Polysubstituted pyridine derivative and preparation method thereof

A derivative and multi-substitution technology, applied in the field of multi-substituted pyridine derivatives and their preparation, can solve the problems of difficulty in synthesizing multi-substituted pyridine derivatives, difficult preparation of raw materials, limited use and the like, and achieves strong reaction specificity, The effect of post-processing green color and short reaction time
CN104744348AActive Publication Date: 2015-07-01HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2015-07-01

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Abstract

The invention discloses a polysubstituted pyridine derivative and a preparation method thereof. The derivative has a structure as shown in specification, wherein R1, R2, R3, R4 and R5 all are any one selected from hydrogen atom, halogen atom, alkyl, aryl, substituted aryl, acyl, amino, nitryl and alkoxy; the invention also discloses a preparation method of the polysubstituted pyridine derivative; the preparation method comprises the following steps: by taking acetyenic ketone and 1-arylethylamine as raw materials, and under the action of appropriate alkali, heating to have a reaction in the solvent to obtain the polysubstituted pyridine derivative as shown in the formula at high yield. The preparation method is mild in reaction condition, short in reaction time, wide in substrate range, high in reaction specifity, high in yield and simple in after-treatment.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, in particular to multi-substituted pyridine derivatives and a preparation method thereof. Background technique

[0002] Multi-substituted pyridine derivatives are a class of organic synthesis intermediates with a wide range of uses, and have important application values ​​in natural products, pharmaceutical production, organic synthesis, and material science. Therefore, the research on new synthesis methods of multi-substituted pyridines has important application value and has attracted the attention of researchers in related fields.

[0003] The traditional methods for synthesizing pyridine derivatives include the condensation reaction of amine compounds and 1,5-dicarbonyl compounds, and transition metal-catalyzed cyclization coupling reactions. But these methods all have many problems: 1) with 1,5-dicarbonyl compound as raw material, raw material is not easy to prepare, and some 1,5-...

Claims

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