129results about How to "Strong response specificity" patented technology

The invention belongs to the technical field of organic synthesis, and particularly relates to application of a cyclopalladated ferrocenylimines-phosphine adduct in the synthesis of a cyclopropyl alkyl aromatic compound. Halogenated aromatic hydrocarbon Aryl-X, alkali and cyclopropyl borate which serve as raw materials, and the cyclopalladated ferrocenylimines-phosphine adduct is used as a catalyst. The catalyst has high stability, efficient catalytic activity and wide application range, and a corresponding coupling product can be synthesized in a mode of high yield (which is up to 96 percent) on the premise of small catalytic quantity; and the method is mild in reaction condition, wide in range of substrates and high in specifity of reaction.

The invention provides a novel bacterial strain-Yokenella sp. WZY002 and an application thereof in preparing alpha, beta-unsaturated olefine aldehyde (ketone) through regioselective reduction and aromatic alcohol through aromatic aldehyde (ketone) reduction. The bacterial strain is preserved in the China general microbiological culture collection center (CCTCC); the address is 430072, Wuhan University, Wuhan, China; the preservation number is CCTCC No: M2013099; the preservation date is March 22, 2013. The novel bacterial strain has the main beneficial effects of high regioselectivity, high stereoselectivity and high enzymatic activity, regioselective reduction of the alpha, beta-unsaturated enol is catalyzed so as to obtain various alpha, beta-unsaturated olefine aldehydes, and reduction of the aromatic aldehyde (ketone) can also be catalyze so as to obtain the aromatic alcohol. The bacterial strain is served as a biocatalyst and has high regioselectivity, high stereoselectivity and strong catalytic activity, the catalytic reaction does not need to add coenzyme, the reaction temperature is moderate, and the novel bacterial strain has a relatively high application value for industrial production.

The invention discloses a preparation method of an N-(2-pyridyl/pyrimidyl)indole derivative. The preparation method of the N-(2-pyridyl/pyrimidyl)indole derivative comprises the following steps: mixing a 2-substituted phenylaminopyridine/pyrimidine derivative, an alkenyl azide compound, a catalyst, an oxidizing agent, alkali and an organic solvent uniformly, heating to 60 to 80 DEG C under nitrogen or air, performing a cyclization reaction for 18 to 24 hours, cooling to room temperature after the reaction, and performing concentration and column chromatographic purification to obtain the N-(2-pyridyl/pyrimidyl)indole derivative. By the preparation method, the N-(2-pyridyl/pyrimidyl)indole derivative with various substituent groups which cannot be synthesized according to other methods canbe synthesized; furthermore, the used raw materials are easily available, the yield is high, the reaction condition is mild, the reaction time is short, the substrate range is wide, the reaction specificity is high and aftertreatment is simple, convenient and green.

A method for synthesizing natural alpha-tocopherol succinic acid monoester using lipase pertains to the field of biological chemicals, which is characterized in that the preparation method includes: adding the substrate of natural alpha-tocopherol and succinic anhydride at molar ratio of 1:1-1:8 in an organic solvent, adding lipase to start the reaction, oscillating or mixing reaction 20-72 hours under the conditions of 20-45 DEG C, wherein, the conversion rate of the alpha-tocopherol is 80-98.39%. Compared with the prior industry process in which esterification is performed at high-temperature by using high toxicity chemical catalyst under, the method has advantages of mild reaction conditions (room temperature, atmospheric pressure), low energy consumption, non-toxic catalyst, specificity, high reaction efficiency fewer accessory substances, and the like.

The invention belongs to the technical field of deep processing of garlic and particularly relates to a process method and a preparation method for synthesizing ajoene from allicin. The process method comprises the steps of extracting allinase, purifying allinase, immobilizing allinase, preparing allicin, synthesizing ajoene, and purifying ajoene. According to the process method, allinase is immobilized by virtue of an enzyme immobilization method and is converted into allicin through catalysis in a bioreactor, the reaction specificity is good, the catalytic efficiency is high, and a high-purity allicin product can be obtained; by aiming at characteristics of cleavage reaction of allicin, allicin is complexed by virtue of a hydrophilous complex in a complex catalysis reaction manner, so that the stability of allicin is improved; allicin is decomplexed in a reaction process and can timely react so as to generate ajoene, so that a large number of side reactions are avoided.

The invention discloses 8, 9-dihydrocannabidiol as well as a synthesis method and an application thereof, and belongs to the field of organic synthesis. According to the invention, alpha-phellandrene and olive alcohol are taken as substrates, and under the action of a Lewis acid catalyst, 8, 9-dihydrocannabidiol is obtained through reaction. The raw materials are cheap, the used catalyst is cheap and easy to separate (filter removal), the usage amount is small (0.9% of the mass of reactants), the catalyst is mild (Lewis acid), the yield is high (90%), the industrialization cost is greatly reduced, and the operation is simple.

The invention belongs to the technical field of organic synthesis, and in particular relates to an application of a cyclopalladated ferrocenylimine-phosphine adduct in synthesis of an asymmetric biaryl compound. In synthesis of the asymmetric biaryl compound, the cyclopalladated ferrocenylimine-phosphine adduct is utilized as a catalyst, and the catalyst has the advantages of good stability, efficient catalytic activity and wide applicability; and by utilizing the catalyst, a corresponding coupling product with high yield (up to 95%) can be obtained on the premise of smaller catalytic amount, and the synthesis process has the characteristics of mild reaction conditions, wide substrate range and strong reaction specificity.

The invention provides a method for synthesizing grafted lysine viscose fibers and belongs to the technical field of modification of fiber materials. According to the method, commercially available viscose fibers and lysine are taken as raw materials, and the grafted lysine viscose fibers with good skin-friendly property, antibacterial property and dyeing property can be prepared stably through steps as follows: preparation of purified viscose fibers, preparation of carboxylated viscose fibers, preparation of ethylene glycol non-aqueous reaction media, preparation of the grafted lysine viscosefibers and preparation of purified ethylene glycol. The carboxylated viscose fibers and the grafted lysine viscose fibers are produced under catalysis of glucose oxidase and protease in sequence, thegrafted lysine viscose fibers are prepared in the ethylene glycol non-aqueous reaction media, reaction conditions are mild, reaction specificity and reaction efficiency are high, no by-products or three wastes are produced, and the method is a typical green production technology; the grafted lysine viscose fibers synthesized with the method are covered with amino acid, can be widely applied to the fields such as textiles, clothes, food and the like and have great social value and economic benefits.

The invention discloses a dendrimer with an alkynyl core and an outer amino acid shell, and a Huisgen 1,3-dipolar cycloaddition synthetic method and application thereof. In the preparation process of the dendrimer, 0.5-G, 1.5-G, 2.5-G or 3.5-G dendrimer molecules with an outer azido shell are synthesized; the dendrimer molecules and ascorbic acid/copper sulfate composing a catalytic system are added into alkynylated tertbutyloxycarbonyl-amino acid dissolved in DMF, so that the dendrimer molecules with the outer azido shell and ethynylated amino acids are bonded together through Huisgen 1,3-dipolar cycloaddition; after a reaction at a temperature of 15 to 35 DEG C for 4 to 24 hours, dichloromethane is added to dilute a reaction solution, and then extraction with water is carried out. The invention has the following advantages: reaction specificity is good, reaction efficiency is high, and the outer shell of the dendrimer has a plurality of amino acid ligands, which enables a prepared adsorption material to have better protein separation or blood purification effects compared with common adsorption materials with a space arm as a single active site.

The invention provides a novel bacterial strain - Rhodococcus erythropolis WZ010 and application thereof in selectively oxidizing racemic aromatic alcohol to prepare R-aromatic alcohol and asymmetrically reducing aromatic ketone to produce S-aromatic alcohol. The bacterial strain is preserved in China Center for Type Culture Collection, Wuhan University, Wuhan, China, the postcode is 430072, the preservation number is CCTCC No: M2011336, and the preservation date is 29 September, 2011. The invention mainly has the advantages that: the invention provides the novel bacterial strain with high stereoselectivity and high enzymatic activity, the R-aromatic alcohol and the S-aromatic alcohol can be obtained at the same time by selective oxidation and asymmetric reduction with the bacterial strain, the reaction specificity and catalytic activity of the bacterial strain are high, the production cost is greatly reduced, moreover, environment pollution is little, and the bacterial strain is suitable for industrialized production.

This invention discloses a method for preparing carnosine analog. The method uses enzyme as the catalyst, and does not need group protection or condensation agent during the reaction, thus having such advantages as simple process, mild reaction conditions, easy operation, complete utilization of resources, no pollution and low cost. The prepared canosine analog has high purity (93.5-95.5%), good quality and strong antioxidative effect, and can be used as antioxidative active substances in medicine, food, health product, cosmetic and feed.

The invention provides an etimicin sulfate preparation method. The method comprises the following steps: taking gentamycin C1a base, dissolving the gentamycin C1a base in a certain proportion of a solvent, adding a certain proportion of a complexing agent to complex, adding a certain proportion of an amino group protection agent, keeping for a certain time, adding a certain proportion of a precipitating agent, stirring above materials, filtering the obtained mixture, adding a certain proportion of an acetylation reagent to the above obtained filtrate, reacting for a certain time, adding a certain proportion of a reducing agent, reacting for a certain time, removing an amino protection group, adding a certain proportion of water, carring out vacuum concentration under certain conditions to remove the solvent, adjusting the pH value with ammonia water, adsorbing with macro-porous resin, carrying out gradient separating purification with diluted ethanol, collecting an etimicin solution with a certain purity, carrying out vacuum concentration under certain conditions, adding sulfuric acid to adjust the pH value, adding a certain proportion of active carbon, decolorizing, filtering, and drying to obtain etimicin sulfate according with relevant standards.

The invention discloses a synthetic method of a doxylamine succinate intermediate, which is characterized by comprising the following steps of: A, 2-pyridine-phenyl methyl methanol synthesis: dissolving acetophenone into methyl tertiary butyl ether, adding a catalyst, then agitating and dropwise adding a Grignard reagent, and obtaining a target product, i.e. 2- pyridine-phenyl methyl methanol after separation and desolvation; and B, 2-pyridine-phenyl methyl methanol purification: dissolving the 2-pyridine-phenyl methyl methanol in the step A into methanol, dropwise adding acetone slowly into solution till a large amount of 2-pyridine-phenyl methyl methanol is crystallized and separated out. The invention aims to overcome the defects in the prior art and provides the synthetic method of the doxylamine succinate intermediate, which has the advantages of simple, safe and reliable process, high efficiency and low production cost.

The invention discloses a preparation method of a trans-trisubstituted alkene derivative. The preparation method comprises following steps: 1, an alkali, an alkyne, a palladium catalyst, a ligand, a halogenated aromatic hydrocarbon, a precursor compound, and an organic solvent are introduced into a reaction container, nitrogen gas is adopted for repeat filling, and reaction is carried out for 12 to 36h at 60 to 140 DEG C; 2, a product obtained in step 1 is diluted with Ethyl Acetate, is washed with water, and is separated so as to obtain an organic phase; and 3, the organic phase obtained in step 2 is subjected to drying, filtering, concentrating, and column chromatography or thin-layer chromatography processing so as to obtain the trans-trisubstituted alkene derivative. According to the preparation method, construction of one carbon boron bond is realized in construction of the trans-tri aromatic hydrocarbon-substituted alkenes, excellent zone selectivity is achieved, and the trans-trisubstituted alkene derivative which is not easily synthesized using other methods is synthesized.

This invention discloses a 6alpha-methylprednisolone and production method of its derivate. This invention uses cortisone acetate and its derivate as raw material to produce 6alpha-methylprednisolone and its derivate. Its production method includes steps such as: lead-in methenyl at sixth position, methenyl is transformed to alpha-methyl, 1,2 position is dehydrogenated to 6alpha-methyl prednisoni acetasby by method of arthrobacterium biotransformation, then selectively hydrogenise 11-ketone to 11 beta-hydroxy group. Using this invention can obtain higher 6alpha-methylprednisolone and yield and quality of its derivate. This invention has characteristics such as: position specificity is high, yield is high. It has important significance for preparing steroid medicine.

The invention discloses a method for preparing L-(+)-lactic acid, relates to an enzyme method for synthesizing the lactic acid, and is a technology for producing the L-(+)-lactic acid by catalyzing asymmetric hydrolytic ethyl lactate in the enzyme method in an organic phase. The method has the steps that the ethyl lactate and water are taken to be added into a reactor, and then organic solvent and lipase catalyst are added, wherein, the materials has the compounding ratio that the mass ratio of the ethyl lactate and the water is 3 to 15:1, the dosage of the lipase catalyst is 0.4 to 1 percent of the mass of the ethyl lactate, and the volume of the water is 1 to 10 percent of the volume of the organic solvent. After being sealed, the reactor is put into a thermostat water bath shaker, the number of revolution of the shaker is 220 to 50 revolution/minute, the reaction temperature is 30 to 70 DEG C, the reaction time is 3 to 28 hours, and after the reaction is finished, the product, namely, the L-(+)-lactic acid can be obtained by distilling the molecules of the resultant. The invention has simple method for preparing the L-(+)-lactic acid, the reaction condition is mild and the environmental pollution is small; the stereo selectivity of the obtained product is high, the ee value of the L-(+)-lactic acid is 50 to 94 percent, and the yield rate thereof is 10 to 40 percent.