3results about How to "Improve antagonistic ability" patented technology

This invention provides a drug for antagonizing bacterial endotoxins, its preparation method, and its application, belonging to the biomedical field. The composition consists of 25-55 parts of dried powdered traditional Chinese medicine extract, 25-70 parts of mixed essential oil powder, and 40-90 parts of lentinan powder. The traditional Chinese medicine extract is prepared by decoction of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Isatis indigotica under reduced pressure at low temperature and spray drying. The mixed essential oil powder is prepared by encapsulating peppermint oil and eucalyptus oil with gelatin and hydroxypropyl cellulose and then spray drying under high pressure. This invention, through specific formulation and processing, significantly enhances the synergistic antagonistic effect of each component against endotoxins. Experiments show that this composition exhibits antagonistic activity far superior to ibuprofen in vitro; in vivo, it significantly reduces the endotoxin content in the plasma of 817 broiler chickens, rapidly alleviates LPS-induced fever and diarrhea, and improves decreased growth performance. Therefore, this invention is of great significance for reducing antibiotic dependence and improving the efficiency of livestock and poultry farming.

This invention discloses a method for controlling bacterial wilt and soil antibiotic resistance genes based on a bio-liquid-microorganism-silicon synergy, belonging to the fields of agricultural microbial technology and soil remediation technology. The method includes the following steps: S1, using straw from fields frequently affected by bacterial wilt as raw material, a renewable antibacterial bio-liquid rich in phenolic and ketone compounds is prepared; S2, Bacillus subtilis is subjected to stress-adaptive screening and continuous domestication culture to obtain domesticated strains; S3, the domesticated strains are expanded to prepare a biocontrol agent with enhanced antagonistic ability and environmental tolerance; S4, under pot conditions, the optimal combination of silicon fertilizer, antibacterial bio-liquid, and stress-adaptive biocontrol agent is screened to clarify its role in reducing the spread of antibiotic resistance genes in the soil-plant continuum; S5, under field conditions, silicon fertilizer, antibacterial bio-liquid, and stress-adaptive biocontrol agent are synergistically applied to inhibit soil-borne diseases and simultaneously reduce the spread of antibiotic resistance genes in the soil-plant continuum. This invention has the advantages of stable and sustained control effect and high ecological safety. It can effectively protect the healthy growth of crops and reduce the risk of the spread of resistance genes.