174results about How to "Improve antifungal effect" patented technology

Provided is a pharmaceutical composition for external use, including: (i) a compound represented by the general structural formula (1) and/or a salt thereof; and (ii) N-methyl-2-pyrolidone:

Where, X represents a hydrogen atom or a chlorine atom.

The invention discloses bactericidal antiviral incense and a preparation method thereof, wherein the incense body comprises a substrate incense body which is prepared by mixing elm bark powder, an air freshening substance, and a bactericidal antiviral substance; the air freshening substance comprises one or more of clove, agilawood, agastache rugosus, sandalwood, and rhizoma cyperi; the bactericidal antiviral substance comprises one or more of radix angelicae, rhizoma atractylodis, and tarragon. The bactericidal antiviral incense comprises the following components by weight: 20-35 parts of elm bark powder, 10-30 parts of clove, 10-30 parts of agilawood, 10-30 parts of agastache rugosus, 10-30 parts of sandalwood, 10-30 parts of rhizoma cyperi, 10-35 parts of radix angelicae, 10-35 parts of rhizoma atractylodis, and 10-35 parts of tarragon. The incense has the characteristics of cold prevention, sterilization and disinfection, immunity improvement, pollution elimination, air purification, dehumidification and turbidity reduction, no western components, no harm to human body, and the like.

Biosurfactants produced by a strain of Bacillus sp and to uses thereof. A composition comprising the biosurfactants, and a method for producing the biosurfactants. A method for obtaining a biosurfactant, and a device for implementing the method. The production of biopesticides or biosurfactants for the phytosanitary industry, and in the fields of the food, cosmetics, pharmaceutical and oil industries and the environment.

The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, this invention relates to compositions and methods for selectively enhancing fungal sensitivity to antifungal compounds.

The invention discloses a method for preparing an antifungal pectin oligosaccharide through citrus peel. The method includes the steps that raw material preprocessing pectin is extracted, and the pectin is hydrolyzed through an enzymic method, wherein the optimal conditions of pectin hydrolysis achieved through the enzymic method include that a pectin solution with the mass concentration being 1.0-1.1% is prepared from an acetic acid-sodium acetate buffering solution with the pH being 4.5, pectinase P21 is added, the adding amount of pectinase is 1.0-1.1U/mL, a stirring reaction is carried out for 20-50 min through water bath at the temperature of 40-50 DEG C, and then enzyme denaturalization is carried out for 5-15 min in boiling water bath. The pectin oligosaccharide prepared through the preparation method is mainly disaccharide and trisaccharide, and the yield is larger than 52%. The pectin oligosaccharide has an obvious antifungal effect and has a good inhibiting function on four common pathogenic fungi. The pectin oligosaccharide is prepared into oligosaccharide composite film liquid, is used for citrus preservation, prolongs citrus fruit storage time easily, and lays a foundation for further utilization of the pectin oligosaccharide. The additional value of citruses is improved, environment pollution can also be reduced, and the oligosaccharide is prepared from the citruses and is used for the citruses.

The invention relates to a preparation method of a biological preservative. The preparation method comprises the following steps of (1) providing anticorrosive base fluid which comprises pimaricin and a solvent, wherein the pimaricin as a solute dissolves in the solvent; (2) providing a stabilizing agent which is one or a mixture of soluble soybean polysaccharide, trehalose, an antioxidant and a chelating agent; (3) performing mixing: mixing the anticorrosive base fluid with the stabilizing agent so as to form mixed fluid; and (4) regulating pH, and adding a pH regulating agent to the mixed fluid, so that the pH value of the mixed fluid is maintained to be 5-7.5. According to the preparation method disclosed by the invention, the stabilizing agent is introduced, so that the preservative is good in stability, and when being stored, high activity of the pimaricin can also be maintained, and the anti-fungal effect is good. According to the preparation method disclosed by the invention, conventional design of the preservative is broken, the prepared preservative is broad in application range, and the difficult problems that the preservative is difficult to dissolve and poor in stability, existing in food processing enterprises are solved, and the method has great significance in popularization. In addition, the invention further provides the biological preservative for fresh keeping of foods.

The invention discloses antifungal application of fraxetin, belonging to the technical field of medicines. In-vitro experiments show that fraxetin has relatively good inhibition effect to the fungi, is capable of restoring the effect of an antifungal drug, namely fluconazole to drug-resistant fungi and therefore can be taken as the antifungal drug and a synergist for the antifungal drug. Accordingto the antifungal application, the new use of fraxetin is opened up, fraxetin is used as the antifungal drug and the synergist for the antifungal drug, a new candidate drug is provided for the fungustreatment, and the antifungal effects of existing drugs are improved. Under the conditions that clinical fungus drug resistance becomes common increasingly and the drug resistance level becomes serious increasingly, the effect of an antifungal drug to the drug-resistant fungi is restored, and the use dosage of the antifungal drug is reduced, so that the medical expense of a patient is saved, andthe toxic and side effects of the drugs are reduced.

The invention relates to a hatching egg cleaning disinfectant and a preparation method thereof. The hatching egg cleaning disinfectant comprises a natural antibiotic traditional Chinese medicinal material, a nonionic surfactant, a cosolvent and deionized water. The hatching egg cleaning disinfectant has no irritation, toxic or side effects, has strong cleaning and disinfecting effects, and can effectively prevent vertical propagation of various diseases of breeding birds, the preparation method has the advantages of simplicity and easy operation, and the hatching egg cleaning disinfectant is suitable for immersion disinfection and foam disinfection of hatching eggs and cleaning of the hatching eggs, and can effectively inhibit vertical propagation of the diseases.

The invention discloses a medicinal composition for treating mycotic infection at the superficial part and application thereof. The medicinal composition comprises miconazole and hanfangchin A, wherein the concentration of the hanfangchin A in a miconazole and hanfangchin A combined system is more than or equal to 40mug/ml. The medicinal composition can be used for an active component for preparing a medicament for treating the mycotic infection at the superficial part. After being verified by an in-vitro antimicrobial test, the hanfangchin A can be used for enhancing the antimycotic effect of the miconazole on dermatophyte and monilial to different degrees, in particular bacteriostasis effect on medicament-resistant fungi; and meanwhile, the dosage of the miconazole is reduced.

The invention discloses a 3, 5-dihydroxy-4-isopropyl diphenyl ethylene-ethyl bromoacetate-polyoxyethylene compound, namely polyoxyethylene-di(acetic acid-4-isopropyl-5-hydroxy diphenyl ethylene-3-phenolic ester). The original medicine is 3, 5-dihydroxy-4-isopropyl diphenyl ethylene (tolylene maud); and the modifier is polyoxyethylene and the linker arm is ethyl bromoacetate. The synthetic method of the compound includes three reactions, namely esterification reaction, hydrolysis reaction and esterification reaction. Compared with the original medicine, the compound has enhanced water-solubility and stability; the internal medicine distribution is changed; the bioavailability is enhanced; the synthetic method is simple; the reaction condition is mild; and the cost is low, without numerous unpleasant experimental procedures. In the method, the 3, 5-dihydroxy-4-isopropyl diphenyl ethylene-ethyl bromoacetate-polyoxyethylene compound can be easily made.

The invention provides Xanthone compounds and a preparation method thereof, and application of the Xanthone compounds in the field of agriculture, belonging to the field of fungus extracts. A fermentation extract is obtained from Aspergillus versicolor D5 derived from ocean, and 15 compounds are obtained through separation and extraction, wherein 6 compounds are identified as new compounds, and 9compounds are identified as known compounds. The resuts of herbicidal activity tests and antifungal activity tests show that the Xanthone compounds have good antifungal and herbicidal activity, are environment-friendly, safe and efficient, and have better or equivalent control effects compared with chemical pesticides.

The invention discloses an eye antifungal nano-micelle solution containing terbinafine hydrochloride. The eye antifungal nano-micelle solution consists of the following raw materials in parts by weight: 0.05-1 part of terbinafine hydrochloride, 0.5-10 parts of a solubilizer, 0.5-10 parts of glycerinum, 0.003-0.05 part of a bacteriostatic agent, 0.05-0.2 part of a thickening agent and 90-99.8 parts of water. According to the eye terbinafine hydrochloride antifungal nano-micelle solution disclosed by the invention, terbinafine hydrochloride nano-micelle is prepared from the solubilizer by self aggregation, the average particle size of the terbinafine hydrochloride nano-micelle is smaller than 30nm, the characters are not greatly changed after the terbinafine hydrochloride nano-micelle is subjected to freezing redissolution and boiling sterilization for 30 minutes and then cooled to room temperature, and the physicochemical properties are also stable. Water is taken as a solvent of the eye antifungal nano-micelle solution, and no organic solvent is used in the preparation process, so that the eye antifungal nano-micelle solution is small in irritation, relatively convenient to drop into eyes, free of phenomenon of adhesion or fuzziness, relatively long in eye acting time, relatively good in absorption by eyes, and relatively good in antifungal effect, and use comfort degree of patients can be greatly increased.

The invention discloses a haze resistant mouth mask. The haze resistant mask comprises a mask body, wherein the mask body comprises an inner layer cloth, a filtering core layer and an outer layer cloth, the inner layer cloth, the filtering core layer and the outer layer cloth are arranged from inside to outside sequentially, the filtering core layer comprises a first spun-bonded cloth layer, a second spun-bonded cloth layer, a filtering layer and a traditional Chinese medicine layer, the filtering layer and the traditional Chinese medicine layer are arranged between the first spun-bonded cloth layer and the second spun-bonded cloth layer, the traditional Chinese medicine layer is internally provided with multiple separating belts which are used for placing traditional Chinese medicine particles, and ventilating gaps are formed between adjacent separating belts. According to the haze resistant mouth mask, the haze resistant mouth mask can be used for multiple times, a filtering core containing a traditional Chinese medicine interlayer can be replaced, on one hand, the haze resistant mouth mask is fresh and pleasant, and has good functions of preventing and prohibiting bacterium-germs, and on the other hand, the mouth mask can be cleaned and used for multiple times.

The invention provides a compound flower fresh-keeping agent containing Chinese herbal medicinal components. The flower fresh-keeping agent is prepared from the following components in parts by mass: 25 to 35 parts of saccharose, 15 to 25 parts of chitosan, 4 to 6 parts of natamycin, 1 to 2 parts of nisin, 1.6 to 2.0 parts of citric acid, 0.8 to 1.2 parts of salicylic acid, 0.6 to 0.8 part of boric acid, 0.6 to 1.0 part of vitamin C, 0.5 to 0.7 part of vitamin E, 30 to 50 parts of Chinese herbal medicine ethanol extracting solution A and 160 to 200 parts of Chinese herbal medicine water extracting solution B, wherein total parts are 1000 parts, and other parts are supplemented by using ultrapure water. The compound flower fresh-keeping agent containing the Chinese herbal medicinal components, provided by the invention, is safe and environment-friendly in component, and has an excellent broad-spectrum antibacterial effect; the invasion of various microorganisms to fresh flowers can be effectively inhibited, the refreshing time of the fresh flowers is greatly prolonged, and remarkable color protecting and adding effects are realized; in addition, the preparation method is simple, and is simple and convenient to operate during use.

The present invention relates to a novel triazole alcohol compound. The triazole alcohol compound has a following chemical structural formula as shown in a chemical structure in the specification, wherein X is CH=CH or O; R is selected from alkyl, halogen, alkoxy or nitryl. The invention has the advantages that: the compound has good antifungal activity for various superficial and deep fungi, has the advantages of high efficiency, low toxicity and wide antifungal spectrum compared with conventional clinical applied antifungal drugs, and can be used in the preparation of antifungal drugs. The compound is simple in the preparation method, high in yield, and good in antifungal effect, and a novel compound is provided for the preparation of antifungal drugs.

The invention discloses a coniothyrium-minitans siderophore transporter (CmSit1) gene as well as a preparation method and application thereof. A coniothyrium-minitans insertion mutant library containing a plurality of T-DNA (transferred deoxyribonucleic acid) markers is obtained by adopting a mature agrobacterium-mediated genetic transformation method of the coniothyrium minitans. Transformants and sclerotinia sclerotiorum Ep-1PNA367 are cultured at the same time in the PDA (potato dextrose agar) culture medium, and as the comparison of a strain ZS-1, a strain ZS-1N1812 with enhanced anti-fungal capacity is selected. The further study shows that the expression of the CmSit1 gene can be improved significantly when T-DNA in the strain ZS-1N1812 is inserted into a promoter area of the CmSit1 gene, and the capacity of resisting the sclerotinia sclerotiorum of a plant can be improved significantly if the CmSit1 gene is transferred into the nicotiana benthamiana. The CmSit1gene can be used for improving the capacity of resisting pathogenic fungi of various biocontrol bacteria and can be also used for the transgenic breeding for disease resistance of crops.

The invention discloses an ionic antibacterial anti-mite heat storage fabric and a processing technology thereof. The ionic antibacterial anti-mite heat storage fabric is obtained by soaking a pretreated fabric matrix in an antibacterial anti-mite finishing solution and then drying. The antibacterial anti-mite finishing solution is prepared from the following raw materials in parts by weight: 1-5 parts of silver-loaded nano zinc oxide, 2.1-5.5 parts of a dispersing agent, 1.2-3.6 parts of a stabilizing agent, 10.2-13.2 parts of a coloring agent, 13.5-16.7 parts of an antibacterial anti-mite agent and 50-70 parts of deionized water. The antibacterial anti-mite agent is chitosan modified by an active component, has a triazole structure and a quaternary ammonium salt group and has a good killing effect on fungi, bacteria and mites, silver ions in silver-loaded nano zinc oxide can be chelated with the fabric pretreated by carboxylic acid, and the antibacterial effect of metal ions can be more effectively exerted for a long time.

The invention belongs to the technical field of drugs, and particularly relates to new triterpenoid saponin compounds as well as a preparation method and an application thereof. The compounds are soapnut saponin W, soapnut saponin S, soapnut saponin T, soapnut saponin U and soapnut saponin V, and chemical structures of the compounds are shown in the description. The preparation method of the compounds are further provided for systematic separation of sapindus, the five triterpenoid saponins are screened out, the antifungal effect is remarkably better than that of total soapnut saponin, soapnutsaponin A and soapnut saponin B, and the compounds are comparable to mainstream drugs in the current market, have better effect on coated candida than the mainstream drugs in the current market, havethe advantages of being clear in mechanism and exact in curative effect and facilitating industrial production, and are particularly suitable for treating drug resistance to the mainstream drugs in the current market and infection caused by coated candida.

The invention discloses an antifungal compound extract, a preparation and a preparation method of the extract. The antifungal compound extract comprises the following components in parts by weight: 1-3 parts of a gallnut extract, 1-3 parts of a fructus cnidii extract, 1-3 parts of a pogostemon cablin extract, 0.5-1.5 parts of a galangal extract, 0.5-1.5 parts of a radix sophorae flavescentis extract, 0.5-1.5 parts of a radix clematidis extract, 0.5-1.5 parts of a fructus kochiae extract and 0-80 parts of an ethanol-water solution. The components of the antifungal compound extract are extractedby adopting a hot reflux extraction method; and ethanol-separated and purified liquid obtained after separation and purification of macroporous adsorption resin has an obvious effect of resisting trichophyton rubrum and tritirachium album and can be used for preventing and treating fungal infection of human skin, hair and nails. Meanwhile, plant extracts are compounded to be prepared into powderygranules, the solubility is increased, the state is good, the medicine curative effect is long, and the medication form is convenient.

The invention provides a novel azole antifungal compound. According to the azole antifungal compound, a structural general formula is shown in the specification, wherein X is hydroxyl, Ar is 2,4-difluoro phenyl, and R is selected from hydrogen, alkyl, halogen, cyano-group, nitryl, amino or alkoxy and can be positioned at the ortho-position, meta-position or para-position of a benzene ring and can be mono-substituted or multi-substituted; the alkyl has 1 to 4 carbon atoms; the halogen is selected from F, Cl, Br and I; the amino is selected from -NH2, one or two aminos substituted by the alkyl and cyclic amino; and the alkoxy is selected from methoxyl, ethyoxyl and tert-butyl oxygroup. The invention also provides a method for preparing the compound and application of the compound to preparation of antifungal medicines. Compared with the conventional antifungal medicines which are applied clinically, the azole antifungal compound has the advantages of high antifungal activity on invasive fungi, high efficiency, low toxicity, broad spectrum and the like; and the method is simple and high in yield, and the prepared compound has a good antifungal effect.

The invention relates to Rhuschalcone compounds and application of the Rhuschalcone compounds. The compounds have two alpha, beta- ketene active structures, and have the specific general formula shown in formula (I) or (II), wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, hydroxy, C1-C6 alkoxy or methoxyl. The invention also relates to the application of the compounds in the aspect of preparing a wood preservation preparation and the aspect of preparing an oxidation resistant preparation.

The invention belongs to the technical field of medicines and particularly relates to application and a preparation method of a triterpenoid saponin compound. The compound is used for preparing a drugfor treating fungal infection and has the following chemical structure as shown in the description. The invention also provides the preparation method. Soapberries are systematically separated to screen two triterpenoid saponins. The compound is clear in anti-fungus mechanism and the anti-fungus action is obviously superior to that of other soapberry total saponins, soapberry saponin A, soapberrysaponin B and Clemontanoside C. The anti-fungus action of the compound is equivalent to that of market main current drugs at present and the action on capsular candida is obviously superior to that of market main current drugs. The compound has the advantages of clear mechanism, exact curative effect and easiness in industrial production, and is particularly suitable for drug resistance of the market main current drugs at present and infection induced by capsular candida.

The invention relates to beta-phosphoryl nitrate ester compounds and a preparation method thereof. Novel compounds, namely the beta-phosphoryl nitrate ester compounds as shown in a general formula (I)are synthesized, and the prepared beta-phosphoryl nitrate ester compounds will have a dual property both of nitrate esters and organic phosphines. The invention also discloses the preparation methodof the beta-phosphoryl nitrate ester compounds, and the preparation method is that olefin compounds, phosphorus reagents and an oxidant are dissolved in a solvent, and are allowed to react at 30-60DEGC under a nitrogen atmosphere, so as to prepare and obtain the beta-phosphoryl nitrate ester compounds in one-step with a one-pot method. According to the beta-phosphoryl nitrate ester compounds andthe preparation method thereof, the starting raw material is olefins which are cheap, readily available, low in cost, and have many types for selection; step economy and atom economy are high; the obtained products have various types and generally have high yields; and meanwhile, the preparation method has mild reaction conditions, is safe for operation, is easy to control, has simple post-treatment, and is suitable for large-scale production.