Calcium carbonate-conjugated polymer composite nanoparticles with anti-tumor and anti-metastasis effects and their application

By rupturing the calcium carbonate-conjugated polymer composite nanoparticles in a weakly acidic environment of tumors, releasing Ca2+ and conjugated polymers, combining photodynamic therapy and calcium overload mechanism, the side effects of existing cancer treatment on normal cells and tumor metastasis problems are solved, and efficient comprehensive cancer treatment is achieved.

CN116920090BActive Publication Date: 2025-08-08SHAANXI NORMAL UNIV
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Patent Information

Application Number
CN202310893463.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-07-20
Publication Date
2025-08-08
Estimated Expiration
2043-07-20

AI Technical Summary

Technical Problem

Existing cancer treatment methods have negative effects on normal cells, and cancer metastasis is difficult to effectively inhibit. Traditional nanoplatforms have great side effects in tumor treatment, and the role of calcium ions in tumor cells has not been fully utilized.

Method used

A calcium carbonate-conjugated polymer composite nanoparticles were developed to encapsulate the conjugated polymer through calcium carbonate nanosphere shells, and rupture the tumor's weak acidic environment to release Ca2+ and conjugated polymers. Combined with photodynamic therapy and calcium overload mechanisms, they jointly kill tumor cells and inhibit metastasis.

Benefits of technology

It achieves efficient anti-tumor and anti-metastasis effects, significantly reduces tumor volume, inhibits tumor cell migration, and has good biocompatibility and safety.

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Abstract

The present invention discloses a calcium carbonate-conjugated polymer composite nanoparticle with anti-tumor and anti-metastasis effects and its application. The nanoparticles rupture and decompose in the weakly acidic microenvironment of the tumor, releasing the conjugated polymer and a large amount of Ca 2+ The conjugated polymer can generate reactive oxygen species or heat energy to kill tumor cells under light. In addition, reactive oxygen species can also put tumor cells in a state of high oxidative stress, causing mitochondrial dysfunction and desensitization of calcium ion-related channels, causing intracellular "calcium overload" and inducing tumor cell death. These multiple effects make the nanoparticles highly effective in cancer treatment. Extracellular Ca 2+ Increased levels can enhance the adhesion between tumor cells by regulating the morphology of cadherin, thereby inhibiting tumor cell migration. In this invention, the calcium carbonate-conjugated polymer composite nanoparticles have excellent anti-tumor and anti-metastasis effects, providing a new approach for the comprehensive treatment of cancer.
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