11 results about "Allene" patented technology

The invention relates to organic electroluminescent materials and devices. Provided are metal complexes comprising a ligand LA wherein the ligand LA is a monodentate ligand comprising a carbon bent allene; wherein the ligand LA is coordinated to a metal M; wherein the metal M is optionally coordinated to one or more additional ligands; and wherein one or more ligands may be linked to form a multidentate ligand. Formulations comprising these compounds are also provided. Further provided are OLEDs and related consumer products utilizing these compounds.

The invention discloses a silicon-containing conjugated olefin compound as well as a preparation method and application thereof, the structural formula of the silicon-containing conjugated olefin compound is shown as (I), and the silicon-containing conjugated olefin compound is obtained by carrying out silicon-carbon bond breakage synthesis on an allenyl functionalized silicon hybrid quaternary compound in the presence of a ligand, a palladium catalyst and a reaction medium, the allene functionalized silicon hybrid quaternary compound is used as a reactant to directly perform intramolecular reaction under the action of a complex formed by a metal catalyst and a phosphine ligand, the reaction condition is mild, the method is simple, and the obtained crude product can be purified by a silica gel rapid chromatography to obtain a pure product. The method has the advantages of mild reaction conditions, wide substrate expansion range, simple preparation operation and the like, and the prepared compound has a certain application prospect in the anti-tumor field.

The application discloses a method for preparing alpha, gamma-unsaturated dienone, which is prepared by isomerization reaction of allene ketone under the action of a catalyst, wherein the catalyst comprises a hydroxyl-functionalized quaternary ammonium salt basic ionic liquid with a structure shown in formula (I); R1, R2, R3 and R4 are independently selected from substituted or unsubstituted alkane, alkene, alkyne and aromatic hydrocarbon, and at least one of R1, R2, R3 and R4 comprises a hydroxyl substituent; and Y is a group alkaline in water. The application catalyzes the isomerization reaction of allene ketone by using the catalyst comprising the hydroxyl-functionalized quaternary ammonium salt basic ionic liquid, and then alpha, gamma-unsaturated dienone is prepared, so that the application has the advantages of small catalyst consumption, high selectivity and yield, low reaction temperature, less pollution, and high yield and selectivity of the catalyst after recycling and multiple reuse.

The invention relates to a polysubstituted bicyclo [2.1. 1] hexane compound and a preparation method thereof, and belongs to the technical field of organic chemistry. According to the method, the bicyclo [1.1. 1] butanone and the allene amine are used as starting materials, the lutetium trifluoromethanesulfonate is used as a catalyst, the 4A molecular sieve is used as an additive, the bicyclo [2.1. 1] hexane compound is obtained through reaction in 1, 2-dichloroethane at room temperature, the reaction condition is mild, the substrate application range is wide, and the method has good scientific significance and application prospects.

The invention provides a method for constructing a substituted pyrimidone skeleton through reaction of gem-difluoroallene and benzamidine hydrochloride compounds, and relates to the technical field of organic synthesis. The method for constructing the substituted pyrimidone skeleton through the reaction of the gem-difluoro allene and the benzamidine hydrochloride compound provided by the invention comprises the following steps: mixing the gem-difluoro allene, the benzamidine hydrochloride compound, alkali and a solvent, heating to react, and after the reaction is finished, performing post-treatment to obtain the substituted pyrimidone compound. The pyrimidone core heterocyclic ring is efficiently constructed by utilizing the special electrophilicity brought by two fluorine atoms in gem-difluoroallene molecules and through a defluorination cyclization mechanism promoted by alkali. The method has the advantages that a noble metal catalyst is not needed, raw materials are easy to obtain, operation is easy and convenient, reaction conditions are mild, one-step synthesis is achieved, functional group compatibility is good, and a new strategy is provided for green and efficient synthesis of pyrimidone compounds.

The invention discloses an allene ketone compound with a structure as shown in a formula (I), or pharmaceutically acceptable salt or stereoisomer thereof, and application thereof. The invention provides an allenone compound which can covalently modify and mark amino acid residues in protein or polypeptide, especially cysteine residues. The method can be used for identifying, analyzing and identifying potential tumor treatment targets and active sites with medicinal values; and the compound has certain anti-tumor activity and can be used for anti-tumor drugs. (I)

This invention provides a cobalt-catalyzed method for synthesizing α-substituted allyl sulfones by reacting sulfonyl allenes with organoboronic acids. Using sulfonyl allenes of Formula I and organoboronic acids of Formula II as raw materials, a cobalt complex as a catalyst, and an organic ligand, the reaction yields α-substituted allyl sulfones of Formula III in the presence of additives. This invention aims to achieve the hydroarylation and hydroalkenylation of sulfonyl allenes with organoboronic acids using an economical and efficient method. The reaction process utilizes an inexpensive cobalt catalytic system, providing a new route for the synthesis of allyl sulfone compounds with highly specific 1,2-regioselectivity.

The invention discloses a preparation method of thioester and epithioester compounds, and belongs to the technical field, the preparation method of the thioester compounds comprises the following steps: in an organic solvent, under the participation of alkali, reacting an alpha-carbonyl alkenyl ester compound with a thiol or thiophenol compound at 0-50 DEG C to obtain the thioester compounds; the preparation method of the episulfide compound comprises the following steps: reacting a sulfydryl-containing carboxylic acid compound with an allene ketone compound or an alkyne amide compound in dichloroethane at 0-70 DEG C to obtain a sulfydryl-containing alkenyl ester compound; then, in an organic solvent, the alkenyl ester compound containing sulfydryl reacts at the temperature of 0-50 DEG C under the participation of alkali and / or an additive, and the episulfide compound is obtained; the method for preparing thioester and epithioester provided by the invention has the advantages of low cost, simple operation, mild reaction conditions, wide substrate adaptability, no racemization of products and the like.

The invention belongs to the technical field of novel synthesis of copper-catalyzed high-molecular polymers, and discloses a synthesis method of a copper-catalyzed allene sulfonyl amidine polymer, which comprises the following steps of: accurately weighing 1 molar equivalent of binary sulfonyl azide monomer SA, 1 molar equivalent of binary secondary amine monomer Nu, 2 molar equivalent of 1, 3-diyne monomer DY and 3 molar equivalent of organic alkali DIPEA, dissolving in a solvent, and uniformly stirring; adding 0.1 mol equivalent of catalyst CuI in the reaction process, stirring for 24 hours at room temperature, and stopping the reaction; and settling the reaction solution by using a settling agent, centrifuging, repeating for three times, collecting a precipitated product, and drying the product to constant weight. The invention provides a one-step synthesis strategy for efficiently preparing polyallene sulfonyl amidine by taking 1, 3-diyne, binary sulfonyl azide and binary secondary amine as monomers based on copper catalysis for the first time.

The present invention relates to the field of catalytic hydrogenation, and more particularly to the hemihydrogenation of allenes to corresponding alkenes in the presence of a homogeneous catalyst system, wherein the homogeneous catalyst system comprises a cobalt salt, a bidentate diphosphine ligand, and a weakly coordinating or non-coordinating monoanion or reducing agent.

The invention discloses a method for synthesizing a 1, 5-diene drug skeleton intermediate, and the method adopts a metallized porous organic polymer catalyst Cu (at) POL-bpy to realize efficient and accurate construction of the 1, 5-diene drug skeleton intermediate through a boryl-allylation coupling reaction of allene, and provides a new strategy for preparation of a 1, 5-diene drug. The method is low in cost and high in catalytic efficiency, the catalyst still keeps stable catalytic activity after being continuously recycled, and the good industrial application prospect is shown.