35 results about "Skin Aging" patented technology

This invention discloses an anti-wrinkle and soothing composition and its preparation method, belonging to the field of cosmetic technology. The composition includes the following steps: mixing and stirring a moisturizer, antioxidant, emollient, deionized water, ginseng root extract, snow lotus (SAUSSUREA INVOLUCRATA) extract, dark green agave (AGAVE ATROVIRENS) extract, umbrella maple leaf extract, and lotus coronulatus flower extract until homogeneous, thus obtaining the anti-wrinkle and soothing composition. Utilizing the synergistic effects between the components, it possesses both anti-wrinkle and soothing effects, synergistically improving skin aging problems.

The present invention provides topical and internal skin preparations containing an extract of soapwort cultivated under artificial light with a specific wavelength range. [Solution] The soapwort of the present invention is cultivated by irradiating it with artificial light having a specific wavelength range, and the extract exhibits excellent collagen production promoting effect, MMP inhibitory effect, hyaluronic acid production promoting effect, cell proliferation promoting effect, and antioxidant effect. Furthermore, topical or internal skin preparations containing these effects are particularly effective and also exhibit excellent safety and stability. The soapwort extract of the present invention can be used not only in the field of beauty, such as preventing skin aging, but also in the field of medicine, such as suppressing functional decline due to aging, and is expected to be applied to cosmetics, foods, quasi-drugs, and pharmaceuticals.

This invention provides an anti-aging and repair dressing containing four complex active factors and its preparation method. The dressing comprises 75-90 parts of a matrix material, 5-15 parts of four complex active factors, and 3-8 parts of a moisturizing auxiliary agent. The four complex active factors are composed of recombinant human type III collagen, acetyl hexapeptide-8, ectoine, and dipotassium glycyrrhizate in a ratio of (3-6):(1-3):(2-4):(1-2). The matrix is ​​a hydrophilic nonwoven fabric or bio-cellulose membrane material that has undergone low-temperature plasma surface grafting activation treatment. The preparation process employs nitrogen combined with vacuum pulse freeze-drying technology, and enhances the activity stability through an ectoine complexation step. This dressing can promote HaCaT cell proliferation, increase collagen secretion, and inhibit inflammatory factors, significantly improving skin barrier function. It has good biocompatibility and can be used to prepare products that improve skin aging and repair.

This invention relates to the field of cosmetic compositions, and more specifically to a synergistic anti-aging composition involving energy metabolism and autophagy, its preparation method, and its application. The composition comprises sea buckthorn fruit extract, trehalose, and a cosmetically acceptable polyol carrier. This invention pioneers a betaine-trehalose-NADES extraction system, achieving low-temperature, high-efficiency extraction while preserving the heat-sensitive active ingredients of sea buckthorn. Trehalose possesses both extraction and autophagy activation effects. A selective separation strategy achieves a balance between efficacy, compliance, and process simplicity. The green, circular process reduces costs and is environmentally friendly. Through the synergistic effect of sea buckthorn fruit extract and trehalose, the composition enhances mitochondrial membrane potential, increases ATP production, inhibits excessive activation of the mTOR pathway, and promotes LC3-II conversion, thus synergistically combating skin aging from multiple targets including cellular energy metabolism, signaling pathways, and autophagy.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

This invention provides an application of a quantitative partial reprogramming system in the preparation of drugs to reverse skin aging, belonging to the fields of regenerative medicine and medical aesthetics. The quantitative partial reprogramming system includes a nucleic acid delivery system or a small molecule induction system; skin aging includes photoaging-induced skin aging; reversing skin aging includes increasing the thickness of the dermis, increasing the density of type I collagen, and improving skin elasticity. The quantitative partial reprogramming system provided by this invention can fundamentally reverse the cellular aging clock and achieve structural regeneration, and can be applied to the preparation of drugs to reverse skin aging.

This invention discloses the application of homoserine as an aging regulator in the preparation of anti-aging skin compositions. As a multidimensional regulator of skin aging, homoserine integrates skin cell lifespan regulation, telomere protection, and oxidative protection, providing a multi-target synergistic mechanism that can comprehensively and effectively delay skin aging, reduce wrinkles and sagging, and enhance vitality. The application of homoserine in cosmetics or skin care products meets consumers' demand for precise anti-aging skincare.

This invention provides a magnesium baicalein hydrogel with whitening and anti-skin aging effects and its preparation method. The formulation includes magnesium baicalein, sodium hyaluronate, carbomer, propylene glycol, niacinamide, a pH adjuster, and purified water. The hydrogel uses magnesium baicalein as the main active ingredient, overcoming the traditional deficiency of baicalein's poor water solubility and exhibiting good gel phase stability. The magnesium baicalein in the hydrogel can effectively scavenge free radicals and prevent collagen degradation to combat aging; simultaneously, it inhibits tyrosinase, synergistically achieving a dual whitening effect with niacinamide.

This invention belongs to the field of cosmetic technology, specifically relating to a collagen peptide with anti-aging effects, its preparation method, and its application. The amino acid sequence of the collagen peptide is shown in SEQ ID NO.1, and the nucleotide sequence is shown in SEQ ID NO.2. This invention constructs and expresses a collagen peptide Sa1 by recombining the effective sequences of human type III and XVII collagen. This collagen peptide Sa1 exhibits significant antioxidant effects, is non-cytotoxic, and has good safety. Skincare products containing collagen peptide Sa1 can promote the absorption of collagen in the skin, effectively exert antioxidant effects, thereby improving skin elasticity and delaying skin aging.

Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

This invention discloses an injection method for CaHA microsphere products that enhance facial three-dimensionality through multi-layering, relating to the field of cosmetic technology. The method includes: precise injection techniques and area division based on specific needs; and a combination of needle angle, injection depth, layer, and dosage for specific anatomical locations. Specifically designed for Asian facial structures, it provides a strong, naturally integrated solution. By using CaHA microsphere injection products, the following effects can be achieved: Facial volume replenishment: effectively replenishing facial soft tissue atrophy and fat loss caused by aging, skin aging, or genetic factors, restoring facial fullness. It is commonly used to fill sunken areas of the face, such as tear troughs, nasolabial folds, sunken temples, and sunken cheeks.

This invention discloses a bio-dress containing multiple anti-aging factors and its preparation method. The bio-dress, by weight percentage, comprises 1-10% collagen solution, 2%-15% styraxine, 0.5%-8% ergothioneine, 1%-12% ectoine, and auxiliary ingredients. This bio-dress integrates multiple anti-aging factors, and through the synergistic effect of these factors, it can effectively improve skin aging problems. It is suitable for medical aesthetics and daily skincare, possessing good anti-aging effects and skin safety.

The present application provides a peptide having the formula (I) R1-Ser-Pro-X1-Gln-R2 or a cosmetically or pharmaceutically acceptable salt thereof, or a cosmetic or pharmaceutical composition thereof, and their use in the preparation of a cosmetic or pharmaceutical composition for treating, preventing or repairing skin aging or photoaging, promoting collagen production, increasing skin elasticity and / or skin firmness, promoting PER1 protein expression, regulating skin circadian rhythm and / or repairing damaged skin cells. The peptide of formula (I) regulates the expression of skin circadian cycle regulation genes and related proteins, regulates skin circadian rhythm and resynchronizes skin cell biological clock, enhances cell vitality, repairs damaged cells, thereby alleviating signs of skin aging, and can be used in the field of cosmetics or medicine to resist skin aging, and can also be used to prepare a PER1 protein activator.

This invention discloses a food composition with antioxidant and collagen synthesis-promoting effects and its preparation method, relating to the field of food technology. The food composition comprises the following ingredients in parts by weight: 300-500 mg collagen, 100-400 mg astragalus polysaccharide, 100-400 mg grape seed proanthocyanidins, 10-200 mg catechins, 5-100 mg ergothioneine, and 5-50 mg soybean oligopeptides. This food composition can increase the collagen content in the skin, enhance facial skin elasticity, reduce transepidermal water loss, and improve skin aging-related conditions. This invention constructs a dual-core synergistic formula of "antioxidant + collagen synthesis promotion" through the scientific formulation of seven active ingredients. All components of this invention use food-grade raw materials, making the formula mild and safe; all ingredients are natural extracts or edible raw materials, ensuring high safety, no obvious toxic side effects, and long-term daily use, making it suitable for a wide range of people.

The application discloses a recombinant membrane-targeting type 17 collagen protein and application thereof. The application realizes gene fusion of a COL17A1 key function domain and an independent membrane-targeting structure domain for the first time, constructs a novel "activity-targeting" integrated recombinant membrane-targeting type 17 collagen protein (M-C17a1), effectively integrates function activity and cell targeting property through ingenious structure design, and exhibits excellent performance in resisting skin aging, tissue repair and promoting hair growth. The application also proposes a complete preparation method based on a Pichia pastoris expression system. The expression system has high-density fermentation capacity and secretory expression characteristics, significantly simplifies a purification process, and has relatively low production cost, so that the expression system is suitable for large-scale production of the recombinant protein and has good industrial application prospect.

The present application relates to a kind of skin aging evaluation method and system based on macrogenomic function-species coupling characteristics.The method comprises: obtaining the skin microbial macrogenomic sequencing data of different aging state population, constructs species abundance matrix, functional pathway abundance matrix and function-species hierarchical annotation matrix;Filtering species and functional pathways related to skin aging;Calculate the relative contribution of each species to the corresponding functional pathway, and construct a function-species coupling index combined with the species abundance, input the feature, establish a skin aging evaluation model using machine learning method, and evaluate skin aging.The present application further integrates function source information based on traditional species or function abundance analysis, constructs a function-species coupling feature system, describes the skin microecological aging state from the structural level, significantly improves the accuracy, stability and individualized quantification ability of evaluation, and is suitable for skin health evaluation, aging monitoring and related health management fields.

The application discloses oleanane triterpene saponin compounds with improved mitochondrial energy anti-aging, a preparation method and application thereof, and belongs to the technical field of medicines and cosmetics. Through systematic chemical component research on Zhejiang Hongshan tea flowers, two new oleanane triterpene saponin compounds CK and CL are separated, and the chemical structures are determined by using high-resolution mass spectrometry and nuclear magnetic technology. In-vitro anti-photoaging activity research shows that the new compounds CK and CL provided in the application have good protection effects on ultraviolet-induced fibroblast photoaging, can significantly improve the content of type I collagen, reduce the expression of matrix metalloproteinases mmp1 and mmp3 , increase the generation of mitochondrial autophagosomes and lysosomes, promote mitochondrial autophagy, relieve mitochondrial damage and improve cell senescence. The preparation method provided in the application is simple, and the activity is significant, so that the application is expected to be developed into a new anti-skin aging medicine or cosmetic.

The application discloses a synergistic ganoderma lucidum fermentation extract composition and application thereof in skin antioxidation, immunoregulation, anti-aging and anti-wrinkle skin tendering. The composition provided by the application contains the following raw materials in percentage by weight: 0.1-10% of ganoderma lucidum fermentation extract, 0.01-10% of magnesium ascorbyl phosphate, 0.01-5% of glycyrrhiza extract, 0.1-5% of tocopherol, 0.05-3% of boswellic acid extract, 0.01-3% of asiaticoside, 0.01-0.5% of coffee acid, and the balance of solvent. The composition provided by the application realizes three-effect synergism of "immune homeostasis-antioxidation repair-antioxidation" through specific component cooperation, can significantly improve skin inflammation, stabilize the skin immune microenvironment, delay skin aging, and has important application value in the development of skin antioxidation, immunoregulation, anti-aging and anti-wrinkle skin tendering products.

The present invention relates to methods for determining skin age, and particularly the severity of skin aging, including wrinkles, as well as for identifying compounds with anti-aging properties. These methods are based on measuring the Corynebacterium durum content within the skin microbiome of subjects. The inventors have demonstrated a correlation between the abundance of Corynebacterium durum in the skin microbiome and the severity of skin signs of aging.

The application discloses a composition for skin repair, a skin conditioner and application, a light damage care agent and a sunscreen agent; the active ingredients of the composition for skin repair include chrysanthemum 0.5-2500 parts by mass, golden mushroom 0.1-500 parts by mass, olive 0.1-500 parts by mass and sophora 0.1-500 parts by mass; the composition can significantly improve the core efficacy activities of skin, such as antioxidation, anti-inflammation and anti-aging, resist the damage of ultraviolet light and the like to the skin, promote the regeneration of collagen and elastin, and realize the all-around anti-skin aging effect covering anti-photoaging; meanwhile, the composition is natural in component source, high in safety and excellent in biocompatibility, has no obvious side effects, has good compatibility and high stability among the active ingredients, and provides a functional active composition which is clear in functional activity, safe and reliable, and wide in adaptability for the field of skin repair.

967.526NL1 Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

The application belongs to the technical field of bioengineering, and particularly relates to a Terminalia chebula Retz. fruit nano vesicle, a preparation method thereof and application of the nano vesicle in anti-skin aging products. In the application, a composite enzyme preparation containing ferulic acid esterase is used to perform enzymolysis on Terminalia chebula Retz. fruit raw materials, sodium alginate and a calcium chloride solution are added to the enzymolysis liquid after the enzymolysis, and the nano vesicle is subjected to precipitation treatment; finally, a sodium carbonate or sodium bicarbonate solution is used to treat the precipitate, the mixture is fully stirred, centrifuged, and the supernatant is collected to obtain a purified product of the Terminalia chebula Retz. fruit nano vesicle. The preparation method of the Terminalia chebula Retz. fruit nano vesicle provided by the application is efficient and low in cost, the nano vesicle obtained has a high miRNA content, animal experiments show that the nano vesicle can reduce the content of IL-6 inflammatory factors in the skin tissue of experimental animals, reduce the loss of collagen caused by ultraviolet rays, has significant anti-aging and light-aging alleviating effects, and can be applied to functional skin care products.

The present invention provides an immediate volumizing effect, a refreshing sensation, and wrinkle removal effects by including hyaluronic acid and peptides, and provides long-term improvement in lip volume and reverse skin aging effects by including an extract of Silybum marianum petals and an extract of Glycyrrhiza glabra leaves. In addition, the purpose of the present invention is to provide a natural plumping effect through long-term improvement in lip volume, amelioration of wrinkles, and increased blood flow by mixing an extract of Silybum marianum petals, which is an anti-aging component that removes and inhibits senescent cells, with ingredients such as hyaluronic acid and peptides that induce a natural plumping effect by ameliorating wrinkles and increasing blood flow.

The present application belongs to the field of microbial technology, and more specifically, the present application relates to an inactivated culture of plant lactobacillus BGI-N6, its use and products containing the inactivated culture. The present application provides an inactivated culture product of probiotics, which can break through the condition limitation of application of active probiotics, effectively eliminate free radicals, inhibit collagenase and elastase, inhibit skin pathogenic bacteria, so as to achieve better effect of slowing down skin aging.

This invention relates to a method for preparing a kapok flower extract. The method includes the following steps: mixing kapok flower raw materials with an ionic reagent and extracting under a high-voltage pulsed electric field; centrifuging, filtering, and collecting the filtrate to obtain the kapok flower extract; the ionic reagent is obtained by reacting glycerol and betaine. This invention utilizes a natural ionic reagent combined with a high-voltage pulsed extraction method. First, a high-voltage pulsed electric field is used to induce biomembrane permeation, causing the relevant active substances in the kapok flower to dissolve. Simultaneously, the ionic reagent can effectively improve the extraction efficiency of relevant active ingredients in the kapok flower. Compared with conventional water extracts, the extract prepared by the process provided by this invention has a significantly increased content of active ingredients and also possesses advantages such as antibacterial, antioxidant, and long shelf life. When applied to skincare products, it can effectively resist oxidation, improve skin radiance, and delay skin aging.

This invention relates to the cosmetic use of at least one compound of formula (I) or its salts and / or solvates and / or isomers thereof, for the care of keratin materials, particularly the skin, to preferably improve signs of skin aging. This invention also relates to the cosmetic use of at least one compound of formula (I) or its salts and / or solvates and / or isomers thereof as an anti-aging active ingredient. Furthermore, this invention relates to cosmetic compositions comprising at least one of said compounds or its salts and / or solvates and / or isomers thereof.

This invention belongs to the field of skincare technology and provides an anti-aging bovine protein peptide composition and its preparation method. Bovine protein peptides with a molecular weight of 300-800 Da are prepared using sequential enzymatic hydrolysis. Active peptides with arginine and lysine content ≥18% are directionally enriched by cation exchange chromatography. These peptides are then combined with sodium ascorbate phosphate, tocopheryl acetate, and phytic acid to construct an antioxidant synergistic network. A biomimetic liposome carrier is prepared using phosphatidylcholine, cholesterol, and ceramide 3. A multilayer responsive coating design is employed, sequentially coating the carrier surface with a poly-L-histidine layer, a hyaluronic acid layer, and a polycaprolactone outer layer, and grafting hyaluronic acid oligosaccharides to form a stable multilayer structure. The prepared composition has an average particle size of 120-280 nm, a drug loading efficiency ≥82%, and a 24-hour cumulative release rate of 58-82%, exhibiting excellent controlled-release performance and anti-aging activity, making it suitable for the development and application of high-end anti-aging skincare products.

The application relates to a ginseng and astragalus medicinal pair extractive and a preparation method and application thereof, relates to the technical field of traditional Chinese medicines, and solves the problem of adverse reactions caused by long-term use of existing skin aging drugs. Ginseng and astragalus raw materials are subjected to freeze-drying treatment, and then are crushed to obtain superfine powder; the ginseng superfine powder and the astragalus superfine powder are extracted by using a supercritical CO2 fluid extraction method, 5% ethanol is used as a carrier agent during the extraction of the ginseng, 70% ethanol is used as a carrier agent during the extraction of the astragalus, and ginseng extract and astragalus extract are collected respectively; the ginseng extract and the astragalus extract are combined and transferred to an ultrafiltration equipment, and the combined extract is subjected to ultrafiltration treatment; the filtrate after the ultrafiltration is transferred to a nanofiltration equipment for nanofiltration treatment, and a nanofiltration concentrated solution is obtained; and the nanofiltration concentrated solution is freeze-dried to obtain the ginseng and astragalus medicinal pair extractive. The ginseng and astragalus medicinal pair extractive can be used as a core component to prepare anti-skin aging products.

The application discloses an extracellular vesicle from atractylodes macrocephala, a preparation method and application thereof, and belongs to the field of biology. The application claims an extracellular vesicle, which is derived from the root of atractylodes macrocephala, has a stable nano-vesicle form, and has uniform particle size distribution and good purity. The in-vivo experimental results show that the extracellular vesicle has obvious anti-aging effect, can significantly improve aging-related cognitive dysfunction, and can significantly improve skin aging. Therefore, the extracellular vesicle has the prospect of being developed into anti-aging drugs, cosmetics or health products.

The present invention relates to biological clocks for measuring skin aging based on the protein expression level measured in a sample of a person's stratum corneum.