31 results about "Calcium overload" patented technology

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described.

The present invention provides a method of treating conditions associated with iron and calcium overload comprising administering an effective amount of dexrazoxane or a non-dexrazoxane compound of formula (IA), (IB), or (IC) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive- compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

The invention discloses an application of GSPE (grape seed proanthocyanidin extract) in preparation of a targeted drug for treating cell calcium overload injury. The cell calcium overload injury means vascular endothelial cell calcium overload injury resulting in pyemia, the GSPE does not influence classic signal channels TLR4 and NFkB of LPS (lipopolysaccharide), Orail signals are specifically blocked, and calcium overload signals are blocked. The application indicates that the GSPE can effectively block activation of Orail mediated SOCE (store-operated calcium entry) by LPS, blocks extracellular calcium ion inflow initiated by the Orail mediated SOCE, reverses lung microvascular endothelial cell calcium overload injury of mice with pyemia and reduces the death rate of the mice with pyemia.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

The invention discloses a hydroxyapatite/saccharomycetes biological hybrid material as well as a preparation method and application thereof, and relates to the field of tumor treatment, and the preparation method comprises the following steps: vibrating saccharomycetes in a liquid culture medium overnight, and dispersing in deionized water to obtain a saccharomycetes dispersion liquid; and respectively taking a Ca (NO3) 2 solution and an ammonium phosphate solution with the same volume, mixing, adding the yeast dispersion liquid, stirring, and centrifugally cleaning to obtain the HA/Yeast biological hybrid material. On the basis of the HA/Yeast biological hybrid material, tumor calcium overload and tumor immune collaborative treatment can be realized, and the problem that the tumor killing effect of a single way is relatively weak is solved. The HA/Yeast nano-particles disclosed by the invention are simple in synthesis method, good in dispersity and uniform in size; the yeast can achieve tumor specific targeting by tending to an acid environment, H2S is generated through fermentation to enhance tumor calcium overload, meanwhile, tumor immunotherapy is activated, and finally tumor synergistic killing is achieved.

The present invention relates generally to novel peptides that are capable of modulating the activity of calcium channels in cardiac cells. More specifically, the present invention provides a method of modulating the activity of a cardiac calcium channel comprising contacting a cardiac ryanodine receptor (RyR2) with an amount of a fragment of a dihydropyridine receptor (DHPR) polypeptide sufficient to modulate the activity of said RyR2, and determining the activity of said calcium channel. The inventive method is useful for the treatment of a range of disorders and diseases associated with cardiac dysfunction, particularly those diseases and disorders involving reduced cardiac output and/or aberrant excitation-contraction coupling, calcium overload, or calcium leakage, in cardiac cells.

The invention discloses an application of snake-gourd-fruit and cinnamon-twig decoction to preparing of medicine for treating cerebral arterial thrombosis sequelae. The application is characterized in that the dosage of radices trichosanthis in traditional snake-gourd-fruit and cinnamon-twig decoction is increased by 5 times to serve as a medicine formula, and the snake-gourd-fruit and cinnamon-twig decoction is used for preparing the medicine for treating cranial nerve injuries in the cerebral arterial thrombosis sequelae. According to the application, overloading of calcium in nerve injured cells of brain tissues is reversed mainly through the interaction between active ingredients in the radices trichosanthis and calcium-overloading-resisting medicine targets in the nerve injured cells of the brain tissues in cerebral arterial thrombosis so that the nerve injuries in the cerebral arterial thrombosis sequelae can be relieved, and the recovery effect is achieved.

The invention relates to a photodynamic combined calcium overload nano-carrier and a preparation method and application thereof, and particularly discloses a tumor cell targeted anti-tumor nano-carrier. The tumor cell targeted anti-tumor nano-carrier is characterized in that the nano-carrier comprises calcium peroxide particles, black phosphorus quantum dots are electrostatically adsorbed on the surfaces of the calcium peroxide particles. The calcium peroxide particles adsorbed with the black phosphorus quantum dots are wrapped by a polymer to form nanoparticles, and the polymer is coupled with a modifier of a targeted tumor surface marker; the modifier is selected from an antibody, folic acid, polypeptide and an aptamer of the targeted tumor surface marker. According to the photodynamic combined calcium overload nano-carrier and the preparation method and application thereof, the nano-carrier can promote apoptosis of tumor cells with high expression of GPC3 or inhibit proliferation of the tumor cells, can be used as a biological nano-drug of a GPC3 binding site, and can be used for preparing a drug for preventing and/or treating liver cancer.

The invention provides a hydrogel precursor and hydrogel formed by curing the hydrogel precursor. The hydrogel precursor comprises the following components: 0.3-0.8 mg/mL of gambogic acid lipidosome; 3 to 8 mg/mL of fibrinogen; 3 to 8 NIHU/mL of thrombin; calcium hydrogen phosphate is 15 to 25 [mu] mol/mL; and the balance of water. The precursor has good injectable performance, hydrogel can be formed through physiological response solidification after local injection at a tumor site, in a tumor acid environment, medicine gambogic acid and calcium ions are released after a hydrogel skeleton containing calcium hydrophosphate is hydrolyzed, on one hand, gambogic acid has an anti-tumor effect, and on the other hand, the calcium ions can be released through calcium ions; on the other hand, hydrolyzed calcium ions can be promoted to enter tumor cells, calcium overload in the tumor cells is caused, apoptosis is caused, and therefore the synergistic effect is achieved for treating tumors. The hydrogel disclosed by the invention can improve the drug concentration of a tumor part through local in-situ injection, and is small in toxic and side effects, excellent in anti-tumor effect and good in clinical application prospect.

The invention relates to a preparation method and an application of H2O2 self-supply type calcium peroxide loaded curcumin nanoparticles, which can effectively solve the problems of preparation of theH2O2 self-supply type calcium peroxide loaded curcumin nanoparticles, calcium overload aiming at tumors, chemotherapy, chemodynamic therapy and drug use for promoting tumor cell apoptosis, the particle size of calcium peroxide is 50-100nm, the pore diameter is 5-8nm, transferrin is loaded in holes of calcium peroxide through electrostatic adsorption, the transferrin is positively charged, the mass ratio of the calcium peroxide to the transferrin is 3-5: 1, and then a micromolecular antitumor drug curcumin is loaded on the surface of the transferrin through electrostatic adsorption, so that H2O2 self-supplied calcium peroxide loaded curcumin nanoparticles with the drug loading weight of 30%-55% and the particle size of 55-105 nm are obtained. The preparation method disclosed by the invention is scientific, reasonable, stable, reliable and low in cost, and the prepared H2O2 self-supplied calcium peroxide loaded curcumin nanoparticles can play a role in triple strike interaction comprehensive treatment of tumors in the aspect of preparation of anti-tumor drugs, so that the anti-tumor effect is enhanced.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described in Formula (I).

The present invention provides an application of a steroid compound in the preparation of a drug for treating cardiovascular and cerebrovascular diseases, wherein the structure of the steroid compound is as follows: the drug prepared by the application of the present invention has the effect of promoting vasodilation and inhibiting cardiomyocytes induced by KCl The protective effect of internal calcium overload can treat cardiovascular and cerebrovascular diseases.