33 results about "Skin sample" patented technology

The invention relates to the technical field of frozen slicing, in particular to a mammal skin embedding method for a spatiomics technology, which comprises the following steps: acquiring an in-vitro skin sample which comprises an epidermal layer, a corium layer and optional subcutaneous tissue; shearing the fat in the skin sample under the condition a to remove the fat in the skin sample, and freezing and embedding the fat-removed skin sample. The mammal skin embedding method provided by the embodiment of the invention provides a standardized overall scheme for sample analysis of mammal skin and hair follicle tissues, is beneficial to obtaining tissue slices with high quality, complete morphology and good cell state, and realizes space omics sequencing with high sample utilization rate.

The invention relates to a high-speed atomic force microscope (AFM, 1) for measuring a relevant sample (S), such as a skin sample, the AFM having a sensor unit (SU, 10) comprising a light source (11) and a collimating lens (12), the collimating lens being mechanically displaced by a collimating lens actuator (12 '). An AFM cantilever having an AFM tip (14) is arranged relative to the photodetection beam (15) for providing a focus error signal (FES) indicative of mechanical engagement with the sample. The collimating lens (12) is arranged to be adjusted by a collimating lens actuator (12 ') along the beam path to compensate for at least thermal drift in the focus error signal (FES). According to the invention, the improved high-speed AFM can be obtained through the internal thermal drift compensation mechanism. The high-speed AFM of the embodiment of the invention can have a theoretical linear scanning speed which can reach 700000 um / s, which allows one-time imaging to be completed within about 3.4 seconds.

This application discloses a method and apparatus for constructing and applying a Parkinson's disease tendency prediction model, relating to the field of Parkinson's disease tendency prediction technology. The method includes: collecting skin samples from different sexes, different skin sampling sites, normal individuals, and Parkinson's patients; extracting DNA and detecting biomarkers from the skin samples to obtain skin biomarker data; the skin biomarker data includes the abundance of fungal biomarkers and bacterial biomarkers; constructing a training sample set from the skin biomarker data from different sexes, different skin sampling sites, normal individuals, and Parkinson's patients, and training a machine learning model to derive a Parkinson's disease tendency prediction model. This application proposes a non-invasive combination of core skin microecological biomarkers that takes into account "bacterial and fungal dual communities, sex specificity, and sampling site differences," enabling non-invasive and accurate prediction of Parkinson's disease tendency.

The invention discloses a multi-stage cooling process for keeping the completeness of an alloy oxide skin, which adopts four-stage temperature control cooling and specifically comprises the following steps: in the first stage, cooling a sample from a heating temperature to 850-900 DEG C at a rate of 8-15 DEG C / min; in the second stage, heat preservation is conducted for 5-10 minutes in the temperature interval of 850-900 DEG C; in the third stage, the temperature is reduced to 240-260 DEG C from 850-900 DEG C at the speed of 3-5 DEG C / min; and a fourth stage: cooling from 240-260 DEG C to room temperature at a rate of 5-10 DEG C / min. By adopting the process disclosed by the invention, a complete oxide skin sample can be provided for researchers, and the process is used for accurately measuring the thickness of an oxide layer, analyzing component distribution and researching the characteristics of an interface transition layer, so that an alloy oxidation mechanism is deeply understood, and a theoretical basis and data support are provided for optimizing a production process and reducing oxide skin generation.

The present invention relates to a system for collecting a skin sample from a test subject, the system comprising a collector device comprising an adhesive surface, said adhesive surface configured to collect the skin sample via adhesion upon contact of the adhesive surface with the skin sample. The present invention also relates to a method for collecting a skin sample from a test subject, the method comprising collecting the skin sample with a system comprising a collector device, said collector device comprising an adhesive surface, said adhesive surface configured to collect the skin sample from the test subject via adhesion upon contact of the adhesive surface with the skin sample.

The invention relates to a skin in-vivo confocal imaging image brightness adaptive adjusting device and method, and the method comprises the steps: employing a scanning imaging device to emit illumination light to a skin sample, and carrying out the point-by-point scanning imaging of the skin sample through a micro-electromechanical system in a point-by-point scanning mode; and the brightness of the illumination light is adaptively adjusted in an iterative mode through the brightness adjusting device. In the iteration process, the average signal intensity of the electric signals of the obtained imaging result in the sampling period and the number of the pixels with the signal intensity higher than the reference value are substituted into an empirical formula, an adjusting parameter value for adjusting the brightness of the illumination light in the next step is obtained, and then the brightness adjustment in the next step is carried out. Therefore, according to the self-adaptive adjusting device disclosed by the invention, the light emitting power of the light source does not need to be frequently and manually adjusted or the signal dynamic range in a software system does not need to be manually changed, special image processing is not needed, and the sample detection efficiency and the imaging effect can be improved.

This invention belongs to the field of biodetection technology, specifically disclosing a novel skin typing method, biomarkers based on skin surface metabolomics typing, and their applications. Based on population-level skin surface metabolite measurement data and through multi-dimensional scientific analysis, this application ultimately discovered that the skin samples of the subjects formed two distinct clusters. This demonstrates that differences in metabolomics clusters based on skin typing objectively exist. Furthermore, the two distinct clusters based on the aforementioned skin surface metabolomics data are named "Metabolic Type 1" or "Metabolic Type 2." Simultaneously, these two typing methods also exhibit differences in various skin condition indicators (e.g., sebum levels, actual age, wrinkles, freckles, etc.). By using the typing method provided in this application to study skin surface metabolomics substances, one or more metabolites can be used as biomarkers to identify the specific skin typing level and guide adjustments to the desired skin condition. This application overcomes the limitations of existing methods that define skin typing solely based on dry, oily, etc., providing more comprehensive guidance for practice.

The invention provides a skin cutting device, and belongs to the technical field of medical equipment.The skin cutting device comprises a shell, a linear motion mechanism and a tool bit, and the shell is provided with a containing space with a first opening; the linear motion mechanism is installed in the containing space, and the motion end of the linear motion mechanism can do reciprocating linear motion in the direction pointing to the first opening. The tool bit is detachably connected to the moving end from the first opening, and the tool bit can be driven by the moving end to do reciprocating rectilinear motion so as to cut the skin. According to the skin cutting device provided by the invention, compared with bare-handed skin cutting, a medical worker can conveniently and quickly cut the skin of a patient through the skin cutting device, so that the operation efficiency is improved, and the pain of the patient is effectively reduced; by reasonably designing the specification and size of the cutter head, a skin sample with standard size and thickness can be cut, and the inspection precision of skin biopsy is improved.

The present invention relates to a system for collecting and storing a skin sample of a test subject, the system comprising a collection device comprising an engaging segment, said engaging segment configured to collect the skin sample from the test subject; and a cartridge configured to receive the skin sample after collection The present invention also relates to a corresponding method and use of the system.

Provided herein are methods for diagnosis and treatment of chronic hand eczema (CHE) using skin surface biomarkers. The methods include obtaining from a subject skin samples, detecting certain biomarkers, determining the levels of the biomarkers, comparing the levels to reference levels, and determining whether the subject has CHE.

A computer implemented method for use in conjunction with a computing device, system, network, and cloud with touch screen two dimension display or augmented / mixed reality three dimension display comprising: obtaining, analyzing and detecting user blood, saliva, hair, urine, stool, fingernail, height, weight and skin sampling analysis chemistry data, mapping the blood, saliva, hair, urine, stool, fingernail, height, weight and skin data into a database associated with a specific user, applying the data with optimization equations, mapping equations to food and beverage chemistry, scoring or ranking a plurality of optimized results such that a user may order food and beverage from a food / beverage distribution point or have food / beverage delivered to the user which has been specifically optimized for their specific biochemistry characteristic target ranges. The method is particularly useful in enhancing online internet search engine results.

The utility model relates to the technical field of skin clamping, and discloses a skin clamping device for a drug transdermal tester, which comprises a mounting seat, a plurality of mounting holes are formed in the top of the mounting seat, a plurality of positioning grooves are formed in the top of the mounting seat, springs are fixedly connected to the bottom ends of the interiors of the mounting holes, and the springs are arranged in the positioning grooves. Protective pads are fixedly connected to the tops of the multiple springs, supporting columns are slidably connected to the interiors of the multiple mounting holes, clamping blocks are fixedly connected to the bottom ends of the front sides and the rear sides of the multiple supporting columns, threaded rods are fixedly connected to the tops of the multiple supporting columns, and two chucks are slidably connected to the outer walls of the multiple threaded rods; the tops of the outer walls of the multiple threaded rods are in threaded connection with nuts. According to the skin sample clamping device, the supporting columns are installed at different positions to adapt to skin samples of different specifications, the clamping force is adjusted through the nuts, the effect that the device is convenient to detach for cleaning and maintenance is achieved, and the service life of the device is prolonged.

The invention provides a Parkinson's disease rapid RT-QuIC diagnostic kit based on A30P mutant alpha-synuclein, and belongs to the technical field of detection kits. The specific A30P mutant protein is used as a reaction substrate, and rapid and high-sensitivity amplification detection can be carried out on trace misfolded alpha-synuclein in a skin sample through an optimized RT-QuIC system. The kit has the characteristics of short detection period and convenience in operation, provides a new tool for molecular diagnosis of Parkinson's disease, is suitable for definite diagnosis of clinical PD suspected cases, and can also be used for screening high-risk groups. The kit has the advantages of mature preparation process, easily available raw materials, easiness in industrial production and large-scale popularization, and important clinical application value.

The invention provides a preparation method and a cryopreservation and recovery method of an immortalized Yangtze globefish lipidated keratinocyte line, and belongs to the technical field of animal cell culture. According to the invention, a set of method for preparing an immortalized Yangtze River globefish lipidated keratinocyte cell line in vitro under laboratory conditions is established by utilizing fresh skin samples of Yangtze River globefish and recent dead individuals or living bodies obtained from water field investigation, and a suitable culture, passage and recovery method is explored and finally invented based on the cell line. According to the present invention, the immortalized Yangtze River globefish lipidated keratinocyte line is successfully prepared, and by using the immortalized Yangtze River globefish lipidated keratinocyte amplification culture medium, the immortalized Yangtze River globefish lipidated keratinocytes can normally adhere to the wall to grow; the cryopreservation liquid and the recovery culture medium for the immortalized Yangtze River globefish lipidated keratinocytes can improve the survival rate of the immortalized Yangtze River globefish lipidated keratinocytes.

The invention provides a skin type detection method, a skin type detection device and a computer readable storage medium. The skin detection method comprises the following steps: acquiring spectral image data of a skin sample and standard instrument detection data; preprocessing the spectral image data of the skin sample; constructing a skin detection model according to the standard instrument detection data and the preprocessed skin sample spectral image data; acquiring spectral image data of the skin to be detected; and inputting the spectral image data of the skin to be detected into the skin detection model, and outputting a multi-dimensional skin detection result. According to the skin type detection method, deep and multi-dimensional detection can be accurately, efficiently and reliably carried out on the real skin type, non-contact detection and overall or local detection are supported, and the user experience can be improved.

The application belongs to the technical field of medical diagnosis, and particularly relates to application of Abiotrophia and related metabolites in preparation of a Kawasaki Disease (KD) diagnostic kit. The metabolites are 1,2-dieicosenoyl-sn-glycero-3-phosphocholine and 1,3-dicaffeoylquinic acid. By detecting the levels of the above markers in the skin samples of subjects, non-invasive auxiliary diagnosis of Kawasaki Disease is achieved, and the problem of poor compliance of existing blood tests is solved.

The invention relates to a distillation learning method and device for a skin problem segmentation model, equipment and a medium. The method comprises the following steps: acquiring a skin sample image and an image labeling result corresponding to the skin sample image; performing skin problem region segmentation on the skin sample image through a teacher model to obtain a first output result; performing skin problem region segmentation on the skin sample image through a student model to obtain a second output result; determining distillation loss according to the first output result, the second output result and the image labeling result; determining segmentation loss according to the second output result and the image annotation result; and based on the distillation loss and the segmentation loss, performing model training on the student model to obtain a trained student model. By adopting the method, the detection precision of the skin problem segmentation model can be improved.

Described herein are personalized skin care compositions including a cultured composition including a milk sample and a skin sample. and optionally an additive. Also described herein are kits and methods for making personalized skin care compositions. Also described herein are methods of treating or preventing skin conditions using personalized skin care compositions.

The utility model discloses a skin biopsy sampling tool, which relates to the technical field of medical treatment, and comprises a tool main body, two cutting plates fixedly connected to the lower end of the main body and symmetrically arranged, and sampling tweezers, the lower end of the main body is provided with a mounting groove, the upper end of the sampling tweezers is mounted in the mounting groove, and the lower end of the sampling tweezers extends out of the lower end of the main body. The extending end of the sampling tweezers and the two cutting plates are combined into an annular structure, a limiting column used for limiting the sampling tweezers is fixedly installed in the installation groove, the annular structure formed by the sampling tweezers and the cutting plates is rotatably inserted into the skin sampling position, the two sides of the sampling tweezers are pressed, the sampling tweezers clamp a skin sample, and then sampling tissue can be pulled out from the skin surface. According to the skin biopsy sampling tool, the combination of the punching sampler and the tweezers is completed, and the problems that when an existing skin biopsy sampling tool is used for sampling, the punching sampler and the tweezers need to be alternately used, the operation time is prolonged, and meanwhile the operation complexity is increased are solved.

The invention relates to a method and a device for testing buckling and pressing parameters of an air spring of a passenger car, which belong to the technical field of air springs and comprise the following steps of: providing a bag skin sample sheet and compressing the bag skin sample sheet to a preset compression amount; under the condition that the compression amount is kept constant, obtaining relational data of the compression load of the capsule skin sample piece attenuating along with time, and converting the relational data into contact stress-time relational data; fitting the contact stress-time relation data into a parameterized relaxation model to determine parameters of the model; and substituting the preset life expectancy into the fitted parameterized relaxation model, and calculating to obtain the predicted minimum contact stress at the last phase of the life expectancy. The method can solve the problems that in the prior art, no effective means is provided for accurately measuring the actual contact stress in the buckling process, and particularly, the real-time monitoring of the time evolution process of the contact stress cannot be realized; and the sealing failure risk cannot be controlled.

A method of obtaining a skin sample can include placing an adhesive on a portion of skin and lifting the adhesive from the skin. The sample can then be tested while the skin sample is still on the adhesive, for example by inoculating the sample with bacteria, fungi, viruses, or combinations.

The invention discloses a sample treatment part of a skin disease diagnosis device, and relates to the technical field of skin tissue sampling. Comprising a sample manufacturing piece, a cutting telescopic piece is installed on the sample manufacturing piece, and the sample manufacturing piece is used for manufacturing a skin sample; a piston suction piece is mounted on the sample manufacturing piece; the piston suction part is used for sucking pus; a suction mounting piece is mounted on the sample manufacturing piece; a skin stretching auxiliary part is arranged on the outer side of the sample manufacturing part; the piston suction part is adopted to prevent fester from leaking and splashing when sampling is carried out on a skin area with a cyst, and particularly for the situation that the pressure is large during ring cutting work and the pressure of the cyst area is large, the structure can quickly suck fester during ring cutting through the cyst puncture needle; the problem that when a sample processing part of an existing skin disease diagnosis device is used for sampling skin tissue with fester, automatic negative pressure fester drainage is not convenient is solved.

Described herein are personalized skin care compositions including a cultured composition including a milk sample and a skin sample, and optionally an additive. Also described herein are kits and methods for making personalized skin care compositions. Also described herein are methods of treating or preventing skin conditions using personalized skin care compositions.

A cutting device for shaving skin samples and for excising skin lesions or abnormalities is provided, the cutting device including: an elongated cutting blade having spaced-apart first and second longitudinal edges, the first longitudinal edge being sharpened along at least a portion thereof; and, a body including a first grip, a second grip, and a flexible blade support affixed between the first and second grips. The cutting blade is supported by the body to extend along the blade support with at least a majority of the first longitudinal edge being proud of the blade support in a direction towards, or beyond, the leading edge of the body. The first grip includes an elongated first grip body disposed transversely to the blade support. The first grip further includes a first engageable grip portion protruding from the first grip body. Advantageously, the subject invention provides a cutting device with an improved grip surface.

The present invention relates to a method for detecting a nucleic acid of a target microorganism from a sample collected from skin by using a nucleic acid of Corynebacterium spp. or Cutibacterium spp. as an endogenous internal control nucleic acid, and a composition for nucleic acid amplification used in the method. The endogenous internal control according to the present invention is present in the sample from the beginning, thereby eliminating the inconvenience of having to add same separately after sample collection, and can be used as an internal control for the sample collection process, an internal control for the nucleic acid extraction process, and an internal control for the nucleic acid amplification process. In addition, by using the nucleic acid of Corynebacterium spp. or Cutibacterium spp. as an endogenous internal control, it is possible to detect the presence or absence of a target microbial nucleic acid in a sample collected from skin with high accuracy by minimizing false negative and false positive determinations.

In order to improve not only facial redness but also other facial conditions (such as edema), there is a need to develop new methods for accurately estimating these conditions. [Solution] The method according to the present disclosure is a method for estimating the facial condition of a subject, and includes estimating the facial condition of a subject by using the expression level of a VEGF-A signaling-related protein gene as an indicator for a skin sample of the subject's face.

The invention provides an LC-OCT skin image noise reduction method based on an improved diffusion probability model. The LC-OCT skin image noise reduction method comprises the following steps: S1, collecting a skin sample; s2, constructing a data loading module, adjusting the size to be 512 * 512, and normalizing; s3, constructing a forward diffusion and reverse denoising process of the diffusion probability model; s4, in the reverse time step, constructing a consistency residual function; s5, minimizing the residual error; s6, performing intensity cutting and structure regularization on the image to obtain an updating result, and entering a next reverse time step; and S7, repeating the steps of diffusion modeling, residual construction, Newton-Raphson correction and constraint updating until convergence, and outputting an image. Therefore, speckle noise can be effectively inhibited and the convergence efficiency and the global search capability of the back diffusion process can be improved while the skin tissue microstructure and the boundary definition are kept, so that the requirements of clinical visualization, automatic segmentation and quantitative analysis on high-quality images are met.

The present disclosure relates to methods for and kits for isolating and sequencing nucleic acid from skin samples.