The invention discloses western medicine composition for preventing and treating acne. The western medicine composition is prepared from raw materials in parts by weight as follows: 5-8 parts of oxytetracycline tablets, 3-5 parts of analgin tablets, 5-8 parts of normal saline, 3-5 parts of compound dexamethasone acetate ointment, 3-10 parts of fluocinonide ointment, 4-6 parts of loratadine tablets, 0.5-2 parts of retinoic acid, 1-3 parts of Xuesaitong tablets, 5-10 parts of bird's nests, 1-3 parts of aloe vera gel, 2-5 parts of miconazole cream, 5-10 parts of sunflower seed oil and 1-3 parts of Amprenavir. The western medicine composition has a synergistic effect through compounding of the raw materials and can effectively inhibit acne growth, promote acne inflammation diminishing and recovery, effectively remove acne marks and promote skin regeneration; furthermore, the western medicine composition adopts the available raw materials, is low in cost, good in curative effect and convenient to apply and has few toxic and side effects; besides, the skin can become fine, smooth and elastic when the western medicine composition is applied to the normal skin.