8results about How to "Avoid first pass effect" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a microneedle patch for disguising a macrophage cell membrane and a preparation method of the microneedle patch. Degradable high polymer material nano-particles camouflaged by the macrophage membrane are embedded in a microneedle array of the microneedle patch camouflaged by the macrophage membrane, and the degradable high polymer material nano-particles camouflaged by the macrophage membrane are wrapped with gambogic acid and oleic acid functionalized cerium dioxide nano-particles. Nanoparticles of the microneedle patch jointly load gambogic acid and oleic acid functionalized cerium dioxide, through microneedle transdermal drug delivery, active targeting of the drug to the liver is achieved by using natural inflammatory taxis of a macrophage membrane, the anti-inflammatory effect of gambogic acid and the anti-oxidation effect of cerium dioxide are synergistically exerted, polarization of macrophages is adjusted, and the anti-inflammatory effect of the drug on the liver is achieved. Therefore, the liver injury caused by the septic shock is treated.

The invention discloses an acupoint application for treating polycystic ovarian syndrome and a preparation and use method thereof. The acupoint application comprises a radix salviae miltiorrhizae acupoint application, a semen cuscutae-radix salviae miltiorrhizae acupoint application, a radix morindae officinalis-radix salviae miltiorrhizae acupoint application and a semen cuscutae-radix morindae officinalis acupoint application. The traditional Chinese medicine composition is prepared from salvia miltiorrhiza, semen cuscutae and salvia miltiorrhiza, morinda officinalis and salvia miltiorrhiza, and semen cuscutae and morinda officinalis. The invention further provides a preparation method of the acupoint application and an artificial cycle therapy using method. The acupoint application medicine cake has the advantages that the acupoint application medicine cake is mainly used for treating the polycystic ovarian syndrome, has the effects of tonifying the kidney, activating blood, removing stasis and promoting follicular maturation and ovulation, is convenient and safe to apply externally, can enhance the compliance of a patient, can be absorbed through peritoneal transdermal absorption, can avoid the first-pass effect of oral administration, is closer to a disease site in the administration position, and takes effect faster.

This invention discloses an orally disintegrating film formulation of BPC-157 sodium salt for treating acute alcohol poisoning and its preparation method. It relates to the field of acute alcohol poisoning treatment technology. The orally disintegrating film formulation comprises, by weight percentage: 0.1-5% BPC-157 sodium salt, 40-70% film-forming material, 5-15% plasticizer, 0.1-15% disintegrant, 0.1-15% sweetener, 0.1-10% salivary stimulant, and 1-5% other excipients. This invention prepares an orally disintegrating film formulation of BPC-157 sodium salt, utilizing its rapid dissolution characteristics and the pharmacological effects of BPC-157, providing a new option for treating acute alcohol poisoning. This formulation has advantages such as rapid onset of action, high bioavailability, and few side effects, and is expected to become an effective drug for treating acute alcohol poisoning.

The invention provides a traditional Chinese medicine composition for improving insomnia and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is an external preparation. The traditional Chinese medicine composition comprises traditional Chinese medicine components and a pharmaceutically acceptable transdermal drug delivery carrier, the traditional Chinese medicine component is prepared from the following components in parts by weight: 50 to 70 parts of dens draconis, 30 to 50 parts of flos albiziae, 10 to 20 parts of radix polygalae, 10 to 20 parts of rhizoma coptidis, 2 to 10 parts of fructus amomi and 10 to 30 parts of wine-processed rhizoma polygonati; the transdermal drug delivery carrier comprises a matrix, a humectant and a penetration enhancer. The traditional Chinese medicine composition is used for preparing acupoint patches for preventing and treating insomnia. The dens draconis, the albizia flowers, the polygala tenuifolia, the coptis chinensis, the fructus amomi and the wine-processed rhizoma polygonati are combined into a synergistic traditional Chinese medicine composition; the composition integrates the effects of tranquilizing by heavy prescription, resolving depression, soothing the nerves, promoting the circulation of heart and kidney, clearing away heart-fire, strengthening the spleen and stomach, supporting healthy energy and the like, and performs comprehensive conditioning on the core pathogenesis of heart-kidney disharmony caused by insomnia and common syndromes (heart fire, phlegm disturbance, spleen deficiency and yin deficiency) of heart-kidney disharmony caused by insomnia and the common syndromes of heart fire, phlegm disturbance, spleen deficiency and yin deficiency).

This invention relates to a technical optimization scheme, specifically disclosing a traditional Chinese medicine rice wine for mental disorders. This rice wine is prepared by the following method: S1, soaking rice: Take glutinous rice and a water tank, place the glutinous rice in the water tank and soak it until the water completely submerges the rice. Soak for 25-32 hours at a temperature of 6-15℃, wherein the ratio of glutinous rice to water is 1:3. This invention focuses on three core dimensions: soothing the liver and relieving depression, calming the mind and stabilizing the will, and resolving phlegm and opening the orifices. Bupleurum, Curcuma, and Cyperus relieve liver depression and regulate Qi; Ziziphus jujuba seed, Platycladus orientalis seed, and Polygala tenuifolia nourish the heart and calm the mind, stabilizing the will and relieving irritability; Acorus tatarinowii, Pinellia ternata, and Citrus reticulata resolve phlegm, open the orifices, and strengthen the spleen and stomach. The multi-component synergistic effect comprehensively regulates the three major pathogenesis mechanisms of liver Qi, heart and mind, and phlegm-dampness, precisely targeting symptoms such as low mood, irritability, insomnia, chest tightness, belching, and restlessness caused by mental disorders.

The invention discloses a ginsenoside-containing flash release agent as well as a preparation method and application thereof. The flash release agent is prepared from red ginseng, dwarf lilyturf tuber, Chinese magnoliavine fruit and specific auxiliary materials, and does not contain any sweetening agent or flavoring agent. The preparation method comprises the steps of superfine grinding, clathration and taste masking and direct tabletting. According to the invention, by optimizing the ratio of auxiliary materials and a tabletting process, the preparation is rapidly disintegrated within 3 seconds under the tongue, active ingredients are directly absorbed by sublingual mucous membrane, the first-pass effect is effectively avoided, and the preparation rapidly takes effect within 3 minutes; meanwhile, a sugar-free formula and a cyclodextrin inclusion technology are adopted, so that the beverage tastes good and is suitable for diabetics. The preparation method is simple and convenient in process and excellent in stability, and can be used for preparing medicines or health-care products for improving learning and memory, relieving fatigue or assisting sedation.

The application relates to the field of traditional Chinese medicine compositions, and particularly discloses a traditional Chinese medicine composition for treating chronic prostatitis and a preparation method thereof; the traditional Chinese medicine composition comprises the following steps: S1: preparing a matrix material by taking amphoteric starch, L-arginine hydrochloride, hydroxypropyl cellulose, water and glutaraldehyde; S2: preparing traditional Chinese medicine extracts by taking sophora flavescens, psoralea corylifolia, patrinia, cuscuta chinensis, herba epimedii, red peony root, verbena, Chinese chive seed, Chinese yam, prepared rehmannia, cornus officinalis, radix paeoniae rubra, alisma orientale, poria cocos, cassia, prepared aconite, and yam of china; S3: preparing a traditional Chinese medicine gel by taking the traditional Chinese medicine extracts, water and the matrix material; S4: preparing a warming agent by taking an emulsifier, water, n-docosane and hydroxypropyl cellulose; and S5: uniformly mixing the traditional Chinese medicine gel, borneol, the warming agent, poloxamer, carboxymethyl cellulose, hydroxypropyl-BETA-cyclodextrin and ethanol, controlling the pH value to be 7.3-7.5, and obtaining the traditional Chinese medicine composition.

The present application relates to the technical field of external treatment of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine acupoint paste for regulating metabolism, a preparation method and application thereof. In view of the deficiency of the existing part of the metabolism regulation paste product in focusing on the function of a single Zang organ, the present application provides a traditional Chinese medicine acupoint paste based on the same regulation theory of liver, spleen and kidney. The paste is composed of the following medicinal materials in parts by weight: 20-30 parts of Radix Astragali, 12-15 parts of Radix Bupleuri, 15-20 parts of Herba Epimedii, 10-12 parts of Rhizoma Chuanxiong, 10-12 parts of Paeonia, 15-18 parts of Rhizoma Corydalis, 10-15 parts of Radix Atractylodis, 15-18 parts of Rhizoma Cyperi and 4-5 parts of Borneolum Syntheticum. The present application is used for the comprehensive regulation of the functions of liver, spleen and kidney through the synergistic effect of drugs and specific acupoints, and is suitable for the auxiliary regulation of the metabolic disorder state caused by liver stagnation, spleen dysfunction and kidney dysfunction.