25 results about "Acid inhibition" patented technology

The invention discloses a method for determining the content of bis (2-aminophenyl) disulfide in 2-aminothiophenol. The method comprises the following steps: preparing an acetonitrile solution of citric acid as a diluent; preparing a system applicability solution, a reference solution and a test solution by using a diluent; a diluent, a system applicability solution, a reference substance solution and a test solution are sequentially injected by adopting a liquid chromatography, and the content of bis (2-aminophenyl) disulfide in a 2-aminothiophenol sample is determined by adopting an external standard method. The antioxidant citric acid is added into the diluent, so that the generation of the disulfide compound is inhibited, the existing disulfide compound is not damaged, the solution stability is high, the operation is simple, the system applicability, specificity, accuracy, precision and durability completely accord with the guidance principle verified by the Chinese pharmacopoeia method, and the method is suitable for industrial production. The method can be used for quality control of 2-aminothiophenol.

The invention provides a method for increasing anaerobic digestion productivity of waste and relieving acid inhibition by adopting nano bubble water. The method comprises the following steps: preparing hydrogen-nano bubble water, preparing inoculation mud, mixing the hydrogen-nano bubble water, the inoculation mud and agricultural wastes, and carrying out anaerobic digestion treatment; according to the method, in the anaerobic digestion process, the hydrolysis rate can be increased, the hysteresis period can be shortened, the methane yield can be increased, ammonia / acid inhibition can be effectively relieved, the consumption speed of volatile fatty acid is increased by 35% or above, and trans-fatty acid inhibition can be effectively relieved. And an innovative solution thought is provided for relieving the inhibition phenomenon generally occurring in the AD process.

The invention relates to the technical field of water pollution control, in particular to a method for rapidly starting a dye-organic wastewater anaerobic co-metabolism system based on S-nZVI, which comprises the following steps: S1, preparing S-nZVI, and S2, optimizing an anaerobic treatment method of dye-organic wastewater by S-nZVI. According to the method, the sulfur-doped nano-iron is applied to a dye-organic wastewater anaerobic co-metabolism system for the first time, the dispersity of the nano-iron is improved through sulfur doping, the hydrogen evolution reaction is inhibited through sulfur doping, and reduction damage of cell membranes is avoided; meanwhile, the formation of FeS endows the nano-iron with stronger conductivity, electron transfer pathways of microorganisms are enriched, the electron transfer efficiency is improved, the optimization method not only realizes efficient degradation of the dye, but also effectively overcomes acid inhibition in the anaerobic digestion process under dye stress, and the degradation efficiency of the dye is improved. And quick start and methane recovery of the reactor can be realized without domesticating the sludge.

The invention belongs to the technical field of medicines, and particularly relates to a bifunctional compound with anti-helicobacter pylori and acid inhibition activity, a preparation method of the bifunctional compound and application of the bifunctional compound in preparation of medicines for treating peptic ulcer and helicobacter pylori infection. According to the compound, a potassium ion competitive acid blocker vonoprazan is used as an acid inhibition unit, and rifobetine is used as an anti-helicobacter pylori unit; the two compounds are respectively subjected to covalent modification through linking groups Linker 1 and Linker 2, and then are connected by virtue of a triazole ring to form a series of bifunctional compounds shown as a general formula (I). The compound can simultaneously and synergistically act on two key targets of gastric acid secretion and helicobacter pylori, so that not only is the treatment effect remarkably enhanced, but also better safety is shown due to the fact that the same curative effect can be achieved at a lower dosage.

The present invention discloses an explosive with a strong acid-inhibiting coating structure and a preparation method thereof. The nano-Fe₂O₃ powder is dispersed in a hot solvent to form a uniform dispersion liquid, which is added to a supersaturated explosive suspension, stirred evenly to obtain a mixed slurry. Then, through a spray drying process, nitrogen is passed through for fine granulation, and finally, after washing and drying, an explosive with a strong acid-inhibiting coating structure is prepared. At the same time, the present invention also discloses an explosive with a strong acid-inhibiting coating structure, which realizes comprehensive functions such as acid inhibition, desensitization, and heat conduction through the coating structure prepared on the surface of the explosive, and solves the contradictory problem of poor safety of existing high-energy explosives.

The invention is applicable to the technical field of preparation of functional materials, and provides a preparation method and application of a cobalt-manganese Prussian blue material based on an acid inhibition strategy, the method comprises the following steps: dissolving cobalt salt, manganese salt, potassium ferricyanide and a chelating agent in water to form a mixed solution, respectively adding a certain volume of acid into the mixed solution, and uniformly stirring; then adding the mixed solution with the acid into a reaction kettle, and carrying out hydrothermal reaction; and after the high-pressure reaction kettle is cooled to room temperature, washing, centrifuging and drying a product to finally obtain the high-stability low-space CoMnPBA material. The method is simple in synthesis process and low in production cost, has relatively low vacancy and interstitial water content, has relatively high desalination capacity and good cycle stability in the presence of high-concentration NaCl, and has a good application prospect.

The present application relates to the technical field of water pollution control, and particularly relates to a method for rapidly starting a dye-organic wastewater anaerobic co-metabolic system based on S-nZVI, comprising the following steps: S1, preparing S-nZVI and S2, an anaerobic treatment method for optimizing dye-organic wastewater by S-nZVI; the present application applies sulfur-doped nano-iron to a dye-organic wastewater anaerobic co-metabolic system for the first time, improves the dispersibility of nano-iron through sulfur doping, inhibits the hydrogen evolution reaction and avoids the reduction damage of the cell membrane through sulfur doping; meanwhile, the formation of FeS endows nano-iron with stronger conductivity, which is conducive to the electron transfer pathway of abundant microorganisms and improves the electron transfer efficiency; the optimization method of the present application not only realizes the efficient degradation of dyes, but also effectively overcomes the acid inhibition of the anaerobic digestion process under dye stress, and realizes the rapid start of the reactor and the recovery of methane without sludge domestication.

The invention discloses an acetic acid inhibition culture medium and application thereof in lactic acid fermentation production. The acetic acid inhibition culture medium is prepared from 15-30 g / L of peptone, 5-10 g / L of yeast extract powder, 50-100 g / L of glucose, 1-2 mL / L of Tween, 1-2 g / L of ammonium citrate, 1-2 g / L of dipotassium phosphate, 0.2-0.4 g / L of magnesium sulfate, 0.1-0.2 g / L of ferrous sulfate, 0.1-0.2 g / L of copper sulfate, 0.05-0.2 g / L of manganese sulfate, 0.005-0.02 g / L of biotin and 0.005-0.02 g / L of riboflavin. The method has remarkable technical advantages in the aspects of inhibiting the generation of a byproduct acetic acid and improving the yield of lactic acid and the fermentation stability, can effectively overcome the defects in the prior art, and has relatively high economic value and popularization and application prospects.

The invention discloses high-reliability halogen-free soldering paste and a preparation method thereof. The high-reliability halogen-free soldering paste is composed of 85-88.5 wt% of coated soldering powder, 3-6 wt% of a film-forming agent, 2-5 wt% of a coated active agent, 0.1-0.3 wt% of a surfactant, 2-5 wt% of a thixotropic agent, 0.1-0.5 wt% of an antioxidant and the balance of a solvent. The coated active agent can well coat and isolate the polybasic acid to inhibit the diffusion of the polybasic acid due to the steric hindrance effect of resin charges and long carbon chains. The weak carboxyl contained in the EAA resin can enable the resin to be firmly adsorbed on the surface of the tin powder, meanwhile, the EAA is a semi-crystalline polymer, and nonpolar and crystallization of an ethylene chain segment can well prevent polybasic acid from diffusing and contacting the surface of the tin powder to corrode the tin powder. According to the invention, the polybasic acid and the tin powder are respectively coated, so that the performance reduction caused by corrosion of the tin powder due to diffusion of the dibasic acid during the room-temperature storage period of the soldering paste is avoided, and the storage stability of the soldering paste is improved.

The invention discloses lactobacillus casei as well as a product and application thereof, and relates to the technical field of microorganisms. The invention discloses a Lactobacillus casei NHNK-609, which is preserved in the China Center for Type Culture Collection on March 7, 2024, and the preservation number of the Lactobacillus casei NHNK-609 is CCTCC (China Center for Type Culture Collection) NO: M 2024422. The NHNK-609 has the effects of inhibiting the growth of klebsiella pneumoniae and producing alcohol, agglutinating klebsiella pneumoniae, inhibiting the virulence gene of klebsiella pneumoniae, promoting alcohol metabolism, reducing alcohol damage, resisting alcohol, degrading uric acid, inhibiting the activity of xanthine oxidase, promoting uric acid excretion, dissolving thrombus, inhibiting the toxicity of klebsiella pneumoniae and the like. The thallus biofilm increases the function of colonization of mucoprotein and intestinal epithelial cells. The method can be used for preparing products for improving metabolism of alcohol, uric acid and thrombus.

One purpose of the present invention is to provide a simple method by which a mutant gene can be detected at a lower mutant gene content than the mutant gene detection limit by the ordinary clamp-PCR method, and a kit for performing the method. Another purpose of the present invention is to provide a simple method by which, in a nucleic acid amplification reaction, the amplification of a target base sequence can be selectively inhibited, and a kit for performing the method. In a nucleic acid amplification reaction, a diallylamine / sulfur dioxide copolymer or an acid addition salt thereof comprising a constituent unit (A) having a structure represented by general formula (I-a) or (I-b):wherein R1 represents an alkyl group having 1-10 carbon atoms that may have a hydroxyl group, a cycloalkyl group having 5-10 carbon atoms or an aralkyl group having 7-10 carbon atoms, and a constituent unit (B) having a structure represented by general formula (I-c):is used as an agent of enhancing nucleic acid amplification inhibition by a clamp nucleic acid.

The present application relates to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating chronic gastritis, a preparation method and application thereof. The traditional Chinese medicine composition comprises chicken gizzard suet, American ginseng and red sage root, and the mass ratio is 5-15:3-10:5-15. The traditional Chinese medicine composition comprises chicken gizzard suet, American ginseng, red sage root and cuttlebone, and the mass ratio is 5-15:3-10:5-15:10-25. The preparation method mainly comprises steps of alcohol extraction, water extraction and mixing. The traditional Chinese medicine composition has the comprehensive effects of invigorating the spleen and replenishing qi, nourishing yin and stomach, promoting digestion and removing stagnation, promoting blood circulation and removing blood stasis, and acid inhibition and mucus protection. The traditional Chinese medicine composition can effectively treat chronic gastritis, promote the repair of gastric mucosa, and is suitable for long-term conditioning and taking.

The present invention is a composition comprising a) water; b) an acid suppressed HEUR thickener; c) an ASE or a HASE thickener; and d) a nonionic surfactant having a hydrophilic lipophilic balance in the range of from 11 to 19; wherein the weight-to-weight ratio of the acid suppressed HEUR thickener to the ASE or the HASE thickener is in the range of from 20:80 to 95:5. The composition of the present invention provides desirable heat-stability.

The utility model discloses an iron removal device for a nickel-containing high-iron solution under a nitric acid system, which is characterized in that a temperature control system is arranged on a kettle body of a reaction kettle, and a stirring device, a gas phase thermometer, a liquid phase thermometer, a breather pipe, a water adding pipeline under pressure and an exhaust pipe are arranged on the reaction kettle. When the temperature detected by the gas-phase thermometer and the liquid-phase thermometer reaches a set value, inert gas is introduced into the kettle from the breather pipe and the exhaust pipe begins to exhaust gas, and in the process, generated nitric oxide is discharged out of the reaction kettle, so that nitric acid is prevented from being quickly formed, and decomposition reaction is inhibited; meanwhile, part of water vapor can be taken away in the exhaust process, and the solution is concentrated, so that water or the solution can be supplemented into the kettle body through the water adding pipeline under pressure, the concentration of the solution in the kettle is basically unchanged or the solution is not dried by burning, and the purpose of removing iron in the nickel-containing high-iron solution which is subjected to oxidation leaching by adopting a nitric acid system under normal pressure can be achieved.

The invention relates to the technical field of tumor treatment, and discloses a tumor mechanical environment recoding nano-carrier as well as a preparation method and application thereof. The tumor mechanical environment recoding nano-carrier designed by the invention comprises a tumor-targeted overexpressed swell-labeled ligand, manganese dioxide with response to an acidic tumor microenvironment (TME), an LDHA inhibitor for inhibiting the generation of lactic acid, and polydopamine modified gold nanoparticles. The tumor mechanical environment recoding nano-carrier which is reasonably designed can synchronously regulate metabolism (lactic acid inhibition) and immune response (cGAS-STING pathway activation), remodeling is carried out according to biomechanical characteristics (such as hardness and permeability) of a tumor mechanical microenvironment, and multi-dimensional coordinated regulation of metabolism, immunity and biomechanics is realized; the synergistic effects significantly enhance the immunotherapy effect, reverse radiation resistance and trigger systemic immune response, and have significant curative effects on primary and distant tumors.

The invention belongs to the technical field of coatings, and provides a high-efficiency mildew-proof coating and a processing technology thereof, and the high-efficiency mildew-proof coating comprises the following components by weight: 25-30 parts of a solvent; 0.3 to 0.8 part of a thickening agent A; 0.3 to 0.8 part of a thickening agent B; 0.3 to 1 part of a dispersing agent; 0.2 to 0.5 part of a wetting agent; 30 to 40 parts of filler; 15 to 20 parts of coating emulsion; 0.5 to 0.8 part of a leveling agent; 0.2 to 0.3 part of a defoaming agent; 10 to 20 parts of an anti-mildew bactericide; 3-8 parts of a self-inhibition mildew inhibitor; and 1-1.5 parts of a coalescing agent. According to the scheme, the pH of a local area is reduced by utilizing metabolites of the mould, so that boric acid ester in the self-inhibition mould inhibitor is promoted to hydrolyze to generate boric acid, and the mould is inhibited and killed by utilizing the boric acid.

This invention provides an oral hydrogel microsphere for targeted intestinal inhibition of gout, its preparation method, and its application, belonging to the field of biomedical technology. The preparation method of the oral hydrogel microsphere of this invention includes the following steps: (1) dissolving uricase and dopamine in sodium alginate solution, controlling the concentration of uricase to 10-20 U / mg and the concentration of dopamine to 0.01-0.1 g / ml, and then dispersing by ultrasound; (2) placing the solution obtained in step (1) in a microfluidic device, and using gas microfluidic technology, shearing the solution into uniform droplets under the action of nitrogen flow; (3) dropping the droplets obtained in step (2) into calcium chloride solution, and cross-linking to form the oral hydrogel microsphere for targeted intestinal inhibition of gout. This invention successfully constructs intestinal "bursting" oral hydrogel microspheres loaded with uricase, effectively immobilizing uricase in the intestinal mucosa, thereby inhibiting gout for the first time by excreting free uric acid through the intestine. The microspheres have high uricase activity and good therapeutic effect on gout.

The invention relates to a preparation method of compound microbial lactic acid bacteria. The preparation method comprises the following specific operation steps: S1, activating bacterial strains; s2, preparing a seed solution; s3, fermentation culture; s4, collecting thalli; s5, preserving the thalli; adding a proper amount of a protective agent into the collected thalli to enable the final concentration of the thalli to reach 10-20%, fully and uniformly mixing the thalli, subpackaging the thalli into sterile cryopreservation tubes, and storing the sterile cryopreservation tubes in a refrigerator at the temperature of-80 DEG C for later use; by adopting the compound strains of enterococcus faecalis, lactobacillus paracasei, lactobacillus acidophilus and lactobacillus plantarum, the utilization range of a fermentation substrate is widened, the product diversity is improved, heterotype / homotype fermentation strains are matched, the lactic acid / acetic acid ratio is balanced, acid inhibition is avoided, the method is suitable for functional preparation development, compound flora competitively inhibits infectious microbes, and the sterilization cost is reduced; the fermentation success rate is improved.

The invention belongs to the technical field of hydrogel materials, and relates to a hydrophobic and hydrophilic interface time sequence reconstruction hydrogel, a preparation method thereof and application of the hydrogel in promoting gastric mucosa wound healing. The hydrophobic and hydrophilic interface time sequence reconstruction hydrogel is formed by a hydrophobic matrix and bioadhesive particles according to a specific mass ratio, wherein the hydrophobic matrix is composed of a hydrophobic pH response drug release porous liquid and a hydrophobic hyperbranched polyethylene oily matrix according to a mass ratio of 1: 5-1: 20. The hydrophobic and hydrophilic interface time sequence reconstruction hydrogel provided by the invention has the advantages of instant and strong tissue sealing and acid inhibition wound repair, and is used for promoting gastric mucosa wound healing.

The invention relates to application of ganoderic acid A in preparation of a medicine for treating hepatoblastoma. It is found and verified for the first time that ganoderic acid A can inhibit growth and metastasis of hepatoblastoma and has a remarkable anti-tumor effect. The invention further verifies that the ganoderic acid A is directly combined with METTL3 and the ganoderic acid A inhibits m6A of METTL3 mediated IGF2BP1, so that the methylation of ACLY is regulated and controlled.

The present application belongs to the field of solid waste resource utilization and biological fermentation technology, and particularly relates to a method for producing L-lactic acid by anaerobic fermentation of kitchen waste by using biochar and alkaline salt in cooperation. In the method, biochar and alkaline salt are added to kitchen waste slurry for anaerobic fermentation to obtain L-lactic acid. In the method, the synergistic effect of biochar and alkaline salt accelerates the decomposition of substrate, shortens the fermentation period, solves the acid inhibition problem, significantly improves the lactic acid yield and the purity of L-lactic acid, and is simple to operate, with controllable and easily available raw materials, thereby significantly reducing the cost and providing a new feasible path for the large-scale production of L-lactic acid.

The invention discloses a solvent-free polyurea material based on activated carboxylic acid and a preparation method thereof, and the preparation method comprises the following steps: mixing an amino compound component with activated carboxylic acid, then adding an isocyanate component, uniformly mixing, and reacting to obtain the solvent-free polyurea material. According to the invention, the reaction of amino and isocyanate is inhibited by activating carboxylic acid, and amino is protonized by introducing carboxylic acid, so that the amino and isocyanate do not react during mixing so as to realize uniform mixing; under the mild heating condition, the activated carboxylic acid is decomposed under the action of alkalinity, namely an amino compound, carbon dioxide is generated and loses acidity, protonated amino is promoted to be dissociated to form active amino, and the active amino reacts with isocyanate; in the heating process, amido is not only a catalyst for catalyzing and activating carboxylic acid decomposition, but also a substrate for reacting with isocyanate; and after the decomposition of the activated carboxylic acid is completed, the protonated amido is thoroughly dissociated and reacts with isocyanate to form a polyurea material, so that solvent-free preparation is realized.

The invention discloses full-amount resourceful treatment equipment for livestock and poultry manure. The full-amount resourceful treatment equipment comprises a first reactor located at an anaerobic acid production stage and a second reactor located at an anaerobic methane production stage, the first reactor is communicated with the second reactor; wherein the first reactor and the second reactor are both internally provided with anode parts of a parallel circuit, the device further comprises a treatment device of a product of the second reactor, and the treatment device is internally provided with an oxygen supply device and a cathode part of the parallel circuit. The first reactor and the second reactor are utilized to realize segmented reaction and function complementation, so that the operation stability and the organic matter removal efficiency of the treatment system can be effectively improved; meanwhile, the acid inhibition effect can be remarkably relieved through a segmented operation mechanism. The invention further discloses a full-amount resourceful treatment method for the livestock and poultry manure.