29 results about "Acute alcohol" patented technology

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for improving acute alcoholic gastric mucosal lesion and application. The invention discloses the new medical application of the lucid ganoderma, ginseng and kudzuvine root formula for the first time, and experiments and clinical verifications prove that the formula can increase the activity of key enzymes in stomach and liver tissues of a mouse with acute alcoholic gastric mucosal injury, reduce the content of a proinflammatory factor TNF-alpha in the stomach tissues, increase the generation of an anti-inflammatory factor IL-10 in the stomach tissues, relieve the inflammatory injury of ethanol to gastric mucosa, improve the curative effect of alcohol on the gastric mucosa and improve the curative effect of alcohol on the gastric mucosa. The levels of protective factors EGF, SS and PGE-2 in serum are increased, the defense mechanism of gastric mucosa is enhanced, and the repairing capacity of the gastric mucosa is improved. The discovery has great influence on the research and treatment of acute alcoholic gastric mucosal injury diseases, and has clinical practical value.

The invention belongs to the technical field of medicines, and particularly relates to a plant lactobacillus for relieving acute alcoholic liver injury as well as a metagen and application of the plant lactobacillus. The strain of the plant lactobacillus L5-13 is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the strain is CCTCC NO: M 20251835. The strain and the metagen thereof can significantly improve pathological symptoms of mice with acute alcoholic liver injury, including: reducing the levels of ALT, AST, TC, TG and LDL-C in serum of the mice with acute alcoholic liver injury, and increasing the level of HDL-C; the abnormal blood lipid level of the mouse caused by acute alcohol is regulated; the activity of antioxidant enzymes in the liver is improved, and the lipid peroxidation level is reduced; the ethanol dehydrogenase activity of the liver is improved, and the ethanol metabolism capability is enhanced. Therefore, the strain and the metagen thereof have wide application prospects in prevention or treatment of acute alcoholic liver injury.

The invention discloses a rhizoma polygonati extract and application thereof in preparation of a functional alcoholic beverage, and belongs to the technical field of functional alcoholic beverages. The prepared rhizoma polygonati extract can be mixed and dissolved with beer and white spirit, and the rise of uric acid caused by drinking a large amount of beer can be remarkably reduced by drinking the beer added with the prepared rhizoma polygonati extract; the increase of AST and ALT caused by drinking a large amount of white spirit can be remarkably reduced by drinking the white spirit added with the rhizoma polygonati extract prepared by the invention, and the rhizoma polygonati extract can be used for developing beer with the function of reducing uric acid and white spirit with the function of preventing acute alcoholic liver injury; the provided rhizoma polygonati extract does not affect the appearance quality and taste of beer and white spirit, the preparation method is simple and easy to operate, special equipment is not needed, high temperature and high pressure are not needed, the preparation process is safe, toxic and harmful substances are not generated, energy is saved, environment friendliness is achieved, and the method is suitable for large-scale production.

The invention discloses application of roxburgh rose exosomes in preparation of products for preventing and treating acute alcoholic liver injury, relates to extraction of the roxburgh rose exosomes and new application of the roxburgh rose exosomes in prevention and treatment of the acute alcoholic liver injury, and belongs to the technical field of biology. The roxburgh rose exosome can also prevent and treat acute alcoholic liver injury. The particle size of the roxburgh rose exosome is 135.2 nm, the particle concentration is 1.3 * 10 < 11 > Particle / mL, and the total protein concentration is 2.12 mu g / mu L. A new thought is provided for research and development of drugs for preventing and treating acute alcoholic liver injury, the extraction method of the roxburgh rose exosome is simple, full development and utilization of food resources can be promoted, and a drug or a health care product for preventing and treating acute alcoholic liver injury is provided.

The invention belongs to the technical field of biological medicines, and relates to application of mannatide in preparation of a medicine for treating alcoholic gastric ulcer. The mannatide disclosed by the invention can be used for remarkably relieving gastric tissue hemorrhagic lesion and ulcer conditions of alcoholic gastric ulcer for the first time, and the mechanism comprises the following steps: reducing active oxygen generated by alcohol toxicity, and improving oxidative stress of a body by improving antioxidant enzyme activity of the gastric tissue; the inflammatory response of the organism is regulated by regulating and controlling an Akt / NF-kB pathway; a Bax-related apoptosis pathway is inhibited to protect gastric mucosa cells from alcohol-induced apoptosis, so that the integrity of gastric tissue mucosa is protected; the intestinal flora disorder caused by alcohol intake is regulated and controlled, and the acute alcoholic gastric ulcer is prevented by improving the intestinal flora composition of the alcoholic gastric ulcer. The application range of the mannatide is widened, and more solutions are provided for prevention or treatment of acute alcoholic gastric ulcer.

The invention discloses a preparation method and application of near-infrared fluorescent dye DOM-O for acute alcoholic liver injury detection. The specific chemical structural formula of the near-infrared fluorescent dye DOM-O is shown in the specification. The near-infrared fluorescent dye prepared by the invention has excellent fluorescence imaging performance, can realize specific fluorescence imaging diagnosis of the acute alcoholic liver injury, and provides an imaging dye with application prospect for early detection and clinical diagnosis of the acute alcoholic liver injury.

The invention discloses a composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof. The composition is prepared from the following raw material medicines: 30-50 parts of oyster peptide, 50-100 parts of radix puerariae, 50-100 parts of hovenia dulcis thunb, 20-30 parts of chrysanthemum, 20-30 parts of endothelium corneum gigeriae galli, 20-30 parts of malt, 20-30 parts of pericarpium citri reticulatae, 20-30 parts of liquorice, 20-30 parts of fructus lycii, 10-20 parts of red dates, 10-20 parts of American ginseng and 10-20 parts of corn oligopeptide. Pharmacodynamic tests show that the composition can significantly reduce drunkenness time, improve activity of ethanol-related metabolic enzymes, reduce levels of serum ALT, AST and ALP induced by acute alcoholic liver injury, enhance expressions of various antioxidant systems in liver tissues, significantly inhibit secretion level of inflammatory factors in serum, and improve liver injury resistance. Meanwhile, hepatic lesions and fat deposition are relieved at a histological level, so that the composition disclosed by the invention has obvious functions of dispelling the effects of alcohol and protecting the liver through scientific proportioning and synergistic interaction of the raw materials.

The present application relates to the technical field of medicine, in particular to a kind of drug composition for improving acute alcoholic gastric mucosal injury and application.The present application discloses the new medical use of ganoherbae decoction for the first time, and the composition can increase the activity of key enzyme in the stomach and liver tissue of acute alcoholic gastric mucosal injury mice, reduce the content of pro-inflammatory factor TNF-α in gastric tissue, increase the production of anti-inflammatory factor IL-10 in gastric tissue, reduce the inflammatory damage of ethanol to gastric mucosa, increase the level of protective factor EGF, SS and PGE-2 in serum, enhance the defense mechanism of gastric mucosa, and improve the repair ability of gastric mucosa.The discovery will have a significant impact on the research and treatment of acute alcoholic gastric mucosal injury disease, and has clinical practical value.

The invention relates to the technical field of medical preparations, and discloses application of HMB (beta-hydroxy-beta-methylbutyric acid) or an HMB-containing substance in preparation of a medicine for preventing and / or relieving alcohol hangover and / or relieving acute alcoholic liver injury. The substance containing HMB comprises calcium beta-hydroxy-beta-methylbutyrate (CaHMB), the CaHMB can significantly improve the tolerance of acute alcohol exposure and improve damaged exercise coordination, and the CaHMB can reduce the content of ethanol in serum and accelerate the change process of acetaldehyde in the serum; meanwhile, CaHMB can enhance the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH2) in the liver and accelerate the alcohol metabolism process; besides, the CaHMB can reduce the levels of ALT and AST in serum, relieve liver inflammation caused by alcohol, effectively relieve liver injury and achieve the effects of dispelling the effects of alcohol and protecting the liver.

The invention provides a hedyotis diffusa extract and a preparation method thereof, the hedyotis diffusa extract is prepared by taking a hedyotis diffusa medicinal material as a raw material, adding a 75-85% ethanol solution for extraction, and filtering; concentrating the filtrate until no alcohol smell exists, precipitating with water, and filtering; separating the filtrate by using macroporous resin, sequentially adding 1.5-2.5 BV of water and 3-4BV of 55-65% ethanol solution for elution, collecting 2BV-3BV sections at the tail end of ethanol eluent, and concentrating to obtain a finished product. The invention further provides application of the oldenlandia diffusa extract in preparation of drugs for preventing and / or treating acute gastric mucosal lesion, gastric ulcer and reflux esophagitis, and particularly, the acute gastric mucosal lesion caused by alcohol or acute alcoholic gastric mucosal lesion and the gastric ulcer caused by excessive gastric secretion are included. In addition, the invention also provides a preparation containing the oldenlandia diffusa extract. The oldenlandia diffusa extract provided by the invention has a better curative effect of resisting acute gastric mucosal lesion, the preparation process is green and environment-friendly, the preparation method is simple, and the oldenlandia diffusa extract is suitable for industrial popularization.

The invention belongs to the technical field of medicines, and particularly relates to lactobacillus rhamnosus for relieving acute alcoholic liver injury as well as a metagen and application of the lactobacillus rhamnosus. The lactobacillus rhamnosus L11-4 strain is preserved in the China Center for Type Culture Collection on August 18, 2025, and the preservation number of the lactobacillus rhamnosus L11-4 strain is CCTCC (China Center for Type Culture Collection) NO: M 20251834. The strain and the metagen thereof can significantly improve pathological symptoms of mice with acute alcoholic liver injury, and have the effects of reducing the levels of ALT, AST, TC, TG and LDL-C in serum of the mice with acute alcoholic liver injury, increasing the level of HDL-C, and regulating abnormal blood lipid level of the mice caused by acute alcohol; the activity of antioxidant enzymes in the liver is improved, and the lipid peroxidation level is reduced; in addition, the ethanol dehydrogenase activity of the liver can be improved, and the ethanol metabolism capability is enhanced. Therefore, the strain and the metagen thereof have wide application prospects in prevention or treatment of acute alcoholic liver injury.

The invention relates to the technical field of biological medicines, in particular to application of a pepper ethanol extract in preparation of medicines and health-care products for preventing and treating alcoholic liver injury. The method has the beneficial effects that the liver index, the liver injury score, the liver tissue TG content, the AST content and the ALT content of a pepper ethanol extract sample group mouse are remarkably reduced compared with those of a model group mouse, and a remarkable acute alcoholic liver injury prevention and treatment effect of the sample is shown.

The invention relates to an RNA (Ribonucleic Acid) medicine, which is used for coding ALDH2 (Alcohol Dehydrogenase 2) protein, can efficiently express ALDH2 and quickly and durably reduce the content of acetaldehyde in a body, and is used for treating acute alcoholism caused by acetaldehyde accumulation as well as diseases such as metabolism, cardiovascular diseases, neurological diseases, malignant tumors and the like.

The invention discloses a phosphodiesterase 9A inhibitor for treating alcohol addiction and acute alcoholism, relates to the technical field of medicines, and has the technical key point that the inhibitor is BI-409306. The BI-409306 can influence the drinking behavior of a mouse with alcohol addiction by adjusting synaptic plasticity and intervene the formation of addiction. In addition, the BI can also reduce acute alcohol toxicity injury by recovering the GPX4 level and reducing inflammatory factors. The invention not only lays a research foundation for exploring the effect and mechanism of BI in alcohol addiction in the future, but also provides a new target and thought for clinically treating alcohol addiction.

The invention discloses an application of a plant extract in preparation of a product for dispelling effects of alcohol and protecting liver. According to the invention, it is proposed for the first time that the gynostemma pentaphyllum extract can reduce the drunkenness rate by enhancing the activity of related enzymes for dispelling the effects of alcohol, reduce liver lipid accumulation and enhance antioxidant activity so as to improve acute alcoholic liver injury induced by ethanol, and a certain theoretical basis is provided for development and utilization of the gynostemma pentaphyllum extract and research and development of products for dispelling the effects of alcohol and protecting liver.

The invention belongs to the technical field of biological pharmacy, and particularly relates to rhizoma polygonati polysaccharide with the effects of preventing acute alcoholism, dispelling the effects of alcohol and protecting the liver as well as a preparation method and application of the rhizoma polygonati polysaccharide. The method comprises the following steps: crushing dried rhizoma polygonati in a crusher, taking a certain amount of rhizoma polygonati powder, adding distilled water according to a set material-liquid ratio, adjusting the pH value to 5.0, adding 1% of compound enzyme, putting into a water bath kettle, carrying out ultrasonic-assisted extraction at 65 DEG C for 55 minutes, carrying out enzyme deactivation at 95 DEG C for 10 minutes, filtering while hot, putting filtrate into a rotary evaporator, carrying out evaporation concentration, adding a Sevage reagent with the volume 4 times that of the filtrate, shaking for 20 minutes, centrifuging to remove protein, and dialyzing with deionized water for 24 hours, and adding 95% ethanol, standing overnight, centrifuging for 15 minutes at the speed of 3500 r / min, and freeze-drying the precipitate to obtain the polygonatum polysaccharide. Polygonatum sibiricum polysaccharide can effectively enhance the activity of ethanol dehydrogenase and acetaldehyde dehydrogenase and promote catabolism of alcohol.

The application belongs to the field of pharmacy, discloses a fused ring morphine derivative and a preparation method and application thereof, and relates to N-cyclopropylmethyl-4'-substituted aminonalepotem series derivatives with formula (I) and pharmaceutically acceptable salts. The derivative with formula (I) is prepared by reacting thebaine with a substituted phenyl vinyl ketone reagent and through a series of conversion methods. Among them, N-cyclopropylmethyl-(4'-benzoyl amino) nalepotem (SLL-1062) is a typical high selectivity mu opioid receptor antagonist, and can be applied to the research and development in the fields of diagnosis and treatment of opioid and other narcotic analgesic dependence, opioid drug-induced intestinal dysfunction, sedative hypnotics and acute alcohol poisoning, opioid and other narcotic analgesic poisoning and the like.

Provided herein are methods for treating acute alcohol toxicity using an agonist for a Fibroblast Growth Factor Receptor (FGFR) andβKlotho complex such as Fibroblast Growth Factor 21 (GFF21). Also provided are compositions and kits comprising these agonists (e.g., FGF21 (for administration to a subject in need.

The invention belongs to the field of development of medicinal and edible plants, and particularly relates to an exocarpium citri grandis composite extract for dispelling effects of alcohol and protecting liver and a preparation method thereof. The compound extract comprises exocarpium polysaccharide, exocarpium oligosaccharide, exocarpium flavone and exocarpium essential oil. Essential oil is treated by adopting a beta-cyclodextrin inclusion technology, polysaccharide and oligosaccharide are compounded into a culture medium, and the culture medium is fermented by complex flora such as lactobacillus plantarum and streptococcus thermophilus and then is mixed with inclusion essential oil and flavone to play a synergistic effect. Experimental results show that the exocarpium citri grandis composite extract has a remarkable hangover alleviating effect and lipid metabolism capability in an acute alcoholism mouse model, and the effectiveness of the exocarpium citri grandis composite extract in the aspects of hangover alleviating and liver protection is proved.

This invention discloses an orally disintegrating film formulation of BPC-157 sodium salt for treating acute alcohol poisoning and its preparation method. It relates to the field of acute alcohol poisoning treatment technology. The orally disintegrating film formulation comprises, by weight percentage: 0.1-5% BPC-157 sodium salt, 40-70% film-forming material, 5-15% plasticizer, 0.1-15% disintegrant, 0.1-15% sweetener, 0.1-10% salivary stimulant, and 1-5% other excipients. This invention prepares an orally disintegrating film formulation of BPC-157 sodium salt, utilizing its rapid dissolution characteristics and the pharmacological effects of BPC-157, providing a new option for treating acute alcohol poisoning. This formulation has advantages such as rapid onset of action, high bioavailability, and few side effects, and is expected to become an effective drug for treating acute alcohol poisoning.

The application belongs to the field of biotechnology and medical health, and discloses a casein preparation capable of delaying alcohol absorption and application of the casein preparation in food. The application provides a preparation formula taking casein as a core active ingredient in view of the problems of obvious side effects and insignificant effect of existing alcohol elimination products. The casein preparation can form a colloid condensation layer in gastric juice to protect gastric mucosa, delay the absorption speed of alcohol in the gastrointestinal tract, reduce the damage of alcohol to the gastrointestinal tract and liver, and up-regulate the activity of liver ethanol dehydrogenase ADH and acetaldehyde dehydrogenase ALDH to accelerate alcohol metabolism. The casein preparation can reduce the drunken rate after acute alcohol intake, significantly prolong the drunken time, has excellent alcohol absorption delaying effect and eating safety, and is suitable for preparing various alcohol absorption delaying, liver and stomach protecting food.

The invention relates to oxazepam and a crystal preparation method thereof. In one aspect, the invention relates to oxazepam in crystalline form that exhibits a diffraction peak at about 6.54 DEG, about 14.78 DEG, about 20.33 DEG in a powder X-ray diffraction pattern, expressed at 2 [theta] angle, using Cu-K [alpha] radiation. The invention also relates to a method for preparing the oxazepam and application of the oxazepam in preparation of drugs for relieving anxiety, tension, excitation, hypnosis, anxiety accompanied with deprementia and relieving acute alcohol withdrawal symptoms.

The invention discloses an application of a boenninghausenia sessilicarpa root extract in preparation of a medicine for treating gastric ulcer. The boenninghausenia sessilicarpa root extract is an alcohol extract of boenninghausenia sessilicarpa root, is preferably extracted by an alcohol solvent (such as ethanol), and can be further obtained by fractional extraction and purification by petroleum ether and ethyl acetate. The invention discovers and verifies that the specific alcohol extract of the sessilicarpa nudiflora root has good anti-gastric ulcer activity for the first time, especially has obvious protection and treatment effects on an acute alcoholic gastric ulcer model, and expands the medicinal part of the sessilicarpa nudiflora and the application range of the sessilicarpa nudiflora; a candidate substance and a feasible way are provided for developing a novel natural anti-gastric ulcer medicine.

The application provides application of Gao Yao-4 medicine powder in preparation of a medicine for treating or preventing acute alcoholic liver, and belongs to the field of medicine. It is found for the first time that the drugs in the Gao Yao-4 medicine powder have a combined effect, can effectively reduce the content of AST, ALT and TBIL in serum and liver tissue after a large amount of drinking, effectively reduce the content of TC, TG, MDA, TNF-alpha, IL-1beta and IL-6 in liver tissue after a large amount of drinking, improve the content of SOD, reduce the apoptosis rate of liver tissue cells, improve the expression amount of Bc1-2 protein, and reduce the expression amount of Bax, caspase3 and C-caspase3 protein, and has a repairing and protecting effect on alcoholic liver cell damage. It is shown that the Gao Yao-4 medicine powder can be used for treating / preventing acute alcoholic liver damage, and does not have side effects, and has high safety.

This invention provides a compound, its preparation method, a pharmaceutical composition, and its applications, relating to the field of pharmaceutical technology. The compound provided by this invention has the structure shown in Formula I. This compound can effectively relieve acute alcohol poisoning and protect the liver from damage. In vitro cell experiments show that this compound can accelerate the excretion of ethanol, acetaldehyde, and their metabolites in vivo, protect hepatocytes from acetaldehyde-induced lipid peroxidation, and prevent acetaldehyde-induced glutathione reduction. In a mouse model of acute alcohol poisoning, this compound can significantly delay the onset of intoxication and significantly accelerate the sobering-up time. Furthermore, the compound provided by this invention has low toxicity and good drug-like properties. This invention provides a method for preparing the compound with the structure shown in Formula I, which is simple to synthesize and has a high yield.

The application discloses an alcoholism-relieving and liver-protecting beverage as well as a preparation method and application thereof, and belongs to the technical field of biotechnology.The alcoholism-relieving and liver-protecting beverage disclosed by the application comprises the following raw materials: Chinese jujube seeds, radix puerariae, dendrobium, rhizoma imperatae, chrysanthemum, raw rehmannia, raw licorice, corn silk and lemon slices.The alcoholism-relieving and liver-protecting beverage disclosed by the application can effectively relieve acute alcohol-induced liver injury by improving liver function, regulating lipid metabolism, reducing liver tissue pathological injury and regulating core metabolic pathways, and provides an experimental basis for the development and application of the alcoholism-relieving and liver-protecting functional beverage.

The invention discloses bitter-removing ganoderma lucidum wine capable of relieving acute alcoholic liver injury and a preparation technology of the bitter-removing ganoderma lucidum wine, and solves the problems that traditional ganoderma lucidum compound wine is heavy in bitter medicine taste, unstable in quality, not remarkable in effect and the like. The preparation method comprises the following steps: obtaining a ganoderma lucidum functional factor concentrated solution through processes such as magnetization bitter removal drying, percolation extraction, vacuum concentration and freeze drying, and further compounding the ganoderma lucidum functional factor concentrated solution with a Maotai-flavor wine base through a targeted percolation blending process. Efficacy verification tests show that compared with white spirit without the lucid ganoderma extract, the bitter-removing lucid ganoderma wine has the effects of reducing the activity of alanine transaminase and the content of malondialdehyde in a mouse body induced by alcohol, improving lipid metabolism and liver injury and relieving acute alcoholic liver injury, so that the liver is prevented from being damaged by alcohol or the damage of alcohol is relieved; compared with traditional ganoderma lucidum compound wine, the ganoderma lucidum compound wine is light in color, free of peculiar smell, stable in quality and capable of improving the capacity of resisting alcohol and tolerance to alcohol of the organism after being drunk for a long time.

The invention discloses application of paraxanthine in preparation of a composition for dispelling the effects of alcohol and / or preventing or improving hangover. The methods and compositions of the present invention can increase the tolerance of a subject to alcohol, alleviate the alcohol-induced drunkenness of a drunken subject, wake up the drunken subject, promote the degradation of alcohol and acetaldehyde in the body of the subject, activate the alcohol metabolism in the liver tissue of the subject, improve or recover alcoholic liver injury, improve alcohol-induced dyskinesia, and improve alcohol-induced dyskinesia. And adverse reactions or symptoms related to hangover caused by hangover or acute alcoholism can be prevented, improved or relieved.

This invention discloses a kudzu root polysaccharide, its preparation method, and its applications, relating to the field of biotechnology. The kudzu root polysaccharide is composed of glucose and fructose, and contains six glycosidic bonds: Glcp-(1→, →1)-Fruf-(2→, →3)-Glcp-(1→, →4)-Glcp-(1→, →3,4)-Glcp-(1→ and →4,6)-Glcp-(1→). Functional verification experiments revealed that this kudzu root polysaccharide can effectively prevent acute alcohol poisoning, has a therapeutic effect on oral ulcers, and exhibits antioxidant, anti-inflammatory, antibacterial, and anti-aging activities. This invention, which extracts polysaccharides from kudzu root, not only has significant health benefits but also substantial economic and social benefits. It provides technical support for expanding the application of traditional Chinese medicinal materials and offers a novel, natural solution to various health problems.