Slow-release composite nanofiber mask with one-way moisturizing and oxidation resistance and preparation method thereof

Abstract

The invention relates to a slow-release composite nanofiber mask with one-way moisturizing and oxidation resistance and a preparation method thereof.The one-way moisturizing nanofiber mask base cloth with asymmetric wettability is obtained through the preparation method, a hydrophilic layer adsorbs a nutrient solution and is dissolved when meeting water, a hydrophobic layer is kept dry, and the effect of delaying liquid volatilization is achieved; the effective time of the mask is prolonged. In addition, the nanofiber mask base cloth obtained through electrostatic spinning has good air permeability.

Description

Technical Field

[0001] The invention belongs to the field of skin care products, and particularly relates to a slow-release composite nanofiber mask with unidirectional moisturizing and antioxidant properties and a preparation method thereof. Background Art

[0002] Driven by the current "appearance economy", my country's skin care market is booming. Among them, facial masks, as an important product for facial care, occupy a prominent position among many skin care products and have a large market share. Relevant data show that my country's facial mask market has broad development prospects, which provides value for in-depth research. However, despite the huge market potential, the market penetration rate of facial mask products in my country still has room for improvement, which means that there are still many opportunities to be explored in this field.

[0003] Currently, more than 80% of facial masks on the market are liquid-based masks, which are usually made of a combination of nonwoven fabrics and liquid essences. However, this traditional facial mask has some disadvantages during use, such as: the active ingredients in the essence are easily ineffective due to deterioration, and there is a risk of adding preservatives; the active ingredients that directly contact the skin surface are difficult to achieve sustained release, which is not conducive to skin absorption; the hydrophilic nature of the mask makes it easy for both sides to absorb the nutrient solution, which not only accelerates the evaporation of the liquid, but may also cause facial moisture loss after long-term use. In addition, the fibers of traditional nonwoven fabrics are rough, the pore size is large, and the fit with the skin is poor, which is also not conducive to the effective absorption of the nutrient solution.

[0004] Electrospinning technology converts polymer solutions or melts into Taylor cone structures with specific shapes under the action of electric field forces. When the electric field force exceeds the surface tension of the polymer, the polymer material forms fine liquid jets through atomization, and these jets are then stretched into nano-scale fibers under the continuous action of the electric field. Electrospinning technology has emerged in the cosmetics industry with its simple equipment structure, low production cost, diversity of applicable materials and high controllability of the production process, and has become a cutting-edge technology for the preparation of solid nanofiber masks. Its advantages include simple manufacturing equipment, low spinning cost, a wide variety of spinnable materials and controllable process. It has become a new material technology for the preparation of solid nanofiber masks in the cosmetics field. The nanofiber mask produced by electrospinning technology not only has high porosity, large specific surface area and high concentration of active substances, but also achieves no need to add preservatives, excellent fit and excellent biocompatibility, providing consumers with a safe and efficient skin care option.

[0005] At present, most of the research on nanofiber masks is about instant nanofiber masks, which are dry masks made by directly preparing water-soluble polymers and active substances through nano-molding technology. The masks can dissolve instantly when they come into contact with water, but there are problems such as too fast release of active substances and lack of sustainability. In addition, nanofiber membranes with non-woven fabrics as the mask base still have the disadvantages of being heavy and thick.

[0006] CN117883320 discloses a preparation method and application of a solid nanofiber mask with Janus structure loaded with Gastrodia elata polysaccharide. The mask comprises hydrophilic fibers spun from GEP / CS / GEL spinning solution and hydrophobic fibers spun from PLA / PVP spinning solution. The Janus structure can delay water loss and improve the moisturizing effect of the mask, but the hydrophilic fiber component dissolves quickly, which is not conducive to the continuous release of the functional substance.

[0007] CN11699934 discloses a nanofiber mask with multi-component sustained-release capability and its preparation method and use method. The nanofiber mask is prepared directly on the face in situ using a two-component portable electrospinning device, taking advantage of the different solubility of polyvinyl alcohol 1799 and polyvinyl butyral, but the use cost is relatively high.

[0008] CN117205115 discloses a composite nanofiber mask with soothing effect and its preparation method. The mask includes a base layer and a composite nanofiber membrane formed on the base layer by coaxial electrospinning technology. The structural characteristics of the shell and core composite fibers prepared by coaxial electrospinning and the difference in hydrophilicity and hydrophobicity between polymers realize the differential release of different active factors. However, degradable non-woven fabric is still used as the supporting layer substrate of the functional membrane, the weight of the mask is relatively large and heavy, and the process cost of the coaxial electrospinning technology is increased.

[0009] Therefore, a sustained-release composite nanofiber mask with asymmetric wettability, moisturizing properties and anti-volatility based on nanofiber membrane has been developed, which can solve the problem of ineffective care of current traditional fiber masks and the defects of existing nanofiber masks. At the same time, it can be used in combination with active factors with different functions to meet people's functional needs for masks. Summary of the invention

[0010] The technical problem to be solved by the present invention is to provide a sustained-release composite nanofiber facial mask with unidirectional moisturizing and antioxidant properties and a preparation method thereof, which can simplify the use process, improve the loading efficiency of active substances, and achieve sustained release, thereby solving the problem that the active ingredients in traditional facial masks are released too quickly and the effect is not lasting.

[0011] The present invention provides a composite nanofiber facial mask, comprising a hydrophobic layer nanofiber membrane and a hydrophilic layer nanofiber membrane; wherein the hydrophobic layer nanofiber membrane is loaded with a second active factor, and the hydrophilic layer nanofiber membrane is loaded with a first active factor.

[0012] Furthermore, a hydrophobic layer nanofiber membrane is prepared on a receiving substrate by electrospinning, and the second active factor is loaded; a hydrophilic layer nanofiber membrane is prepared on the surface of the hydrophobic layer nanofiber membrane away from the receiving substrate by electrospinning, and the first active factor is loaded to form a double-layer composite nanofiber membrane; the receiving substrate is removed, and the double-layer composite nanofiber membrane is dried to obtain the sustained-release composite nanofiber mask with unidirectional moisturizing and antioxidant properties.

[0013] The present invention provides a method for preparing a composite nanofiber facial mask, comprising:

[0014] (1) mixing a high molecular polymer, a second active factor, and a solvent to obtain a hydrophobic electrospinning stock solution, electrospinning, collecting and preparing a hydrophobic layer nanofiber membrane on a receiving substrate, and placing the nanofiber membrane together with the receiving substrate at room temperature for standby use;

[0015] (2) A high molecular polymer, a first active factor and a solvent are mixed to obtain a hydrophilic electrospinning stock solution, and electrospinning is performed and a hydrophobic layer nanofiber membrane is used to receive the hydrophilic layer nanofiber membrane to obtain a composite nanofiber mask.

[0016] Preferably, the high molecular polymer in step (1) includes one or more of polycaprolactone, polylactic acid, nylon 6, polyvinylidene fluoride, and polyurethane; the second active factor is an antioxidant factor; the antioxidant factor includes one or more of niacinamide, vitamin C, ursi, tea polyphenols, and coenzyme Q1; the solvent includes one or more of dichloromethane, N,N-dimethylformamide, tetrahydrofuran, chloroform, and hexafluoroisopropanol.

[0017] Preferably, in step (1), the mass ratio of the high molecular weight polymer, the second active factor and the solvent is (8-15):(0.1-1):100.

[0018] If the content of the second active factor is too low, the performance effect will not be obvious, and if it is too high, it will affect the spinning performance and hydrophobicity; and if the content of the high molecular polymer is too low or too high, it will affect its viscosity and the final spinning performance.

[0019] In the preparation process of the hydrophobic layer nanofiber membrane, the role of the high molecular polymer is to increase the tensile strength and elongation at break of the mask base fabric and enhance the mechanical properties; the introduction of the second active factor can increase the antioxidant properties of the mask, making it more effective. Compared with traditional mask base fabrics, this mask base fabric is lighter, thinner and more breathable.

[0020] Preferably, the mixing in step (1) is followed by stirring for 6 to 10 hours; the electrospinning comprises: a voltage of 12 to 18 kV, a needle specification of 18 to 21 G, a distance between the receiving substrate and the needle of 15 to 20 cm, a spinning speed of 0.8 to 1 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 22 to 25°C, and an environment humidity of 25 to 40% RH.

[0021] Preferably, the receiving substrate is one of a silk mask substrate, a spunlace non-woven fabric, a Tencel non-woven fabric, a biofiber mask substrate, a hydrogel mask substrate, a meltblown non-woven fabric, a chitosan mask substrate, and a release paper.

[0022] Preferably, the high molecular weight polymer in step (2) includes one or more of polyvinyl alcohol, polyethylene glycol, polyvinyl pyrrolidone, and polyethylene oxide; the first active factor is a moisturizing factor; the moisturizing factor includes one or more of sodium alginate, collagen peptide, glycerol, sodium hyaluronate, gelatin, and urea; and the solvent is water, further deionized water.

[0023] Preferably, in step (2), the mass ratio of the high molecular weight polymer, the first active factor and deionized water is (8-20):(1-10):100.

[0024] During the preparation of the hydrophilic layer nanofiber membrane, the function of the first active factor is to retain moisture, and the high molecular polymer can improve the spinnability of the spinning solution, making it better for filament formation. Compared with traditional facial mask base fabrics, this facial mask base fabric has a hydrophobic / hydrophilic double-layer structure, which can achieve unidirectional moisture conduction and stronger water retention. At the same time, the first and second active factors provide differential release over a period of time due to the structural differences of the fiber membranes.

[0025] In the step (2), the mixture is mixed and stirred at room temperature for 4 to 6 hours.

[0026] Preferably, the electrospinning in step (2) includes: a voltage of 12 to 18 kV, a needle specification of 18 to 21 G, a distance between the receiving substrate and the needle of 15 to 20 cm, a spinning speed of 0.1 to 0.4 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 22 to 25 ° C, and an ambient humidity of 25 to 40% RH.

[0027] In the above preparation process of the hydrophobic layer nanofiber membrane and the preparation process of the hydrophilic layer nanofiber membrane, preferably, the electrospinning is completed using a single-needle electrospinning device; the conditions of the electrospinning include: voltage of 12-20kV, needle specification of 18-21G, distance between the receiving substrate and the needle of 10-20cm, spinning speed of 0.1-1mL / h, roller speed of 220rpm, spinning environment temperature of 22-25℃, and ambient humidity of 25-40%RH. In the preparation process of the hydrophobic layer nanofiber membrane and the hydrophilic layer nanofiber membrane, the electrospinning conditions of the two times can be the same or different, and the solvents used can also be the same or different

[0028] Furthermore, in step (2), the hydrophilic electrospinning stock solution is prepared on the surface of the hydrophobic layer nanofiber membrane away from the receiving substrate by an electrospinning device to obtain the hydrophilic layer nanofiber membrane, thereby forming the double-layer composite nanofiber membrane.

[0029] Preferably, in step (2), the hydrophobic layer nanofiber membrane is electrospun and used to receive the hydrophilic layer nanofiber membrane, and the receiving substrate of step (1) is removed and dried, wherein the drying temperature is 40-60° C. and the time is 12-24 hours.

[0030] The hydrophilic layer nanofiber membrane side of the composite nanofiber mask is the skin-contacting side.

[0031] The present invention provides an application of the composite nanofiber mask in the field of cosmetics.

[0032] In the present invention, a hydrophobic layer nanofiber membrane is prepared on a receiving substrate by electrospinning; a hydrophilic layer nanofiber membrane is prepared on the surface of the hydrophobic layer nanofiber membrane away from the receiving substrate by electrospinning to form a double-layer composite nanofiber membrane; the receiving substrate is removed, and the double-layer composite nanofiber membrane is dried to obtain the unidirectional moisturizing nanofiber mask with asymmetric wettability.

[0033] Among them, the double-layer composite nanofiber membrane includes a hydrophilic layer nanofiber membrane and a hydrophobic layer nanofiber membrane, a first active factor loaded on the hydrophilic layer, and a second active factor loaded on the hydrophobic layer; the double-layer membrane provides a phased release of the first active factor and the second active factor over a period of time.

[0034] The mask base fabric obtained by the preparation method is hydrophilic on one side and hydrophobic on the other side. It is a unidirectional moisturizing nanofiber mask with asymmetric wettability. After the preferential rapid release of the first active factor, it improves the skin's hydration state, keeps the skin hydrated, opens the skin's absorption channel, and is conducive to the second active molecule to smoothly enter the deep skin and achieve full absorption, thereby achieving the effect of slowly releasing the active factor, and synergistically promoting the realization of moisturizing and antioxidant effects.

[0035] The preparation process of the invention is simple, the raw materials are easily available, it is non-toxic and environmentally friendly, and the cost is low, thus solving several key problems existing in the current commercial facial mask base fabrics.

[0036] The present invention provides a double-layer nanofiber mask with asymmetric wettability, which uses a nanofiber membrane as a self-supporting skeleton to reduce transportation costs. The mask prepared by the present invention has hydrophilicity on one side, which can absorb and retain nutrient solution, directly act on facial skin, and exert its expected skin care effect; while the other side has hydrophobicity, facing the external environment, which not only helps to maintain the support state of the mask and reduce the overall weight, but also effectively controls the release rate of effective ingredients and slows down the evaporation of water in the hydrophilic layer. Through this innovative design, the mask of the present invention can provide a more lasting and effective skin care experience while maintaining the stability of active ingredients, meeting consumers' expectations for high-quality skin care products.

[0037] Beneficial Effects

[0038] The hydrophilic layer nanofiber membrane in the double-layer composite nanofiber mask obtained by the present invention dissolves and can quickly release the first active ingredient, the moisturizing factor, so that the facial skin is moisturized; while the hydrophobic layer nanofiber membrane does not dissolve in water and can relatively slowly release the second active factor, the antioxidant factor, and at the same time has a supporting effect, which can prevent the nutrient solution from slipping during use and causing the loss of nutrients.

[0039] Another aspect of the present invention provides a unidirectional moisturizing nanofiber mask base fabric with asymmetric wettability obtained by the above preparation method, wherein the hydrophilic layer absorbs the nutrient solution and dissolves in water, while the hydrophobic layer remains dry, which plays a role in delaying the volatilization of the liquid and prolonging the effective time of the mask. In addition, the nanofiber mask base fabric obtained by electrospinning has good air permeability.

[0040] The double-layer composite nanofiber membrane of the present invention is a unidirectional moisturizing nanofiber membrane with a Janus structure, one side is hydrophobic and the other side is hydrophilic. At the same time, the double-layer composite nanofiber membrane provides a phased release of the first active factor and the second active factor over a period of time. The innovation of this facial mask lies in that the structural characteristics of the double-layer membrane prepared by electrospinning and the difference in hydrophilicity and hydrophobicity of the polymer material achieve the unidirectional moisture retention and orderly phased release of the active factors of the facial mask. This design not only promotes the effective skin absorption of the active factors, but also its hydrophilic layer can adsorb and retain the nutrient solution and directly act on the skin surface; while the hydrophobic layer helps to maintain the support state of the membrane and reduce the volatilization of the nutrient solution. This design reduces the amount of nutrient solution used while ensuring that the facial skin is always in an environment rich in nutrient solution, thereby significantly improving the moisturizing and anti-oxidation effects of the facial mask. The present invention provides a new technical solution and application prospect in the field of solid facial mask technology. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 (a-b) are scanning electron microscope images of the hydrophobic layer in the facial mask base fabric obtained in Example 1 of the present invention;

[0042] Figure 2 (a-b) are scanning electron microscope images of the hydrophilic layer in the facial mask base fabric obtained in Example 1 of the present invention;

[0043] Figure 3 (a-b) are electron microscope images of the double-layer nanofiber mask in Example 1 of the present invention;

[0044] Figure 4 (a-b) are photos of contact angles of the hydrophobic layer and the hydrophilic layer in the facial mask base fabric obtained in Example 1 of the present invention;

[0045] Figure 5 This is the stretching / breaking curve of the double-layer nanofiber mask obtained in Example 2 of the present invention;

[0046] Figure 6 This is a quality comparison chart of the double-layer nanofiber facial mask obtained in Example 2 of the present invention and the traditional commercial facial mask on the market;

[0047] Figure 7 (a-f) are photos of the use process of the double-layer nanofiber mask obtained in Example 2 of the present invention;

[0048] Figure 8 This is a graph showing the change trend of the concentration of the functional substance in water with the immersion time in Example 2 of the present invention. DETAILED DESCRIPTION

[0049] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms fall within the scope limited by the appended claims of the application equally.

[0050] All numerical specifications herein (e.g., temperature, time, concentration, and weight, etc., including ranges for each thereof) are generally approximate values ​​that may be appropriately varied (+) or (-) in increments of 0.1 or 1.0. All numerical specifications may be understood as being preceded by the term "about."

[0051] Example 1

[0052] This embodiment prepares a sustained-release composite nanofiber mask with unidirectional moisturizing and antioxidant properties and a preparation method thereof, comprising the following steps:

[0053] (1) Preparation of hydrophobic electrospinning solution A:

[0054] 1 g of polycaprolactone (PCL) solid and 0.06 g of tea polyphenol (TP) powder were dissolved in 10 g of dichloromethane / N,N-dimethylformamide solvent (v / v=7 / 3). After heating and stirring for 6 h, a viscous and uniform hydrophobic electrospinning solution A was obtained, which was cooled to room temperature for use.

[0055] (2) Preparation of hydrophobic layer nanofiber membrane:

[0056] The hydrophobic electrospinning solution A obtained in step (1) was collected and prepared on a non-woven fabric by a single-needle electrospinning device under the conditions of a voltage of 18 kV, a needle specification of 18 G, a distance between the receiving substrate and the needle of 15 cm, a spinning speed of 1 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 25 ° C, and an ambient humidity of 40% RH to obtain a hydrophobic layer nanofiber membrane. The scanning electron microscopy results are as follows: Figure 1 a and Figure 1 As shown in b, the fibers are arranged in a staggered manner, with an average diameter of about 0.43 μm. Figure 4 As shown in a, the layer has certain hydrophobic properties, and the contact angle of the water droplet is about 120°.

[0057] Place it together with the non-woven fabric at room temperature for later use.

[0058] (3) Preparation of hydrophilic electrospinning solution B:

[0059] 0.9 g polyvinyl alcohol (PVA), 0.8 g collagen tripeptide (CTP) and 0.04 g sodium alginate (SA) were dissolved in 10 g deionized water, stirred in a 45° C. water bath for 6 h to obtain a viscous and transparent hydrophilic electrospinning solution B, which was cooled to room temperature for use.

[0060] (4) Preparation of hydrophilic layer nanofiber membrane:

[0061] The hydrophilic electrospinning solution B obtained in step (3) was collected on the hydrophobic layer nanofiber membrane obtained in step (2) by a single needle electrospinning device under the conditions of voltage of 15 kV, needle specification of 18 G, distance between the receiving substrate and the needle of 15 cm, spinning speed of 0.2 mL / h, roller speed of 220 rpm, spinning environment temperature of 25 ° C, and environment humidity of 40% RH to prepare a hydrophilic layer nanofiber membrane, and its scanning electron microscopy was as follows: Figure 2 a and Figure 2 As shown in b, the average diameter of the fibers is about 0.3 μm, and they are randomly arranged. Figure 4 As shown in b), the hydrophilic layer nanofiber membrane has relatively good hydrophilicity, the water droplets will be completely absorbed, and the contact angle is 0°.

[0062] (5) Finally, the double-layer membrane was removed from the non-woven fabric and placed in an oven at 40°C for 12 h to obtain an independent sustained-release composite nanofiber mask with unidirectional moisturizing and antioxidant properties. Its scanning electron micrograph is shown in the figure. Compared with the electron micrograph of the single-layer nanofiber membrane, it can be observed that the diameter of PCL fibers is slightly thicker than that of PVA / COP / SA, and the Janus composite structure can be clearly observed.

[0063] The mechanical properties of the obtained mask were tested. The nanofilm was cut into samples of 5 mm × 40 mm in size and stretched at a speed of 10 mm / min with a clamping distance of 20 mm. The obtained stretch-fracture curve is shown in Figure 5 As shown, its breaking strength can reach 51.28% cN and its breaking elongation can reach 79.46%. The mask base fabric can fully meet the needs of daily use, is not easy to break and has good tensile strength.

[0064] Example 2

[0065] Embodiment A sustained-release composite nanofiber mask with unidirectional moisturizing and antioxidant properties and a preparation method thereof are prepared, comprising the following steps:

[0066] (1) Preparation of hydrophobic electrospinning solution A:

[0067] 0.9g of polycaprolactone (PCL) solid, 0.1g of polylactic acid (PLA) solid, and 0.01g of tea polyphenol (TP) powder were dissolved in 10g of dichloromethane / N,N-dimethylformamide solvent (v / v=7 / 3). After heating and stirring for 6h, a viscous and uniform hydrophobic electrospinning solution A was obtained, which was cooled to room temperature for use.

[0068] (2) Preparation of hydrophobic layer nanofiber membrane:

[0069] The hydrophobic electrospinning solution A obtained in step (1) was collected on a non-woven fabric using a single-needle electrospinning device under the conditions of a voltage of 18 kV, a needle specification of 18 G, a distance of 15 cm between the receiving substrate and the needle, a spinning speed of 1 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 25°C, and an ambient humidity of 40% RH to prepare a hydrophobic layer nanofiber membrane.

[0070] Place it together with the non-woven fabric at room temperature for later use.

[0071] (3) Preparation of hydrophilic electrospinning solution B:

[0072] 1 g of polyvinyl alcohol (PVA), 0.8 g of collagen tripeptide (CTP) and 0.04 g of sodium alginate (SA) were dissolved in 10 g of deionized water, stirred in a 30° C. water bath for 6 h to obtain a viscous and transparent hydrophilic electrospinning solution B, which was cooled to room temperature for use.

[0073] (4) Preparation of hydrophilic layer nanofiber membrane:

[0074] The hydrophilic electrospinning solution B obtained in step (3) is collected on the hydrophobic layer nanofiber membrane obtained in step (2) by using a single needle electrospinning device under the conditions of a voltage of 15 kV, a needle specification of 18 G, a distance between the receiving substrate and the needle of 15 cm, a spinning speed of 0.2 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 25°C, and an ambient humidity of 40% RH to prepare a hydrophilic layer nanofiber membrane.

[0075] (5) Finally, the double-layer film was peeled off from the non-woven fabric and placed in an oven at 40°C for 12 h to obtain an independent sustained-release composite nanofiber mask with unidirectional moisturizing and antioxidant properties.

[0076] The double-layer nanofiber mask and the wet commercial mask with nutrient solution of the same area were weighed and compared. Figure 6 As shown, the weight of the double-layer nanofiber mask is about 20% to 30% of that of commercial masks.

[0077] Deionized water was sprayed on the skin, and the composite nanofiber mask was applied to the skin surface. Since the PCL / PLA / TP fiber membrane had a certain degree of hydrophobicity, water droplets would not spread on the membrane, e.g. Figure 7 However, when a layer of PVA / CTP / SA film is added to the bottom layer of PCL / PLA / TP film, the water droplets are able to penetrate this hydrophobic film and spread within the area of ​​the PVA / CTP / SA film, as shown in Fig. Figure 7 In addition, when the positions of the two films are swapped, the side containing the PVA / CTP / SA film can quickly absorb water droplets, as shown in Figure 2. Figure 7 c. These findings reveal the working principle of the double-layer fiber membrane during application: the PCL / PLA / TP fiber membrane as the outer layer can not only efficiently transfer water molecules to the PVA / CTP / SA fiber membrane, but also reduce the evaporation rate of water, thereby improving the moisturizing ability of the mask. Figure 7 Masks d to f changed from white to transparent within a few seconds, which shows that the double-layer composite mask has the ability of directional moisture transmission.

[0078] The quantitative double-layer membrane was placed in 50 mL PBS buffer and the sustained release experiment was carried out in a constant temperature shaker at 37°C with a shaking speed of 100 rpm / min. 2 mL of solution was taken out at set time intervals (0, 5, 10, 15, 20, 30, 60 minutes), the absorbance of TP and CTP at the maximum absorption wavelength was measured, and an equal amount of PBS buffer was added to keep the total volume constant, and the following results were obtained: Figure 8The release curve of the functional substance is shown. It can be seen that the release speed of CTP is faster than that of TP. Due to its water-soluble nanofiber membrane carrier, it has the effect of rapid dissolution and rapid release; while TP can form a slow release effect in water due to its hydrophobic nanofiber membrane carrier, and then the functional substances of the two form a differential release slow release effect. The test results show that in a water environment, both TP and CTP can be released smoothly, and can play a good role in skin care. The controllable and slow release of functional ingredients is easier to be absorbed by human skin than a short and sudden release, thereby improving the absorption rate of active ingredients.

Claims

1. A composite nanofiber facial mask, characterized in that: The composite nanofiber mask comprises a hydrophobic layer nanofiber membrane and a hydrophilic layer nanofiber membrane; wherein the hydrophobic layer nanofiber membrane is loaded with a second active factor, and the hydrophilic layer nanofiber membrane is loaded with a first active factor.

2. A method for preparing a composite nanofiber facial mask, comprising: (1) mixing a high molecular polymer, a second active factor, and a solvent to obtain a hydrophobic electrospinning solution, electrospinning, collecting on a receiving substrate, and preparing a hydrophobic layer nanofiber membrane; (2) The high molecular polymer, the first active factor and the solvent are mixed to obtain a hydrophilic electrospinning stock solution, and the hydrophobic layer nanofiber membrane is used to receive the hydrophilic layer nanofiber membrane to obtain a composite nanofiber mask.

3. The preparation method according to claim 2, characterized in that: The high molecular weight polymer in step (1) includes one or more of polycaprolactone, polylactic acid, nylon 6, polyvinylidene fluoride, and polyurethane; the second active factor is an antioxidant factor; the antioxidant factor includes one or more of nicotinamide, vitamin C, ursi, tea polyphenols, and coenzyme Q1; the solvent includes one or more of dichloromethane, N,N-dimethylformamide, tetrahydrofuran, chloroform, and hexafluoroisopropanol.

4. The preparation method according to claim 2, characterized in that: In the step (1), the mass ratio of the high molecular weight polymer, the second active factor and the solvent is (8-15):(0.1-1):

100.

5. The preparation method according to claim 2, characterized in that: The mixing in step (1) is followed by stirring for 6 to 10 hours; the electrospinning comprises: a voltage of 12 to 18 kV, a needle specification of 18 to 21 G, a distance between the receiving substrate and the needle of 15 to 20 cm, a spinning speed of 0.8 to 1 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 22 to 25° C., and an environment humidity of 25 to 40% RH; The receiving substrate is one of a silk mask substrate, a spunlace nonwoven fabric, a Tencel nonwoven fabric, a biofiber mask substrate, a hydrogel mask substrate, a meltblown nonwoven fabric, a chitosan mask substrate, and a release paper.

6. The preparation method according to claim 2, characterized in that: The high molecular weight polymer in step (2) includes one or more of polyvinyl alcohol, polyethylene glycol, polyvinyl pyrrolidone, and polyethylene oxide; the first active factor is a moisturizing factor; the moisturizing factor includes one or more of sodium alginate, collagen peptide, glycerin, sodium hyaluronate, gelatin, and urea; and the solvent is water.

7. The preparation method according to claim 2, characterized in that: In the step (2), the mass ratio of the high molecular weight polymer, the first active factor and deionized water is (8-20):(1-10):

100.

8. The preparation method according to claim 2, characterized in that: The electrospinning in step (2) includes: a voltage of 12 to 18 kV, a needle specification of 18 to 21 G, a distance between the receiving substrate and the needle of 15 to 20 cm, a spinning speed of 0.1 to 0.4 mL / h, a roller speed of 220 rpm, a spinning environment temperature of 22 to 25° C., and an environment humidity of 25 to 40% RH; after mixing in step (2), stirring at room temperature for 4 to 6 hours.

9. The preparation method according to claim 2, characterized in that: In step (2), the hydrophobic nanofiber membrane is electrospun and used to receive the hydrophilic nanofiber membrane, and the receiving substrate of step (1) is removed and dried, wherein the drying temperature is 40-60° C. and the time is 12-24 hours; The hydrophilic layer nanofiber membrane side of the composite nanofiber mask is the skin-contacting side.

10. Use of the composite nanofiber mask according to claim 1 in the field of cosmetics.

Images