Polysubstituted benzo[b][1,4] oxazepine derivative and preparation method thereof

Abstract

The invention discloses a polysubstituted benzo[b][1,4] oxazepine derivative and a preparation method thereof. The polysubstituted benzo[b][1,4] oxazepine derivative has the structural formula as shown in the description. The benzo[b][1,4] oxazepine derivative with multiple substituents, which cannot be synthesized by other methods, is synthesized, and profound and lasting significance is achieved from the angle of medical chemistry; the method has the advantages of easily available raw materials, high yield, mild reaction conditions, short reaction time, wide substrate range, strong reaction specificity, simple post-treatment and greenness.

Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and specifically relates to a multi-substituted benzo[b][1,4]oxazepine derivative and a preparation method thereof. Background technique

[0002] [1,4] Oxazepine compounds are a class of pharmaceutical molecules with various biological activities, and have important application value in anti-tumor, anti-depression, anti-inflammatory and anti-HIV drugs. Therefore, the research on new synthesis methods of [1,4]oxazepine compounds and their analogues has important application value and has attracted the attention of researchers in related fields.

[0003] The research on the synthesis of traditional [1,4]oxazepine compounds mainly focuses on dibenzoxazepine compounds, while the synthesis of monobenzoxazepine compounds, especially multi-substituted benzo[b][1 ,4] The synthesis of oxazepine derivatives is rarely reported. Based on the wide range of biological activities of [1,4]oxazepine c...

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