169 results about "Skin Aging" patented technology

The invention belongs to the field of biological materials, and particularly relates to recombinant V-type humanized collagen and application thereof. The invention provides a recombinant V-type humanized collagen, the amino acid sequence of the recombinant V-type humanized collagen comprises (repetitive unit) n, and the repetitive unit comprises a sequence as shown in SEQ ID NO.1; each repeating unit is directly linked and the number n of repeating units is 10. The recombinant V-type humanized collagen can comprehensively resist skin aging.

The invention belongs to the field of skin care products, and particularly relates to an anti-wrinkle and anti-aging composition as well as a preparation method and application thereof, and the anti-wrinkle and anti-aging composition comprises neurotransmitter inhibition peptide, signal peptide, madecassoside, inositol and glycosylglycerol. The neurotransmitter inhibition type peptide is at least three of acetyl hexapeptide-8, arginine / lysine polypeptide, dipeptide diaminobutyrylbenzylamide diacetate and acetyl octapeptide-3, and the signal type peptide is at least two of palmitoyl pentapeptide-4, decapeptide-4 and acetyl tetrapeptide-9. Compared with the prior art, all the components of the anti-wrinkle and anti-aging composition act on different anti-aging pathways and can be matched with one another from multiple aspects of oxidation resistance, inflammation resistance, moisturizing, cell viability enhancement, wrinkle reduction and the like, a more comprehensive and better anti-aging effect is provided, skin aging is comprehensively resisted, the skin is in a more young state, and the anti-wrinkle and anti-aging composition has the advantages that the anti-wrinkle and anti-aging effects are achieved. And the anti-wrinkle and anti-aging composition is small in irritation and good in stability.

The invention discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application of the anti-wrinkle composition, and belongs to the technical field of cosmetics and skin care products. The composition is prepared from the following active ingredients in percentage by mass: 0.01 percent to 20 percent of recombinant humanized I type collagen, 0.01 percent to 20 percent of recombinant humanized III type collagen, 0.01 percent to 10 percent of recombinant humanized XVII type collagen and 0.01 percent to 20 percent of space breeding desert algae extract. The three kinds of recombinant humanized collagen and the space breeding desert algae extract form a compound system, and when the total mass ratio of the three kinds of recombinant humanized collagen and the space breeding desert algae extract is within a specific range of 1.3: 1-4: 1, the three kinds of recombinant humanized collagen and the space breeding desert algae extract can achieve synergistic interaction to improve the skin barrier function. Based on the synergistic mechanism of the compound system, the composition disclosed by the invention can effectively promote and enhance the skin moisturizing and anti-wrinkle capability and repair the skin barrier, and is suitable for the development and application of anti-wrinkle, tightening and skin aging delaying skin care products.

The invention relates to the technical field of cosmetics, in particular to an efficient anti-aging composition and a skin care product containing the composition. The invention discloses an efficient anti-aging composition which is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of Ectoine, 12-16 parts of TWEEN 20 and 22-25 parts of isosorbide dimethyl ether, and the oil-based concentrated active ingredients are prepared from safflower seed oil, an extract of flowers / leaves / stems of herba lysimachiae, an extract of radix astragali membranaci, ubiquinone and vitamin E; the base collagen liquid comprises XVII type collagen, VII type collagen and IV type collagen. Aiming at the problems that an existing skin care product cannot effectively reduce skin wrinkles, improve skin compactness, reduce skin sagging and prevent skin aging for a long time, the composition disclosed by the invention realizes long-term aging resistance from epidermis to dermis, effectively reduces wrinkles, improves compactness and improves skin sagging.

The invention relates to a composition for preventing and improving skin aging and a cosmetic containing the same. The composition comprises a red rice extract and PDRN. The composition disclosed by the invention has a synergistic effect on promoting the generation of type I collagen, so that skin aging can be remarkably prevented and / or improved.

The invention provides a preparation method of human collagen and an application of the human collagen in anti-aging. The amino acid sequence of the human collagen is as shown in SEQ ID NO: 1; based on a natural collagen structure, a fusion sequence structure is provided, and the proportion of individual amino acids is adjusted; the collagen can promote skin cell growth and hyaluronic acid secretion; skin aging caused by ultraviolet radiation is resisted, inflammatory factor expression is inhibited, and oxidative stress is resisted.

The invention relates to a repairing composition for reducing senescence cell cumulant and a preparation method and application thereof, and the repairing composition comprises the following components in parts by weight: 0.01-7.0 parts of probiotic pellets PDRN, 0.01-3.0 parts of microspheroidized PDRN, 0.01-10.0 parts of a ginseng root extract, 0.01-10.0 parts of red ginseng fermented vesicles, a thickening agent, functional components and water. Under a formula system of a thickening agent and functional components, the probiotic pellets PDRN, the microspheroidized PDRN, the ginseng root extract and the red ginseng fermented vesicles are added, and all the components have a synergistic effect, so that the composition can penetrate into skin to achieve the effect of accurately repairing mitochondrial dysfunction, can directly remove senescent cells, reduces the senescent cell cumulant in a body in multiple ways, and has a good effect on repairing mitochondrial dysfunction. Therefore, the prepared skin care composition can effectively delay skin aging.

This invention discloses an anti-wrinkle and soothing composition and its preparation method, belonging to the field of cosmetic technology. The composition includes the following steps: mixing and stirring a moisturizer, antioxidant, emollient, deionized water, ginseng root extract, snow lotus (SAUSSUREA INVOLUCRATA) extract, dark green agave (AGAVE ATROVIRENS) extract, umbrella maple leaf extract, and lotus coronulatus flower extract until homogeneous, thus obtaining the anti-wrinkle and soothing composition. Utilizing the synergistic effects between the components, it possesses both anti-wrinkle and soothing effects, synergistically improving skin aging problems.

The present invention provides topical and internal skin preparations containing an extract of soapwort cultivated under artificial light with a specific wavelength range. [Solution] The soapwort of the present invention is cultivated by irradiating it with artificial light having a specific wavelength range, and the extract exhibits excellent collagen production promoting effect, MMP inhibitory effect, hyaluronic acid production promoting effect, cell proliferation promoting effect, and antioxidant effect. Furthermore, topical or internal skin preparations containing these effects are particularly effective and also exhibit excellent safety and stability. The soapwort extract of the present invention can be used not only in the field of beauty, such as preventing skin aging, but also in the field of medicine, such as suppressing functional decline due to aging, and is expected to be applied to cosmetics, foods, quasi-drugs, and pharmaceuticals.

The invention provides a method for improving the oxidation resistance of phenylalanine based on N-nicotinoyl modification and application of the method. According to the method, N-nicotinoyl phenylalanine amide with antioxidant activity is obtained through chemical synthesis or enzymatic synthesis, and the antioxidant performance of N-nicotinoyl phenylalanine amide is evaluated by using an ABTS free radical scavenging method. Results show that the N-nicotinoyl phenylalanine amide can delay lipid oxidation in a food system, prolong the shelf life of the product and maintain the nutritional stability; in a cosmetic system, skin oxidative damage can be relieved, skin aging can be delayed, and skin color can be improved. The compound disclosed by the invention can show a remarkable antioxidant effect under the condition of a relatively low addition amount, so that a safe and effective antioxidant is provided for the fields of foods and cosmetics, and the compound has a good application value and a good popularization prospect.

This invention relates to a fermented product with moisturizing and soothing effects, its preparation method, and its application. The preparation method of the fermented product with moisturizing and soothing effects includes the following steps: mixing kiwifruit and blueberry with a carbon source, water, and fermentation bacteria; fermenting; centrifuging to separate the fermentation broth; and filtering the fermentation broth to obtain a fermented product filtrate. This invention creatively uses the fermented product of kiwifruit and blueberry as an active ingredient in cosmetics. Kiwifruit and blueberry are rich in antioxidants, which can help the skin resist free radical damage and slow down the skin aging process. The fermented product of kiwifruit and blueberry contains moisturizing ingredients, which help retain skin moisture, reduce dryness, and make the skin smooth and soft.

The invention discloses an application of eclipta source extracellular vesicles. The extracellular vesicles are extracted from the eclipta by adopting an overspeed combined ultrafiltration centrifugation method, and the extracted vesicles are complete in morphology and good in dispersity, and have the characteristics of high yield, high separation speed, low cost and easiness in large-scale production. The extracted vesicles can be successfully taken by animal cells. The yerbadetajo herb alcohol extract has the advantages that the yerbadetajo herb alcohol extract has antioxidant and anti-aging effects after being taken in, ultraviolet-induced matrix metalloproteinase 1 (MMP1) expression can be obviously reduced, collagen I (COL-I) generation can be promoted, ultraviolet-induced skin light aging can be improved, and the effect is better than that of the yerbadetajo herb alcohol extract, so that the yerbadetajo herb alcohol extract can be used for preparing the skin The eclipta-derived extracellular vesicles provided by the invention provide a new strategy for skin aging and anti-aging treatment.

This invention provides an anti-aging and repair dressing containing four complex active factors and its preparation method. The dressing comprises 75-90 parts of a matrix material, 5-15 parts of four complex active factors, and 3-8 parts of a moisturizing auxiliary agent. The four complex active factors are composed of recombinant human type III collagen, acetyl hexapeptide-8, ectoine, and dipotassium glycyrrhizate in a ratio of (3-6):(1-3):(2-4):(1-2). The matrix is ​​a hydrophilic nonwoven fabric or bio-cellulose membrane material that has undergone low-temperature plasma surface grafting activation treatment. The preparation process employs nitrogen combined with vacuum pulse freeze-drying technology, and enhances the activity stability through an ectoine complexation step. This dressing can promote HaCaT cell proliferation, increase collagen secretion, and inhibit inflammatory factors, significantly improving skin barrier function. It has good biocompatibility and can be used to prepare products that improve skin aging and repair.

The invention relates to the technical field of biomedical materials, in particular to a sodium hyaluronate composite solution for relieving skin aging and a preparation method thereof, the sodium hyaluronate composite solution comprises sodium hyaluronate, taurine, proline, glutamic acid, glycine and valine; sodium hyaluronate has a specific molecular weight, the composite solution has a specific pH value and osmotic pressure, and all the components have a synergistic effect, so that a moist environment is provided for skin, free radicals are removed, collagen synthesis is promoted, and aging phenomena such as skin laxity and wrinkles are improved. The composition can maintain skin moisture for a long time, scavenge free radicals, resist oxidation and promote collagen synthesis to improve skin aging, the preparation process guarantees stable components, the solution is matched with the physiological environment of the skin, and the composition is non-irritant, safe to use and good in anti-aging effect.

This invention relates to the field of cosmetic compositions, and more specifically to a synergistic anti-aging composition involving energy metabolism and autophagy, its preparation method, and its application. The composition comprises sea buckthorn fruit extract, trehalose, and a cosmetically acceptable polyol carrier. This invention pioneers a betaine-trehalose-NADES extraction system, achieving low-temperature, high-efficiency extraction while preserving the heat-sensitive active ingredients of sea buckthorn. Trehalose possesses both extraction and autophagy activation effects. A selective separation strategy achieves a balance between efficacy, compliance, and process simplicity. The green, circular process reduces costs and is environmentally friendly. Through the synergistic effect of sea buckthorn fruit extract and trehalose, the composition enhances mitochondrial membrane potential, increases ATP production, inhibits excessive activation of the mTOR pathway, and promotes LC3-II conversion, thus synergistically combating skin aging from multiple targets including cellular energy metabolism, signaling pathways, and autophagy.

The invention belongs to the technical field of cosmetics, and particularly relates to collagen peptide with an anti-aging effect as well as a preparation method and application of the collagen peptide. The amino acid sequence of the collagen peptide is as shown in SEQ ID NO.1, and the nucleotide sequence of the collagen peptide is as shown in SEQ ID NO.2. According to the invention, effective sequences of human III type and XVII type collagen are recombined to construct and express the collagen peptide Sa1, and the collagen peptide Sa1 has obvious antioxidant effect, no cytotoxicity and good safety. The skin care product added with the collagen peptide Sa1 can promote skin collagen absorption and effectively exert the anti-oxidation effect, so that the effects of improving skin elasticity and delaying skin aging are achieved.

The invention discloses a skin care product containing SOD (superoxide dismutase) oil extract for delaying skin aging and removing wrinkles, which is prepared by the following steps: S1, preparing the SOD oil extract: selecting fresh animal and plant raw materials, obtaining a crude extract rich in SOD by adopting a low-temperature extraction method, and separating and purifying by utilizing technologies such as high-speed centrifugation and ultrafiltration to obtain the high-purity SOD extract, so as to obtain the SOD oil extract; the purified SOD extract is mixed with natural oil in proportion. The invention relates to the technical field of skin care products. According to the SOD oil extract-containing skin care product for delaying skin aging and removing wrinkles, SOD and natural oil are mixed to form the SOD oil extract, the stability of SOD in the skin care product is effectively improved, the activity preservation time of the SOD is prolonged, various effective components in the formula cooperate with one another, the SOD is responsible for scavenging free radicals, and the skin care effect is improved. Sodium hyaluronate and collagen maintain skin moisture and enhance skin elasticity, and vitamin E assists in resisting oxidation, so that the effects of delaying skin aging and removing wrinkles are jointly achieved.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

The disclosure provides methods of improving skin health parameters and / or reducing signs of skin aging comprising administering to a human subject in need thereof an effective amount of resveratrol.

The invention provides a pedicel and inflorescence extract ZTM100 of Gastrodia elata Blume, a preparation method of the pedicel and inflorescence extract ZTM100 and application of the pedicel and inflorescence extract ZTM100 in the technical field of cosmetics and medicines. Belongs to the technical field of cosmetics and medicines. The ZTM100 (100 [mu] g / mL) provided by the invention can significantly improve the expression quantity of human dermal fibroblast elastin gene Elastin under UVA radiation, and does not show obvious cytotoxicity to human fibroblasts in a concentration range of 800 [mu] g / mL. The ZTM100 can be used for preparing medicines or cosmetics for resisting skin aging caused by UVA, reducing scar formation, repairing skin injury and repairing wounds.

This invention provides an application of a quantitative partial reprogramming system in the preparation of drugs to reverse skin aging, belonging to the fields of regenerative medicine and medical aesthetics. The quantitative partial reprogramming system includes a nucleic acid delivery system or a small molecule induction system; skin aging includes photoaging-induced skin aging; reversing skin aging includes increasing the thickness of the dermis, increasing the density of type I collagen, and improving skin elasticity. The quantitative partial reprogramming system provided by this invention can fundamentally reverse the cellular aging clock and achieve structural regeneration, and can be applied to the preparation of drugs to reverse skin aging.

This invention relates to a method for obtaining aqueous extracts of tea leaves (Camellia sinensis), particularly fresh tea leaves, Pu-erh tea, matcha, or green tea. The invention also relates to tea extracts rich in small RNAs, sugars, phenolic compounds, organic acids, catechins, and theanine, as well as cosmetic compositions comprising such extracts and their cosmetic uses for the care of the skin, scalp, and appendages, particularly for protecting the skin from external aggressors and oxidation, combating signs of skin aging, enhancing photoprotection, brightening the skin, and improving skin hydration.

This invention discloses the application of homoserine as an aging regulator in the preparation of anti-aging skin compositions. As a multidimensional regulator of skin aging, homoserine integrates skin cell lifespan regulation, telomere protection, and oxidative protection, providing a multi-target synergistic mechanism that can comprehensively and effectively delay skin aging, reduce wrinkles and sagging, and enhance vitality. The application of homoserine in cosmetics or skin care products meets consumers' demand for precise anti-aging skincare.

Granular structure of a fermented pomegranate product, characterized in that the granular structure of a fermented pomegranate product comprises an active core layer and an antioxidant layer, wherein the active core layer contains the fermented pomegranate product and the antioxidant layer comprises animal protein, vegetable protein or a combination thereof.

This invention provides a magnesium baicalein hydrogel with whitening and anti-skin aging effects and its preparation method. The formulation includes magnesium baicalein, sodium hyaluronate, carbomer, propylene glycol, niacinamide, a pH adjuster, and purified water. The hydrogel uses magnesium baicalein as the main active ingredient, overcoming the traditional deficiency of baicalein's poor water solubility and exhibiting good gel phase stability. The magnesium baicalein in the hydrogel can effectively scavenge free radicals and prevent collagen degradation to combat aging; simultaneously, it inhibits tyrosinase, synergistically achieving a dual whitening effect with niacinamide.

The invention relates to the field of skin care products, and discloses a nano-emulsion with high oxidation resistance as well as a preparation method and application of the nano-emulsion. The nano-emulsion is prepared from the following raw materials in percentage by mass: 0.1 to 2.0 percent of antioxidant compound extract, 0.1 to 4.0 percent of vegetable oil, 2.0 to 20.0 percent of saccharides, 0.3 to 8.5 percent of stabilizer and water. The vegetable oil is selected from one or more of camellia oil, sweet almond oil, apricot kernel oil, avocado oil, wheat germ seed oil and baobab oil. The nano-emulsion disclosed by the invention has excellent stability, anti-oxidation effect and biological safety, and can be applied to anti-skin aging products.

The application discloses a skin aging diagnosis system and grade determination method based on physical perception diffusion, relates to the field of biomedical imaging and artificial intelligence technology assisted diagnosis, and comprises a data acquisition and preprocessing module, a training data set construction module, a three-dimensional diagnosis module and a report generation and output module.The data acquisition and preprocessing module is used for receiving continuous two-dimensional skin tissue slice images of a target object, and performing standardization processing on the continuous two-dimensional skin tissue slice images.The training data set construction module is used for mapping and stacking two-dimensional labeling information by using a space alignment and dimensionality increasing algorithm based on the labeling of collagen fiber age state, constructing a three-dimensional collagen structure true value label body with spatial continuity, forming a gold standard data set to train a physically constrained end-to-end deep learning model.The application can significantly improve the accuracy and interpretability of skin aging diagnosis.

The application discloses application of a novel peptide UHP in preparation of a medicine for treating and / or preventing delayed aging, and belongs to the technical field of biological medicines.The novel peptide UHP is composed of 37 L-type amino acids including a transmembrane peptide HIV-TAT.It is proved by cell experiments that the novel peptide UHP significantly improves the aging phenotype of a HGPS cell model simulated by overexpression of progerin and a replicative senescent human normal fibroblast cell, reduces the SA-beta-gal positive cell proportion and the expression of SASP factors, and increases the expression levels of cell proliferation markers Ki67, Lamin B1 and Cyclin A2.It is proved by animal experiments that the novel peptide UHP can improve the progeria phenotype, body weight and exercise capacity of a progeria mouse, relieve fibrosis in multiple tissues, improve the skin aging phenotype, and prolong the survival period of the progeria mouse, thereby providing a new medicine selection for clinical treatment of aging-related diseases.

The utility model discloses an anti-static sunscreen quick-dry oversleeve which comprises an oversleeve body, the oversleeve body is made of anti-static sunscreen fabric in a tailoring mode, the anti-static sunscreen fabric comprises a quick-dry layer, an elastic layer, an anti-UV layer and an anti-static outer layer, the anti-static outer layer is arranged on the outer side of the elastic layer, the anti-UV layer is arranged between the elastic layer and the anti-static outer layer, and the anti-UV layer is arranged between the elastic layer and the anti-static outer layer. The quick-drying layer is arranged on the inner side of the elastic layer, and conductive wires are embedded in the anti-static outer layer. By means of the conductive wires embedded in the anti-static outer layer, the oversleeve has the function of eliminating static electricity, various problems caused by the static electricity are prevented, the oversleeve can be suitable for the industries needing static electricity prevention such as electronics, chemical engineering, medicine and textile, meanwhile, the anti-UV layer can efficiently block ultraviolet radiation, the skin of a user is protected against ultraviolet damage, and the anti-static effect is good. The risk of skin aging and skin cancer is reduced.

The invention relates to a melanin aging evaluation method based on skins with different depths. The melanin aging evaluation method comprises the following steps: acquiring an ultrasonic image of a skin cross section structure and a photoacoustic image containing melanin photoacoustic signals; performing skin boundary positioning and extraction on the ultrasonic image; based on the boundary relation between the ultrasonic image and the photoacoustic image, the skin boundary of the ultrasonic image and the photoacoustic image is set to the same height, the ultrasonic image and the photoacoustic image are fused, and a three-dimensional image is obtained through reconstruction and used for researching melanin space distribution at different depth positions; based on the distribution characteristics of melanin photoacoustic signals along with the depth of the skin, the skin is divided into three anatomical characteristic areas of a keratinization layer (I), a basal layer (II) and a dermal superficial layer (III); respectively calculating the melanin deposition rate of the keratinization layer, the melanin metabolism rate of the substrate layer and the melanin content of the dermal superficial layer; and comprehensively evaluating the skin aging degree by combining a calculation result. The method can improve the accuracy of aging degree evaluation.