to the principle that Ag sol is loaded to ZnO / CuO / Fe3O4 / Cu and then the electron transfer efficiency of the material is improved by utilizing the characteristic that the oxidation-reduction potential of Ag is similar to that of Cu, so that the antibacterial efficiency of the composite material is improved, and the core-shell type magnetic nano ZnO / CuO / Fe3O4 / Cu (at) Ag composite material is prepared. In combination with the synergistic effect of multiple antibacterial components, the advantages that magnetic components are convenient to separate and recycle, electron transfer and ROS generation enhance bacteriostasis are achieved, escherichia coli and staphylococcus aureus are used as experimental strains to research the antibacterial activity of the antibacterial agent, and the toxicology of human cells and the healing promotion research of a rat skin infection model are researched.