7 results about "Indometacin" patented technology

The application discloses a stomach-derived limosilactobacillus fermentum LAF-09 and application thereof, and the preservation number of the stomach-derived limosilactobacillus fermentum LAF-09 is GDMCC No. 65656. The inventor of the application screens a stomach-derived limosilactobacillus fermentum LAF-09 from stomach mucosa tissue of healthy people, the strain has strong acid resistance and high proliferation capacity in the stomach, has strong adhesion properties to stomach epithelial GSE-1 cells, can be effectively applied to prevent and treat gastric ulcers caused by indomethacin, and has no obvious side effects.

To provide a topical pharmaceutical composition containing indomethacin, diclofenac sodium, felbinac, salicylic acids, or heparins, wherein irritation to the application site is reduced. [Solution] A topical pharmaceutical composition that contains component (A) and component (B) below, wherein component (A) is one or more selected from the group consisting of components (A-1) to (A-5) below, and which reduces irritation to the application site. Ingredient (A-1): Indomethacin Ingredient (A-2): Diclofenac sodium Ingredient (A-3): Felbinac Ingredients (A-4): Salicylic acids Ingredient (A-5): Heparinoid Ingredient (B): One or more selected from the group consisting of loxoprofen, its salts, and their hydrates.

The application belongs to the technical field of anti-inflammatory drug development, and discloses an indometacin derivative containing 2-amino-1,3,4-thiadiazole and preparation and application thereof. The derivative is a compound with the structure shown in formula 2 or a pharmaceutically acceptable salt thereof. The application first designs and successfully synthesizes a novel indometacin derivative containing 2-amino-1,3,4-thiadiazole, and the structure is characterized. The preparation method of the indometacin derivative containing 2-amino-1,3,4-thiadiazole is simple, convenient to operate, and can quickly synthesize the compounds. Research shows that the indometacin derivative containing 2-amino-1,3,4-thiadiazole has good anti-inflammatory activity and good application prospect in inflammatory diseases.

The application discloses a palmitoyl hydrochloride-indometacin pharmaceutical cocrystal as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical crystallization. 21 H 22 ClNO4]·[C 19 H 16 ClNO4]. The palmitoyl hydrochloride-indometacin pharmaceutical cocrystal is prepared by mixing palmitoyl hydrochloride hydrate and indometacin in a solvent system according to a molar ratio of 1:1 and through stirring treatment in a suspended state. The process flow is simple, the operation is convenient, and the cocrystal has a high yield. In a pH 6.8 simulated intestinal fluid medium, the dissolution rate of palmitoyl hydrochloride in the pharmaceutical cocrystal is obviously lower than that of pure palmitoyl hydrochloride, and the pharmaceutical cocrystal presents a sustained-release behavior. On the contrary, the dissolution rate of indometacin in the pharmaceutical cocrystal is obviously improved, which is beneficial to the improvement of the bioavailability of indometacin. The palmitoyl hydrochloride-indometacin pharmaceutical cocrystal also has good human colon cancer cell inhibition activity.

The application discloses a kind of sorafenib co-amorphous drug and its preparation method and application.Co-amorphous drug is made of active ingredient sorafenib and ligand according to 1:1 mole ratio;Ligand is selected from any one of L-phenylalanine, L-proline, L-arginine and indometacin;Sorafenib and ligand form single homogeneous amorphous structure by intermolecular interaction.By X-ray powder diffraction, differential scanning calorimetry and infrared spectroscopy, the results show that sorafenib and ligand form single homogeneous amorphous structure by intermolecular hydrogen bond interaction.Compared with sorafenib crystalline raw material and physical mixture, the application improves the equilibrium solubility and dissolution rate of sorafenib in physiological medium, and shows excellent physical stability, can effectively inhibit the recrystallization of drug during storage, provides a new preparation strategy for improving the oral bioavailability of sorafenib.

The application discloses a kind of stable indometacin tablets and its preparation process, belong to pharmaceutical preparation technical field.The tablet is composed of indometacin, hydroxypropyl beta-cyclodextrin, soybean phospholipid, composite stabilizer, binder and lubricant, and the composite stabilizer is compounded by succinylated c14-c18 alkyl sulfonate sodium, N-ethyl-L-glutamine and maltodextrin according to specific mass ratio.Preparation process includes liposome inclusion compound preparation, mixing granulation, drying whole particle, total mixing and tabletting.The application realizes the preparation of high drug loading design, and the composite stabilizer forms a multilayer coating protection system with hydroxypropyl beta-cyclodextrin and soybean phospholipid, which synergistically improves the dissolution performance and stability of the preparation, makes the dissolution rate of the preparation fast, and the content of the main component decreases little during long-term storage, solves the problems of low drug loading, poor stability and dissolution of existing indometacin tablets.

The application discloses an anchor COX-2 protein responsive photosensitizer and a preparation method and application thereof, relates to the technical field of biological medicine and disease treatment. The compound IRID-SS shown in formula (I) prepared by the application is provided with a near-infrared cyanine as a photosensitive unit, an indomethacin as a COX-2 targeting ligand and a disulfide bond as a glutathione response unit. The compound can be activated under the condition of high glutathione in a tumor microenvironment, specifically anchors Golgi COX-2 protein, generates reactive oxygen species in situ through near-infrared laser irradiation, realizes irreversible oxidative damage of COX-2 protein, and induces pyroptosis of tumor cells through a Caspase-3 / GSDME channel. The compound has a simple synthesis method, does not introduce toxic reagents, does not have the problem of toxic reagent residue, has high biological safety, and therefore has good practical application value.