9 results about "Cutaneous infections" patented technology

This invention provides an antimicrobial peptide spray, its preparation method, and its application in the prevention and treatment of peristomal skin infections. The spray comprises, by weight percentage, 0.05%-0.5% of a complex antimicrobial peptide, 0.1%-5% of a moisturizing and repairing film-forming matrix, 0.05%-0.2% of a buffer, 0.8%-1.2% of an isotonic regulator, 0.01%-0.5% of a stabilizer, and 0.005%-0.05% of a metal ion chelating agent, with the balance being water for injection. The complex antimicrobial peptide is composed of bovine lactoferrin antimicrobial peptide, sericin oligopeptide, and buckwheat-derived anti-inflammatory active peptide in a weight ratio of (3-5):(2-3):1. This spray possesses four core functions: broad-spectrum antibacterial activity, inhibition of bacterial biofilm, anti-inflammatory and soothing effects, and skin barrier repair. It is less likely to induce bacterial resistance, does not irritate damaged skin around the stoma, and can effectively prevent and treat peristomal skin infections.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

This invention relates to a composite hydrogel with hemostatic and antibacterial functions, its preparation method, and its application. The nanocomposite hydrogel is prepared by copolymerizing graphene oxide loaded with silver nanoparticles and chitosan grafted with dihydroporphyrin E6 during the preparation of thermosensitive poly(N-isopropylacrylamide) hydrogel. This composite hydrogel integrates multiple functions such as antibacterial, hemostatic, and cell proliferation and migration promotion. It possesses excellent thermosensitivity, injectability, swelling properties, tissue adhesion, and biodegradability. It achieves highly efficient antibacterial activity through photothermal-photodynamic synergy and multiple antibacterial components. Furthermore, it effectively controls bleeding by utilizing the sealing effect of the hydrogel and the hemostatic properties of chitosan, while simultaneously promoting fibroblast proliferation and migration. It plays a positive role in all stages of wound healing and is suitable for use as a dressing for infected skin wounds.

This invention discloses a core-shell microneedle loaded with silver nanoparticles and growth factors, its preparation method, and its application, belonging to the field of biomedical technology. The core-shell microneedle includes a backing layer and an array of needle tips disposed on the backing layer; the needle tips in the needle tip array have a core-shell structure, with the shell layer of the needle tip loaded with protein-Ag2O2 composite nanoparticles and the core layer of the needle tip loaded with growth factors. The preparation method of the protein-Ag2O2 composite nanoparticles is as follows: a protein aqueous solution is mixed with a silver nitrate solution, and under alkaline conditions, it is reacted with a hydrogen peroxide solution to obtain the protein-Ag2O2 composite nanoparticles. The core-shell microneedles prepared by this invention, through hierarchical loading of silver peroxide nanoparticles and growth factors, respond to the microenvironment of infected skin wounds and perform programmed release, effectively preventing bacterial infection, promoting cell proliferation and angiogenesis, and driving tissue repair, effectively solving the problem of stagnant healing of infected wounds.

This invention relates to a traditional Chinese medicine composition and its preparation, comprising the following raw materials in parts by weight: rhubarb 18-30 parts, gardenia 18-30 parts, chuanxiong rhizome 9-16 parts, cinnamon twig 9-16 parts, safflower 1-10 parts, and frankincense 1-10 parts. This invention relates to the technical field of external preparations of traditional Chinese medicine. In the traditional Chinese medicine composition of this invention, rhubarb: clears heat and detoxifies, drains heat and promotes bowel movement, cools blood and detoxifies, removes blood stasis and unblocks meridians, has anti-inflammatory effects, and immunomodulatory effects; gardenia: clears heat and promotes diuresis, cools blood and detoxifies; chuanxiong rhizome: invigorates blood and promotes qi circulation, dispels wind and relieves pain; safflower: invigorates blood and unblocks meridians, disperses blood stasis and relieves pain; cinnamon twig: induces sweating and relieves muscle tension, warms and unblocks meridians, promotes qi circulation, calms the bladder and lowers qi, relieves joint pain, has antibacterial effects, anti-inflammatory and anti-allergic effects, dilates blood vessels, and promotes sweating. Frankincense: promotes blood circulation, relieves pain, reduces swelling and promotes tissue regeneration; when used together, these herbs target the core pathogenesis of traumatic swelling and pain (blood stasis), gouty arthritis (damp-heat stagnation), and skin infections (heat toxicity), achieving the treatment of three types of diseases with one ointment, filling a market gap.

This invention discloses a traditional Chinese medicine composition for treating skin infections, which is made from the following components in parts by weight: 50-200 parts of catechu, 50-200 parts of coptis chinensis, 10-100 parts of stir-fried borax, 10-100 parts of red ochre, 10-100 parts of prepared calamine, and 10-100 parts of borneol. The traditional Chinese medicine composition provided by this invention has a reasonable formulation, and the various raw materials work synergistically to exert the effects of clearing heat and drying dampness, astringing sores, reducing swelling and relieving pain. It is suitable for topical application to treat skin infections.

The utility model relates to medical instrument technical field especially, and more particularly to a kind of measuring scale of vaccine clinical test inoculation local reaction.The technical scheme, including measuring scale main part, is provided with graduated scale for vaccine inoculation site reaction on the measuring scale main part;The measuring scale main part includes the first circular disc, second circular disc, third circular disc and fourth circular disc of increasing diameter in turn;The first circular disc, second circular disc, third circular disc and fourth circular disc and connecting strip are all transparent flexible material.The utility model can quickly and accurately measure the maximum diameter of irregular shape, reduce measurement error, can be visually fast and carry out the grading evaluation of local reaction, use disposable film, reduce the risk of skin infection.

This utility model relates to the field of disinfection supports, and discloses a multifunctional lower limb skin infection disinfection support, including a support plate. A support component and a guide component are provided on the upper surface of the support plate. The guide component includes a guide box, which is fixedly connected to the lower surface of the support plate. The guide box is a trapezoidal box with openings at the top and bottom. A through groove is provided on the upper surface of the support plate, and a sealing plate is inserted into the front surface of the guide box. The support component includes rotating sleeves, and multiple sets of rotating sleeves are symmetrically arranged and fixedly connected to the upper surface of the support plate. In this utility model, by setting the guide component, during wet compresses, the patient's leg can be placed above the support strap. When the baffle is moved, the through groove is exposed, allowing the iodine dripping during the wet compress to directly enter the guide box, which then guides the iodine into a waste container.