46 results about "Kojic acid" patented technology

The invention discloses a phenolic acid inhibitor and a use method and application thereof.The phenolic acid inhibitor comprises a component A. The component A comprises phenolic acid, polyethylene glycol and a phosphate buffer solution, and the phenolic acid is one or more of cumaric acid, kojic acid, chlorogenic acid, gallic acid and ferulic acid; the phenolic acid inhibitor is prepared from the following raw materials in parts by weight: 1 to 3 parts of phenolic acid, 0.1 to 0.3 part of polyethylene glycol and 8 to 12 parts of phosphate buffer solution, and the phenolic acid is two or three of coumaric acid, chlorogenic acid and ferulic acid. The PPO inhibition activity of the phenolic acid inhibitor can reach 70%-80%, the quality of fruits is well maintained, and browning caused by fruit processing is delayed.

The invention provides a gene Aokap10 for improving the kojic acid yield of aspergillus oryzae, a method and application. The invention finds that in the Aspergillus oryzae Aokap10 gene, nucleotide sequences from the 198 site to the 217 site are taken as target sequences, the site-specific knockout of the Aokap10 gene can be efficiently realized, and when insertion or deletion occurs at the 198 site to the 217 site of the sequence as shown in SEQ ID NO.2, the encoding protein of the Aokap10 gene can be damaged, so that the kojic acid yield of the Aspergillus oryzae is increased, and the application prospect is broad. The construction efficiency of the engineering strain for high yield of kojic acid based on Aokap10 gene mutation is effectively improved.

The invention relates to a method for screening a whitening effect of raw materials by utilizing a 3D melanin skin model, which comprises the following steps: S1, selecting the 3D melanin skin model, and respectively setting a blank control group, a positive control group, a negative control group and a sample group; s2, the positive control group and the sample group are subjected to UVB irradiation, kojic acid is added into the negative control group, UVB irradiation is carried out, and the blank control group is not treated in the culture period and is kept away from light; s3, after the irradiation is finished, adding a raw material sample to be detected into the sample group, and continuing to culture; s4, after culture is finished, respectively detecting skin apparent brightness, melanin content, MITF gene expression and TYR gene expression of the sample group, the blank control group, the positive control group and the negative control group; and S5, judging the whitening effect of the raw material sample according to the detection results of the four indexes in the step S4. The screening and evaluation indexes of the invention cover two dimensions of skin appearance and microcosmic, and the result is more accurate.

The invention belongs to the technical field of cosmetics, and particularly relates to a silk fibroin aggregate-based dispersed organic active substance as well as a preparation method and application thereof. The preparation method of the silk fibroin aggregate-based dispersed organic active substance comprises the following steps: (1) dissolving an organic active substance in a first solvent to obtain a first solution; dissolving the silk fibroin aggregate in a second solvent to obtain a second solution; (2) slowly adding the second solution into the first solution, mixing and homogenizing to obtain a silk fibroin aggregate-based dispersed organic active substance; wherein the silk fibroin aggregate is prepared by mixing a silk fibroin aqueous solution and alcohol. The silk fibroin aggregate-based dispersed organic active substance prepared by the preparation method can improve the bioavailability of the organic active substance (such as vitamin C, hyaluronic acid, coenzyme Q10, nicotinamide, arbutin, kojic acid, licorice extract, centella extract, chamomile extract or green tea extract) in cosmetics.

The application belongs to the technical field of microbial fermentation, and particularly relates to a kind of cytolysis product of mixed bacteria fermentation and a preparation method. The cytolysis product is prepared by mixed bacteria fermentation of two kinds of aerobic probiotics, i.e. Lactobacillus plantarum and Aspergillus oryzae are used as fermentation strains to carry out mixed bacteria fermentation treatment on rice milk, and membrane filtration and column chromatography system are used for filtration and enrichment, so as to obtain a cytolysis fermentation product filtrate rich in kojic acid, the content of kojic acid is greater than 200 g / L, which is significantly improved compared with conventional process. The obtained cytolysis product has no bad smell and clear color, so that the beneficial function of kojic acid can be played only with a low addition amount in cosmetics, and the addition of odor masking and color correcting auxiliaries is reduced, and the cytolysis product can be used for preparing cosmetics with skin repair, whitening and other functions.

The present invention belongs to the field of pharmaceutical synthesis and specifically discloses an L-phenylalanine derivative tyrosinase inhibitor and its preparation method. The tyrosinase inhibitor comprises a compound represented by formula (I) or a pharmaceutically acceptable salt, ester, stereoisomer, solvate, prodrug, or isotopic variant thereof. The compound represented by formula (I) of the present invention has tyrosinase inhibitory activity superior to that of kojic acid, can inhibit excessive melanin accumulation, and has great application potential in inhibiting mushroom tyrosinase. Therefore, it can be used as a mushroom preservative. The compound represented by formula (I) of the present invention exerts tyrosinase inhibitory activity by acting on amino acid residues and copper ions within the active site and is a reversible competitive inhibitor. #imgabs0#

This invention discloses a thermally conductive and wear-resistant lubricating oil and its preparation method. The specific preparation method is as follows: Silicon carbide and boron nitride powders are ball-milled at a mass ratio of 1:(0.5-2) using methanol as the ball milling medium to obtain a ball milling fluid. Then, kojic acid and silane coupling agent are added to the ball milling fluid at a mass ratio of 1:(3-10), with the total mass of kojic acid and silane coupling agent being 2-10% of the ball milling fluid. The fluid is then sheared and emulsified in a high-speed shear mill. The sheared emulsion is centrifuged to obtain a precipitate. The precipitate is added to deionized water and then boiled until crystallization occurs. The precipitate is ground and passed through a 1000-3000 mesh sieve. The base oil is heated to 70-90 degrees Celsius, and then detergent, antioxidant, dispersant, passivator, rust inhibitor, and the sieved precipitate are added according to the mass proportions. The mixture is stirred and mixed to obtain the thermally conductive lubricating oil. This invention achieves a significant improvement in the thermal conductivity of lubricating oil by uniformly dispersing functionalized silicon carbide and boron nitride in the lubricating oil, thereby effectively dissipating heat and maintaining the stable operation of mechanical equipment in high-temperature environments.

The invention belongs to the field of medicine synthesis, and particularly discloses an L-phenylalanine derivative tyrosinase inhibitor and a preparation method thereof. The tyrosinase inhibitor comprises a compound shown in a formula (I) or pharmaceutically acceptable salt, ester, stereoisomer, solvate, prodrug or isotope variant thereof. The compound shown in the formula (I) has tyrosinase inhibitory activity superior to that of kojic acid, can play a role in inhibiting excessive accumulation of melanin, and has great application potential in inhibiting mushroom tyrosinase, so that the compound can be used as a mushroom preservative. According to the invention, the compound shown in the formula (I) exerts tyrosinase inhibitory activity through amino acid residues and copper ions acting on active sites, and is a reversible competitive inhibitor. # imgabs0 #

The present invention provides a gene Aokap10, a method and an application for improving the kojic acid production of Aspergillus oryzae. The present invention discovers that the nucleotide sequence from the 198th to the 217th position in the Aspergillus oryzae Aokap10 gene can be used as a target sequence to efficiently achieve site-directed knockout of the Aokap10 gene, and insertions or deletions at the 198th to the 217th positions of the sequence shown in SEQ ID NO.2 will both cause the encoded protein of the Aokap10 gene to be disrupted, improving the kojic acid production of Aspergillus oryzae and effectively improving the construction efficiency of engineering strains with high kojic acid production based on Aokap10 gene mutations.

The invention relates to a whitening and spot-fading composition containing 4-butylresorcinol and application thereof, and belongs to the technical field of cosmetics, the whitening and spot-fading composition comprises the following raw materials: black mulberry, spearmint, crithmum maritimum, 4-butylresorcinol, kojic acid, ascorbyl tetraisopalmitate, ethylhexylglycerin and a solvent; the whitening and spot-fading composition further comprises lactobacillus plantarum, lactobacillus rhamnosus and lactobacillus bulgaricus. The black mulberry, the spearmint and the crithmum maritimum are selected for compounding and water extraction, and the lactobacillus plantarum, the lactobacillus rhamnosus and the lactobacillus bulgaricus are used as mixed bacteria to ferment the water extract, so that the prepared composition finished product has excellent oxidation resistance; 4-butylresorcinol and kojic acid enable the prepared composition to have whitening and spot-fading effects, meanwhile, ascorbyl tetraisopalmitate is added to further enhance the whitening and spot-fading effects of the system, and ethylhexylglycerin is added to improve the moisturizing effect of the composition finished product.

The invention belongs to the field of organic electroluminescent materials, and in particular relates to a pyrone type iridium phosphorescent complex as well as a preparation method and application thereof, the pyrone type iridium phosphorescent complex takes (ppy) 2Ir2Cl2 (ppy) 2 as a dimer, 3-hydroxy-2-methyl-gamma-pyrone, 2-ethyl-3-hydroxy-4-pyrone, 5-hydroxy-2-hydroxymethyl-1, 3, 4-triazole-1, 3, 5-triazole-1, 3, 5-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3- 3, 4-pyrone is used as an auxiliary ligand, and three pyrone type iridium phosphorescent complexes are obtained under simple operation steps and mild reaction conditions. Maltol, ethyl maltol and kojic acid which are selected as pyrone auxiliary ligands are all food additives and are easy to purchase and low in price, the cost of the organic electroluminescent material can be greatly reduced, and industrial conversion is effectively achieved.

The invention relates to the technical field of food preservation, in particular to a green litchi preservation solution, a preparation method and a preservation method.The green litchi preservation solution comprises 1-5 g / L of L-ascorbic acid, 0.1-0.5 g / L of kojic acid, 0.02-0.08 g / L of salicylic acid, 0.04-0.08 g / L of anhydrous magnesium sulfate, 0.04-0.08 g / L of anhydrous aluminum sulfate and the balance water. Compared with traditional chemical preservatives, the green litchi preservative provided by the invention has the advantages that the addition of chemical bactericides such as prochloraz is avoided, and the food safety guarantee is improved; the harvested litchis are subjected to pre-cooling treatment, soaked in the green fresh-keeping liquid provided by the invention and then subjected to physical irradiation treatment; the green fresh-keeping method for the litchis provided by the invention further reduces the browning degree of the litchis, greatly prolongs the storage period and shelf life of the litchis, and extends the industrial chain and economic value of the litchis.

An edible treatment composition is disclosed that includes non-toxic and harmless chemicals to extend the shelf life of mushrooms and maintain the freshness of the mushrooms over a long period of time during storage and transportation. The disclosed edible treatment compositions include kojic acid, L-arginine, hydroxycinnamic acid (HCA), and optionally other active or inactive ingredients, such as antibacterial agents, etc. The present invention relates to the treatment of mushrooms with the disclosed edible treatment compositions before or after harvest to extend their shelf life by imparting one or more characteristics over an extended period of time, such as maintaining whiteness, delaying browning, delaying pileus (cap) opening, better robustness, maintaining structural integrity, slowing weight loss, and the like.

The present invention discloses an edible treatment composition comprising non-toxic and non-hazardous chemicals to extend the shelf-life and maintain freshness of mushroom for prolonged time during its storage and shipment. The disclosed edible treatment composition includes Kojic Acid, L-arginine, Hydroxycinnamic acid (HCA) and optionally additional active or inactive components like antimicrobial agent, etc. This invention is concerned with the treatment of mushroom with disclosed edible treatment composition, pre- or post-harvest, to extend its shelf-life by imparting one or more properties like, maintained whiteness, delayed browning, delated pileus (cap) opening, better firmness, maintained structural integrity, slower weight-loss, etc. for prolonged time, amongst others.

The invention discloses a nickel-containing liquid iron removal adsorption material and a preparation method thereof, the method comprising the following steps: (a) preparation of amine balls: mixing a chlorine ball with a first solvent for swelling, then adding an amine compound, heating and refluxing; (b) purification: recovering the solvent of the composite material obtained in step (a) to obtain an amine ball; (c) preparation of a functional monomer: mixing kojic acid, an aldehyde compound, and an ammonium salt, adding a second solvent, stirring evenly, and heating to react; (d) grafting reaction: adding the amine ball obtained in step (b) to the monomer prepared in step (c), controlling the speed of the stirrer, and heating the system to perform a reflux reaction; (e) purification: recovering the solvent of the material obtained in step (d) to obtain an adsorption material for removing iron from a nickel-containing liquid. The adsorption material synthesized by the present invention has excellent performance in selectively adsorbing iron ions, and is suitable for selective adsorption and separation of iron ions in a complex multi-component heavy metal ion environment.

The invention discloses an application of a herba ecliptae extract in preparation of a whitening product. The skin-whitening product takes the herba perillae extract as a main functional component, and comprises a skin-care product, a washing care product and an aromatherapy product with a skin-whitening effect. The herba ecliptae extract comprises guaiacol, alpha-eudesmol, beta-eudesmol, D-camphor and beta-caryophyllene, and is obtained by performing steam distillation extraction on the overground part of herba ecliptae as a raw material. The invention discloses an effect of inhibiting melanin synthesis of the herba perillae acutae extract, can directly reduce the melanin content of human melanoma cells MNT1, and also can indirectly reduce the melanin content of the MNT1 cells by influencing human immortalized keratinocytes HaCaT. Under the same mass concentration, the effect of the whitening agent is superior to that of the whitening agents alpha-arbutin and kojic acid which are widely used at present. Therefore, the herba perillae extract can be used as a natural extract component to be applied to development of related whitening products such as cosmetic technology and aromatherapy.

The invention relates to walnut pentapeptide and analogues thereof as well as a preparation method, application and composition thereof, belongs to the technical field of organic synthesis, and aims to solve the problems of high toxicity, poor stability and insufficient water solubility of existing tyrosinase inhibitors such as kojic acid and the limitation of difficulty in large-scale application of natural walnut pentapeptide due to low content. The pentapeptide compound is prepared by screening a high-affinity structure by taking tyrosinase as a target spot and combining a solid-phase synthesis method by taking 2-CTC resin as a carrier and taking Oxyma / DIC as a condensing agent, the water solubility is remarkably improved to Log P =-3.21, the tyrosinase inhibitory activity IC50 is 83.32 + / -0.92 mu g / mL, which is superior to that of kojic acid, and the cytotoxicity is small. Experiments show that the compound has DPPH free radical scavenging capacity IC50 of 113.95 + / -3.92 mu g / mL, can effectively inhibit browning of fresh-cut fruits and vegetables, and is suitable for the fields of food preservatives, tyrosinase inhibitors and medicines.

The invention belongs to the technical field of biological prevention and treatment of postharvest diseases, and particularly relates to a method for preventing and treating postharvest diseases of tomatoes with kojic acid and for storage and preservation. The method comprises the following steps: preparing a kojic acid solution, and sterilizing for later use; then, punching holes in the surfaces of the tomatoes, injecting the holes into the tomatoes, standing, and injecting the same volume of pectobacterium carotovorum suspension, so that the soft rot caused by the pectobacterium carotovorum is effectively controlled; or taking tomatoes in a natural state, soaking the tomatoes in a kojic acid solution, and naturally airing the tomatoes to realize the purposes of disease control, storage and fresh-keeping of the picked tomatoes. The method can significantly reduce the occurrence of soft rot after tomato harvesting, reduces the natural rotting rate after tomato harvesting, is safe and environmentally friendly, has no significant adverse effect on the main quality indexes of the harvested tomatoes, can slow down the deterioration of the storage quality of the tomatoes, achieves significant technical effects, and has wide application prospects.

The invention discloses a radix et rhizoma rhei extract as well as a preparation method and application of the radix et rhizoma rhei extract. The radix et rhizoma rhei extract is prepared from eudesmol, 4-isopropyl toluene, beta-pinene, gamma-terpinene and Helminthogermacene. The preparation method of the rheum officinale extract comprises the step of extracting the overground part of rheum officinale through a steam distillation method. The invention also discloses an application of the rheum officinale extract in preparation of a product with a whitening effect. The Rheum officinale extract has oxidation resistance and melanin synthesis inhibition capability, can directly reduce the melanin content of human melanoma cells MNT1, can indirectly reduce the melanin content of the MNT1 cells by influencing human immortalized keratinocytes HaCaT, and has better effects than the whitening agents alpha-arbutin and kojic acid which are widely used at present. Therefore, the rheum officinale extract can be used as a natural extract component to be applied to the fields of cosmetic technology and aromatherapy and the development of whitening products in related industries.

The invention discloses a leucaena leucocephala-sourced dihydrochalcone compound, a preparation method thereof and application of the dihydrochalcone compound as a tyrosinase inhibitor. According to the invention, the tyrosinase inhibitor dihydrochalcone compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxychalcone is extracted and separated from the leucaena leucocephala plant, the structural formula of the compound is as shown in the formula (I), the plant material is rich in source and is a renewable tissue part, and not only is the economic benefit good, but also the environment-friendly effect is achieved. Pharmacological experiments show that the tyrosinase inhibitory activity of the compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxycholone is stronger than that of kojic acid, and the compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxycholone) is expected to be further developed into a new whitening cosmetic synergist, a drug for treating pigmentation dermatosis, an insect control agent or a food preservative and the like, and has a good prospect.

The present application relates to the field of cosmetic technology, and particularly relates to a low-irritation soothing plant cosmetic lotion and a preparation method thereof.The low-irritation soothing plant cosmetic lotion comprises 80-95 parts of a solvent, 0.1-10 parts of a skin conditioning agent, 0.5-10 parts of a humectant, 0.01-1 parts of a chelating agent and 0.001-1 parts of a pH regulator; the skin conditioning agent comprises an active ingredient and a cactus extract compound in a mass ratio of (40-70):1; the active ingredient comprises at least one of 377, arbutin, nicotinamide, kojic acid and glycolic acid; the cactus extract compound comprises an aggregate of cactus extract and cerium oxide particles doped with each other; and the cactus extract compound is prepared from cerium oxide and cactus extract in a mass ratio of 1:(1-50). The present application adds a specific skin conditioning agent, which can effectively reduce the irritation of active ingredients such as whitening agents and acids in the lotion to the skin.

The present invention relates to a whitening and freckle-removing composition containing 4-butylresorcinol and its application, and belongs to the technical field of cosmetics. The whitening and freckle-removing composition includes the following raw materials: black mulberry, spearmint, sea fennel, 4-butylresorcinol, kojic acid, ascorbyl tetraisopalmitate, ethylhexylglycerol and solvent; the whitening and freckle-removing composition also includes plant lactobacillus, rhamnosus lactobacillus and bulgaricus lactobacillus. The present invention selects black mulberry, spearmint and sea fennel for compounding and water extraction, and uses plant lactobacillus, rhamnosus lactobacillus and bulgaricus lactobacillus as mixed bacterial agents to ferment the water extract, so that the obtained composition finished product has excellent antioxidant properties; and 4-butylresorcinol and kojic acid can make the obtained composition have whitening and freckle-removing effect, and at the same time, ascorbyl tetraisopalmitate is added to further strengthen the whitening and freckle-removing effect of the system and improve the moisturizing effect of the composition finished product with ethylhexylglycerol.

To provide novel active components which can be added to skin external agents and are useful for promoting extracellular matrix production and preventing or improving skin thinning.SOLUTION: Provided is a skin external agent containing a pyridine derivative, or a pyridine derivative and at least any one of an ascorbic acid derivative, tranexamic acid or a derivative thereof, hydroquinone or a derivative thereof and kojic acid or a derivative thereof, collagen or a derivative thereof, hyaluronic acid or a derivative thereof, as well as a component derived from plants, animals, or microorganisms.SELECTED DRAWING: None

The present invention discloses a kojic acid-coumarin tyrosinase inhibitor and a preparation method and application thereof. The chemical structural formula of the tyrosinase inhibitor is shown in formula (I): The tyrosinase inhibitor provided by the present invention has good tyrosinase inhibition activity and can be used as a lead compound for novel anti-tyrosinase research.

The object of the present invention is to provide a novel kojic acid derivative with excellent solubility in water, and its applications. [Solution] A compound (compound of general formula (1) below) is used in which a phosphocholine group is introduced to the hydroxymethyl group at the 2-position of the γ-pyrone ring of kojic acid via a phosphate ester bond. The kojic acid derivative of the present invention has high solubility in water and can be incorporated into cosmetics and topical skin preparations at high concentrations. Furthermore, the kojic acid derivative of the present invention can be converted to kojic acid in the body, thereby exhibiting the excellent physiological activity of kojic acid, such as melanin production inhibition. TIFF2026055125000008.tif39110

The invention relates to the field of biological medicine, in particular to a kojic acid ester tyrosinase inhibitor and a synthesis method and application thereof. The invention provides kojic acid ester compounds (5-hydroxy-4-oxypyran-2-yl) methyl-2-furan carboxylic acid ester and (5-hydroxy-4-oxypyran-2-yl) methyl-3-(4-hydroxyphenyl) propionate, and an application of the kojic acid ester compounds in preparation of a tyrosinase inhibitor. The kojic acid ester compound has an inhibiting effect on tyrosinase, and a theoretical basis is provided for development of whitening products.

The invention provides a catalyst component for olefin polymerization, a catalyst and application of the catalyst component. The catalyst component comprises Mg, Ti, halogen and kojic acid ester internal electron donors, wherein the kojic acid ester internal electron donor has a structure as shown in a formula I: # imgabs0. The catalyst component and the catalyst have high catalytic activity and high biological safety, can reduce the total ash content of polypropylene resin, residual components of the catalyst and toxicity of the residual components, and are especially suitable for production of medical polypropylene materials.

The invention belongs to the field of bioengineering pharmacy, and particularly relates to an effective pain relieving and scar removing burn medicament and a preparation method thereof. The burn medicament capable of effectively relieving pain and removing scars is prepared from the following raw materials in parts by weight: 40 to 50 parts of N-carboxymethyl chitosan / cross-linked sodium alginate hydrogel, 4 to 8 parts of witch hazel extract, 6 to 10 parts of turmeric extract, 0.5 to 1 part of nano-silver, 2 to 3 parts of radix angelicae, 1 to 2 parts of bark mixture, 1 to 2 parts of flos sophorae, 1 to 2 parts of rhizoma paridis, 5 to 15 parts of aloe extract, 5 to 10 parts of herba centellae extract and 1 to 3 parts of adjuvant. Aloe and turmeric extracts are combined to stabilize kojic acid, so that the drug effect is enhanced, and the shelf life is prolonged; kojic acid adjusts fibroblasts and relieves scars; the aloe promotes skin regeneration, and the hydrogel matrix is moisturized and breathable and accelerates healing; the witch hazel tannin astringes the skin and has a synergistic effect to promote repair and reduce scars.

The invention discloses a fresh-cut areca taros preservation method, which comprises: picking areca taros, carrying out pressure difference pre-cooling so as to reduce the center temperature to 7-10 DEG C, washing the pre-cooled areca taros, peeling, and cutting into areca taros strips with the size of 5 cm * 1 cm * 1 cm so as to obtain the fresh-cut areca taros; the fresh-cut areca taros are placed in a fresh-keeping solution prepared from citric acid, phytic acid, kojic acid and ethyl alcohol to be soaked for 8-10 min, after water is drained, the areca taros are packaged with PET fresh-keeping boxes and then sealed with fresh-keeping films, and the weight of each box is 320-350 g; the packaged fresh-cut areca taros are subjected to 1.5-1.6 kGy irradiation treatment and then refrigerated at the temperature of 4-6 DEG C. According to the fresh-keeping method for the fresh-cut areca taros, PPO activity can be effectively inhibited, browning is reduced, the quality of the fresh-cut areca taros is improved, the shelf life is prolonged, and the fresh-keeping method is easy to operate and suitable for large-scale application and popularization.

The present invention discloses a preparation method and application of a kojic acid derivative, tromethamine C, and relates to the technical field of preparation and application of kojic acid derivatives. The structural formula of the compound is #imgabs0#. Subsequent studies have found that tromethamine C has significant antioxidant activity and EC50 activity against ABTS and DPPH free radicals. 50 The inhibitory activity of kojic acid against tyrosinase was stronger than that of kojic acid, with IC 50 The concentrations of kojic acid were 10.8±1.9μM and 8.9±1.5μM, respectively. Even at 10μM, kojic acid exhibited significant anti-browning effects in fresh-cut fruit and fruit juice. Kojic acid provides an effective precursor compound for the development of anti-browning food additives, potentially contributing to meeting social needs, reducing production costs, and increasing market value. This also lays a foundation for further research into the efficacy of kojic acid, drug development, and future applications.