20 results about "Kojic acid" patented technology

The invention belongs to the technical field of cosmetics, and particularly relates to a silk fibroin aggregate-based dispersed organic active substance as well as a preparation method and application thereof. The preparation method of the silk fibroin aggregate-based dispersed organic active substance comprises the following steps: (1) dissolving an organic active substance in a first solvent to obtain a first solution; dissolving the silk fibroin aggregate in a second solvent to obtain a second solution; (2) slowly adding the second solution into the first solution, mixing and homogenizing to obtain a silk fibroin aggregate-based dispersed organic active substance; wherein the silk fibroin aggregate is prepared by mixing a silk fibroin aqueous solution and alcohol. The silk fibroin aggregate-based dispersed organic active substance prepared by the preparation method can improve the bioavailability of the organic active substance (such as vitamin C, hyaluronic acid, coenzyme Q10, nicotinamide, arbutin, kojic acid, licorice extract, centella extract, chamomile extract or green tea extract) in cosmetics.

The application belongs to the technical field of microbial fermentation, and particularly relates to a kind of cytolysis product of mixed bacteria fermentation and a preparation method. The cytolysis product is prepared by mixed bacteria fermentation of two kinds of aerobic probiotics, i.e. Lactobacillus plantarum and Aspergillus oryzae are used as fermentation strains to carry out mixed bacteria fermentation treatment on rice milk, and membrane filtration and column chromatography system are used for filtration and enrichment, so as to obtain a cytolysis fermentation product filtrate rich in kojic acid, the content of kojic acid is greater than 200 g / L, which is significantly improved compared with conventional process. The obtained cytolysis product has no bad smell and clear color, so that the beneficial function of kojic acid can be played only with a low addition amount in cosmetics, and the addition of odor masking and color correcting auxiliaries is reduced, and the cytolysis product can be used for preparing cosmetics with skin repair, whitening and other functions.

The present invention belongs to the field of pharmaceutical synthesis and specifically discloses an L-phenylalanine derivative tyrosinase inhibitor and its preparation method. The tyrosinase inhibitor comprises a compound represented by formula (I) or a pharmaceutically acceptable salt, ester, stereoisomer, solvate, prodrug, or isotopic variant thereof. The compound represented by formula (I) of the present invention has tyrosinase inhibitory activity superior to that of kojic acid, can inhibit excessive melanin accumulation, and has great application potential in inhibiting mushroom tyrosinase. Therefore, it can be used as a mushroom preservative. The compound represented by formula (I) of the present invention exerts tyrosinase inhibitory activity by acting on amino acid residues and copper ions within the active site and is a reversible competitive inhibitor. #imgabs0#

This invention discloses a thermally conductive and wear-resistant lubricating oil and its preparation method. The specific preparation method is as follows: Silicon carbide and boron nitride powders are ball-milled at a mass ratio of 1:(0.5-2) using methanol as the ball milling medium to obtain a ball milling fluid. Then, kojic acid and silane coupling agent are added to the ball milling fluid at a mass ratio of 1:(3-10), with the total mass of kojic acid and silane coupling agent being 2-10% of the ball milling fluid. The fluid is then sheared and emulsified in a high-speed shear mill. The sheared emulsion is centrifuged to obtain a precipitate. The precipitate is added to deionized water and then boiled until crystallization occurs. The precipitate is ground and passed through a 1000-3000 mesh sieve. The base oil is heated to 70-90 degrees Celsius, and then detergent, antioxidant, dispersant, passivator, rust inhibitor, and the sieved precipitate are added according to the mass proportions. The mixture is stirred and mixed to obtain the thermally conductive lubricating oil. This invention achieves a significant improvement in the thermal conductivity of lubricating oil by uniformly dispersing functionalized silicon carbide and boron nitride in the lubricating oil, thereby effectively dissipating heat and maintaining the stable operation of mechanical equipment in high-temperature environments.

The invention belongs to the field of organic electroluminescent materials, and in particular relates to a pyrone type iridium phosphorescent complex as well as a preparation method and application thereof, the pyrone type iridium phosphorescent complex takes (ppy) 2Ir2Cl2 (ppy) 2 as a dimer, 3-hydroxy-2-methyl-gamma-pyrone, 2-ethyl-3-hydroxy-4-pyrone, 5-hydroxy-2-hydroxymethyl-1, 3, 4-triazole-1, 3, 5-triazole-1, 3, 5-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3-triazole-1, 3- 3, 4-pyrone is used as an auxiliary ligand, and three pyrone type iridium phosphorescent complexes are obtained under simple operation steps and mild reaction conditions. Maltol, ethyl maltol and kojic acid which are selected as pyrone auxiliary ligands are all food additives and are easy to purchase and low in price, the cost of the organic electroluminescent material can be greatly reduced, and industrial conversion is effectively achieved.

The present invention discloses an edible treatment composition comprising non-toxic and non-hazardous chemicals to extend the shelf-life and maintain freshness of mushroom for prolonged time during its storage and shipment. The disclosed edible treatment composition includes Kojic Acid, L-arginine, Hydroxycinnamic acid (HCA) and optionally additional active or inactive components like antimicrobial agent, etc. This invention is concerned with the treatment of mushroom with disclosed edible treatment composition, pre- or post-harvest, to extend its shelf-life by imparting one or more properties like, maintained whiteness, delayed browning, delated pileus (cap) opening, better firmness, maintained structural integrity, slower weight-loss, etc. for prolonged time, amongst others.

The invention discloses a radix et rhizoma rhei extract as well as a preparation method and application of the radix et rhizoma rhei extract. The radix et rhizoma rhei extract is prepared from eudesmol, 4-isopropyl toluene, beta-pinene, gamma-terpinene and Helminthogermacene. The preparation method of the rheum officinale extract comprises the step of extracting the overground part of rheum officinale through a steam distillation method. The invention also discloses an application of the rheum officinale extract in preparation of a product with a whitening effect. The Rheum officinale extract has oxidation resistance and melanin synthesis inhibition capability, can directly reduce the melanin content of human melanoma cells MNT1, can indirectly reduce the melanin content of the MNT1 cells by influencing human immortalized keratinocytes HaCaT, and has better effects than the whitening agents alpha-arbutin and kojic acid which are widely used at present. Therefore, the rheum officinale extract can be used as a natural extract component to be applied to the fields of cosmetic technology and aromatherapy and the development of whitening products in related industries.

The invention discloses a leucaena leucocephala-sourced dihydrochalcone compound, a preparation method thereof and application of the dihydrochalcone compound as a tyrosinase inhibitor. According to the invention, the tyrosinase inhibitor dihydrochalcone compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxychalcone is extracted and separated from the leucaena leucocephala plant, the structural formula of the compound is as shown in the formula (I), the plant material is rich in source and is a renewable tissue part, and not only is the economic benefit good, but also the environment-friendly effect is achieved. Pharmacological experiments show that the tyrosinase inhibitory activity of the compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxycholone is stronger than that of kojic acid, and the compound (+ / -)-4, 4 '-Methoxy-3, 3', beta-trihydroxydihydroxycholone) is expected to be further developed into a new whitening cosmetic synergist, a drug for treating pigmentation dermatosis, an insect control agent or a food preservative and the like, and has a good prospect.

The present application relates to the field of cosmetic technology, and particularly relates to a low-irritation soothing plant cosmetic lotion and a preparation method thereof.The low-irritation soothing plant cosmetic lotion comprises 80-95 parts of a solvent, 0.1-10 parts of a skin conditioning agent, 0.5-10 parts of a humectant, 0.01-1 parts of a chelating agent and 0.001-1 parts of a pH regulator; the skin conditioning agent comprises an active ingredient and a cactus extract compound in a mass ratio of (40-70):1; the active ingredient comprises at least one of 377, arbutin, nicotinamide, kojic acid and glycolic acid; the cactus extract compound comprises an aggregate of cactus extract and cerium oxide particles doped with each other; and the cactus extract compound is prepared from cerium oxide and cactus extract in a mass ratio of 1:(1-50). The present application adds a specific skin conditioning agent, which can effectively reduce the irritation of active ingredients such as whitening agents and acids in the lotion to the skin.

The object of the present invention is to provide a novel kojic acid derivative with excellent solubility in water, and its applications. [Solution] A compound (compound of general formula (1) below) is used in which a phosphocholine group is introduced to the hydroxymethyl group at the 2-position of the γ-pyrone ring of kojic acid via a phosphate ester bond. The kojic acid derivative of the present invention has high solubility in water and can be incorporated into cosmetics and topical skin preparations at high concentrations. Furthermore, the kojic acid derivative of the present invention can be converted to kojic acid in the body, thereby exhibiting the excellent physiological activity of kojic acid, such as melanin production inhibition. TIFF2026055125000008.tif39110

The invention belongs to the field of bioengineering pharmacy, and particularly relates to an effective pain relieving and scar removing burn medicament and a preparation method thereof. The burn medicament capable of effectively relieving pain and removing scars is prepared from the following raw materials in parts by weight: 40 to 50 parts of N-carboxymethyl chitosan / cross-linked sodium alginate hydrogel, 4 to 8 parts of witch hazel extract, 6 to 10 parts of turmeric extract, 0.5 to 1 part of nano-silver, 2 to 3 parts of radix angelicae, 1 to 2 parts of bark mixture, 1 to 2 parts of flos sophorae, 1 to 2 parts of rhizoma paridis, 5 to 15 parts of aloe extract, 5 to 10 parts of herba centellae extract and 1 to 3 parts of adjuvant. Aloe and turmeric extracts are combined to stabilize kojic acid, so that the drug effect is enhanced, and the shelf life is prolonged; kojic acid adjusts fibroblasts and relieves scars; the aloe promotes skin regeneration, and the hydrogel matrix is moisturized and breathable and accelerates healing; the witch hazel tannin astringes the skin and has a synergistic effect to promote repair and reduce scars.

The present invention discloses a preparation method and application of a kojic acid derivative, tromethamine C, and relates to the technical field of preparation and application of kojic acid derivatives. The structural formula of the compound is #imgabs0#. Subsequent studies have found that tromethamine C has significant antioxidant activity and EC50 activity against ABTS and DPPH free radicals. 50 The inhibitory activity of kojic acid against tyrosinase was stronger than that of kojic acid, with IC 50 The concentrations of kojic acid were 10.8±1.9μM and 8.9±1.5μM, respectively. Even at 10μM, kojic acid exhibited significant anti-browning effects in fresh-cut fruit and fruit juice. Kojic acid provides an effective precursor compound for the development of anti-browning food additives, potentially contributing to meeting social needs, reducing production costs, and increasing market value. This also lays a foundation for further research into the efficacy of kojic acid, drug development, and future applications.

1. Name of the designed product: Package bottle (Kojin sin KOJIC ACID BODY LOTION). 2. Use of the designed product: for packaging or transportation, bottle or similar container. 3. Design points of the designed product: in the perspective view. 4. Picture or photograph best indicating the design points: perspective view.

The application relates to the technical field of preservatives, and particularly provides a food natural preservative composition and application thereof. The food natural preservative composition of the application is composed of kojic acid, cinnamaldehyde and eugenol in a weight ratio of 1:(0.1-5):(0.1-5), or epsilon-polylysine can also be added. The food natural preservative composition of the application synergistically plays the preservative performance of each natural preservative component, and has better preservative performance.

This invention discloses the application of a kojic acid derivative containing a thioether structure in the preparation of a fungicide for controlling plant bacterial diseases. The compound has the following general structural formula: R is a substituted phenyl group, and the substituent is fluorine, chlorine, bromine, methyl, methoxy, amino, or nitro. The focus of this invention is that this type of compound exhibits excellent biological activity in controlling plant bacterial diseases, especially against rice bacterial blight (… Xanthomonas oryzae pv. oryzae It exhibits significant inhibitory effects, with some compounds showing superior activity compared to commercial agents such as thiabendazole and tebuconazole. The preparation process is simple and suitable for widespread application.

The application discloses a kuroic acid-sensitized anthocyanin indicator, which comprises kuroic acid, anthocyanin and deionized water or an ethanol aqueous solution; the concentration of the kuroic acid is 0.2-80 mg / mL; and the concentration of the anthocyanin is 0.8-40 mg / mL. The kuroic acid-sensitized anthocyanin indicator is mixed with a matrix solution containing sodium alginate, hydroxypropyl methyl cellulose and glycerol to form a film-forming solution; after air bubbles in the film-forming solution are eliminated, a food freshness indicator label is prepared by a flow casting method in an environment with a temperature of 25 DEG C and a relative humidity of 50%. The kuroic acid can enhance the sensitivity of the indicator label to volatile biological amines, and regulate the color response behavior of the anthocyanin to the biological amines. When aquatic animal products and the indicator label are placed in a sealed package, the volatile total nitrogen content generated in the corruption process of the aquatic animal products corresponds to the color of the indicator film, so that the freshness degree of salmon during transportation, storage and shelf life can be indicated.

The present application relates to the technical field of honey detection, and particularly relates to a vitexin, a preparation method thereof and a method for identifying vitex honey. The vitexin has a structure shown in formula 1: The present application finds a new compound, vitexin, in vitex honey through research on the vitex honey. The present application also finds that when the to-be-tested honey contains vitexin (p-hydroxybenzoic acid 1-O-gentio-bioside-5-hydroxy-3,7-diene-[2,6] cyclopentanopyranyl-3-methyl ester), or contains vitexin and new chlorogenic acid, 4-hydroxybenzoic acid, chlorogenic acid, caffeic acid, p-coumaric acid, red flower phaseolus acid, trans, trans-epiabscisic acid, cis, trans-epiabscisic acid, 5-methoxy pinocembrin, pinocembrin, kaempferol, pinocembrin, benzyl caffeate, kojic acid, galangin at the same time, the to-be-tested honey can be determined as vitex honey. The present application also provides a new method for constructing a vitex honey authenticity and quality evaluation system.

The invention relates to the technical field of tetrahydroisoquinoline derivatives, in particular to a water-soluble kojic acid-tetrahydroisoquinoline derivative with tyrosinase inhibitory activity as well as a preparation method and application thereof, and the structural formula of the compound is # imgabs0 # or a pharmaceutically acceptable salt with the structure shown in the specification. The brand-new water-soluble kojic acid-tetrahydroisoquinoline compound provided by the invention is used as a tyrosinase inhibitor, has good effects of inhibiting the activity of tyrosinase and inhibiting melanin generation, and can be used as a novel whitening agent or a food antibacterial and anti-browning agent. The kojic acid-tetrahydroisoquinoline derivative provided by the invention is wide in application range, relatively low in toxicity to human normal cells, relatively high in safety, simple in preparation method and relatively short in synthesis route.

The present invention relates to a cosmetic skin lightening composition comprising the combination of sclareolide, kojic acid and ascorbyl glucoside, wherein kojic acid is encapsulated within a targeted microcapsule or nanocapsule having a melanocortin 1 receptor (MC1R) agonist peptide bound to the surface. It was found that such combination of active substances provided synergistic kin-whitening effect. The present invention also relates to the cosmetic use of this composition for skin whitening, particularly, for the elimination or reduction of hyperpigmented marks of the skin, such as UV exposure related marks, post-scar marks, post-inflammation marks, melasma marks, lentigo marks or age-related marks.