64 results about "LIVER CELL DAMAGE" patented technology

The invention discloses a composite probiotic beverage for dispelling the effects of alcohol and special composite probiotic thereof. The composite probiotic is composed of streptococcus thermophilus,lactobacillus paracasei, lactobacillus acidophilus, lactobacillus bulgaricus, lactobacillus plantarum, bifidobacterium longum and bifidobacterium breve according to a CFU ratio of 2: 3: 4: 1: 1: 1: 3. The composite probiotic beverage for dispelling the effects of alcohol is composed of composite probiotic powder, prebiotics, amino acid and fruit powder. Through use of seven kinds of active probiotics, the composite probiotic beverage can adjust the balance of intestinal flora, improve the immunity of the human body, effectively remove acetaldehyde in the small intestine and colon and relievethe symptoms of headache, dizziness and the like caused by drinking, can be colonized in the intestines, can prevent intestinal flora disturbance caused by drinking, can reduce liver cell damage and can effectively protect liver health. The probiotics contain alcohol dehydrogenase and acetaldehyde dehydrogenase and can effectively decompose alcohol through synergizing with human alcohol dehydrogenation and acetaldehyde dehydrogenase.

The invention relates to a method for separating, culturing and identifying primary hepatic cells of livestock and fowl, which integrates a chelation process and an in-situ two-step perfusion process. Ca<2+> and Mg<2+> in hepatic tissues of livestock and fowl are previously removed so that the hepatic tissues maximally release the primary hepatic cells; and the formula of additives of the culture fluid is adjusted to perfect the serum-free culture system and identify the glycogen of the obtained primary hepatic cells. The invention can effectively enhance the quantity, motility and purity of the separated primary hepatic cells of livestock and fowl, and is applicable to various animals; and the obtained primary hepatic cells have the advantages of fewer traumas, high wall attaching tendency and high activity, can be widely used for physiological function adjustment, metabolic diseases, and pharmacological and toxicological mechanisms of hepatic cells of livestock and fowl, can establish a virus infected cell model, and can be used for research in the fields of physics and chemistry, toxicant factor influence and the like.

Nonalcoholic steatohepatitis (NASH) is a disease of the liver characterized by inflammation and damage to the liver cells. Typically, steatohepatitis involves inflammation of the liver related to fat accumulation, and mimics alcoholic hepatitis but is observed in patients who seldom or never consume alcohol. Nonalcoholic steatohepatitis can lead to serious liver damage, and ultimately cirrhosis. The present invention provides methods and compositions useful for the treatment or alleviation of nonalcoholic steatohepatitis and the pharmaceutical formulations for their administration to a human. Specifically, compositions comprised of lecithin, antioxidants and vitamin B complex are administered parenterally, most preferably by oral administration. Specific therapeutic formulations include admixtures of these compounds and specific dosage formulations include daily oral administrations of these compounds in tablet or powder forms.

The invention relates to application of a peptide containing a sequence as shown in a formula I or a derivant thereof in preventing or treating liver damage, in particular to application of the peptide or the derivant thereof in preventing or treating the liver damage and hepatitis C. The formula I is as follows: Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4, wherein Xaa1 is deficiency, Ala, Gly, Val and Leu or Ile; Xaa2 is Thr or Ser; Xaa3 is Tyr and Phe or Trp; and Xaa4 is deficiency, Ala, Gly, Val, Leu and Ile or Pro. The invention also relates a medicine composite containing the peptide or the derivant thereof, a preparation method thereof and polynucleotide coding the peptide.

An application of human s DR5 protein in preparing the medicines for treating the viral hepatitis B, especially the acute severe viral hepatitis B, by protecting liver cells and preventing the wither of liver cells is disclosed.

The present invention is a beverage for relieving and preventing harmful effects of alcohol consumption such as hangover and liver cell damage, which includes Curcuma longa Rhizome extract, L-Ornithineamino acid, and Inositol as active ingredients. The curcumin extracts standardized to ≥95% pure curcuminoids having at least 12% in the form of water-dispersible micelle liquid or at least 10% in the form of nanosuspension. A method for beverage composition includes a defined amount of curcumin extract, L-Ornithine Inositol, and sugar syrup, wherein the curcumin extract, L-Ornithine and Inositol Powder added to the separately prepared sugar syrup under constant stirring. The present invention accelerates In vivo decomposition of alcohol after drinking, thereby helping to relieve and prevent harmful effects of alcohol such as hangover and liver damage.

The invention designs a novel lipid-lowering polypeptide P48. The novel lipid-lowering polypeptide P48 is prolonged in a half-life period, plays the role of a GLP-1 receptor agonist and also plays therole of a GLP-1 analogue to adjust the fat content of an individual. The P48 peptide can be used for inhibiting feed intake of a non-alcoholic fatty liver model mouse induced by high-fat diet, remarkably reduce the weight of an obese mouse, lower the blood fat level of the obese mouse, maintain the normal form of the liver, inhibit liver cell injury, reduce accumulation of lipid in the liver andvacuolar deformation of cells, increase the level of adiponectin leptin in blood, and give a play to the blood glucose reducing and blood fat regulating effects of the adiponectin leptin; meanwhile, the P48 peptide obviously improves insulin tolerance and sugar tolerance. The novel lipid-lowering polypeptide P48 of the invention has potential pharmaceutical application in preparation of drugs fortreating and preventing obesity or complications thereof, namely non-alcoholic fatty liver diseases.

The invention discloses a new clinical use of scorpion grass, which more particularly relates to the application of the scorpion grass in drugs for treating liver damage, nephritis, benign prostatic hypertrophy, tumor and blood clots diseases. The invention uses the scorpion grass as raw material to produce extract of scorpion grass by extraction according to conventional technology; then accessory material is added, so as to prepare conventional oral dosage or non-oral dosage formulas suitable for clinical use. The invention can be applied to treating liver damage, nephritis, benign prostatic hypertrophy, tumor and blood clots diseases and other cardiovascular diseases.

The invention provides a medicine for treating blood sugar type fatty liver, which is prepared from the following raw materials in parts by weight: 50-70 parts of angelica, 100-150 parts of radix salviae miltiorrhizae, 55-60 parts of astragalus, 60-80 parts of codonopsis pilosula, 50-70 parts of radix rehmanniae, 50-60 parts of gentiana macrophylla, 50-70 parts of radix isatidis, 60-80 parts of medicinal fermented mass, 100-150 parts of oriental wormwood, 40-50 parts of cortex eucommiae, 40-60 parts of milled glutinous broomcorn millet, 40-60 parts of tuckahoe, 30-50 parts of seed of job's tears and 60-70 parts of rhizoma alismatis. The medicine provided by the invention can significantly reduce blood fat, decrease blood viscosity and improve liver cell damage, also has a function of protecting liver and reducing enzyme and has a significant prevention and treatment effect on blood sugar type fatty liver.

The invention relates to a composition for preventing damage on human liver caused by alcoholic liver diseases, especially relates to application of the composition to food, health food or medicine. The composition for preventing alcoholic liver diseases comprises 20-80 parts of rhizoma imperatae, 20-100 parts of root of kudzu vine, 20-100 parts of mulberry, 10-50 parts of dark plum, 1-20 parts of tea, 30-150 parts of corn oligopeptides, 20-80 parts of xylo oligosaccharide, 1-20 parts of gamma-aminobutyric acid and 1-20 parts of taurine. The formula of the composition provided by the present invention is screened based on combination of traditional Chinese medicine prescription application and clinical pharmacology. After heavy drinking, free radicals and superoxide anions produced in the body cause lipid peroxidation, leading to liver cell damage; and ethanol entering into the body is mainly oxidized, under the effect of alcohol dehydrogenase, into acetaldehyde, which further generates carbon dioxide and water. The selection of materials in the formula is based on inhibitory effect of the formula on the pyrogallic acid autoxidation, and alcohol dehydrogenase (ADH) activation ratio measurement.

The invention relates to the technical field of medicine, provides an application of koumine or pharmaceutically acceptable salt of koumine to preparation of drugs for treating hepatocyte damage, andfurther provides pharmaceutically composition for treating the hepatocyte damage. The pharmaceutically composition comprises an active ingredient and pharmaceutically acceptable auxiliary materials, and the active ingredient is koumine or the pharmaceutically acceptable salt of koumine, or is composition of koumine or the pharmaceutically acceptable salt of koumine and one or more other active ingredients. A pharmacology experiment shows that lower-concentration koumine can improve normal and aflatoxin-exposed human liver L02 cell activity; and by transcriptomics analysis, koumine can improveexpression of liver cell growth related genes, so that the effect of promoting liver cell growth is realized, for example, koumine can remarkably improve transcriptional level of genes such as EGR3, CCN2 and CCN1 related to L02 cell division, proliferation and growth functions. Therefore, new theoretical foundation is provided for koumine or the salt of koumine in the aspect of hepatocyte damage treatment.

The invention discloses an application of eupatorin in preparation of a medicine for preventing or treating alcoholic liver diseases, and belongs to the technical field of medicines. According to theinvention, an alcoholic liver disease animal model and a cell model are established through alcohol stimulation, the influence of eupatilin on alcohol-induced hepatocyte damage, oxidative stress and alcohol metabolic enzyme activity is observed, and research finds that eupatilin can significantly reduce alcohol-induced hepatocyte damage in both in-vivo and in-vitro experiments; oxidative stress isrelieved, the activity of alcohol metabolic enzymes is enhanced, and a new thought is provided for preventing and treating alcoholic liver diseases.

The invention discloses a meroterpenoid compound with liver protecting nourishing functions. The meroterpenoid compound with liver protecting nourishing functions comprises structures represented by formula I and II. It is confirmed by experiments that the meroterpenoid compound represented by the formula I and II possesses obvious protective effects on liver cell damage caused by paracetamol, sothat the meroterpenoid compound represented by the formula I and II can be taken as a liver protecting nourishing medicine, and is promising in study development prospect.

The invention discloses a recombined Q-typed hPON1Q in the biological pharmaceutical technological domain, which is characterized by the following: transmitting expressive plasmid to do ectopic secretory expression through skeletal muscle excited by electricity; improving serum PON1 level effectively; preventing liver from damaging as new gene drug; maintaining the activity of phosphoroso enzyme over 16d; making the genome-switching mouse serum ALT and AST level lower than positive contrast group (P<0.01).

Anglerfish skin-sourced collagen peptide with a liver damage repairing effect uses anglerfish skin as a raw material, and is prepared through pretreatment, enzymolysis with alkaline protease and ultrafiltration, wherein the pretreatment comprises the following specific steps: firstly washing the fish skin, soaking in distilled water with the temperature of 2-8 DEG C for 10-30min, then soaking in a6-12-fold sodium hydroxide solution with the concentration of 0.08-0.12mol / L by volume of for 20-24h, then washing by using clear water till a neutral state, draining the water, swelling for 9-15h byusing glacial acetic acid with the concentration of 0.08-0.12mol / L, and pulverizing to obtain anglerfish skin powder; the enzymolysis comprises the following specific steps: adding distilled water and the alkaline protease into the anglerfish skin powder, performing enzymolysis, deactivating enzyme after completion of the enzymolysis, centrifuging and taking a supernatant; the ultrafiltration comprises the following specific steps: performing ultrafiltration by using ultrafiltration membranes with the molecular weight of 8-10KDa, 5-8KDa, 3-5KDa, 1-3KDa and 1KDa below sequentially, and takinga part under the ultrafiltration membrane with the molecular weight of 1KDa below, and removing salt through nanofiltration, and then performing freeze drying. The anglerfish skin-sourced collagen peptide is applied to treatment of the nonalcoholic fatty liver disease.

The invention discloses a turmeric extract, a preparation method and use thereof, and a health care product, and the preparation method is as follows: (1) crushing turmeric to obtain turmeric powder;(2) performing supercritical CO2 extraction on the turmeric powder to obtain deoiled turmeric powder; (3) mixing the deoiled turmeric powder with an entrainer for supercritical CO2 extraction to obtain turmeric extract. The method has the advantages of simple process and high turmeric extract extraction rate, the turmeric extract has an obvious inhibitory effect on the proliferation of hepatoma carcinoma cells, has a good protective effect on acetaminophen (APAP) induced liver cell damage with glutathione (GSH) depletion a main mechanism, and has a significant inhibitory effect on oleic acid-induced lipid content increase and triglyceride content increase in hepatic cells.

The invention discloses a probiotic-containing solid beverage with functions of dispelling effects of alcohol and protecting liver and a preparation method thereof, and belongs to the technical field of health-care food. The invention discloses the probiotic-containing solid beverage with functions of dispelling effects of alcohol and protecting liver. The probiotic-containing solid beverage comprises the following probiotics of lactobacillus reuteri E9, lactobacillus paracasei E6, lactobacillus plantarum P3 and lactobacillus acidophilus LA-03. Meanwhile, the solid beverage comprises the following auxiliary materials of a hawthorn extract, barley grass powder, green tea powder, a fructus gardeniae extract, maltodextrin, juicy peach powder, papaya enzyme, mint powder and erythritol. Through the compatibility and synergistic effect of the components, the effects of nourishing and protecting the liver, protecting the gastric mucosa and eliminating gastrointestinal dysfunction caused by alcoholism can be achieved by effectively improving the hangover alleviating speed, reducing hangover discomfort caused by excessive drinking and reducing hepatocyte damage. The solid beverage is convenient to process, economical in cost and convenient to use by consumers, and has a wide application prospect.

The invention relates to a cosmetic- nutrient black hair caring spray used for preventing and treating white hair generation. In a formula, a plurality of endogenous active substances capable of adjusting melanin through biosynthesis are contained, and an endogenous active substance capable of preventing hair cell damage due to pathology factor such as aging and a natural plant component are contained. The active components in the formula provided by the invention can enhance the metabolism capability of scalp cell and supplement the nutrition of hair quality, the nutrient black hair caring spray has the advantages of safety and no toxicity, and has important meaning for preventing and treating white hair generation.

The invention relates to a microorganism strain and application thereof, in particular to lactobacillus reuteri JYLB-131 for increasing vitality of alcohol dehydrogenase of people after drinking, andan application of the lactobacillus reuteri JYLB-131 to foods and drugs. The preservation number of the lactobacillus reuteri is CGMCC NO.18040, and the lactobacillus reuteri is preserved in the ChinaGeneral Microbiological Culture Collection Center. The lactobacillus reuteri JYLB-131 can increase antioxidant activity of organisms, eliminate free radicals, adjust endocrine, restrain propagation and colonization of harmful bacteria of intestinal tracts, reduce production of endotoxin, adjust balance of intestinal floras, alleviate liver cell damage, increase disease resistance, and have the effects of increasing the vitality of the alcohol dehydrogenase of people after drinking, reducing propanedial content of people after drinking, increasing the activity of superoxide dismutase of peopleafter drinking, and increasing the content of reduced glutathione content of people after drinking, so that discomfort of people after drinking is relieved and improved, and the problems of headache,vomiting, dizziness, fall of blood pressure, cardioacceleration and incontinence of faeces and urine of people after drinking can be solved.

The invention discloses a kudzu flower and ginseng compound anti-alcohol and liver-protecting oral liquid and a preparation method thereof. The kudzu flower and ginseng are used as the monarch medicine and supplemented with six traditional Chinese medicines of ganoderma lucidum, chrysanthemum, skullcap, astragalus, mulberry and thyme. The effective essence of traditional Chinese medicine is extracted by CO2 supercritical, and the extract powder is dried and sieved, and then 9% of the extract powder, 15% of jujube honey, 26% of fresh lotus root juice, and 50% of purified water are mixed and stirred to make an oral liquid. Taking it in time before and after drinking can enhance the function of the liver enzyme system, accelerate the decomposition of alcohol, and improve alcohol tolerance to prevent drunkenness and sobering up. Effectively relieves headache, dizziness, polydipsia and vomiting caused by alcoholism, protects and repairs liver cell damage caused by alcoholism; daily use can also nourish and protect the liver, and remove alcohol poisoning accumulated in the body for many years; it is simple and convenient to take, without side effects; and The curative effect is remarkable, the effect is quick, the course of treatment is short, and the total effective rate reaches 100%.

The invention relates to a Ganoderma lucidum crabapple tea and a preparation method thereof. The Ganoderma lucidum crabapple tea is made of Ganoderma lucidum powdered Begonia tea in bag, Ganoderma lucidum spore powdered Begonia tea in bag or Ganoderma lucidum fermented Begonia tea in bag. The ganoderma lucidum crabapple tea is a health product, and the invention applies the crabapple tea to the preparation, treatment or prevention of liver cell damage in vitro, chronic alcoholic liver cell damage, breast cancer, and lowering blood fat and blood sugar. The preparation process of the invention is simple, the material is easy to obtain, and the application in health tea is considerable. The health tea has a better synergistic effect on CCL4-induced liver cell injury. At the same time, the health tea has obvious inhibitory effect on ALT in the serum of mice with chronic alcoholic liver injury, showing a better synergistic effect. Can be widely promoted.

The invention relates to the field of a new medical purpose of chemical substances, in particular to application of Rhus chinensis Mill. fruits in preparation of a medicine for treating or preventingthe non-alcoholic fatty liver disease. Researches found that different extracts of the Rhus chinensis Mill. fruits can effectively inhibit lipid particle deposition in the liver of a NAFLD model rat and liver cell injuries under a low dosage, and therefore, the extracts of the Rhus chinensis Mill. fruits can serve as a candidate medicine for treating the non-alcoholic fatty liver disease, especially simple fatty liver, fatty liver hepatitis, simple fatty liver merged with glycolipid regulation injuries, fatty hepatitis merged with glycolipid regulation injuries, fatty liver hepatitis liver cirrhosis and fatty hepatitis associated liver cancer. In addition, the medicine raw materials of the invention are from natural edible plant raw materials, and therefore, safety is high.

The invention provides a Chinese medicinal preparation for treating hypoproteinemia caused by liver damage, which is prepared from panax ginseng, siberian solomonseal rhizome, rehmanniae praeparatum, Chinese angelica, figwort root, tortoise-shell glue, szechuan lovage rhizome, large-headed atractylodes rhizome, Chinese thorowax root and the like. The Chinese medicinal preparation has the effects of soothing the liver and tonifying the spleen, invigorating blood circulation and removing blood stasis, softening hard lumps and dispelling nodes and nourishing vital qi, can eliminate ascites and improve plasma albumin obviously on patients who suffer from cirrhosis ascites with low albumin so as to regulate the viscera function of bodies integrally without attending to one thing and losing another, and has the advantages of long-term administration and no toxic or side effect.

The invention relates to a composition for supporting a liver in alcohol toxic substance filtering and a preparation method thereof. The composition comprises the following substances of silybum marianum, rhizoma curcumae longae, fructus arctii and fructus schisandrae chinensis. The composition disclosed by the invention can quickly support the liver to filter alcohol toxic substances, is helpfulfor relieving hangover symptoms, and can supplement moisture and provide liver nutrient components to relieve fatigue and can take effect quickly, and has no toxic or side effect; The present inventors have discovered through a large number of tests that when the silybum marianum is soaked in a vitamin C water solution and then extracted with ethanol in the extraction process, that the content offlavonoids in the extract can be increased, so that liver functions can be protected and supported, and liver cells damaged by alcohol and other toxic substances can be repaired; and the content of rhizoma curcumae longae in the extract can be obviously improved through extraction of a mixed solvent of ethanol and ethyl acetate in the extraction of rhizoma curcumae longae, the antioxidant effect is improved, and free radicals in the human body are removed. The preparation method is simple, and large-scale production can be achieved.

5′-methylthioadenosine (MTA) is described as a compound that is susceptible to inhibiting and / or blocking the epithelial-mesenchymal transition (EMT), a process whereby epithelial cells become mesenchymal cells.The periodical intake of MTA [every 24 h for 21 days] significantly improves fibrosis and the markers for hepatic cellular damage in KO-Mdr2 mice with MTA (28 mg / kg). Following the daily oral administration of MTA, both the expression of EMT markers in the total liver and appreciable signs of fibrosis are significantly reduced, indicating the beneficial effect of MTA on the liver affected by the lack of Mdr2. MTA is proposed to be a safe drug, suitable for oral formulation and without secondary effects, to be used in the prevention and / or treatment of diseases associated with EMT, including chronic cholestatic diseases, fibrosis and cholangiocarcinoma. On the other hand, MTA is proposed for application in anti-tumor therapies by inhibiting or blocking the EMT properties of CSC cells, in order to improve the prognosis of tumor development and the malignancy thereof.

The invention discloses an anti-hepatic fibrosis traditional Chinese medicine compound composition and application thereof The traditional Chinese medicine compound composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-30 parts of astragalus membranaceus, 10-30 parts of radix pseudostellariae, 5-15 parts of angelica sinensis, 5-15 parts of glossy privet fruit, 5-15 parts of poria cocos, 10-30 parts of roasted rhizoma atractylodis macrocephalae, 5-15 parts of pericarpium citri reticulatae, 5-15 parts of wine-processed scutellaria baicalensis and 3-10 parts of honey-fried licorice root. According to the pathogenesis of hepatic fibrosis, a syndrome differentiation and treatment method is adopted, a prescription is screened in combination with pharmacological experiments, and after the medicines in the prescription are scientifically compatible, the traditional Chinese medicine composition has a good liver protection effect on chronic and acute hepatic failure patients clinically, has a good prevention and treatment effect on hepatic fibrosis in vivo, inhibits proliferation of activated hepatic stellate cells in vitro, has the efficacy of preventing liver cell injury, has a good anti-hepatic fibrosis effect, is a promising traditional Chinese medicine compound, and has a good market promotion value.

The invention discloses novel application of blueberry general flavone in the preparation of drugs for preventing and treating liver damage and especially acute liver damage. The inventor of the invention uses mice with LPS / D-GalN induced acute liver damage as the models to research the prevention and protection effects of the blueberry general flavone on the acute liver damage and discovers thatthe blueberry general flavone can evidently increase the 24-hour survival rate of the mice and reduce hepatic cell damage degree, and the serum ALT and AST level of the mice which use the blueberry general flavone is evidently lower than that of the mice which does not use the blueberry general flavone. In addition, the TNF-alpah, IL-1beta and IL-6 content in the hepatic tissue of the models is evidently increased as compared with that of a normal control, the increasing can be effectively inhibited by the blueberry general flavone, and accordingly liver inflammatory reaction inhibition playsan important role in the liver cell protecting activity of the blueberry general flavone.

The invention relates to a use of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of liver-protecting medicaments, foods or health care products. The invention further relates to a use of the 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in the preparation of the medicaments, the foods or the health care products for treating or preventing liver diseases and complications thereof. The 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone is found to have an obvious protecting role for in vitro liver cell injuries through the research of the invention, and can be used for preparing the liver-protecting medicaments, the foods or the health care products; and the 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone further has an obvious repair role for in vivo liver organ injuries, and can be used for preparing the medicaments, the foods or the health care products for treating or preventing liver diseases and the complications thereof, thereby bringing the gospel to patients with the liver diseases and being applicable to large-scale popularization and application.

The invention discloses a functional beverage capable of protecting liver and clearing away toxin and a preparation method thereof. The functional beverage is prepared from, by mass, 30-50 parts of Sabia parviflora Wall.ex Roxb., 10-20 parts of fructus ziziphi jujubae, 5-10 parts of fructus gardeniae, 10-15 parts of kudzuvine root, 10-15 parts of semen cassiae and 10-15 parts of momordica grosvenori. The functional beverage is obtained by directly decocting the materials according to the mass ratio, or, preparing after obtaining mixed material powder by decoction. The Sabia parviflora Wall.ex Roxb. in the functional beverage has the effects of clearing away heat, promoting diuresis, resisting liver cell damage, protecting liver and clearing away toxin; the fructus gardeniae and semen cassiae have the effects of clearing away heat, calming liver, cooling blood and clearing way toxin; the kudzuvine root and momordica grosvenori have the effects of promoting the production of body fluid to relieve thirst and relaxing bowel, and the fructus ziziphi jujubae has the effects of tonifying middle-Jiao and Qi and relieving drug properties. The functional beverage takes full use of the medicinal effects of each material, is reasonable in matching, has the effects of clearing away heat, promoting diuresis, resisting liver cell damage, protecting liver and clearing away toxin, enhancing human immunity, relieving summer-heat and the like, is fragrant, tasty and refreshing, has better mouthfeel and no side effects, and can be suitable for long-term drinking.

The invention relates to the technical field of medicine synthesis, and provides a cholic acid derivative as well as a preparation method and application thereof. The cholic acid derivative provided by the invention has a remarkable effect of inhibiting hepatocyte apoptosis, can effectively inhibit hepatocyte damage induced by glycochenodeoxycholic acid, and the inhibition rate of part of the derivative is superior to that of a positive control tauroursodeoxycholic acid; the cholic acid derivative provided by the invention provides a reference for research and development of liver protection drugs, and has a wide application prospect in preparation of the liver protection drugs.