83 results about "Methyl benzoate" patented technology

The invention discloses a synthesis method of a Vinetoram key intermediate and Vinetoram, and relates to the technical field of organic synthesis.The synthesis method comprises the steps that 1-((4 '-chloro-5, 5-dimethyl-3, 4, 5, 6-tetrahydro-[1, 1'-biphenyl]-2-yl) methyl) piperazine hydrochloride and 2-((1H-pyrrolo [2, 3-b] pyridine-5-yl) oxy)-4-bromobenzoic acid methyl ester are used as reaction raw materials, a reaction is carried out, and the Vinetoram key intermediate and the synthesis method of the Vinetoram key intermediate are synthesized; the method comprises the following steps: carrying out a substitution reaction and a hydrolysis reaction to obtain a key intermediate of the Venotocork, and carrying out a condensation reaction on the intermediate and 3-nitro-4-((tetrahydro-2H-pyran-4-yl) methylamino) benzenesulfonamide to obtain the Venotocork. The synthesis method has the advantages of short process route, easily available raw materials, mild reaction conditions, high yield and purity of the intermediate and the Vinetoram, facilitation of the improvement of the yield and quality of the Vinetoram, and reduction of the production cost of the Vinetoram.

The present application belongs to the technical field of fermented fruit juice, and particularly relates to a method for preparing high-quality probiotic fermented strawberry juice based on magnetic field assistance. The present application first uses Lactobacillus plantarum CTCF-LP-1 to perform static fermentation on the strawberry juice to be fermented in a fermentation device for more than 24 hours, and then places the fermentation device in a static magnetic field. The static magnetic field reduces the generation of organic acid components by Lactobacillus plantarum during the fermentation process of the strawberry juice, reduces the acidity, and improves the fermentation quality of the strawberry juice. The magnetic field strength of the static magnetic field is 1.0-2.5 mT, and the fermentation time in the static magnetic field is 0.5-1.5 h. After the static fermentation and the magnetic field treatment, the content of malic acid, isocitric acid, glutaconic acid and other organic acid components in the fermented strawberry juice is significantly reduced, while the content of alcohol and ester components such as n-octanol, 2-phenylethanol, methyl benzoate, 3-hexyl hexanoate and butyl valerate is increased, the types of aroma components are more abundant, and the taste and quality of the strawberry juice are significantly improved.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of a 3-phenoxy substituted benzofuran compound. In an inert gas environment, a 2-fluorobenzyl phenyl ether compound as shown in a formula 1 and a methyl benzoate compound as shown in a formula 2 are mixed with an organic solvent tetrahydrofuran to react in the presence of bis (trimethylsilyl) caesium amino, and the 3-phenoxy substituted benzofuran compound as shown in a formula 3 is synthesized under a heating condition. According to the method, the raw materials which are easy to obtain are used, benzofuran is synthesized through a transition-metal-free method, and the method has potential application value in synthesis of active pharmaceutical ingredients.

The application relates to a preparation method of a benzylamine compound and belongs to the field of organic synthesis. The preparation method of the benzylamine compound is as follows: a reaction formula is shown in the description. The application also provides a preparation method of the compound of the above formula (VI). Compared with methyl o-bromomethylbenzoate used in the prior art, methyl o-chloromethylbenzoate used in the application is cheaper, has lower preparation cost, less pollution and is more environment-friendly. Compared with the prior art, the benzylization reaction of the application has higher reaction conversion rate, less dibenzyl impurities, is convenient for product post-treatment and purification, has higher yield, and has better product quality.

The invention relates to the technical field of ceramic substrates, and provides a high-heat-conductivity multilayer ceramic substrate and a preparation method thereof. The high-thermal-conductivity multilayer ceramic substrate comprises the following raw materials in parts by weight: 80-90 parts of aluminum oxide, 10-15 parts of modified silicon carbide, 5-10 parts of a sintering aid, 3-7 parts of a binder, 5-10 parts of a toughening aid and 60-70 parts of water, wherein the modified silicon carbide is obtained by modifying silicon carbide with 2-amino-5-methyl benzoate. According to the technical scheme, the problem of low heat conductivity of the ceramic substrate in the prior art is solved.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of a benzofuran compound. In an inert gas environment, a 2-fluorotoluene compound as shown in a formula 1 and a methyl benzoate compound as shown in a formula 2 are mixed and reacted with an organic solvent methyl tert-butyl ether in the presence of bis (trimethylsilyl) amino cesium and cesium sulfate, and the benzofuran compound as shown in a formula 3 is synthesized under a heating condition. Wherein the methyl benzoate compound as shown in the formula 2 can also be replaced by 2-naphthoic acid methyl ester or 1-naphthoic acid methyl ester. The research develops a benzofuran synthesis strategy without transition metal catalysis. According to the method, on the basis of commercially available raw materials, the construction of a benzofuran skeleton is realized through a simple and efficient path. Due to the mild and green reaction characteristic, a route with practical value is provided for synthesis of active medicine molecules and key intermediates of the active medicine molecules.

The objective is to provide a fragrance composition that has high reproducibility of the fragrance of forsythia flowers and excellent palatability. [Solution] The forsythia flower fragrance composition comprises (A) methyl salicylate and / or ethyl salicylate, (B) methyl benzoate and / or ethyl benzoate, and (C) linalool and / or limonene, wherein the total content of component (A) and component (B) is 50 to 90% by mass, and the mass ratio (A / B) is 1 to 10.

The application provides a synthesis method and application of an N-phenyl carbazole fluorescent compound for alcohol compound labeling, and belongs to the technical field of fluorescent labeling of organic small-molecule alcohol compounds. The application takes N-phenyl carbazole as a fluorescent parent ring, and imidazole as a reactive group, and the chemical name is 4-(9-carbazole)-benzoylimidazole. The specific preparation method is as follows: (1) reacting carbazole with p-iodobenzoate to obtain 4-(9-carbazolyl)-benzoic acid methyl ester a; (2) reacting a with a potassium hydroxide aqueous solution to obtain 4-(9-carbazolyl)-benzoic acid b; and (3) reacting b with N,N'-carbonyldiimidazole to obtain a target product. The fluorescent labeling reagent can accurately and sensitively label twelve kinds of fatty alcohols, so that the separation and detection of trace fatty alcohols in a complex system can be realized, and the fluorescent labeling and analysis of various fatty alcohols in the research fields of life and food can be carried out, and the application prospect is wide.

The application discloses a compound flower and fruit fragrance type latent fragrance compound, a preparation method and application and an application method, and has the following general formula: wherein R represents or. In the technical scheme, 2-amino methyl benzoate is used as raw material, and two acylated derivatives are prepared through acylation reaction. The two compounds are stable in chemical properties, and can release 2-amino methyl benzoate and phenylacetic acid (cinnamic acid) when pyrolyzed at high temperature, and can be applied to cigarettes as stable fragrance precursors to improve smoke and highlight product characteristics.

The application discloses a preparation method of 1,2-propylenediamine, which comprises the following steps: (1) 2-phenyl-5-methyl-2-oxazoline, ZIF-8 catalyst and liquid ammonia are added into a high-pressure reaction kettle, and after temperature rising, stirring and filtration, benzoyl 1,2-propylenediamine is obtained; (2) the benzoyl 1,2-propylenediamine obtained in the step (1), methanol and an alkali metal catalyst are added into an atmospheric pressure reaction kettle with a reflux device, after temperature rising and stirring, sulfuric acid is added to neutralize the alkali metal catalyst, after neutralization, the mixture is filtered, and the filtrate is subjected to distillation to obtain a mixture of methyl benzoate and 1,2-propylenediamine; (3) the mixture obtained in the step (2) is separated by rectification to obtain 1,2-propylenediamine products. The preparation method can reduce the production cost, the process condition is relatively mild, hydrogen is not needed to participate in the amination reaction, the process safety is higher, the raw material conversion rate is high, close to 100% conversion, the synthesis yield is higher than 90%, the preparation process is efficient and safe.

The invention relates to a separation and detection method of oxopyrrolidine compounds and isomers thereof, and belongs to the technical field of pharmaceutical analysis. The separation and detection method comprises the following steps: adopting a high performance liquid chromatography; cellulose-tri-(4-methyl benzoate), cellulose-tri-(halogenated methyl phenyl carbamate), cellulose-tri-(4-chloro-3-methyl phenyl carbamate), amylose-tri-((s)-alpha-methyl benzyl carbamate) and amylose-tri-(3-(4, 5-dichlorophenyl carbamate) are bonded through covalent bonds, and cellulose-tri-(4-methyl benzoate), cellulose-tri-(halogenated methyl phenyl carbamate), cellulose-tri-(4-chloro-3-methyl phenyl carbamate), cellulose-tri-((S)-alpha-methyl benzyl carbamate) and cellulose-tri-(4-chloro-3-methyl phenyl carbamate) are bonded through covalent bonds. A chromatographic column which takes amylose-tri (3-chloro-4-methylphenylcarbamate) covalently bonded on the surface of silica gel as a filler is a separation chromatographic column; a chromatographic column which takes amylose-tri (3-chloro-4-methylphenylcarbamate) or silica gel covalently bonded on the surface of the silica gel as a filler is a separation chromatographic column; and eluting by taking a mixed solution of normal hexane and ethanol as a mobile phase. The method is high in separation degree, high in sensitivity and good in peak pattern.

The present application relates to the technical field of polyurethane coating, in particular to a waterproof polyurethane composite coating and a preparation process thereof. The preparation process of the waterproof polyurethane composite coating comprises the following steps: preparing quercetin grafted composite filler, preparing modified isophorone diisocyanate solution and preparing polyurethane composite coating. In the present application, polybutylene adipate, dimethylol butyric acid and dibutyltin dilaurate are mixed with the modified isophorone diisocyanate solution to carry out pre-polymerization, then 2-hydroxy-5-substituted long-chain fatty acyloxy methyl benzoate is added to carry out reaction, long-chain fatty acyloxy and methyl benzoate structure are introduced into the polyurethane molecular chain, trimethylolpropane is added to carry out crosslinking reaction, finally, 1,4-butanediol is added as a chain extender to react with the remaining -NCO to prepare the polyurethane composite coating, which can effectively improve the water resistance and adhesion of the polyurethane composite coating.

The invention discloses a method for synthesizing loxapine succinate, which comprises the following steps of: carrying out substitution reaction by using 2-nitrofluorobenzene and 2-hydroxy-4-chloromethyl benzoate as raw materials to generate 5-chloro-2-(2-nitrophenoxy) benzoate; nitryl is reduced, and 5-chloro-2-(2-aminophenoxy) benzoate is generated; the method comprises the following steps: carrying out an intramolecular ring closing reaction to generate 2-chlorodibenzo [b, f] [1, 4] oxazepine-11 (10H)-ketone; 2, 11-dichlorodibenzo [b, f] [1, 4] oxazepine is obtained through a reaction and chlorination; the method comprises the following steps: carrying out a C-N coupling reaction of methyl piperazine to generate 2-chloro-11-(4-methylpiperidine-1-yl) dibenzo [b, f] [1, 4] oxazepine; and salifying with succinic acid to generate the loxapine succinate. The method is easily available in raw materials, simple in process and suitable for large-scale production.

The present application relates to the technical field of corrosion inhibitor, and proposes a thiourea modified imidazoline corrosion inhibitor and a preparation method thereof, which comprises the following components by weight: 40-50 parts of thiourea modified imidazoline, 6-8 parts of isopropyl alcohol, 0.1-0.2 parts of potassium iodide, 10-15 parts of an additive, and 35-40 parts of a solvent; the additive is composed of 2-amino-5-iodobenzoic acid methyl ester and a surfactant. Through the above technical solution, the problem of low corrosion inhibition rate and fast corrosion speed of the thiourea modified imidazoline corrosion inhibitor in the prior art is solved.

This invention relates to the field of seawater desalination technology, specifically to a high-permeability and selective reverse osmosis membrane and its preparation method. The high-permeability and selective reverse osmosis membrane is obtained by sequentially immersing a porous support layer in an aqueous solution and an oil solution for interfacial polymerization, thereby forming a desalination layer on the surface of the porous support layer. This invention increases the compatibility of the water / oil phases by adding N-methylpyrrolidone to the aqueous phase and methyl benzoate to the oil phase, thereby reducing the surface tension of the two phase solutions, promoting the diffusion of amine monomers into the organic phase, and altering the surface morphology and polymer chain aggregation state of the separation layer. This results in a higher roughness and cross-linking degree of the desalination layer, and improved permeability and selectivity.

The invention belongs to the technical field of battery electrolyte, and particularly relates to nicotinamide-containing aqueous zinc ion battery electrolyte, a battery and a preparation method. The aqueous zinc ion battery electrolyte provided by the invention comprises the following components: a solvent, zinc salt, nicotinamide and 3-(1, 2, 4-triazole-1-yl) methyl benzoate. Nicotinamide is enriched on an anode / electrolyte interface through chemical adsorption, so that by-product deposition is blocked, dendritic crystals are inhibited, zinc nucleation overpotential is remarkably reduced, uniform nucleation sites are increased, three-dimensional diffusion growth is induced, (002) crystal face dominated compact zinc deposition is realized, and polarization voltage is remarkably reduced. And the 3-(1, 2, 4-triazole-1-yl) methyl benzoate preferentially reacts with water to passivate the reaction activity of the water and further inhibit the side reaction in the aqueous electrolyte. By virtue of the synergistic mechanism, the electrolyte endows the aqueous zinc ion battery with high specific capacity and excellent cycling stability.

The present application relates to a kind of preparation methods of 3,4-dihydroxy-5-methoxybenzoic acid methyl ester, with gallic acid as raw material, it is reacted with trimethyl orthoformate or trimethyl orthoacetate, trimethyl orthoformate or trimethyl orthoacetate can realize the protection of adjacent diphenol hydroxyl on one hand, on the other hand, carboxyl esterification and 5-hydroxyl are methylated, form the methyl ester of 5-phenolic hydroxyl methylation and 3,4-orthoester protection benzoic acid shown in formula 1a or formula 1b, further by acidic solution treatment, deprotection is carried out, and the target product 3,4-dihydroxy-5-methoxybenzoic acid methyl ester is prepared.The preparation method is mild in reaction condition, process is simple, easy to operate, product yield and purity are high, solve the wastewater problem in borax protection method, and avoid using toxic dimethyl sulfate for methylation, process condition is simple, easy to operate, convenient for industrialization, with very high application value.

The invention discloses a high and low temperature resistant coal-pitch-containing asphalt mixture and a preparation method thereof, and relates to the field of asphalt mixtures, the high and low temperature resistant coal-pitch-containing asphalt mixture comprises the following raw materials by weight: 20-25 parts of modified coal pitch, 40-45 parts of gravel, 10-15 parts of an auxiliary agent, and 8-10 parts of mineral powder. The modified coal pitch is obtained by modifying coal pitch through modified SBS (styrene butadiene styrene), and the modified SBS is obtained by grafting SBS and a reaction product of 5-amino-2-hydroxycycloheptyl-2, 4, 6-triene-1-ketone, 3-hydroxy-5-nitrothiophene-2-carboxylic acid methyl ester, 4-acetyl-3-nitrobenzoic acid methyl ester and the like. The auxiliary agent is an epoxy group-containing expanded graphite-glass fiber grafted product obtained by reaction of expanded graphite, glass fiber and the like. And the modified coal pitch and the auxiliary agent are combined for use, so that the interface bonding force between the modified coal pitch and the glass fibers and the expanded graphite is enhanced, and the asphalt mixture is endowed with relatively strong high and low temperature resistance, flame retardance, smoke suppression and aging resistance.

The invention relates to a Cu-Zn-Zr catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, mixing a copper source, a zinc source, a zirconium source, an alkaline precipitator and water to obtain precipitation slurry; and S2, carrying out aging treatment and roasting treatment on the precipitation slurry. According to the Cu-Zn-Zr catalyst provided by the invention, benzyl alcohol can be generated through one-step selective hydrogenation of methyl benzoate, and the Cu-Zn-Zr catalyst has relatively high conversion rate of methyl benzoate and selectivity of benzyl alcohol.

The invention relates to the technical field of material detection, in particular to a rapid characterization method of an OCA light curing rate. According to the rapid characterization method for the light curing rate of the OCA, the light curing rate of the OCA can be dynamically monitored by testing the content and the change rate of the photoinitiator 651, the free radical quenching product benzophenone and the methyl benzoate in an OCA system and combining the conversion rate of monomers; in addition, a photocuring end point can be further obtained, and the optimal curing time is obtained. According to the method, by monitoring byproducts generated by free radical self-quenching, rapid and high-sensitivity characterization of the whole curing reaction process can be achieved, and the method does not need to use an organic solvent and is safe and environmentally friendly.

The invention discloses a preparation method of movabearing and an intermediate thereof, and belongs to the technical field of medicine preparation, and the method comprises the following steps: taking 3-halogenated methyl benzoic acid or 3-halogenated methyl benzoate as a starting material to react to prepare a key intermediate, and then removing a substituent group and a nitrogen protecting group of the intermediate to obtain movabearing; the trimer intermediate is synthesized from cheap raw materials and then coupled with a high-price intermediate, the process route is short, the yield is high, the total cost is reduced, and the whole process is mild in reaction condition, simple in post-treatment and more suitable for industrial production; the yield of the prepared movabearing reaches 47%, and the purity of the prepared movabearing reaches 99% or above.

This invention relates to the fields of fine chemicals and polymer materials technology, specifically a method for manufacturing toy adhesives. It includes steps for preparing the adhesive base material, preparing borax solution, and cross-linking molding. Polyvinyl alcohol, guar gum, methylparaben, etc., are prepared as base materials, which are then reacted with borax solution to undergo a cross-linking reaction. The core of this invention is the strict limitation of specific high-temperature ranges and constant-temperature stirring times during the base material preparation process, which promotes the complete extension and entanglement of molecular chains, constructing a dense and uniform three-dimensional network structure. This invention effectively avoids microscopic particle residue and stress concentration, achieving a significant improvement in the tensile strength, elongation at break, and resilience of the toy adhesive.

The application provides an A,A'-dihydroxynaphthaldehyde hydrazone functionalized conjugated pillar[5]arene and a synthesis method thereof. First, a di-m-benzoic acid methyl ester functionalized conjugated pillar[5]arene and hydrazine hydrate are used as substrates to react in anhydrous ethanol solvent to obtain a di-m-benzoic acid hydrazine functionalized conjugated pillar[5]arene; then the di-m-benzoic acid hydrazine functionalized conjugated pillar[5]arene and 2-hydroxy-1-naphthaldehyde are used as substrates to react in anhydrous methanol to obtain the A,A'-dihydroxynaphthaldehyde hydrazone functionalized conjugated pillar[5]arene HGP5. The sensor molecule HGP5 in the application can detect Arg in a "colorimetric fluorescence" dual-channel mode, and can also detect Al 3+ in a super-sensitive mode under fluorescence. In addition, the chemical sensor has potential application in cell imaging, and can detect Al 3+ and Arg in cells. The application provides a new idea for developing a novel supramolecular fluorescent material for detecting Arg and Al 3+ in an aqueous solution.

The invention belongs to the technical field of lignin depolymerization catalysts, and particularly relates to a vanadium salt and carbon-based composite lignin depolymerization catalyst and application thereof. The vanadium salt and carbon-based composite lignin depolymerization catalyst comprises vanadium salt and a carbon base. Wherein the mass ratio of the vanadium salt to the carbon base is (3.7-12.5): 40. The vanadium salt is any one of vanadium acetylacetonate, vanadyl acetylacetonate, vanadyl sulfate, vanadyl oxalate, vanadyl triisopropoxide and ammonium metavanadate. The carbon base is biochar or activated carbon. According to the vanadium salt and carbon-based lignin depolymerization catalyst, under the synergistic effect of vanadium salt and activated carbon, the conversion rate of 2-phenoxy-1-phenethyl alcohol reaches up to 100%, the yield of phenol reaches up to 68%, the yield of methyl benzoate reaches up to 77%, and the catalyst has high lignin depolymerization catalytic activity and can efficiently catalyze the lignin depolymerization reaction.

The application belongs to the field of organic synthesis, and particularly relates to a synthesis method of diaryl acetylene. A toluene compound shown in formula 1 and a methyl benzoate compound shown in formula 2 are mixed with an organic solvent (toluene or dimethyl tetrahydrofuran) in the presence of a strong base (lithium bis(trimethylsilyl)amide), a cesium salt additive (cesium fluoride), an amidine additive (DBU) and an activating agent (Nf-F), and then reacted to synthesize the diaryl acetylene shown in formula 3. The raw material used in the application is simple and easy to obtain, a one-pot synthesis method of the diaryl acetylene is constructed, and the application has the advantages of simple synthesis method, economy, environmental protection and wide application range.

The invention relates to an application of a deep-eutectic solvent in catalyzing a reaction of benzoic acid and methanol to synthesize methyl benzoate, and discloses a method for catalytically synthesizing methyl benzoate by using a choline chloride deep-eutectic solvent. The corresponding eutectic solvent can be prepared by mixing choline chloride and p-toluenesulfonic acid according to a certain proportion, heating and stirring. Mixing the prepared eutectic solvent with benzoic acid and methanol, and heating and stirring at a certain temperature to perform esterification reaction; after the reaction is finished, methyl benzoate can be obtained through the processes of liquid separation, evaporation and the like, and meanwhile, the recycled eutectic solvent can also be obtained. Compared with corresponding traditional inorganic acid catalytic esterification, the method has the great advantages of being small in equipment corrosion degree, simple in technological process, capable of saving cost, recyclable in catalyst, high in environment friendliness and the like, can be used for large-scale industrial production of methyl benzoate and has certain commercial value.

The invention discloses a method and a process device for preparing acetic acid through catalysis of methyl acetate, and in a reaction system containing a catalyst, the methyl acetate is contacted and reacted with carbon monoxide and water to prepare the acetic acid; the catalyst contains an active element M, and M is Rh and / or Ir. According to the method, methyl acetate reacts with carbon monoxide and water under metal catalysis under the action of an Rh or Ir catalyst to be converted into acetic acid and corresponding acid. Different from a traditional concentrated sulfuric acid or benzenesulfonic acid resin catalyzed methyl acetate hydrolysis catalytic reaction process, the invention creatively provides a method for converting methyl acetate into acetic acid in a high-activity and high-selectivity manner through reaction of metal catalyzed methyl acetate with carbon monoxide and water under the action of an Rh or Ir catalyst; the catalytic activity is more than 10 times that of concentrated sulfuric acid or benzenesulfonic acid resin for catalyzing the hydrolysis reaction of methyl acetate to prepare acetic acid, and the method can also be applied to other methyl ester compounds, such as methyl formate, methyl propionate, methyl butyrate and methyl benzoate.

The invention provides a preparation method of 3-cyanomethyl-5-methyl benzamide, and belongs to the technical field of medicine preparation.The preparation method comprises the steps that 5-methyl isophthalic acid serves as a raw material, 5-methyl isophthalic acid diester is prepared through a double-esterification reaction, then 3-hydroxymethyl-5-methyl benzoate is obtained through a selective reduction reaction, and the 3-cyanomethyl-5-methyl benzamide is obtained. The preparation method comprises the following steps: taking 3-hydroxymethyl-5-methylbenzoic acid as a raw material, carrying out hydrolysis to obtain 3-hydroxymethyl-5-methylbenzoic acid, then carrying out a hydroxymethyl substitution reaction, carrying out amidation to obtain 3-substituted methyl-5-methylbenzamide, and finally carrying out a cyanation reaction to obtain the target product 3-cyanomethyl-5-methylbenzamide. The preparation method disclosed by the invention is simple in process, easy to operate, milder in reaction and high in overall product yield, has the characteristics of economy and environmental protection, and has relatively high industrial production and commercial application prospects.

The application discloses a kind of 4-methyl 4-hydroxybenzoate organic single crystals and preparation method and application thereof, and relates to the technical field of organic crystal.The method comprises uniformly dispersing 4-methyl 4-hydroxybenzoate polycrystal material in acetone, then removing impurities and insoluble substances by filtration to obtain a filtered solution;the filtered solution is placed at 0-5℃ for 12-48 hours to obtain 4-methyl 4-hydroxybenzoate organic single crystals.The application effectively overcomes the problems of poor crystalline quality, small crystal size, complex process and high equipment requirement in the growth of existing 4MHB crystals by combining low-temperature solvent evaporation method with low-temperature seed crystal method, thereby realizing the growth of large-size and high-quality 4MHB single crystals.