28 results about "Cutaneous infections" patented technology

This invention provides an antimicrobial peptide spray, its preparation method, and its application in the prevention and treatment of peristomal skin infections. The spray comprises, by weight percentage, 0.05%-0.5% of a complex antimicrobial peptide, 0.1%-5% of a moisturizing and repairing film-forming matrix, 0.05%-0.2% of a buffer, 0.8%-1.2% of an isotonic regulator, 0.01%-0.5% of a stabilizer, and 0.005%-0.05% of a metal ion chelating agent, with the balance being water for injection. The complex antimicrobial peptide is composed of bovine lactoferrin antimicrobial peptide, sericin oligopeptide, and buckwheat-derived anti-inflammatory active peptide in a weight ratio of (3-5):(2-3):1. This spray possesses four core functions: broad-spectrum antibacterial activity, inhibition of bacterial biofilm, anti-inflammatory and soothing effects, and skin barrier repair. It is less likely to induce bacterial resistance, does not irritate damaged skin around the stoma, and can effectively prevent and treat peristomal skin infections.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

The invention discloses a medicinal moxa composition for preventing and treating atherosclerosis and suppurative bacterial infection co-disease. The medicinal moxa composition comprises coptis chinensis, radix rehmanniae, polygala tenuifolia, juncus effuses and moxa. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for effectively preventing and treating atherosclerosis and skin suppurative bacterial infection co-diseases through a multi-target synergistic effect. The medicinal moxa composition has the core effects of clearing away heart-fire, inducing diuresis for treating stranguria and promoting blood circulation to remove meridian obstruction, and forms a complete treatment system which uses cold and warm as well as treats both symptoms and root causes by purging fire for removing toxin through coptis chinensis, clearing heat and cooling blood through radix rehmanniae, soothing nerves and promoting intelligence through polygala, inducing diuresis and conducting heat downward movement through juncus effuses and combining moxa floss for warming and dredging meridians, eliminating cold to stop pain, resisting bacteria and diminishing inflammation. By inhibiting inflammatory factors, regulating epithelial cell proliferation and reaction to oxidative stress, regulating fluid shear force, atherosclerosis and Kaposi sarcoma-related herpesvirus infection-related pathways and other mechanisms, the medicinal folium artemisiae argyi composition realizes synergistic prevention and treatment of atherosclerosis and skin infection, and provides a basis for co-disease treatment.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and to methods for promoting healthy skin aging, treating skin disorders, treating cardiovascular disorders, treating renal disorders, treating angiogenesis disorders, such as cancer, treating tissue damage, such as non-cardiac tissue damage, treating progressive myocardial infarction, and treating various other disorders, such as complications resulting from diabetes with the compounds and compositions of the invention. Other disorders may include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infections, peripheral vascular disease, stroke, and the like.

The invention relates to the technical field of biological fermentation, and discloses a wormwood enzyme and a fermentation method thereof.The wormwood enzyme is prepared from, by mass, 0.5-1.5 parts of brown sugar, 2-4 parts of wormwood and 8-12 parts of purified water, S1, material pretreatment is conducted, specifically, the brown sugar is smashed till the particle size is smaller than or equal to 2 mm, and the wormwood is cut up after being cleaned; according to the wormwood enzyme disclosed by the invention, the brown sugar is firstly crushed, so that the brown sugar can be quickly dissolved, wormwood is cleaned and then cut up, so that the contact area with fermentation liquor can be increased, the growth and metabolism of beneficial microorganisms are facilitated under the conditions of shady, cool and dark places, the wormwood enzyme is fully fermented, and rich active ingredients are generated; the antibacterial components in the prepared wormwood enzyme can effectively inhibit bacterial reproduction, reduce the risk of skin infection, inhibit generation and release of inflammatory factors and relieve inflammatory reactions such as red and swollen skin and pain, and meanwhile, the wormwood enzyme can promote wound healing, stop bleeding and diminish inflammation and has an obvious treatment effect.

A Pharmaceutical composition for treating bacterial skin infections, burns and wounds is disclosed. It comprises an active ingredient, preferably Mupirocin, a biopolymer, preferably Chitosan, with molecular weight ranging from 250,000 Da to 600,000 Da, and a degree of deacetylation of not less than 80%, hydrolyzed Collagen, preferably of type I, with molecular weight ranging from 3 kDa to 6 kDa, and an ointment base comprising emulsifying agents, glycols and solubilizers. The invention has improved stability than the existing ointments, it heals skin and re-epithelializes faster than existing treatments thereby reducing hospitalisation period.

The defeatherer comprises a machine body and a defeathering head, the defeathering head comprises a fixed seat, a movable seat, a defeathering wheel assembly and an arc-shaped shaft, the movable seat is rotatably connected with the fixed seat, the arc-shaped shaft is connected with the defeathering wheel assembly in series, and the two ends of the arc-shaped shaft are connected with the movable seat and the fixed seat respectively; wherein an ozone generator is fixedly mounted on the fixed seat, and ozone generated by the ozone generator is blown to one side, which is gradually widened, of the dehairing wheel assembly. According to the defeatherer, ozone is generated through the ozone generator, the defeathering area is sterilized and disinfected through the strong oxidizing property of the ozone, bacterium breeding is effectively restrained, skin infection or discomfort is reduced, meanwhile, the hygiene, safety and use experience of equipment are improved, and the requirement of a user for efficient and healthy personal care equipment is met.

The utility model relates to the technical field of medical equipment, and provides an illumination control device for a photodynamic antibacterial product, which comprises a support plate and two square grooves symmetrically arranged on one side of the support plate. According to the illumination lamp, the first fastening screw rod and the second fastening screw rod are loosened by hands, limitation on the round block and the movable rod is relieved, at the moment, the movable rod can be pushed to drive the movable ring, the second rotating rod and the like to rotate by a proper angle, the movable rod slides towards one side along the interior of the movable ring, and the position of the illumination lamp is adjusted; the illumination lamp is fixed by rotating the first fastening screw rod and the second fastening screw rod reversely, and other illumination lamps can be adjusted similarly, so that the illumination lamp can be used for performing irradiation treatment on multiple skin infection areas of the patient and activating the photodynamic antibacterial product. Therefore, the number of equipment is reduced, and the use cost of the equipment is reduced.

This invention relates to a composite hydrogel with hemostatic and antibacterial functions, its preparation method, and its application. The nanocomposite hydrogel is prepared by copolymerizing graphene oxide loaded with silver nanoparticles and chitosan grafted with dihydroporphyrin E6 during the preparation of thermosensitive poly(N-isopropylacrylamide) hydrogel. This composite hydrogel integrates multiple functions such as antibacterial, hemostatic, and cell proliferation and migration promotion. It possesses excellent thermosensitivity, injectability, swelling properties, tissue adhesion, and biodegradability. It achieves highly efficient antibacterial activity through photothermal-photodynamic synergy and multiple antibacterial components. Furthermore, it effectively controls bleeding by utilizing the sealing effect of the hydrogel and the hemostatic properties of chitosan, while simultaneously promoting fibroblast proliferation and migration. It plays a positive role in all stages of wound healing and is suitable for use as a dressing for infected skin wounds.

The application discloses synthesis of a novel Schiff base gold (III) compound and antibacterial application thereof, and belongs to the technical field of medicine preparation; gold sodium aurothiomalate has significant antibacterial activity, but the Au-S bond thereof is easily broken by intracellular reducing thiol, and the gold sodium aurothiomalate is metabolized before reaching a target point to produce toxic side effects; based on the gold sodium aurothiomalate, developing a gold compound with stronger stability is one of strategies for overcoming drug-resistant bacteria; the Schiff base itself has antibacterial activity, and after being combined with gold (III) ions, the Schiff base can stabilize gold atoms and improve the activity of the gold atoms; in vitro antibacterial activity shows that Au6 and Au13 have significant antibacterial advantages on carbapenem and polymyxin-resistant Klebsiella pneumoniae, the minimum inhibitory concentration (MIC) is 10 micromoles, and the antibacterial activity is at least 16 times higher than that of the gold sodium aurothiomalate; in vivo antibacterial activity experiments prove that Au6 and Au13 can reduce mouse skin infection and promote wound healing, and can prolong the survival time of abdominal infection mice, and have important practical application value.

The application discloses a composition for treating stubborn skin infection, ulcer and inflammation and a preparation method and application thereof, and belongs to the technical field of functional compositions. The composition is prepared from components containing baicalin 1-5 parts, antibacterial alkaloids 0.5-3 parts, asiaticoside 2-6 parts, salvianolic acid B 3-8 parts, gallic acid 1-4 parts, white plant polysaccharide 5-10 parts, konjac glucomannan 3-10 parts, chitosan 3-5 parts, glycerol 8-20 parts, genipin 0.5-2 parts, calcium chloride 1-3 parts, laurazepam 1-3 parts and water 40-80 parts. The antibacterial alkaloids include berberine or phellodendrine. The application scientifically matches the above components based on deep understanding of the stubborn skin pathological mechanism, and the composition exhibits a significant synergistic effect in in-vitro antibacterial, antibiofilm and anti-inflammatory experiments. The preparation process is simple, the cost is low, and the application is suitable for industrial production.

This invention discloses a core-shell microneedle loaded with silver nanoparticles and growth factors, its preparation method, and its application, belonging to the field of biomedical technology. The core-shell microneedle includes a backing layer and an array of needle tips disposed on the backing layer; the needle tips in the needle tip array have a core-shell structure, with the shell layer of the needle tip loaded with protein-Ag2O2 composite nanoparticles and the core layer of the needle tip loaded with growth factors. The preparation method of the protein-Ag2O2 composite nanoparticles is as follows: a protein aqueous solution is mixed with a silver nitrate solution, and under alkaline conditions, it is reacted with a hydrogen peroxide solution to obtain the protein-Ag2O2 composite nanoparticles. The core-shell microneedles prepared by this invention, through hierarchical loading of silver peroxide nanoparticles and growth factors, respond to the microenvironment of infected skin wounds and perform programmed release, effectively preventing bacterial infection, promoting cell proliferation and angiogenesis, and driving tissue repair, effectively solving the problem of stagnant healing of infected wounds.

This invention relates to the field of materials science and technology, providing a live probiotic culture and delivery hydrogel scaffold, its preparation method, and its applications. The method provided by this invention is simple to operate and offers significant potential for application. The prepared hydrogel scaffold, when used in medical dressings for treating infected skin wounds, exhibits characteristics such as ultra-efficient polymerization, bioprintability, and injectability. It also demonstrates significant antibacterial and repair effects on infected skin wound models, achieving in-situ curing and sealing of the wound with only 1 second of UV irradiation. The method provided by this invention ensures excellent survival rates, controllable colonization efficiency, and sufficient biocompatibility of the probiotics embedded within the hydrogel scaffold. The antibacterial strategy of this invention significantly inhibits the colonization of pathogenic microorganisms, reshapes the composition of the host's symbiotic microbiota, and is microenvironmentally friendly.

The application discloses a water-absorbing low-swelling bacteriostatic hydrogel dressing and a preparation method and application thereof. The hydrogel dressing is prepared by taking chitosan, polyvinyl alcohol and oxidized chitosan as a skeleton and introducing natural extract berberine as a crosslinking agent and an antibacterial agent. The hydrogel dressing prepared by the method has good water absorption performance and low swelling performance. The hydrogel dressing can effectively manage wound exudates and provide stable interface protection for the wound. Meanwhile, the hydrogel has good anti-inflammatory, antioxidant, bacteriostatic and excellent biological safety. The hydrogel dressing can be applied to the treatment of skin infectious injury as a wound dressing, and has important significance in clinical production practice.

Compositions for preventing and treating bacterial infections include artificial sweeteners such as ace-k, saccharin and cyclamate. The compositions are particularly envisaged for topical administration for treating skin infections and for treating or preventing infections caused by Pseudomonas aeruginosa and / or Acinetobacter baumannii. Compositions including artificial sweeteners at sub-minimum inhibitory concentrations can also be used to disrupt virulence or increase the sensitivity of antibiotic-resistant bacteria to those antibiotics.

This invention relates to a traditional Chinese medicine composition and its preparation, comprising the following raw materials in parts by weight: rhubarb 18-30 parts, gardenia 18-30 parts, chuanxiong rhizome 9-16 parts, cinnamon twig 9-16 parts, safflower 1-10 parts, and frankincense 1-10 parts. This invention relates to the technical field of external preparations of traditional Chinese medicine. In the traditional Chinese medicine composition of this invention, rhubarb: clears heat and detoxifies, drains heat and promotes bowel movement, cools blood and detoxifies, removes blood stasis and unblocks meridians, has anti-inflammatory effects, and immunomodulatory effects; gardenia: clears heat and promotes diuresis, cools blood and detoxifies; chuanxiong rhizome: invigorates blood and promotes qi circulation, dispels wind and relieves pain; safflower: invigorates blood and unblocks meridians, disperses blood stasis and relieves pain; cinnamon twig: induces sweating and relieves muscle tension, warms and unblocks meridians, promotes qi circulation, calms the bladder and lowers qi, relieves joint pain, has antibacterial effects, anti-inflammatory and anti-allergic effects, dilates blood vessels, and promotes sweating. Frankincense: promotes blood circulation, relieves pain, reduces swelling and promotes tissue regeneration; when used together, these herbs target the core pathogenesis of traumatic swelling and pain (blood stasis), gouty arthritis (damp-heat stagnation), and skin infections (heat toxicity), achieving the treatment of three types of diseases with one ointment, filling a market gap.

This invention discloses a traditional Chinese medicine composition for treating skin infections, which is made from the following components in parts by weight: 50-200 parts of catechu, 50-200 parts of coptis chinensis, 10-100 parts of stir-fried borax, 10-100 parts of red ochre, 10-100 parts of prepared calamine, and 10-100 parts of borneol. The traditional Chinese medicine composition provided by this invention has a reasonable formulation, and the various raw materials work synergistically to exert the effects of clearing heat and drying dampness, astringing sores, reducing swelling and relieving pain. It is suitable for topical application to treat skin infections.

The application discloses an RB@PDA hydrogel precursor for treating skin infection, a preparation method and application, and belongs to the technical field of biomedical materials. The RB@PDA hydrogel precursor comprises a sodium alginate aqueous solution and RB@PDA nanoparticles dispersed in the sodium alginate aqueous solution, wherein the RB@PDA nanoparticles are prepared through a hydrothermal synthesis reaction of a dopamine precursor and rose Bengal under alkaline conditions. 2+ The material can realize photothermal therapy and photodynamic therapy under 808 nm near-infrared laser irradiation, effectively destroy the structure of bacteria and biofilms, and has excellent antibacterial performance. The hydrogel has good biocompatibility and can significantly accelerate the healing process of bacterial infection wounds.

The utility model relates to medical instrument technical field especially, and more particularly to a kind of measuring scale of vaccine clinical test inoculation local reaction.The technical scheme, including measuring scale main part, is provided with graduated scale for vaccine inoculation site reaction on the measuring scale main part;The measuring scale main part includes the first circular disc, second circular disc, third circular disc and fourth circular disc of increasing diameter in turn;The first circular disc, second circular disc, third circular disc and fourth circular disc and connecting strip are all transparent flexible material.The utility model can quickly and accurately measure the maximum diameter of irregular shape, reduce measurement error, can be visually fast and carry out the grading evaluation of local reaction, use disposable film, reduce the risk of skin infection.

N-Functionalized Indole Compounds as Antimicrobial Agents and Process for Preparation Thereof The present invention relates to novel N-functionalized indole compounds and their synthesis using ionic liquids as green reagents and / or solvents in a two to four-step process. The compounds exhibit potent antibacterial activity against multi-drug resistant and susceptible gram-positive bacteria, including Staphylococcus aureus and Enterococcus sp. Synergistic effects are observed when combined with gentamicin or levofloxacin, including activity against resistant MRSA (NRS 119). In-vivo efficacy is demonstrated in a murine skin infection model via topical and oral administration.

The invention discloses an RB (at) PDA hydrogel precursor for treating skin infection as well as a preparation method and application thereof, and belongs to a biomedical material technology. The RB (at) PDA hydrogel precursor comprises a sodium alginate aqueous solution and RB (at) PDA nanoparticles dispersed in the sodium alginate aqueous solution, wherein the RB (at) PDA nanoparticles are prepared by a hydrothermal synthesis reaction of a dopamine precursor and rose bengal under an alkaline condition. After the hydrogel precursor is locally applied, rapid in-situ gelling can be realized under the induction of a Ca < 2 + >-containing cross-linking agent, a three-dimensional network structure is constructed, and local enrichment and release of drugs are realized. The material can synergistically realize photothermal therapy and photodynamic therapy under 808 nm near-infrared laser irradiation, effectively destroys bacteria and biological membrane structures, and has excellent antibacterial performance. The hydrogel is good in biocompatibility, and the healing process of bacterial infected wounds can be remarkably accelerated.

This utility model relates to the field of disinfection supports, and discloses a multifunctional lower limb skin infection disinfection support, including a support plate. A support component and a guide component are provided on the upper surface of the support plate. The guide component includes a guide box, which is fixedly connected to the lower surface of the support plate. The guide box is a trapezoidal box with openings at the top and bottom. A through groove is provided on the upper surface of the support plate, and a sealing plate is inserted into the front surface of the guide box. The support component includes rotating sleeves, and multiple sets of rotating sleeves are symmetrically arranged and fixedly connected to the upper surface of the support plate. In this utility model, by setting the guide component, during wet compresses, the patient's leg can be placed above the support strap. When the baffle is moved, the through groove is exposed, allowing the iodine dripping during the wet compress to directly enter the guide box, which then guides the iodine into a waste container.

The invention relates to the technical field of medicine, in particular to application of a quinazoline compound ZJCK-6-68 in preparation of antibacterial, anti-inflammatory and anti-skin infection drugs, and the ZJCK-6-68 provided by the invention has the advantages of antibacterial property, low cytotoxicity, low hemolytic toxicity, good in-vivo biological safety and low drug resistance tendency. An antibacterial mechanism research shows that the ZJCK-6-68 can inhibit the formation of a biological membrane, reduce the generation of golden pigment and destroy cell membranes. This disruption results in membrane depolarization, cytoplasmic DNA leakage and DNA synthesis inhibition, ultimately accelerating bacterial death. The ZJCK-6-68 can inhibit the expression of inflammatory factors TNF-alpha, IL-6 and NO, and can play an anti-inflammatory role by inhibiting a DYRK1A signal channel. It is worth noting that ZJCK-6-68 has anti-MRSA activity and anti-inflammatory activity in a mouse skin infection model, and has great clinical application value.

The present application relates to a new use of deer blood peptide and a preparation method of deer blood peptide hydrogel, wherein the new use is the application of deer blood peptide in drugs or cosmetics for promoting skin repair of diabetes, and the preparation method comprises the following steps: (1) enzymolysis: preparing deer blood solution, adjusting pH, preheating, adding pepsin, digesting, adjusting pH with NaOH, adding trypsin, further reacting, heating to deactivate the enzyme after digestion, centrifuging to obtain supernatant of the enzymolysis solution, and filtering to obtain deer blood peptide; (2) separation and freeze-drying: preparing deer blood peptide solution, sequentially performing fractionation treatment with molecular cut-off to obtain corresponding components, performing desalting treatment, and freeze-drying to obtain deer blood peptide with different components; (3) preparation of deer blood peptide hydrogel: adding chitosan into glacial acetic acid solution to fully dissolve, adding β-GP solution to obtain chitosan / β-GP solution, adding sodium alginate powder to dissolve, then dropping CaCl2 solution to obtain blank hydrogel, and finally adding deer blood peptide to obtain deer blood peptide hydrogel. The discovery of the new use provides a new method and favorable basis for the treatment of chronic skin infectious diseases of diabetes.

The synergistic antibacterial auricular point patch comprises a fixed layer, a first fiber membrane layer, a second fiber membrane layer and an acupoint stimulation part, a first cavity is formed between the first fiber membrane layer and the fixing layer, and a medicine for promoting qi to activate blood is loaded in the first cavity; the second fiber membrane layer is arranged on the periphery of the first fiber membrane layer in a concentric-square-shaped surrounding mode. A second cavity is formed between the second fiber membrane layer and the fixing layer, and an antibacterial medicine is loaded in the second cavity; a first mounting hole of the first fiber membrane layer is matched with an acupoint stimulation component, the upper end of the acupoint stimulation component penetrates through the first mounting hole and then is fixedly connected with the surface of the side, facing the ear skin, of the fixing layer, and the lower end of the acupoint stimulation component is higher than the lower end of the first fiber membrane layer. Therefore, the design reduces the risk of skin infection while enhancing the conditioning effect.

The invention relates to the field of medical treatment, in particular to a medicine introduction injection needle for skin infection. The invention provides a skin infection drug introduction injection needle which can mix drugs and convey the drugs into an injection cylinder, does not need additional manual mixing and is convenient to use. A medicine introduction injection needle for skin infection comprises an injection cylinder, an injection needle, a connecting sleeve, an extrusion rod and the like, the lower portion of the injection cylinder is in threaded connection with the connecting sleeve, the connecting sleeve is connected with the injection needle, the upper portion of the injection cylinder is provided with a cover in a threaded mode, and the cover is in sliding connection with the extrusion rod. According to the device, the motor is started to drive the spiral piece to rotate, so that medicine in the conveying pipe moves towards the injection cylinder, meanwhile, the medicine is mixed through the spiral piece, the mixed medicine is injected into the injection cylinder, and the effects that the medicine can be mixed and conveyed into the injection cylinder, additional manual mixing is not needed, and use is convenient and fast are achieved.