12 results about "Oxazepine" patented technology

This invention relates to novel compounds structurally derived from 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine and their synthesis. Comparative studies have shown that the compounds of this invention bind to and activate potassium channels, particularly Slack. Based on their activating activity, the compounds of this invention and pharmaceutical compositions containing them can be used in a variety of therapeutic applications for the treatment or prevention of disease conditions.

To provide pyrido[2,3-b] [1,4] oxazine or tetrahydropyrido[2,3-b][1,4] oxazepine derivatives as antagonists of IAPs.SOLUTION: Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b ][1,4] oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives used as antagonists of IAPs (Inhibitors Apoptosis Proteins), also known as Smac mimetics. Disclosed herein is the use of these antagonists for inducing or sensitizing cells to the induction of apoptotic cell death, and the use of such compounds for treating proliferative disease such as cancer.SELECTED DRAWING: None

To provide a new compound useful for treatment, prevention and / or diagnosis of seizure or the like in diseases accompanied by epileptic seizure or convulsive seizure (including multidrug-resistant seizure, intractable seizure, acute symptomatic seizure, febrile seizure and status epilepticus).SOLUTION: There are provided a compound represented by formula [I] and a salt thereof. Ring C is selected from pyridazine, pyrimidine, indole, pyrrolopyridine, indazole, pyrazolopyridine, imidazopyridine, imidazopyrazine, imidazopyridazine, triazolopyridine, pyrazolopyrimidine, imidazopyrimidine, triazolopyrimidine, isoquinoline, naphthyridine, quinazoline, quinoxaline, benzodioxole, oxazine, oxazepine, benzothiazole, and triazolopyridazine, with the proviso that pyrimidine-2, 4-dione and dihydropyrimidine-2, 4-dione are excluded.SELECTED DRAWING: None

The present disclosure relates in some aspects to compositions, such as pharmaceutical compositions for topical administration, which are useful for treating or preventing hair loss, hair graying, and dermatological conditions in a subject, such as comprising a substituted diazepine, for example olanzapine. Also provided are kits comprising the compositions, and methods of using the compositions for treating or preventing hair loss, hair graying, and dermatological conditions.

The application belongs to the technical field of chemical medicine preparation, and particularly relates to a 12-aryl-11H-benzo[b]indeno[1,2-e][1,4]oxazepine compound and a preparation method and application thereof. The structure of the compound is shown as formula I. The preparation method of the application is as follows: under a protective gas atmosphere, a compound with a structure of formula II and a compound with a structure of formula III are used as reaction substrates, a solvent, an oxidant and an additive are added, and heating reaction is carried out, and the compound is obtained. The compound provided by the application has significant biological activity and application function, can be applied to preparation of medicines for preventing or treating cancers, such as ovarian cancer, nasopharyngeal cancer and colon cancer, and the preparation method of the application is simple in operation, wide in substrate applicability, can be used for amplification reaction of a gram scale, and has a broad market prospect. Formula I.

To provide compounds for therapeutically and / or prophylactically treating cancers containing KrasG12D mutations.SOLUTION: Provided is a compound represented by the following formula (I) or a stereoisomer, an atropisomer, a tautomer or a pharmaceutically acceptable salt thereof: Wherein X is O or NR6, m and n are 1 or 2, and R5 is independently halogen, oxo, unsubstituted C1-3 alkyl or unsubstituted C1-3 haloalkyl; or two R5 taken together form a bridge between two carbons of ring A, the bridge comprising 1 to 3 carbons and optionally 1 heteroatom selected from O and N.SELECTED DRAWING: None

Polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizine-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (compounds of chemical formula (I)), pharmaceutical compositions thereof, and methods of using them, for example, in the treatment of cancer are provided herein. A synthesis process for the preparation of a compound of formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizine-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline) is also provided herein. Compounds useful for the synthesis thereof (e.g., compounds of formulas (A), (B), (By), and (H)) and a synthesis process relating thereto are also provided.

Provided herein are oxazepinyl compounds comprising a 6-aza moiety that are useful in the treatment of cancers.

This specification discloses a method for treating a subject having an autoimmune or inflammatory disease, and a related formulation comprising administering to the patient a compound of (S)-5-benzyl-N-(7-(3-hydroxy-3-methylbuta-1-in-1-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepine-3-yl)-1H-1,2,4-triazole-3-carboxamide, or a pharmaceutically acceptable salt thereof, wherein the compound or pharmaceutically acceptable salt is administered in doses of approximately 12.5 mg to approximately 125 mg of the free base equivalent of the compound per dose, and related formulations.

Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives used as antagonists of IAPs (Inhibitors Apoptosis Proteins), also known as Smac mimetics. Disclosed herein is the use of these antagonists for inducing or sensitizing cells to the induction of apoptotic cell death, and the use of such compounds for treating proliferative disease such as cancer.