79results about How to "Simple post-processing" patented technology

The present application relates to the technical field of laser processing, especially to a lock processing and cutting device, which comprises a machine table and a transfer module installed on the machine table; a laser head is fixedly installed at the end of the execution component of the transfer module; a conveying assembly for conveying a sheet is fixedly installed above the machine table; wherein a positioning assembly for side positioning of the sheet and a stop assembly for stopping the end of the sheet are installed above the machine table; through the synergistic effect of the positioning assembly and the stop assembly, the present application realizes accurate positioning of the sheet, effectively guarantees the cutting accuracy and consistency of the lock panel; secondly, the traditional bench type single piece processing is replaced by a pipeline type continuous operation; the conveying, positioning and cutting processes of the sheet can be seamlessly connected, the auxiliary time of equipment waiting and manual intervention is reduced, the production efficiency is greatly improved, the finished product and waste after cutting can be automatically separated along the pipeline, and the post-processing process is greatly simplified.

This invention discloses a highly efficient asymmetric synthesis method for aryl propionic acid drug molecules. The method uses racemic aldehydes as substrates and thiamine pyrophosphate-dependent enzymes as biocatalysts. Electrolysis is performed in a diaphragm-free electrolytic cell under conditions of an external redox dielectric and constant current, in a buffer salt solution and nitrogen atmosphere. This method achieves dynamic kinetic oxidation of aldehydes via bioelectrocatalysis, enabling the high-efficiency and high enantioselectivity synthesis of aryl propionic acid drug molecules. The method eliminates the need for redox agents and additives, is simple to operate, operates under mild reaction conditions, and is green and sustainable. This invention applies bioelectrocatalysis to asymmetric synthesis, providing a green and efficient new enzymatic synthetic route for the asymmetric synthesis of aryl propionic acid drug molecules, which has significant application prospects in the pharmaceutical industry.

The invention discloses a method for dehalogenation reduction of electron-rich aryl halide, which comprises the following step: by taking aryl halide as a raw material, carrying out heating reaction in the presence of phosphorous acid, elemental iodine and a solvent to prepare a corresponding aromatic compound. According to the method, the defect that expensive transition metal catalysts and equivalent metal reagents need to be used for participation in current mainstream methods is directly avoided, the electron-rich aryl halide is subjected to one-step dehalogenation reduction to obtain the corresponding aromatic hydrocarbon by taking low-cost, low-toxicity and relatively stable phosphorous acid as a reducing agent and taking the iodine elementary substance as a catalyst, and the method has the advantages of no metal participation, simple operation, low cost and the like. The method has the advantages of simple operation, low cost, environmental protection and the like, avoids the use of a metal reagent and the limitation that special equipment is not easy to amplify production, after the phosphorous acid reaction is finished, byproducts are generally phosphoric acid and corresponding phosphorus salts thereof and can be quickly removed by washing, the post-treatment is simple, and the method is beneficial to industrial production.

The application discloses a method for preparing mesoporous zeolite under normal temperature and pressure and application thereof, and the preparation method comprises the following steps: (1) preparation of a functional protein biomodule: cationic polypeptide is loaded on yeast to obtain a biomodule aqueous solution; (2) deposition of silicon and aluminum: the pH of the biomodule solution obtained in the step (1) is adjusted to neutral, then a silicon source, an aluminum source and a titanium source are added into the solution, and the solution is incubated on a shaking table for 3 days; (3) calcination: the solid obtained in the step (2) is collected by centrifugation, washed with ethanol and water alternately for 3 times, and calcined at 500 DEG C for 4h under an air atmosphere to obtain a zeolite molecular sieve adsorption material. The application can prepare porous molecular sieve small balls by using a simple method, and can provide a brand-new thought for synthesizing molecular sieve materials.

The invention discloses a method for preparing phenyl acetate with high selectivity. A phosphoric acid solution is added into a magnesium chloride solution, stirring and heating are performed to obtain a suspension, the suspension is dried to constant weight to obtain a white solid, the white solid is ground to obtain powder, and the powder is calcined to obtain the catalyst. Then mixing phenol and a catalyst, placing the mixture in an oil bath for reflux reaction, dropwise adding acetic anhydride, distilling after the reaction is finished, and collecting a fraction at 190-195 DEG C, namely phenyl acetate. According to the magnesium chloride loaded phosphoric acid type catalyst (MgCl2-H3PO4) prepared by the method disclosed by the invention, phenol and acetic anhydride react without a solvent, MgCl2-H3PO4 is a solid catalyst, can be recycled only by filtering and can be repeatedly used after being washed, and MgCl2-H3PO4 also improves the selectivity of phenyl acetate and reduces the production cost.

The invention discloses a preparation method of an optically pure mepivacaine hydrochloride intermediate. According to the method, N-(2, 6-dimethylphenyl) pyridine carboxamide is used as a starting material, hydrogenation reduction is carried out in the presence of a ligand and a catalyst to obtain the mepivacaine hydrochloride intermediate ((S)-N-(2, 6-dimethylphenyl) piperidine-2-carboxamide), the ee value of the obtained mepivacaine hydrochloride intermediate can reach 93%, the yield can reach 95%, post-treatment is simple, and the method is suitable for industrial production. The method is very suitable for large-scale workshop production. The ligand used in the invention is cheap and easily available, and can be refined and recovered through column chromatography, and the catalytic effect of the recovered ligand is consistent with that of a newly purchased ligand.

The invention relates to an ether bond type covalent organic polymer (TPTF-AO) containing an amidoxime group and a synthesis method thereof. The method comprises the following steps: by taking 2, 4, 6-tri (4-hydroxyphenyl)-1, 3, 5-triazine and tetrafluoroterephthalonitrile as raw materials, constructing a covalent organic polymer precursor (TPTF) connected by a stable ether bond through nucleophilic substitution reaction of hydroxyl and fluorine atoms; further, the cyano group in the TPTF is subjected to amidoximation reaction under a mild condition and is efficiently converted into an amidoxime group, and the target product TPTF-AO is obtained. The polymer has a rigid skeleton connected by ether bonds and a mesoporous-macroporous composite pore channel structure, and has excellent chemical stability, thermal stability, rapid mass transfer capability and high-density metal ion coordination sites. The bottleneck that a traditional imine bond material is insufficient in stability is broken through, the problem that functional modification and skeleton stability are difficult to be compatible is solved, and the obtained material has wide application prospects in the fields of uranyl ion adsorption, catalysis, energy storage and the like.

The invention discloses a preparation method of ethylhexyl palmitate, and relates to the technical field of ethylhexyl palmitate. According to the method, firstly, isooctanol is gasified and then introduced into a methyl palmitate solution, ethylhexyl palmitate is prepared through transesterification, gaseous feeding can improve the instantaneous concentration of alcohol in a liquid phase, the reaction is promoted to be carried out in the positive direction, the reaction rate is increased, meanwhile, methanol generated through the transesterification method can be gasified and taken out of a system, and the yield of ethylhexyl palmitate is increased. Forward proceeding of the reaction is further promoted, so that the reaction is more thorough; secondly, chromium salt is used as a metal source precursor and a 2-sulfo-4, 4 '-biphenyldicarboxylic acid ligand to synthesize a catalyst, a biphenyl group in the ligand provides rigid and hydrophobic large pore channels and provides a local high-concentration reaction environment, gaseous isooctanol can be easily diffused into the pore channels of the catalyst and is in contact with enriched methyl palmitate, and the reaction efficiency is improved; and sulfonic acid groups uniformly distributed in the ligand serve as solid superacid, strong acid sites are provided, and the production efficiency is improved.

This invention discloses a hydrazone-linked fluorine-substituted covalent organic framework material, its preparation method, and its applications, belonging to the field of semiconductor photocatalysis technology. The material is synthesized by hydrazone condensation of 1,3,5-trifluoro-2,4,6-tris(4-formylphenyl)benzene and terephthalohydrazide, denoted as F-TPDH-COF. A one-step solvothermal synthesis is employed, resulting in a mild, environmentally friendly, low-cost, and easily scalable process. The material obtained by this invention utilizes hydrazone bonds to achieve proton enrichment in acidic media, and fluorine atoms regulate the electronic structure to improve charge separation efficiency. Under pH=2 conditions, the photocatalytic hydrogen peroxide production rate reaches as high as 5825.2 μmolg. ‑1 h ‑1 Its activity and stability are significantly better than most existing COF photocatalytic materials, and it can be used for efficient photocatalytic preparation of hydrogen peroxide in acidic systems, showing good prospects for industrialization.

This invention relates to the field of electrochemical organic synthesis technology, specifically providing an electrochemically promoted method and application for the synthesis of indole-benzo[selenium]azine ketones. A C3-selenoindole derivative, an organoselenium catalyst, an electrolyte, and an acid are added to an organic solvent to form a reaction system. A graphite felt is used as the anode, and a platinum sheet as the cathode, and a constant current reaction is carried out at room temperature in an air atmosphere. After the reaction is complete, the reactants are post-treated to obtain indole-benzo[selenium]azine ketones. The obtained compounds exhibit significant anti-inflammatory and anti-ulcer dual activities, achieving dual anti-inflammatory and anti-ulcer effects. This solves the problem that traditional NSAIDs only have anti-inflammatory properties but easily cause gastrointestinal damage, and has value for further research and application.

This invention discloses a method for preparing pentaerythritol oleate based on sodium bisulfite. The method involves the esterification reaction of pentaerythritol and oleic acid with sodium bisulfite as an auxiliary agent. Sodium bisulfite, as an auxiliary agent, possesses both catalytic and antioxidant functions, effectively improving the reaction rate and product yield while suppressing oxidation side reactions. This eliminates the need for additional antioxidants, improving product quality and reducing costs. The preparation method is simple, mild, and environmentally friendly, with readily available raw materials, low-cost auxiliary agents, and easy separation. After the reaction, the catalyst is removed by hot filtration, and unreacted oleic acid is removed by solvent extraction, effectively reducing the product's acid value. The extracted potassium oleate byproduct has a purity of 80%–90% and can be used as a flotation agent, release agent, or raw material for lubricant production, making it suitable for industrial applications. The resulting pentaerythritol oil is suitable for high-end lubricants, bio-based plasticizers, and environmentally friendly coatings.

The invention discloses a method for synthesizing mesalazine and application of mesalazine. The method comprises the following steps: introducing p-nitrophenol, formic acid and a Cu-Co-coated MFI-NS molecular sieve catalyst into a continuous flow reaction zone, and sequentially carrying out electrophilic substitution and nitro hydrogenation cascade reaction at normal pressure and 50-70 DEG C; the catalyst has a micropore-mesopore stepped pore channel, and contains a Cu0 metal cluster and a framework Co < 2 + > acid site. And separating, acidifying and crystallizing the reaction liquid to obtain a finished product. According to the invention, the shape-selective selectivity and difunctional synergistic effect of the molecular sieve are utilized, high conversion rate (gt, 98%) and high selectivity (gt, 94%) under mild conditions are realized, the product purity is greater than or equal to 99.5%, and the Cu / Co residue meets the ICHQ3D standard. The catalyst can be recycled for 10 times or more, the yield is reduced by 5% or less, iron mud pollution of a traditional iron powder method and the metal leaching risk of a noble metal catalyst are thoroughly eliminated, and the method has the remarkable advantages of being environmentally friendly, efficient, low in cost, easy to industrially amplify and the like and is suitable for preparing the medicine for treating the inflammatory bowel disease.

The application relates to the technical field of organic synthetic chemistry, in particular to a preparation method of an azole group substituted ether compound promoted by visible light, the azole group substituted ether compound is prepared by stirring reaction of azole and ethylene ether as reaction raw materials under certain temperature conditions and light source irradiation to obtain an azole group hemiacetal amine compound. The application has the advantages of simple reaction condition, first realization of N-alkylation reaction of azole compound in the absence of a light catalyst, environmental friendliness, mild condition, simple operation, wide substrate application range and the like; and the application provides a convenient means for constructing azole hemiacetal amine compounds with potential biological activity and pharmacological action.

The invention discloses photocatalytic stereoselective E-type olefination of alkynyl amide and a preparation method of the alkynyl amide. The method is carried out in a water-phase micelle reaction system and is completed under the driving of visible light. According to the method, an alkynyl amide compound is taken as a raw material, sodium ascorbate is taken as a green reducing agent, Ru (bpy) 3 (PF6) 2 or [Ir (dtbpy) (ppy) 2] PF6 is taken as a photocatalyst in a water-phase micelle environment formed by a surfactant lauryl sodium sulfate (SDS), and under the protection of inert gas, catalytic circulation is initiated by visible light irradiation at 20-40 DEG C, so that the alkynyl amide compound is highly selectively converted into an E-type olefin product. The method is mild in condition, simple in step, high in stereoselectivity, environment-friendly and safe to operate, the problem that flammable and explosive reagents or harsh reaction conditions need to be used in a traditional method is solved, and a green and efficient preparation way is provided for preparation of the E-type acrylamide compound.

This invention discloses a method for preparing 1-(3,4-diaminophenyl)ethyl ketone. The method includes the following steps: reducing 4-ethynyl-3-nitroaniline with iron powder to obtain 1-(3,4-diaminophenyl)ethyl ketone, as shown in the reaction formula below. The preparation method of this invention does not require the use of concentrated nitric acid or concentrated sulfuric acid as nitrating agents, resulting in less environmental pollution. Furthermore, the reduction of the nitro group and the hydration of the ethynyl group to synthesize the acetyl group are completed in a one-pot process, making the preparation method simple and eliminating the need for complex purification of intermediate products, thus making it highly suitable for industrial production.

This invention discloses a method for synthesizing an intermediate of retinoic acid, relating to the field of pharmaceutical organic synthesis technology, comprising the following steps: S1, in the presence of a base, 2-amino-3-chloropyridine and 4-bromopiperidine undergo a nucleophilic substitution reaction in solvent A to prepare compound III; S2, in the presence of a catalyst and ammonia solution, compound III undergoes an amination reaction in solvent B to prepare compound II; S3, compound II is dissolved in solvent C, and sequentially undergoes CDI cyclization and hydrogen chloride solution salt formation to prepare compound I, namely 1-(piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one. This invention is low-cost, uses mild reaction conditions, has a simple synthesis process, high yield, and eliminates the need for expensive and potentially unsafe excipients, effectively improving reaction safety, being environmentally friendly, and suitable for industrial production.

This invention provides an indene-based organic compound, its preparation method, and its applications, relating to the technical field of organic synthesis. The preparation method includes the following steps: mixing and reacting a benzyl alcohol-based compound, an alkyne, a catalyst, and an auxiliary agent in a solvent to obtain the indene-based organic compound; the catalyst includes at least one selected from ferric chloride, trifluoromethanesulfonic acid, boron trifluoride diethyl ether, and scandium trifluoromethanesulfonate; the auxiliary agent includes at least one selected from p-toluenesulfonyl isocyanate, chlorosulfonyl isocyanate, dibenzoylmethane, and aminosulfonic acid. The method of this invention not only features mild reaction conditions and high product selectivity, but also a broad substrate range, simple post-processing, and convenient operation, enabling efficient and rapid synthesis of the target product.

The invention relates to the field of drug synthesis, and discloses a method for preparing semeglutide through fragment condensation, which comprises the following steps: taking 1-4 amino acids of a semeglutide amino acid sequence as a fragment I, 1-16 amino acids of the amino acid sequence as a fragment II, 17-29 amino acids of the amino acid sequence as a fragment III, and 30-31 amino acids of the amino acid sequence as a fragment IV; preparing the first fragment, the second fragment, the third fragment and the fourth fragment into a semeglutide product by adopting a solid-liquid combination method; the fragment I of the method can effectively inhibit racemization impurities of His; the C-terminal amino acids of the second fragment, the third fragment and the fourth fragment in the method are all Gly, and racemization impurities cannot be generated when the three fragments are condensed. In addition, the fragment synthesized by the fragment II, the fragment III and the fragment IV is high in purity and good in solubility, the condensation reaction efficiency of the polypeptide fragment is high, the fragment utilization rate is high, the cost is low, the unutilized fragment can be extracted and separated, and the post-treatment is simple.

The invention belongs to the field of chemical synthesis of medicines, and discloses a preparation method of doxylamine succinate, which comprises the following steps: step 1, by taking 1-phenyl-1-(pyridine-2-yl) 1-ethanol and a compound 3 as raw materials, carrying out substitution reaction on the 1-phenyl-1-(pyridine-2-yl) 1-ethanol and the compound 3 under the action of an alkali reagent to obtain N, N-dimethyl formamide; the preparation method comprises the following steps: adding N, N-dimethyl-2-[1-phenyl-1-(2-pyridine) ethyoxyl] ethylamine; and 2, carrying out a salt forming reaction on the N, N-dimethyl-2-[1-phenyl-1-(2-pyridine) ethyoxyl] ethylamine and succinic acid, so as to obtain the doxylamine succinate. According to the invention, sulfonic acid 2-(dimethylamino) ethyl ester which has a high boiling point and is efficiently converted is used, so that the yield of the product is greatly improved; in addition, the target crystal form can be stably reproduced and obtained in a low-temperature salt forming and crystallization mode. According to the method, the total yield reaches 93.5% or above, and the purity reaches 99.7% or above.

The application discloses a thiazole-containing flavonol derivative and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. A thiazole-containing flavonol derivative is generated by substitution reaction of 3-(bromoalkyloxy)-7-substituent-2-(4-substituent phenyl)-4H-chromone-4-ketone and 5-substituent-2-thiol-1,3,4-thiadiazole, and a structural formula is shown as formula Y: wherein n is 3 or 4; R1 is hydrogen or an amino group; R2 is hydrogen, an alkyl group or an alkoxy group; and R3 is hydrogen, a halogen, an alkyl group or an alkoxy group. The thiazole-containing flavonol derivative has good bacteriostatic activity and can be applied to the preparation of bacteriostatic medicaments.

This invention discloses a method for preparing allene compounds. The method involves adding a 1,3-enyne compound, a hydrazone compound, a palladium catalyst, and a base promoter to a solvent, and performing a coupling reaction under a nitrogen atmosphere, stirring, and at 60–100°C. After the reaction is complete, the reaction is quenched, and the reaction products are extracted and the organic phases are combined. The obtained organic phases are then washed, dried, and vacuum concentrated to obtain a crude product. The crude product is then purified to obtain the allene compound. The method of this invention features mild reaction conditions, good functional group tolerance, and advantages such as simple post-processing, green procedures, low pollution, and high economic efficiency.

The invention belongs to the technical field of synthesis of organic compounds, and relates to a synthesis method of drometrisiloxane, which comprises the following steps: carrying out Williamson etherification reaction on an ultraviolet light absorber UV-P and methyl allyl chloride to obtain an intermediate I; carrying out Claisen rearrangement reaction on the intermediate I to obtain an intermediate II; and carrying out hydrosilylation reaction on the intermediate II and heptamethyltrisiloxane to obtain dromethicone, the Williamson etherification reaction comprises the following steps: dissolving an ultraviolet light absorber UV-P in an alcohol ether solvent, and reacting with methyl allyl chloride under the condition of an acid-binding agent. According to the synthesis method of the drometrisiloxane, the etherification reaction is efficient, simple and convenient, the hydrosilylation reaction catalyst is high in efficiency, the solvent system is green and economical, the overall process is high in yield and purity, and the product quality is excellent.

The present application relates to the field of molecular sieve preparation, discloses a kind of molecular sieve matrix pellet strength improver and its preparation method and application and the preparation method of molecular sieve matrix pellet, the preparation method of molecular sieve matrix pellet strength improver includes: 1) clay mineral aggregate is mixed with sodium source, and clay base material is obtained;2) after being pulverized treatment, clay base material is calcined with hole expansion aid;Wherein, the clay mineral aggregate is the mixture of halloysite, kaolinite and montmorillonite, the water content of the clay mineral aggregate is 20-40wt%, the Fe2O3 content in the clay mineral aggregate is 0.01-0.1wt%, in the mixture of the clay mineral aggregate and the hole expansion aid, the particle size of 300-600 mesh accounts for more than 98%, and the sodium source is Na2O.The strength improver prepared by the method has high viscosity and hygroscopicity, and good plasticity.

The application discloses a preparation method of alpha-tuliketone, relates to organic synthesis technology utilization, and the preparation is that 4,8-dimethyl-3,7-nonadiene-2-ketone and triacetal are subjected to aldol condensation reaction under the action of acid-base bifunctional catalyst to generate alpha-tuliketone; the acid-base bifunctional catalyst is obtained by grafting organic base onto carboxylic acid functionalized mesoporous material.The acid-base bifunctional catalyst is simple in preparation, good in stability and reusable, is used for catalyzing the reaction of 4,8-dimethyl-3,7-nonadiene-2-ketone and triacetal, can directly generate target product alpha-tuliketone by one-pot method, is high in reaction activity, short in reaction period, simple in post-treatment, simplifies process, is high in yield, and the yield can reach more than 95%.

This invention provides a terminal alkenyl-containing liquid crystal compound, its preparation method, and its applications. The terminal alkenyl-containing liquid crystal compound has the structure shown in general formula P. Liquid crystal compositions containing the terminal alkenyl-containing liquid crystal compound of this invention exhibit a fast response speed, a large refractive index and clearing point, and a wide phase transition temperature. The synthesis method of the compound of this invention has high yield, simple post-processing, and is suitable for industrial production.

The invention belongs to the technical field of organic synthesis, and discloses a preparation method of alkane diol random polyether. The preparation method comprises the following steps: adding an initiator alkane diol, a main catalyst and a cocatalyst into a reaction kettle, adding ethylene oxide and epoxypropane, controlling the feeding time to be 4-8 hours, controlling the feeding rate of the ethylene oxide to be linearly increased to 40-65 g / 10 min from 10-30 g / 10 min, and controlling the feeding rate of the epoxypropane to be linearly reduced to 10-30 g / 10 min from 40-65 g / 10 min. According to the preparation method provided by the invention, ethylene oxide and propylene oxide are taken as comonomers, and the random copolyether with uniformly distributed molecular chain sequences is prepared in a compound base catalysis system through a special feeding mode. The random copolyether is high in random degree, low in surface tension, high in emulsion stability and narrow in molecular weight distribution; and the preparation method can follow the post-treatment method of the traditional alkali catalysis process, and has the advantages of simple process and low cost.

The application discloses a preparation method of a nickel catalyst for olefin polymerization, and comprises the following steps: (1) reacting acenaphthenequinone, a water-removing agent and a substituted aniline in a first solvent under the action of a catalyst; after the reaction is completed, cooling, filtering and concentration crystallization are performed to obtain a diimine ligand; and (2) reacting the diimine ligand and a nickel salt in a second solvent; after the reaction is completed, concentration crystallization, filtering and washing are performed to obtain the nickel catalyst. The application effectively solves the problems of poor selectivity, low yield and complex post-treatment in the preparation process of the nickel catalyst, and has the advantages of a short process flow, high yield and simple post-treatment.

This invention discloses a method for preparing high-purity carbazole alkylphosphonic acid derivatives, specifically a method for preparing high-purity MeO-2PACZ, 4PADCB, Me-4PACZ, and 2PACZ. This invention simplifies the post-reaction processing flow and employs a specific preparative chromatography combined with lyophilization for purification, achieving a product purity ≥99.0%. When used in the fabrication of perovskite solar cells, the products show a significant improvement in photoelectric conversion efficiency. Furthermore, the process is highly automated and easier to operate, directly adaptable to large-scale industrial production, meeting the high-purity application requirements of core functional materials for high-efficiency perovskite photovoltaic devices.

The present application provides a kind of deuterated composition, organic electroluminescent device and display device.The deuterated composition includes the deuterated mixture prepared by deuterium reaction of compound A;The compound A has the structure shown as formula I.In the present application, the deuterated mixture obtained by deuterium reaction of the compound with a specific structure is used as the host material of light-emitting layer, and further an organic electroluminescent device with lower driving voltage, higher efficiency and longer service life is obtained.

The invention discloses a polynitrogen heterocyclic chemical 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole and a synthesis method thereof.The synthesis method comprises the steps that 4-pyrazolecarboxylic acid and hydrazine hydrate serve as starting raw materials, the 4-pyrazolecarboxylic acid and the hydrazine hydrate are added into a high-pressure-resistant reaction kettle according to the molar ratio of 1: 1-1: 5 and react for 1-5 days at the temperature of 100-220 DEG C, and the 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole is synthesized through a ring formation reaction; the catalyst is 1, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole. The 4-amino-1, 2, 4-triazole derivative 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole with 3, 5-position symmetrical substituted pyrazolyl is synthesized for the first time, a multi-nitrogen heterocyclic compound library is enriched, and the synthesis method has the advantages of cheap and easily available initial raw materials, mild reaction conditions, high product yield and simple post-treatment, and is suitable for large-scale production.