The application belongs to the technical field of biological
medicine, and particularly relates to a kind of
composite nanoparticles and its preparation method and application.The
composite nanoparticles provided by the application include nano
calcium peroxide,
hyaluronic acid coated on the surface of the nano
calcium peroxide and
urease coated on the surface of the
hyaluronic acid.In the application, the
hyaluronic acid has tumor
cell targeting property, which is conducive to accurately delivering the
composite nanoparticles to
tumor cells;at the same time, the hyaluronic acid can fix the
urease on the surface of the nano
calcium peroxide, which is conducive to improving the biological mineralization rate.In the application, when the composite nanoparticles enter the
tumor microenvironment under the condition of providing
urea outside, they are affected by the acidic microenvironment, the nano
calcium peroxide decomposes to release calcium ions, and at the same time, the
urease specifically decomposes
urea in the microenvironment to release
carbonate ions, the calcium ions and
carbonate ions produce a mineral layer on the surface of the
cell membrane through synergistic effect, thereby blocking the channel of
cell material exchange and inducing cell
apoptosis.