Nanometer solid lipid carrier covering kojic acid dipalmitate and preparing method thereof

A technology of kojic acid dipalmitate and solid lipid, which is applied to a nano solid lipid carrier coated with kojic acid dipalmitate and its preparation, in the field of kojic acid dipalmitate, which can solve the problem of kojic acid dipalmitate Ester has weak dispersing ability, is not easy to penetrate into the skin, unstable in high temperature environment, etc., to achieve the effect of increasing the coating amount, promoting absorption and permeability, and good stability

Active Publication Date: 2014-10-29
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a nano-solid lipid carrier coated with kojic acid dipalmitate and a preparation method, to solve the problem of kojic acid dipalmitate in the prior art Weak dispersing ability, easy to precipitate during storage, unstable in high temperature environment, poor affinity with skin, and difficult to penetrate into the technical problems of skin

Method used

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  • Nanometer solid lipid carrier covering kojic acid dipalmitate and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A nano solid lipid carrier coated with kojic acid dipalmitate, calculated according to the total amount of 100g, its composition and content are as follows:

[0036] Kojic acid dipalmitate 1g (1%)

[0037] Phospholipids 0.1g (0.1%)

[0038] Solid lipid 2g (2%)

[0039] Liquid lipid 3g (3%)

[0040] Solid emulsifier 3g (3%)

[0041] Polyol additive 2g (2%)

[0042] Preservative 0.01g (0.01%)

[0043] The balance is deionized water

[0044] The kojic acid dipalmitate is a whitening agent;

[0045] The phospholipid is soybean lecithin;

[0046] The solid lipid is stearyl alcohol;

[0047] The liquid lipid is butyl stearate;

[0048] The solid emulsifier is coconut glucoside and coco alcohol;

[0049] The polyol additive is glycerin;

[0050] The preservative is methyl benzoate;

[0051] The aforementioned nano-solid lipid carrier coated with kojic acid dipalmitate is characterized in that it specifically includes the follow...

Embodiment 2

[0063] A nano solid lipid carrier coated with kojic acid dipalmitate, calculated according to the total amount of 100g, its composition and content are as follows:

[0064] Kojic acid dipalmitate 3g (3%)

[0065] Phospholipids 1g (1%)

[0066] Solid lipid 5g (5%)

[0067] Liquid lipid 6g (6%)

[0068] Solid emulsifier 6g (6%)

[0069] Polyol additive 5g (5%)

[0070] Preservative 0.03g (0.03%)

[0071] The balance is deionized water

[0072] The kojic acid dipalmitate is a whitening agent;

[0073] The phospholipid is egg yolk phospholipid;

[0074] The solid lipid is myristyl myristate;

[0075] The liquid lipid is ethylhexyl cocoate / isooctyl cocoate;

[0076] The solid emulsifier is C20-22 alkyl phosphate and C20-22 fatty alcohol;

[0077] The polyol additive is propylene glycol;

[0078] The preservative is diazoalkyluria;

[0079] The preparation method of the above-mentioned nano solid lipid carrier coated with kojic acid dipalmitate is th...

Embodiment 3

[0081] A nano solid lipid carrier coated with kojic acid dipalmitate, calculated according to the total amount of 100g, its composition and content are as follows:

[0082] Kojic acid dipalmitate 6g (6%)

[0083] Phospholipids 1.5g (1.5%)

[0084] Solid lipid 10g (10%)

[0085] Liquid lipid 10g (10%)

[0086] Solid emulsifier 10g (10%)

[0087] Polyol 12g (12%)

[0088] Preservative 0.6g (0.6%)

[0089] The balance is deionized water

[0090] The kojic acid dipalmitate is a whitening agent;

[0091] The phospholipids in question are hydrogenated phospholipids;

[0092] The solid lipid is pentaerythritol tetracaprylate / caprate;

[0093] The liquid lipid is macadamia oil;

[0094] The solid emulsifier is polyglycerol-6 distearate;

[0095] The polyol additive is 1,3-butanediol;

[0096] The preservative is glycerol monolaurate

[0097] The preparation method of the above-mentioned nano solid lipid carrier coated with kojic acid dipalmi...

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Abstract

A nanometer solid lipid carrier covering kojic acid dipalmitate is disclosed. The nanometer solid lipid carrier comprises 1-25% by weight of the kojic acid dipalmitate, 0.1-5% by weight of phospholipid, 2-15% by weight of solid lipid, 3-20% by weight of liquid lipid, 3-20% by weight of a solid emulsifying agent, 2-20% by weight of a polyalcohol additive and 0.01-0.8% by weight of a preservative, with the balance being deionized water. A preparing method of the nanometer solid lipid carrier is also provided. The preparing method includes: melting an oil phase comprising the kojic acid dipalmitate, the phospholipid, the solid lipid, the liquid lipid and the solid emulsifying agent at 75-95 DEG C and uniformly dispersing to obtain an oil phase; heating a water phase comprising the deionized water and the polyalcohol additive to 75-95 DEG C; stirring the water phase and adding the oil phase; performing high-pressure homogenization after uniform mixing; and stirring and cooling to form the nanometer solid lipid carrier. The nanometer solid lipid carrier and the preparing method promote permeation of the kojic acid dipalmitate on skin, increase the utilization rate, and enhance the whitening effect.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to kojic acid dipalmitate, in particular to a nanometer solid lipid carrier coated with kojic acid dipalmitate and a preparation method thereof. Background technique [0002] With the development of the economy and the improvement of living standards, people pay more and more attention to the natural whitening of the skin, which provides a broad application prospect for various active substances that inhibit the synthesis of skin melanin and then achieve natural whitening of the skin. , the whitening active substances are divided into: (1) inhibition of melanocyte proliferation; (2) ① inhibition of melanin formation: inhibition of tyrosinase, dopa interconverting enzyme, dihydroxyindole oxidase activity, ② reduction of melanin Intermediaries in the formation process or combined with them to block the formation of melanin; (3) Inhibit the transfer of melanin granules to k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/49A61K8/55A61Q19/02
Inventor 张婉萍朱海洋刘晓慧
Owner SHANGHAI INST OF TECH
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