47 results about "Dithiete" patented technology

The invention relates to the technical field of preparation of compounds, in particular to a sulfenamide compound and a preparation method thereof. Compared with the prior art, a mild electrochemical method is adopted for preparing the sulfenamide compound forming the N-S bond, in the reaction process, halide salt serving as electrolyte is subjected to oxidation reaction at an anode to obtain free radicals, and after decarburization of an amine compound is promoted by the free radicals and alkali together, the free radicals react with disulfide or mercaptan to form the sulfenamide compound forming the N-S bond; the method disclosed by the invention has the advantages of good substrate compatibility and functional group tolerance, no need of additional addition of an oxidizing agent and a transition metal catalyst, simple reaction post-treatment operation and the like, is convenient to operate, high in atom utilization rate and mild in reaction condition, meets related requirements of green chemistry, and has a good development prospect.

The invention discloses high-toughness self-repairing polyurethane based on a ureido / disulfide bond dual dynamic network and a preparation method of the high-toughness self-repairing polyurethane, and belongs to the technical field of self-repairing high polymer materials. The structural formula of the thermal stimulation repairing polyurethane is shown in the specification. The polyurethane is formed by mixing and polycondensing polyether amine, diaminodiphenyl disulfide and dicyclohexylmethane diisocyanate. According to the invention, polyether amine is used as a raw material, green synthesis without a catalyst is realized, ureido generated by the reaction forms a hydrogen bond network with extremely strong dynamic property and cooperates with a disulfide bond, a repair process is completed at 50 DEG C, the toughness can reach 40.55 MJ / m < 3 >, the fast recovery capability is realized, the material can be stretched to be 20 times of the original length, and the service life of the material is prolonged. Good network dynamic property is achieved at the room temperature, and high self-repairing efficiency is achieved at the room temperature.

The invention belongs to the technical field of organic synthesis, and discloses a symmetric disulfide compound containing a sulfoxide group and application of the symmetric disulfide compound in glycosylation reaction, and the structural general formula of the compound is as shown in formula (I). According to the present invention, the compound represented by the structural general formula (I) contains sulfoxide and disulfide structures, and the sulfinyl forming the sulfoxide and the disulfide bond-containing group are located at the ortho-position of the aromatic ring, such that the compound can be used as the activation reagent for the glycosylation reaction, and particularly, activation of the glycosyl donor and glycosylation reaction can be efficiently promoted by only using 0.25 times of equivalent weight of the glycosyl donor, so that the use of a highly toxic, expensive, unstable or metal-containing activating reagent is avoided, and the problems that the activating reagent of the thioglycoside donor in the existing glycosylation reaction is unstable, is not easy to prepare and often needs equivalent weight or excessive amount are solved.

The present disclosure relates to a method for oxidation of mercaptans, comprising the following steps: contacting mercaptan compounds with a catalyst for oxidation reaction in the presence of oxygen; the catalyst is a composite catalytic material, which comprises a full-silica molecular sieve and a metal element M dispersed in the intracrystalline of the full-silica molecular sieve; the metal M is selected from one or more of manganese, iron, cobalt, nickel, palladium, platinum, copper and gold. The present disclosure uses a metal-containing hierarchical porous molecular sieve for mercaptan oxidation and dehydrogenation reaction, without adding additional alkali, high conversion rate and disulfide selectivity can be obtained at a lower temperature, which has high industrial application value.

This invention relates to a non-natural methionine and its synthesis method, using inexpensive and readily available transition metals as catalysts. N Using arylglycine, styrene compounds, and disulfides as raw materials, a series of non-natural methionine compounds were obtained with high selectivity and high yield through a three-component reaction under mild conditions. The compounds prepared in this invention are multifunctional non-natural methionine derivatives, representing a novel class of natural methionine derivatives. They can be used in drug modification, biosensor fabrication, and other fields, possessing significant research and application value and providing new synthetic strategies for the preparation of novel peptide drugs.

The invention discloses a synthesis process of high-yield sodium benzenesulfinate, and belongs to the technical field of synthesis of sodium benzenesulfinate. The synthesis process of the high-yield sodium benzenesulfinate comprises the following preparation steps: S1, mixing a first catalyst, sodium hydroxide and a first solvent, then adding powdered sulfur, reacting for a first reaction time under microwave radiation, then adding chlorobenzene, continuously reacting for a second reaction time under microwave radiation, then filtering, carrying out reduced pressure distillation to remove the solvent, and recrystallizing, so as to obtain the high-yield sodium benzenesulfinate. The diphenyl disulfide is obtained; s2, mixing the diphenyl disulfide prepared in the step S1, alcohol, an oxidizing agent and a second solvent, stirring in the air at room temperature for a third reaction time, diluting with ultrapure water, extracting with ethyl acetate for multiple times, combining organic layers, drying, concentrating and purifying to obtain benzene sulfinate, and keeping in a dark place and in an oxygen-isolated manner; s3, under the dark and nitrogen conditions, benzene sulfinate prepared in the step S2 is hydrolyzed and refined under the alkaline condition, and sodium benzene sulfinate is obtained.

The invention provides application of a dialkyl disulfide compound as a collecting agent in copper-molybdenum bulk flotation, the general formula of the dialkyl disulfide compound is R1-S-S-R2, R1 and R2 are respectively and independently at least one of C1-C12 alkyl and C1-C12 alkenyl, and R1 and R2 are respectively and independently at least one of C1-C12 alkyl and C1-C12 alkenyl. According to the method, the dialkyl disulfide compound serves as the collecting agent to be applied to copper-molybdenum bulk flotation, the recovery rate of copper and molybdenum in minerals can be effectively increased, and loss of valuable metal in tailings is reduced.

This invention relates to a method for synthesizing aromatic carbon-10 sulfur-containing compounds from isoprene. Specifically, using disulfide, isoprene, and 2-methyl-1-buten-3-yne as raw materials, aromatic carbon-10 sulfur-containing compounds are constructed under cobalt catalyst and iodine tandem catalysis. This invention has the following advantages: the raw materials are simple and readily available, the synthesis is simple, it is environmentally friendly, the conditions are mild, and it has high atom economy. The compounds obtained from the bulk chemical isoprene have structures similar to natural terpenes and represent an important class of terpenes.

A novel disulfide biphenol ether compound and its preparation method and application for treating inflammatory skin diseases, the structural formula of the disulfide biphenol ether compound is: biphenyl diester is first dissolved in anhydrous tetrahydrofuran solvent, lithium aluminum hydroxide is added, quenched, filtered, extracted with dichloromethane, water is added to quench the reaction, extracted with dichloromethane, the organic phases are combined, after removing residual moisture, the reduced pressure rotary evaporation and recrystallization are removed to obtain intermediate 2; intermediate 2 and potassium thioacetate are added to solvent N, N-dimethylformamide and extracted, the organic phases are combined, and the solvent is evaporated and concentrated to obtain a light intermediate 3; intermediate 3 is dissolved in anhydrous methanol, sodium methoxide is added, stirred, extracted with ethyl acetate, and the organic phases are combined to obtain. The disulfide biphenyl compound prepared by the present invention has good anti-inflammatory ability, can effectively reduce inflammatory infiltration in tissue, improve the inflammatory phenotype of animal models, and can prevent and treat inflammatory skin diseases.

The invention discloses a Karl Fischer moisture determination method for sulfur-containing organic compounds, and belongs to the technical field of chemical analysis. The method comprises the following steps: adding absolute methanol, imidazole and an inhibitor (selected from N-substituted maleimide or acrylate compounds) into a titration system, then adding a sample, and titrating with a pyridine-containing Karl-Fischer reagent to the end point. The inhibitor can effectively capture reducing sulfur species and eliminate interference of the reducing sulfur species on iodine. Experiments show that for sulfur-containing samples such as 2, 2-dimethylthiopropane, dimethyl sulfide, dimethyl disulfide and the like, the deviation reduction rate of the method is more than 60% compared with that of a traditional method; the method is easy and convenient to operate, high in accuracy and suitable for moisture analysis of sulfur-containing organic matter in the fields of petrifaction, pharmacy and the like.

The application discloses a kind of high selectivity β-triazole (β-triazole trifluoromethyl, β-triazole ketone, β-triazole thio, β-triazole selenide) Derivative and its synthesis method and application, with triazole compound, alkyl compound / aldehyde / dithioether / diselenide and styrene as raw material, in oxidant, additive and organic solvent, through one step reaction can high selectivity, high yield product is obtained.The method of the application has the advantages of good selectivity, mild reaction condition, high yield, simple and safe operation and high efficiency etc.The β-triazole ketone derivative compound involved in the application is a kind of new structure, has good anti-osteosarcoma activity, biological activity analysis shows that part of compounds can reach 99% inhibition rate to osteosarcoma (OS) cell line 143B, MNG / HOS and SJSA-1 at 10 μM concentration.Therefore, the compound can be used as important pharmaceutical and chemical intermediates, and has wide application prospect in the field of medicine.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing 1-(2,4-dimethylphenyl)thio-N-benzyl-2-naphthylamine by a continuous flow light-heat integrated method. The method is performed in a micro-channel reaction device provided with light and heat. N-benzyl-2-naphthylamine, 2,2',4,4'-tetramethyl diphenyl disulfide and a catalyst sodium iodide are dissolved in acetonitrile solvent to obtain a reaction solution. A blue light is used as a light source of a reaction module, and the temperature is adjusted to 25-60 DEG C. Air or oxygen is introduced into the reaction solution, and magnetic stirring is performed. Then, the gas-liquid mixed reaction solution is input into the reaction module through a peristaltic pump to obtain 1-(2,4-dimethylphenyl)thio-N-benzyl-2-naphthylamine. The application creatively uses the continuous flow light-heat integrated reaction technology to synthesize 1-(2,4-dimethylphenyl)thio-N-benzyl-2-naphthylamine, greatly improves the reaction efficiency, shortens the reaction time, improves the safety and controllability of the reaction, solves the amplification effect of the conventional reaction, and provides a reaction technology without bottleneck amplification for the synthesis of the compound.

The invention provides a method for synthesizing a series of polyfluoroalkyl 1, 2-alkene disulfide compounds by performing dehalogenation 1, 2-double vulcanization reaction on polyfluoroalkyl olefin and a disulfide compound under the promotion of sodium hydroxide under a metal-free condition. The reaction conditions are mild, the tolerance of functional groups is good, the method has the characteristics of simple post-treatment, green steps, low pollution, high economic benefits and the like, and part of the polyfluoroalkyl 1, 2-ene disulfide compounds show certain activity of inhibiting human colon cancer cells (HT-29) and are used for preparing the human colon cancer cell activity inhibitor.

This invention relates to a weather-resistant and anti-aging coating for coastal port cranes and its preparation method, belonging to the field of coating materials technology. The coating comprises component A and component B; component A includes an isocyanate-terminated prepolymer, a tri(dibenzoylmethane) ytterbium(III) complex, a spiropyran derivative, and additives; component B is obtained by dissolving isophorone diamine and 2,2'-diaminodiphenyl disulfide in ethyl acetate solvent, with a solid content of 40-60 wt%, and a molar ratio of isophorone diamine to 2,2'-diaminodiphenyl disulfide of (1-4):1; the molar ratio of isocyanate groups in component A to imino groups in component B is (1-1.05):1. This invention accelerates the exchange of dynamic disulfide bonds by constructing a photothermal conversion system, thereby enhancing the coating's ability to dissipate mechanical stress under ultraviolet light irradiation and simultaneously imparting long-term weather resistance to the coating.

This invention discloses a method for preparing monohydroxymethylcyclopropane nucleoside analogs. The method includes: sequentially adding a vinyl nucleobase derivative and a propynyl thioacetal compound to a mixture of a gold-nitrogen heterocyclic carbene catalyst and a silver salt under inert gas protection. After reaction, a highly stereospecific and selective disulfide vinylcyclopropane nucleoside analog is obtained. Following hydrodesulfurization, a vinylcyclopropane nucleoside analog is obtained. Further oxidation, reduction, or deprotection in three steps yields the monohydroxymethylcyclopropane nucleoside analog. This invention provides a concise new route for the synthesis of vinylcyclopropane nucleoside and monohydroxymethylcyclopropane nucleoside analogs, with mild reaction conditions, overcoming the potential explosiveness and lengthy synthetic routes of traditional methods. The raw materials are readily available, and the product can be converted into various other useful potential bioactive molecules, demonstrating strong practicality.

The invention relates to the technical field of optical materials, in particular to a high-refractive-index optical resin material composition and an optical resin material, and the high-refractive-index optical resin material composition comprises an episulfide compound and a catalyst; the episulfide compound comprises one or more of bis (beta-episulfide propyl) thioether and bis (beta-episulfide propyl) disulfide; the mass content of the catalyst is 0.001%-10%; the activation energy of the optical resin material composition with the high refractive index is 35 to 160 KJ.mol <-1 >. According to the method, the activation energy is calculated through simulation, the appropriate catalyst is used for polymerizing the material, the bubble problem of the high-refractive-index optical resin material is solved, the yield is greatly improved, meanwhile, the curing time is shortened, manpower and material resources are greatly saved, and the wide market application prospect is achieved.

The application relates to the technical field of organic synthesis, in particular to a preparation method of propyl hexyl disulfide. The propyl hexyl disulfide is synthesized through one-step reaction by taking cheap and easily-obtained bromopropane and bromohexane as raw materials, the amount of sulfur powder is adjusted, the side reaction in the reaction process is reduced to the maximum extent, the product purity is as high as 99% or more after crude product rectification, the by-product symmetrical disulfide is used in the reaction, the total yield is as high as 86.1% after ten times, and the method has the advantages of low material cost, simple process flow, green safety, high production efficiency and the like.

The invention discloses a low-temperature lithium-sulfur battery based on monatomic catalysis and organic sulfur electrolyte and a preparation method of the low-temperature lithium-sulfur battery. The low-temperature lithium-sulfur battery comprises a lithium negative electrode, a sulfur-carbon positive electrode, an organic sulfur added electrolyte and a monatomic catalyst modified diaphragm, and organic sulfur comprises dimethyl disulfide, tert-butyl disulfide, diphenyl disulfide, p-p-toluene disulfide, bis (2-nitrophenyl) disulfide, dibenzyl disulfide, diallyl disulfide, 4, 4 '-dipyridyl disulfide, 2, 2'-dithiobipyridine, 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The low-temperature lithium-sulfur battery is one or more of 1, 1 '-dithiobis (caprolactam), 3, 3'-dithiobis (1-propanesulfonic acid) disodium salt, 2, 2 '-[dithiobis (methylene)] difuran, 3, 3'-dithiobis (propionitrile) and carbon disulfide. And the organic sulfur is added into the electrolyte to generate an intermediate product organic polysulfide through interaction between the organic sulfur and the polysulfide so as to realize depolymerization of polysulfide clusters in a low-temperature environment.

The invention is directed to an improved process for producing at least one thioether-substituted, preferably thioalkylated, aromatic diamine X. Thioether-substituted aromatic diamines are aromatic diamines with at least one thioether group bound to the aromatic ring via the sulfur atom. They are of particular interest for use as curing agents. Preferred thioether-substituted aromatic diamines are monomethylthiotoluene diamine ("MMTDA") and dimethylthiotoluene diamine ("DMTDA"). In the process according to the invention, an aromatic diamine A is reacted with at least one organic disulfide B in the presence of at least one Lewis-acid catalyst D and at least one polyol E. A and E are obtained by depolymerization of at least one polyurethane PU. Preferably, the organic phase, comprising A, of the depolymerization raw product RP is employed in the reaction of the aromatic diamine with the organic disulfide B. The yield of mono- versus di-thioether substituted aromatic diamines may advantageously be controlled by drying the employed organic phase.

The invention provides high-refractive-index light-cured resin and a preparation method thereof. An intramolecular structure of the light-cured resin comprises a flexible block, a rigid block and an active block. The flexible block is realized by introducing a high-refractive-index dithioether derivative, the rigid block is realized by introducing an arylethene derivative, and the active block introduces a photocuring active group through a hydroxyl derivative. The light-cured resin provided by the invention is prepared through two-step reaction, the refractive index can reach 1.7 or above, and the light-cured resin has relatively high mechanical strength and good flexibility, and can be used for manufacturing products such as high-refractive-index optical cement, high-refractive-index nanoimprint adhesive, high-refractive-index adhesive, high-refractive-index lens, high-refractive-index ink and the like.

The invention belongs to the field of fine organic synthesis and catalytic oxidation synthesis, and relates to a method for synthesizing disulfide compounds. According to the invention, various alkyl mercaptan skeleton raw materials developed by using a green catalytic oxidation method are oxidized to prepare corresponding products with a functional group disulfide bond structure. The method provided by the invention is mild in conditions in the tank reactor and the microchannel reactor, low in catalyst dosage, low in waste salt and waste water amount, high in product yield and purity under neutral reaction conditions, and capable of preparing a series of disulfide products with potential biological activity.

The invention discloses a preparation method of a fluorine-substituted trans-olefin compound. Specifically, the invention discloses a preparation method of a compound as shown in a formula VII, which comprises the following steps: in a solvent, in the presence of a free radical initiator and a free radical source, a compound as shown in a formula VI-1 is subjected to an isomerization reaction to prepare the compound as shown in the formula VII, the free radical initiator is dimethyl azobis (2-methylpropionate), and the free radical source is dimethyl azobis (2-methylpropionate). The free radical source is diphenyl disulfide.

The invention provides a method for preparing chiral sulfinic acid thioester through asymmetric oxidation, which is characterized in that a disulfide compound is used as a raw material, a chiral aminoindanol-derived alloxan compound is used as a chiral catalyst, hydrogen peroxide or oxygen is used as an oxidant, and the chiral sulfinic acid thioester is prepared through asymmetric oxidation. Compared with a traditional chiral imine ligand matched with a vanadyl acetylacetonate catalyst, an aminoindanol-derived alloxan compound is used as a chiral small-molecule catalyst, so that the chiral small-molecule catalyst has higher catalytic stability and high optical purity of a product, is not influenced by factors such as the stirring speed, the shape and size of a reaction bottle and the like, and is convenient for engineering amplification; meanwhile, compared with a chiral resolution method, the method for synthesizing the chiral sulfinic acid thioester in one step by using a chiral small molecule catalysis method has higher step economy, and the method is simple to operate, high in raw material conversion rate, good in reaction enantioselectivity, high in product yield and high in optical purity.

The application discloses a preparation method of bis(2,3-cyclopropyl sulfide) disulfide and belongs to the technical field of organic synthesis. Epoxy chloropropane is reacted with thioacetate to obtain 2-(acetyl thiomethyl) oxirane; then, the acetyl group is removed by reaction with hydrochloric acid; then, the 2-(acetyl thiomethyl) oxirane is reacted with hydrogen peroxide under the catalysis of iodine or is reacted with sulfur powder and sodium hydroxide; finally, the 2-(acetyl thiomethyl) oxirane is reacted with thiourea to obtain bis(2,3-cyclopropyl sulfide) disulfide. In the application, chloroepoxy propane is used as a raw material, and intermediates in the whole reaction process can be purified, the purity of the final product is high, the obtained product can be used for high refractive index resin lenses (refractive index is greater than or equal to 1.70) and high-temperature-resistant optical coatings, and the product meets the requirements of the electronic and medical fields.

The invention discloses a UV heating dual-curing adhesive and a preparation method thereof, and belongs to the technical field of adhesives. The UV heating dual-curing adhesive is prepared from the following raw material components in parts by mass: 60 parts of epoxy resin, 30 parts of oxetane, 8 parts of a diluent, 13 to 16 parts of an amine curing agent, 2 parts of a photoinitiator, 2 parts of a thermal initiator, 3 to 6 parts of a toughening modifier and 12 to 18 parts of flame-retardant filler. The amine curing agent is any one or a combination of at least two of 4, 4-diaminodiphenylmethane, 4, 4 '-diaminodiphenyl disulfide and phenylhydrazine; 2, 3, 5, 6-tetrafluorobenzyloxy glycidyl ether is adopted as the toughening modifier, and 2, 3, 5, 6-tetrafluorobenzyloxy glycidyl ether is adopted as the toughening modifier; the flame-retardant filler is prepared by compounding a 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative and composite boron nitride, and the flame-retardant filler is prepared by compounding the 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide The invention discloses a 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative, which is characterized in that the 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative is obtained by reacting 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide with vinyl imidazole.

The application discloses a preparation method of an ultraviolet curing antistatic coating and relates to the technical field of antistatic coatings. In the application, hydrochloric acid doped polyaniline is used as a core material, 1-butyl-3-methyl imidazole bistrifluoromethanesulfonylimide ionic liquid is introduced as a dopant, and the carrier mobility of the polyaniline is significantly improved. Urea-formaldehyde resin is used as a wall material to coat the surface of the polyaniline to form microcapsules. The microcapsules release polyaniline and ionic liquid compounds after being broken to fill the crack gap. Secondly, 3,3'-dihydroxy diphenyl disulfide and acryloyl chloride are used as raw materials to generate a disulfide bond diacrylate monomer through an esterification reaction. The monomer, tetra(3-mercaptopropionic acid) pentaerythritol ester crosslinking agent and epoxy vinyl ester resin form a three-dimensional crosslinking network. The mercapto groups in the crosslinking agent and the acrylate groups of the disulfide bond diacrylate monomer undergo a click reaction to realize the topological structure reorganization of the molecular chain. The coating prepared by the application has the effect of long-acting antistatic.

This invention belongs to the field of organic synthesis and relates to a method for preparing organosulfur ether compounds using photocatalysis. A disulfide compound 1 and tetrahydrofuran undergo a coupling reaction under the action of a base and a catalyst, and under ultraviolet light irradiation, to obtain organosulfur ether compound 3. This invention provides a novel method for preparing organosulfur compounds. Under light irradiation, a photocatalyst extracts hydrogen atoms from tetrahydrofuran to obtain alkyl radicals, which are then converted into carbocations through redox reactions. Simultaneously, the disulfide ether generates sulfur radicals under light irradiation, which produce sulfide anions under alkaline conditions. The sulfide anions and carbocations then undergo a coupling reaction to obtain sulfide compounds. The method provided by this invention is rationally designed, with mild reaction conditions, is environmentally friendly, and has low cost, achieving a yield of up to 91%. It provides a new method for the synthesis of organosulfur ether compounds and has promising industrial applications.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of propyl hexyl disulfide. According to the method, bromopropane and bromohexane which are low in price and easy to obtain are used as raw materials, the propylhexyl disulfide can be synthesized only through one-step reaction, side reactions in the reaction process can be reduced to the maximum extent by adjusting the dosage of the sulfur powder, the product purity reaches 99% or above after a crude product is rectified, the total yield reaches 86.1% after the byproduct symmetric disulfide is applied to the reaction ten times, and the method is suitable for industrial production. Meanwhile, the method also has the advantages of low material cost, simple process flow, greenness, safety, high production efficiency and the like.

The application belongs to the field of novel functional materials, and particularly relates to a high-recovery self-healing polyurethane elastomer material and a preparation method thereof. The self-healing elastomer material is prepared from the following components: 50-100 parts by weight of a polyurethane prepolymer, and 13-28 parts by weight of a chain extender composition. The polyurethane prepolymer is obtained from a polyol with a molecular weight of 2000 and isophorone diisocyanate under catalytic reaction of dibutyltin dilaurate. The chain extender is a combination of a pendant chain chain extender, 4,4'-diamino diphenyl disulfide and 4,4'-diamino diphenyl ethane. The solvent is N,N-dimethylacetamide. The polyurethane elastomer provided by the application has a self-healing performance recovery rate of more than 90% at 60 DEG C for 12 hours, is suitable for precision instrument laboratory floor coating, medical materials and aerospace fields, realizes scratch self-repairing, and prolongs the service life.

The invention discloses a method for rapidly preparing aza-aryl thioether compounds through mechanical piezoelectric catalysis C-S coupling reaction. According to the technical scheme, a chlorinated aza-aryl compound and a disulfide compound are used as raw materials, and a C-S coupling reaction is carried out under the conditions of normal temperature, normal pressure and air in a Ni catalysis and trace liquid auxiliary mechanical grinding mode to prepare a series of aza-aryl sulfide coupling products in a green and safe mode. According to the invention, a mechanical force method is adopted to rapidly and simply carry out C-S coupling reaction to prepare an organic sulfide intermediate or carry out thioetherification modification on molecules, the operation and treatment method is simple, the reaction mode is green and safe and is environment-friendly, BaTiO3 / Zn / Ni concerted catalysis is adopted, the reaction condition is mild, and the reaction can be completed in 100 minutes.