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Compound radix angelicae pubescentis transdermal patch used for treating rheumatism and preparation method thereof

A technology of transdermal patch and Duhuo, applied in the field of Duhuo compound patch and preparation thereof, can solve the problems of slow onset of pain, large volatilization of active ingredients, inaccurate administration, etc., and achieves high content of active ingredients and avoids irritation. effect, high bioavailability

Inactive Publication Date: 2016-02-03
周菊香
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this invention is to provide a kind of Duhuo compound transdermal patch for treating rheumatism and its preparation process, which overcomes the large volatilization of active ingredients in existing liniments, inaccurate administration, and the pain-relieving effects of existing Chinese medicine compound patches. Slow down

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 120g of Duhuo, 18g of Angelica, 18g of Guizhi, 28g of Qinpi, and 18g of Rhizoma Cyperi, take the crude drug powder and grind it into a coarse powder, then soak it in water for 1 hour, and extract it by steam distillation for more than 8 hours to obtain 2.475g of its volatile oil mixture.

[0012] Precisely weigh 2.0 g of polyvinylpyrrolidone and 3.0 g of polyacrylic acid, respectively add water to swell, dissolve in water, and mix.

[0013] Chinese medicine compound volatile oil extract 2.5g, indomethacin 1.5g, and borneol 1g were dissolved in 75% ethanol, and then added 2.5g of glycerin, 3g of propylene glycol, 3g of azone, and 5g of sodium carboxymethylcellulose and stirred evenly.

[0014] Mix the above liquid medicine and matrix evenly, and add purified water to 100g. Then spread the drug evenly on the back weighing layer, smear polyacrylic resin pressure-sensitive adhesive around the drug, cover with release paper, cut into a specified size area, and seal the ...

Embodiment 2

[0016] Take 100g of Duhuo, 28g of Angelica, 28g of Guizhi, 28g of Qinpi, and 18g of Rhizoma Cyperi, take the crude drug powder and grind it into a coarse powder, then soak it in water for 1 hour, extract it by steam distillation for more than 8 hours, and obtain 2.698g of its volatile oil mixture.

[0017] Precisely weigh 2.0 g of polyvinylpyrrolidone and 3.0 g of polyacrylic acid, respectively add water to swell, dissolve in water, and mix.

[0018] Chinese medicine compound volatile oil extract 2.5g, indomethacin 1.5g, and borneol 1g were dissolved in 75% ethanol, and then added 2.5g of glycerin, 3g of propylene glycol, 3g of azone, and 5g of sodium carboxymethylcellulose and stirred evenly.

[0019] Mix the above liquid medicine and matrix evenly, and add purified water to 100g. Then spread the drug evenly on the back weighing layer, smear polyacrylic resin pressure-sensitive adhesive around the drug, cover with release paper, cut into a specified size area, and seal the pa...

Embodiment 3

[0021] 80g of Duhuo, 32g of Angelica, 32g of Guizhi, 28g of Qinpi, and 28g of Rhizoma Cyperi, the crude drug powder was taken into a coarse powder, then soaked in water for 1 hour, and extracted by steam distillation for more than 8 hours to obtain 3.785g of its volatile oil mixture.

[0022] Precisely weigh 2.0 g of polyvinylpyrrolidone and 3.0 g of polyacrylic acid, respectively add water to swell, dissolve in water, and mix.

[0023] Chinese medicine compound volatile oil extract 2.5g, indomethacin 1.5g, and borneol 1g were dissolved in 75% ethanol, and then added 2.5g of glycerin, 3g of propylene glycol, 3g of azone, and 5g of sodium carboxymethylcellulose and stirred evenly.

[0024] Mix the above liquid medicine and matrix evenly, and add purified water to 100g. Then spread the drug evenly on the back weighing layer, smear polyacrylic resin pressure-sensitive adhesive around the drug, cover with release paper, cut into a specified size area, and seal the package to get t...

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Abstract

The invention discloses a compound radix angelicae pubescentis transdermal patch used for treating rheumatism and a preparation method thereof. The Chinese herb compound is prepared from radix angelicae pubescentis, angelica sinensis, cassia twigs, ash bark and cyperus rotundus. A volatile oil mixture of the Chinese herb compound is extracted, then a transdermal patch matrix is prepared, the volatile oil extract of the Chinese herb compound, indometacin and borneol are dissolved with 75% ethyl alcohol and then evenly mixed with the matrix, the medicine is evenly applied on a back layer, a polyacrylic resin pressure-sensitive adhesive is smeared around the medicine, the product is covered with release paper and cut to have a regulated area, and the transdermal patch is obtained after sealed packaging. The patch can stop pain rapidly and prevent stimulation to the gastrointestinal tract, the liver and the kidneys from indometacin.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a Duhuo compound patch for treating rheumatism and a preparation process thereof. technical background [0002] Duhuo is the dry root of the Umbelliferae plant Angelica Placiformis. Traditional Chinese medicine believes that Duhuo has the effects of dispelling wind and dampness, dispelling cold and relieving pain. Commonly used for anemofrigid-damp arthralgia, waist and knee pain, Shaoyin headache, etc. Modern research proves that its active ingredients are coumarin compounds and some alcohols and esters, so the extracted volatile oil has higher active ingredients. [0003] The existing Duhuo compound preparations are mostly volatile oil liniments. Because the volatile oil has strong volatility, the drug release amount of the liniments is small, which cannot meet the long-term administration needs of rheumatism patients, and the dosage is inaccurate. In addit...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61K9/70A61K47/32A61P29/00A61K31/045A61K31/405
Inventor 周菊香
Owner 周菊香
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