163 results about "Indometacin" patented technology

The invention discloses a hot-melt extrusion process for preparing an indometacin quick release preparation from multi-element auxiliary materials and belongs to the field of pharmacy. The method comprises the following steps of: crushing indometacin and medicinal auxiliary materials, and after screening the powder with a 60 to 120-mesh sieve, uniformly mixing the powder into a physical mixture; according to the melting points or the glass transition temperatures of the medicament and the auxiliary materials, setting the extrusion temperature of a double-screw hot melt extruder to be between 50 and 150 DEG C, after the extrusion temperature reaches the preset temperature, starting a screw, adding the prepared physical mixture into the extruder, and extruding the physical mixture into strips through the screw; and after crushing the strips, screening the powder with a 20 to 80-mesh sieve to obtain medicinal solid dispersoid particles or powder. The auxiliary materials comprise the following components in percentage by weight: 10 to 90 percent of polymer, 5 to 50 percent of plasticizer, 0 to 10 percent of lubricant, 0 to 5 percent of surfactant and 0 to 20 percent of disintegrant. A sugar alcohol with a relatively low softening point or melting point, and the like, serving as the plasticizer, is added into the polymer with a relatively high softening point or melting point so as to reduce the extrusion temperature and make the extrusion process easy. The prepared indometacin solid dispersoid has the characteristic of quickly dissolving out.