211 results about "Dermatophyte" patented technology

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and / or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

The invention relates to an irradiation device and method for the treatment of totally or partially cell-mediated inflammations of the skin, the connective tissue and the viscera, viral and other infectious diseases such as HIV and prionic infections, fungal infections of the skin and the mucous membranes, bacterial diseases of the skin and the mucous membranes as well hand eczema and anal eczema which comprises at least one irradiation device to irradiate a surface treatment area where the wavelength of the emitted radiation to a treatment area is longer than 400 nm and comprises at least one spectral band between 400-500 nm while the radiation device contains means for the generation of optical pulses towards a treatment area with a power density of the optical pulse peaks larger than 0.5 W / cm2 and smaller than 100 kW / cm2. The energy of one pulse relates to 0.05-10 J / cm2.

A device is provided that allows for target treatment of infections, caused by dermatophytes, yeast fungus, and mould fungus, such as onychomycosis and dermatophytosis. The device comprises a nitric oxide (NO) eluting polymer arranged to contact the infected area, such that a therapeutic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO). Furthermore, a corresponding manufacturing method is provided.

PCT No. PCT / US93 / 04763 Sec. 371 Date Mar. 18, 1997 Sec. 102(e) Date Mar. 18, 1997 PCT Filed May 19, 1993 PCT Pub. No. WO93 / 23061 PCT Pub. Date Nov. 25, 1993A new class of general antiinfective agents extracted from pepper, ginger, and other plant species containing vanillyl and piperidine ring structures typical of the pungent principal found in pepper and ginger. The role of these structures, their attached hydrocarbons groups, and other agents found with the plant extract is demonstrated in the topical treatment of dermatophyte infections, tissue injuries, and abnormal proliferations of keratin.

The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such a mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

The invention belongs to the field of biomedical engineering materials and discloses a nitric oxide loaded cationic polymer, a preparation method therefor and an application of the nitric oxide loaded cationic polymer in the field of biomedicine. A cationic polymer which is used for loading nitric oxide and containing a dendritic polyamide element specifically is a polyethyleneimine grafted dendritic polyamide polymer and has a molecular formula shown in the description. The invention further provides the nitric oxide loaded cationic polymer based on the polymer. The nitric oxide loaded cationic polymer disclosed by the invention can be applied to the field of biomedicine as a nitric oxide donor material through loading NO, is used as a biomedical material and particularly is applied to the preparation of antibacterials; and the nitric oxide loaded cationic polymer has the effects of effectively inhibiting the growth and reproduction of bacteria and fungi, has remarkable inhibitory effects on common oral cavity pathogenic bacteria, dermatophyte, wound infection bacteria and the like, has the functions of promoting wound healing, diminishing inflammation and the like and provides a support for the application of the nitric oxide loaded cationic polymer in preparation of the biomedical engineering materials.

A composite medicine with skin target for treating pointed condyloma, viral or fungal infection of skin, and eczema is prepared from oil, surfactant, surfactant assistant, osmotic promoter, active medicine and water through proportional mixing, and adding gel matrix.

This present teaching describes how to treat substrates with novel compositions in order to limit fungi, dermatophytes, yeasts, and bacteria thereon.

The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

An antifungal composition and penetrating carrier system for topical treatment of dermatophytic infection and secondary bacterial infections. The antifungal composition includes various fungistatic and fungicidal essential oil components, or combinations thereof. The penetrating carrier system may include various ingredients, including a penetration enhancer, such as isopropyl myristate.

The invention provides Tibetan medicine medicated bath for treating psoriasis. The Tibetan medicine medicated bath is prepared by preparing ephedra saxatilis, shug-pa, artemisia sieversiana, german tamarisk, rhododendron anthopogonoide, mirabilis jalapa, sealwort, radix asparagi, caltrop, sphallerocarpus gracilis, semen cassia, ambrette, frankincense, sulphur, orpiment, saffron crocus, ginger and rheum officinale, partially fermenting and decocting the components. The Tibetan medicine medicated bath provided by the invention can quickly and directly act on the lesions, perfect the vitality of skin tissues, enhance the metabolism of skin, promote the blood circulation of a human body, adjust the endocrine, discharge toxins in vivo, kill dermatophyte, enhance the immune function and ensure an obvious treatment effect; and the treatment process is comfortable and convenient and is free of toxic or side effect.

The invention provides an external medicine for treating tinea manuum and athlete's foot, which is a liniment prepared by immersing solomonseal, kuhseng, broom cypress fruit, cnidium fruit, stemona root, yellow-corktree bark, cotex dictamni, ageratum and dandelion in mature vinegar for 7 to 15 days, sterilizing and sealed-packaging the filtrate. The medicine clears away heat and toxic material, removes dampness to relieve itching, dries damp, expels the wind, destroys parasites, and has strong epiphyte killing function and infiltration function. The medicine can effectively eliminate pathogenic dermatophyte, has good curative effect on tinea manuum and athlete's foot, and has little irritation, low pain degree, light side effect and good curative effect; tinea manuum and athlete's foot have little possibility of relapsing. 100 cases of clinical experiments show that the effective rate of the medicine is 90%.

The invention relates to application of caragana korshinskii extract in preparing a medicine for treating and preventing skin tinea. The caragana korshinskii extract refers to the extract obtained from the plant seed of the caragana korshinskii seed of leguminosae faboideae caragana by a conventional supercritical fluid extraction method; and each dosage form of the medicine for treating and preventing skin tinea at least comprises the caragana korshinskii extract. In the invention, the caragana korshinskii extract can obviously inhibit the active ingredients of three kinds of common dermatophytes including microsporum canis, trichophyton mentagrophytes and trichophyton rubrum.

The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

The invention provides novel soluble conazole crystalline forms (e.g., cisitraconazole, saperconazole) that include salts, co-crystals and polymorphs useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.

Provided herein is a method of detecting an onychomycotic fungus in a sample, wherein the onychomycotic fungus belongs to a secondary clade member including one or more primary clade members. The method may include the steps of i) screening a sample using a first and second sets of secondary clade-specific primers to determine whether a secondary clade member among a plurality of secondary clade members is present or absent in the sample, where the plurality of secondary clade members includes (a) a dermatophyte, (b) a candida, and (c) a saprophyte, and ii) after determining the presence of the secondary clade member, screening the sample to determine whether an onychomycotic fungus is present or absent in the sample using primary clade-specific primers that are specific to a primary clade member that belongs to the secondary clade member. Also provided is a kit that finds use in implementing the present method.

A natural preservative composition obtained from plant materials provides antimicrobial activity for use as an antifungal agent. The antifungal agent is effective in inhibiting the growth of Epidermophyton floccosum, Trichophyton mentagrophytes and Microsporum canis. The antimicrobial agent has a MIC as low as 0.03 μl / ml capable of inhibiting and / or killing these organisms. The antimicrobial agent includes selective mixtures of Origanum vulgare L., Thymus vulgaris L., Cinnamomum zeylanicum Nees, Rosmarinus officinalis L., Lavandula officinalis L., Mentha piperita L., Citrus Limon L., Hydrastis canadensis L. and Olea europaea L.

A broad-spectrum bactericide is prepared from the nano-porous material chosen from the molecular sieves of A, X and Y-type zeolite, mordenite, Si-Al zeolite, etc. and the silicate-base zinc oxide ions as active component. It is suitable for skin tinea fungus, multiple pathogenic funguses, and other 10 bacteria including candida, blue mold, aspergillus, etc.

The invention discloses traditional Chinese medicine bacteriostasis skin-care liquid soap. According to the liquid soap, by weight, every 100 parts of liquid soap comprise 10-20 parts of traditional Chinese medicine extracting solutions, 3-6 parts of cocounut oil acyl sodium glutamate, 7-15 parts of decyl glucoside, 3-5 parts of cocounut oil amido-propyl lycine, 0.5-1 part of triethanolamine, 0.8-2 parts of glycerinum, 0.03-0.08 part of cason, 0.1-0.2 part of essence and the balance water, wherein the traditional Chinese medicine extracting solutions are extracted from medicinal raw materials including sophora flavescens, artemisia apiacea, rhizoma kaempferiae, white poria and platycodon grandiflorum. The traditional Chinese medicine bacteriostasis skin-care liquid soap can resist to various types of bacteria, an inhibition effect on various types of pathogenic dermatophyte is achieved, certain prevention efficacy on eczema, cutaneous pruritus and the like is achieved as well, and the liquid soap has the advantages of being little in using amount, high in decontamination capability, good in sterilization effect, low in irritation, fine and smooth and free of dryness and roughness in hand feeling after the liquid soap is used for washing hands and the like.

The present invention relates to liquid detergent, and is especially antiseptic liquid detergent with Chinese medicine component as one fine chemical product. The liquid detergent consists of two parts including Chinese medicine liquid and chemical preparation. The Chinese medicine liquid is prepared with moxa leaf, broom cypress fruit, sessile stemona root and other Chinese medicinal materials; and the chemical preparation is prepared with betaine, fatty alcohol-polyoxyethylene ether, disodium sulfosuccinate, etc. The Chinese medicine liquid can kill and inhibit staphylococcus aureus, staphylococcus albus, dermatophyte, etc., kill head louse, clothes louse, crab louse, etc., inhibit viruses, and stopping itching. The liquid detergent has high detergency and skin care function.

A liquid carrier for topical administration is provided that contains a mineral oil, turpentine and, optionally, camphor, and optionally other terpenoid components containing pinene, and its use to provide an antifungal composition a mixture of antifungal essential oils and the carrier system, wherein the mixture of antifungal essential oils includes an effective amount of each of eucalyptus globulus, peppermint, cedarwood, and Manuka; along with the use of this composition in the topical treatment of fungal infection, particularly of the nail.

The present invention belongs to the technical field of pharmaceutical preparations, discloses a transdermal delivery system for long-acting treatment of fungal skin infections, ie., a terbinafine hydrochloride long-acting spraying agent, and particularly provides a terbinafine hydrochloride water-soluble stable system preparation method, wherein the terbinafine hydrochloride long-acting sprayingagent can form a true film layer after the terbinafine hydrochloride long-acting spraying agent is sprayed onto the skin surface, such that the maintenance time of the preparation on the skin can be prolonged, the drug can be slowly released on the skin, and can act and be stored at lesions, and the long-acting treatment of fungal skin infections can be achieved.

The invention relates to an externally applied medicine for curing tinea pedis, which is an externally used liniment made using dark plum, bletilla, cortex meliae, atractylodes, phellodendron bark and Lightyellow Sophora Root as the active pharmaceutical ingredients. The externally applied medicine has strong both fungus killing and permeating effects, can effectively refrain pathogenic dermatophytes, and has good therapeutic effects for various tinea pedis and rot foot, foot decortication and smelly foot caused by tinea pedis. The externally applied medicine has the advantages of small side effects, fast effects, high cure rate and recurrence eliminating. Through the clinical experiments of 124 cases of tinea pedis patients, the tinea pedis can be cured after the medicine is applied for 3 to 5 weeks and the cure rate can reach 97.6%.

The invention discloses an oil-in-water compound ketoconazole nano-medicament. The grain diameter of the medicament is 1-100nm. The oil-in-water compound ketoconazole nano medicament comprises the following raw materials in percentage by weight: 0.01-8.0 percent of ketoconazole, 0.01-10 percent of eugenol, 0.001-5.0 percent of clobetasol propionate, 25.0-45.0 percent of surfactant, 0-10.0 percentof cosurfactant, 0.1-25.0 percent of oil and the balance of distilled water. The oil-in-water compound ketoconazole nano-medicament can be used for treating stubborn skin mycotic infection, mycodermatitis, chronic mucocutaneous candidiasis, dermatitis blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis and paracoccidioidomycosis, and dermatomycosis and tinea versicolor caused by dermatophyte and microzyme as well as trichophyton disease, scytitis and pruritus. The oil-in-water compound ketoconazole nano-medicament has the advantages of strong osmosis, favorable stability, favorable infiltrating property, durable acting time, remarkable effect, low cost, simple preparation method and convenience in popularization and application.

A liquid carrier for topical administration is provided that contains a mineral oil, turpentine and, optionally, camphor, and optionally other terpenoid components containing pinene, and its use to provide an antifingal composition a mixture of antifungal essential oils and the carrier system, wherein the mixture of antifungal essential oils includes an effective amount of each of eucalyptus globulus, peppermint, cedarwood, and Manuka; along with the use of this composition in the topical treatment of fungal infection, particularly of the nail.

The invention belongs to the field of biotechnology, and discloses an anti-dermatophyte specific yolk antibody, a preparation method and the application thereof. The preparation method comprises the following steps: 1) selecting two major pathogenic bacteria of tinea, and culturing the two major pathogenic bacteria to respectively extract the bacteria cell wall-associated proteins of the bacteria; 2) preparing antigen-immunized hens based on obtained proteins for five times in total so as to obtain eggs, extracting and purifying egg yolk antibodies from the eggs; 3) preparing an anti-dermatophyte formulation based on obtained IgY. According to the technical scheme of the invention, by utilizing two cell wall-associated proteins of tinea pathogenic bacteria, the prepared anti-dermatophyte egg yolk antibody is high in specificity and free of toxic and side effects, which can effectively inhibit dermatophyte. Meanwhile, the preparation method is easy for mass production, low in cost, and simple in process. based on the method, the obtained formulation is very safe and can prevent dermatophyte diseases.