64 results about "Dithiete" patented technology

The invention discloses a method for determining the content of bis (2-aminophenyl) disulfide in 2-aminothiophenol. The method comprises the following steps: preparing an acetonitrile solution of citric acid as a diluent; preparing a system applicability solution, a reference solution and a test solution by using a diluent; a diluent, a system applicability solution, a reference substance solution and a test solution are sequentially injected by adopting a liquid chromatography, and the content of bis (2-aminophenyl) disulfide in a 2-aminothiophenol sample is determined by adopting an external standard method. The antioxidant citric acid is added into the diluent, so that the generation of the disulfide compound is inhibited, the existing disulfide compound is not damaged, the solution stability is high, the operation is simple, the system applicability, specificity, accuracy, precision and durability completely accord with the guidance principle verified by the Chinese pharmacopoeia method, and the method is suitable for industrial production. The method can be used for quality control of 2-aminothiophenol.

The invention relates to the technical field of preparation of compounds, in particular to a sulfenamide compound and a preparation method thereof. Compared with the prior art, a mild electrochemical method is adopted for preparing the sulfenamide compound forming the N-S bond, in the reaction process, halide salt serving as electrolyte is subjected to oxidation reaction at an anode to obtain free radicals, and after decarburization of an amine compound is promoted by the free radicals and alkali together, the free radicals react with disulfide or mercaptan to form the sulfenamide compound forming the N-S bond; the method disclosed by the invention has the advantages of good substrate compatibility and functional group tolerance, no need of additional addition of an oxidizing agent and a transition metal catalyst, simple reaction post-treatment operation and the like, is convenient to operate, high in atom utilization rate and mild in reaction condition, meets related requirements of green chemistry, and has a good development prospect.

The invention discloses high-toughness self-repairing polyurethane based on a ureido / disulfide bond dual dynamic network and a preparation method of the high-toughness self-repairing polyurethane, and belongs to the technical field of self-repairing high polymer materials. The structural formula of the thermal stimulation repairing polyurethane is shown in the specification. The polyurethane is formed by mixing and polycondensing polyether amine, diaminodiphenyl disulfide and dicyclohexylmethane diisocyanate. According to the invention, polyether amine is used as a raw material, green synthesis without a catalyst is realized, ureido generated by the reaction forms a hydrogen bond network with extremely strong dynamic property and cooperates with a disulfide bond, a repair process is completed at 50 DEG C, the toughness can reach 40.55 MJ / m < 3 >, the fast recovery capability is realized, the material can be stretched to be 20 times of the original length, and the service life of the material is prolonged. Good network dynamic property is achieved at the room temperature, and high self-repairing efficiency is achieved at the room temperature.

The invention belongs to the technical field of organic synthesis, and discloses a symmetric disulfide compound containing a sulfoxide group and application of the symmetric disulfide compound in glycosylation reaction, and the structural general formula of the compound is as shown in formula (I). According to the present invention, the compound represented by the structural general formula (I) contains sulfoxide and disulfide structures, and the sulfinyl forming the sulfoxide and the disulfide bond-containing group are located at the ortho-position of the aromatic ring, such that the compound can be used as the activation reagent for the glycosylation reaction, and particularly, activation of the glycosyl donor and glycosylation reaction can be efficiently promoted by only using 0.25 times of equivalent weight of the glycosyl donor, so that the use of a highly toxic, expensive, unstable or metal-containing activating reagent is avoided, and the problems that the activating reagent of the thioglycoside donor in the existing glycosylation reaction is unstable, is not easy to prepare and often needs equivalent weight or excessive amount are solved.

The present disclosure relates to a method for oxidation of mercaptans, comprising the following steps: contacting mercaptan compounds with a catalyst for oxidation reaction in the presence of oxygen; the catalyst is a composite catalytic material, which comprises a full-silica molecular sieve and a metal element M dispersed in the intracrystalline of the full-silica molecular sieve; the metal M is selected from one or more of manganese, iron, cobalt, nickel, palladium, platinum, copper and gold. The present disclosure uses a metal-containing hierarchical porous molecular sieve for mercaptan oxidation and dehydrogenation reaction, without adding additional alkali, high conversion rate and disulfide selectivity can be obtained at a lower temperature, which has high industrial application value.

This invention relates to a non-natural methionine and its synthesis method, using inexpensive and readily available transition metals as catalysts. N Using arylglycine, styrene compounds, and disulfides as raw materials, a series of non-natural methionine compounds were obtained with high selectivity and high yield through a three-component reaction under mild conditions. The compounds prepared in this invention are multifunctional non-natural methionine derivatives, representing a novel class of natural methionine derivatives. They can be used in drug modification, biosensor fabrication, and other fields, possessing significant research and application value and providing new synthetic strategies for the preparation of novel peptide drugs.

The invention discloses a preparation method of bis (2, 3-epithiopropyl) disulfide, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: reacting epichlorohydrin with thioacetate to obtain 2-(acetylthiomethyl) ethylene oxide; then reacting with hydrochloric acid for deacetylation protection; reacting with hydrogen peroxide under the catalysis of iodine, or reacting with sulfur powder and sodium hydroxide; and finally, reacting with thiourea to obtain the bis (2, 3-epithiopropyl) disulfide. The chloropropylene oxide is used as the raw material, the intermediate in the whole reaction process can be purified, the final product is high in purity, and the obtained product can be used for high-refractive-index resin lenses (the refractive index is larger than or equal to 1.70) and high-temperature-resistant optical coatings and meets the requirements of the electronic and medical fields.

The invention discloses a preparation method of bis (2, 3-epithiopropyl) disulfide, which comprises the following steps: step 1, dissolving epichlorohydrin in a solvent, adding a catalyst A, and introducing a vulcanizing agent A for reaction; step 2, adding a catalyst B into a system in the step 1, stirring and dissolving, then adding an oxidant, and controlling the temperature to carry out oxidation reaction; 3, after the reaction is finished, cooling, adding an organic solvent, dropwise adding an alkaline reagent, continuing the reaction, after the reaction is finished, standing for layering, separating out an organic layer, and washing with water; and step 4, supplementing the same amount of organic solvent into the organic layer obtained in the step 3, adding a vulcanizing agent B under the protection of inert gas, carrying out temperature control reaction, washing the reaction liquid after the reaction is finished, and carrying out rotary evaporation to remove the solvent to obtain a finished product. The temperature is controllable, high-temperature and high-pressure conditions do not exist, the purity of the obtained product is high, and industrial production is facilitated.

The present invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing thiosemicarbazone compounds. The method for synthesizing thiosemicarbazone compounds uses (isocyanimino) triphenylphosphine and one of thiophenol substances, thiol substances, and disulfide substances as reactants, and uses methanol or a mixed solution of methanol and water as a solvent for reaction. After separation and purification, thiosemicarbazone compounds are obtained. The synthesis method of the present invention has mild conditions, does not require additional metals and additives, the product is easy to separate and has a high yield, and the reaction is green and efficient.

The invention belongs to the field of organic synthesis, and relates to a method for constructing S-glucoside through visible light catalysis of a sugar molecule deoxidation vulcanization reaction. Mixing a carbohydrate compound, an additive, first alkali and a first solvent to obtain a first mixed solution; uniformly mixing a disulfide compound, a photocatalyst, second alkali and a second solvent to obtain a second mixed solution; and mixing the first mixed solution with the second mixed solution, and carrying out a photoreaction under visible light to obtain the thioether compound containing S-glucoside. Through an NHC-photooxidation reduction synergistic mechanism, the reaction can be efficiently completed within 2 hours, the yield can reach 26%-67%, the reaction efficiency and the operation safety are remarkably improved, and meanwhile, the problems of energy consumption and metal catalyst residues are reduced.

The present invention belongs to the field of preparation methods of aliphatic disulfides, and particularly relates to a method for catalytic synthesis of symmetrical dialkyl disulfides, which is implemented according to the following steps: (1) Place a magnetic stirrer bar, measured thiol, sulfur, and an organic superbase catalyst into a reaction flask; (2) Place the reaction flask in an oil bath of a magnetic heating stirrer, install a condenser, and connect the condenser to a drainage bottle through a silicone rubber tube. A saturated aqueous solution of H<subgt;2< / subgt;S is pre-added to the drainage bottle; (3) Start heating and begin stirring the reaction, start timing, and determine the amount of H<subgt;2< / subgt;S released and the reaction termination time by the drainage method to obtain the target product. The reaction conditions of the present invention are mild, the reaction rate is fast, the atomic utilization rate and the yield are high, and the by-product H<subgt;2< / subgt;S gas is easily separated and utilized.

The invention discloses a synthesis process of high-yield sodium benzenesulfinate, and belongs to the technical field of synthesis of sodium benzenesulfinate. The synthesis process of the high-yield sodium benzenesulfinate comprises the following preparation steps: S1, mixing a first catalyst, sodium hydroxide and a first solvent, then adding powdered sulfur, reacting for a first reaction time under microwave radiation, then adding chlorobenzene, continuously reacting for a second reaction time under microwave radiation, then filtering, carrying out reduced pressure distillation to remove the solvent, and recrystallizing, so as to obtain the high-yield sodium benzenesulfinate. The diphenyl disulfide is obtained; s2, mixing the diphenyl disulfide prepared in the step S1, alcohol, an oxidizing agent and a second solvent, stirring in the air at room temperature for a third reaction time, diluting with ultrapure water, extracting with ethyl acetate for multiple times, combining organic layers, drying, concentrating and purifying to obtain benzene sulfinate, and keeping in a dark place and in an oxygen-isolated manner; s3, under the dark and nitrogen conditions, benzene sulfinate prepared in the step S2 is hydrolyzed and refined under the alkaline condition, and sodium benzene sulfinate is obtained.

The invention provides application of a dialkyl disulfide compound as a collecting agent in copper-molybdenum bulk flotation, the general formula of the dialkyl disulfide compound is R1-S-S-R2, R1 and R2 are respectively and independently at least one of C1-C12 alkyl and C1-C12 alkenyl, and R1 and R2 are respectively and independently at least one of C1-C12 alkyl and C1-C12 alkenyl. According to the method, the dialkyl disulfide compound serves as the collecting agent to be applied to copper-molybdenum bulk flotation, the recovery rate of copper and molybdenum in minerals can be effectively increased, and loss of valuable metal in tailings is reduced.

This invention relates to a method for synthesizing aromatic carbon-10 sulfur-containing compounds from isoprene. Specifically, using disulfide, isoprene, and 2-methyl-1-buten-3-yne as raw materials, aromatic carbon-10 sulfur-containing compounds are constructed under cobalt catalyst and iodine tandem catalysis. This invention has the following advantages: the raw materials are simple and readily available, the synthesis is simple, it is environmentally friendly, the conditions are mild, and it has high atom economy. The compounds obtained from the bulk chemical isoprene have structures similar to natural terpenes and represent an important class of terpenes.

The present invention relates to the technical field of composite films, specifically a low-reflection explosion-proof multi-layer composite film and its preparation process, which comprises a base film, an antireflection layer, and a protective layer laminated in sequence. A self-healing prepolymer, amino-functionalized composite zinc oxide, a leveling agent, and a dialdehyde-based ionic liquid are introduced to construct a low-reflection explosion-proof multi-layer composite film with a self-healing antibacterial superhydrophobic surface; an amino-terminated polydimethylsiloxane reacts with diphenylmethane diisocyanate and isophorone diisocyanate to prepare a prepolymer containing silicone, and then diaminodiphenyl disulfide is used as a chain extender, and polyether triol and perfluorooctylethanol are used as end-capping agents; titanium dioxide is first synthesized on the surface of zinc oxide, and using the hydroxyl groups on its surface, asparagine is used as a raw material to obtain amino-functionalized composite zinc oxide; a dialdehyde-based ionic liquid is introduced into the protective layer.

A novel disulfide biphenol ether compound and its preparation method and application for treating inflammatory skin diseases, the structural formula of the disulfide biphenol ether compound is: biphenyl diester is first dissolved in anhydrous tetrahydrofuran solvent, lithium aluminum hydroxide is added, quenched, filtered, extracted with dichloromethane, water is added to quench the reaction, extracted with dichloromethane, the organic phases are combined, after removing residual moisture, the reduced pressure rotary evaporation and recrystallization are removed to obtain intermediate 2; intermediate 2 and potassium thioacetate are added to solvent N, N-dimethylformamide and extracted, the organic phases are combined, and the solvent is evaporated and concentrated to obtain a light intermediate 3; intermediate 3 is dissolved in anhydrous methanol, sodium methoxide is added, stirred, extracted with ethyl acetate, and the organic phases are combined to obtain. The disulfide biphenyl compound prepared by the present invention has good anti-inflammatory ability, can effectively reduce inflammatory infiltration in tissue, improve the inflammatory phenotype of animal models, and can prevent and treat inflammatory skin diseases.

The invention discloses a Karl Fischer moisture determination method for sulfur-containing organic compounds, and belongs to the technical field of chemical analysis. The method comprises the following steps: adding absolute methanol, imidazole and an inhibitor (selected from N-substituted maleimide or acrylate compounds) into a titration system, then adding a sample, and titrating with a pyridine-containing Karl-Fischer reagent to the end point. The inhibitor can effectively capture reducing sulfur species and eliminate interference of the reducing sulfur species on iodine. Experiments show that for sulfur-containing samples such as 2, 2-dimethylthiopropane, dimethyl sulfide, dimethyl disulfide and the like, the deviation reduction rate of the method is more than 60% compared with that of a traditional method; the method is easy and convenient to operate, high in accuracy and suitable for moisture analysis of sulfur-containing organic matter in the fields of petrifaction, pharmacy and the like.

The application discloses a kind of high selectivity β-triazole (β-triazole trifluoromethyl, β-triazole ketone, β-triazole thio, β-triazole selenide) Derivative and its synthesis method and application, with triazole compound, alkyl compound / aldehyde / dithioether / diselenide and styrene as raw material, in oxidant, additive and organic solvent, through one step reaction can high selectivity, high yield product is obtained.The method of the application has the advantages of good selectivity, mild reaction condition, high yield, simple and safe operation and high efficiency etc.The β-triazole ketone derivative compound involved in the application is a kind of new structure, has good anti-osteosarcoma activity, biological activity analysis shows that part of compounds can reach 99% inhibition rate to osteosarcoma (OS) cell line 143B, MNG / HOS and SJSA-1 at 10 μM concentration.Therefore, the compound can be used as important pharmaceutical and chemical intermediates, and has wide application prospect in the field of medicine.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing 1-(2,4-dimethylphenyl)thio-N-benzyl-2-naphthylamine by a continuous flow light-heat integrated method. The method is performed in a micro-channel reaction device provided with light and heat. N-benzyl-2-naphthylamine, 2,2',4,4'-tetramethyl diphenyl disulfide and a catalyst sodium iodide are dissolved in acetonitrile solvent to obtain a reaction solution. A blue light is used as a light source of a reaction module, and the temperature is adjusted to 25-60 DEG C. Air or oxygen is introduced into the reaction solution, and magnetic stirring is performed. Then, the gas-liquid mixed reaction solution is input into the reaction module through a peristaltic pump to obtain 1-(2,4-dimethylphenyl)thio-N-benzyl-2-naphthylamine. The application creatively uses the continuous flow light-heat integrated reaction technology to synthesize 1-(2,4-dimethylphenyl)thio-N-benzyl-2-naphthylamine, greatly improves the reaction efficiency, shortens the reaction time, improves the safety and controllability of the reaction, solves the amplification effect of the conventional reaction, and provides a reaction technology without bottleneck amplification for the synthesis of the compound.

The invention provides a method for synthesizing a series of polyfluoroalkyl 1, 2-alkene disulfide compounds by performing dehalogenation 1, 2-double vulcanization reaction on polyfluoroalkyl olefin and a disulfide compound under the promotion of sodium hydroxide under a metal-free condition. The reaction conditions are mild, the tolerance of functional groups is good, the method has the characteristics of simple post-treatment, green steps, low pollution, high economic benefits and the like, and part of the polyfluoroalkyl 1, 2-ene disulfide compounds show certain activity of inhibiting human colon cancer cells (HT-29) and are used for preparing the human colon cancer cell activity inhibitor.

The invention discloses a remodelable and degradable bismaleimide resin and a preparation method thereof, which is prepared by 4,4'-dithiodiphenylamine bismaleimide (AM), 4,4'-diallyloxydiphenyl disulfide (DS) and phenolphthalein polyaryletherketone. The bismaleimide resin prepared by the invention not only has excellent heat resistance, but also can be remodeled under hot pressing conditions; it can achieve faster degradation in conventional solvents, and the degradation solution can be evaporated of the solvent, heated and pressurized to achieve closed-loop recovery, which overcomes the shortcomings of bismaleimide resins containing reversible covalent bonds that are difficult to have high heat resistance, remodelability and degradability, and provides new resins and preparation strategies for achieving sustainable development of heat-resistant thermosetting resins.

This invention relates to a weather-resistant and anti-aging coating for coastal port cranes and its preparation method, belonging to the field of coating materials technology. The coating comprises component A and component B; component A includes an isocyanate-terminated prepolymer, a tri(dibenzoylmethane) ytterbium(III) complex, a spiropyran derivative, and additives; component B is obtained by dissolving isophorone diamine and 2,2'-diaminodiphenyl disulfide in ethyl acetate solvent, with a solid content of 40-60 wt%, and a molar ratio of isophorone diamine to 2,2'-diaminodiphenyl disulfide of (1-4):1; the molar ratio of isocyanate groups in component A to imino groups in component B is (1-1.05):1. This invention accelerates the exchange of dynamic disulfide bonds by constructing a photothermal conversion system, thereby enhancing the coating's ability to dissipate mechanical stress under ultraviolet light irradiation and simultaneously imparting long-term weather resistance to the coating.

This invention discloses a method for preparing monohydroxymethylcyclopropane nucleoside analogs. The method includes: sequentially adding a vinyl nucleobase derivative and a propynyl thioacetal compound to a mixture of a gold-nitrogen heterocyclic carbene catalyst and a silver salt under inert gas protection. After reaction, a highly stereospecific and selective disulfide vinylcyclopropane nucleoside analog is obtained. Following hydrodesulfurization, a vinylcyclopropane nucleoside analog is obtained. Further oxidation, reduction, or deprotection in three steps yields the monohydroxymethylcyclopropane nucleoside analog. This invention provides a concise new route for the synthesis of vinylcyclopropane nucleoside and monohydroxymethylcyclopropane nucleoside analogs, with mild reaction conditions, overcoming the potential explosiveness and lengthy synthetic routes of traditional methods. The raw materials are readily available, and the product can be converted into various other useful potential bioactive molecules, demonstrating strong practicality.

The present application discloses an anti-glare coating liquid, a preparation method thereof, an anti-glare coating, and a display. The anti-glare coating liquid comprises Compound I, wherein n = 5 to 15; R is selected from any one of methylenediphenyl, 1,6-hexyl, isophorone group, polyisophorone group, 1,5-naphthyl, 2,4-tolyl, 1,6-hexyl, 1,4-cyclohexyl, toluenedimethyl, methylene, ethylphenyl, trimethylhexamethylene, phthalic dimethyl, 2,4-dodecylphenyl or dimethylbiphenyl. When the anti-glare coating is mechanically damaged, on the one hand, the imino group in Compound I can provide unique quadruple H-bonds, and the disulfide bond and the amino group are ortho-position, which can form a zigzag structure and are not easy to crystallize. Therefore, the H-bonds can be exchanged at room temperature to physically repair the structure of Compound I; on the other hand, the imino group and the aldehyde group in Compound I can undergo a reversible reaction at room temperature to chemically repair the structure of Compound I.

The invention relates to the technical field of optical materials, in particular to a high-refractive-index optical resin material composition and an optical resin material, and the high-refractive-index optical resin material composition comprises an episulfide compound and a catalyst; the episulfide compound comprises one or more of bis (beta-episulfide propyl) thioether and bis (beta-episulfide propyl) disulfide; the mass content of the catalyst is 0.001%-10%; the activation energy of the optical resin material composition with the high refractive index is 35 to 160 KJ.mol <-1 >. According to the method, the activation energy is calculated through simulation, the appropriate catalyst is used for polymerizing the material, the bubble problem of the high-refractive-index optical resin material is solved, the yield is greatly improved, meanwhile, the curing time is shortened, manpower and material resources are greatly saved, and the wide market application prospect is achieved.

The application relates to the technical field of organic synthesis, in particular to a preparation method of propyl hexyl disulfide. The propyl hexyl disulfide is synthesized through one-step reaction by taking cheap and easily-obtained bromopropane and bromohexane as raw materials, the amount of sulfur powder is adjusted, the side reaction in the reaction process is reduced to the maximum extent, the product purity is as high as 99% or more after crude product rectification, the by-product symmetrical disulfide is used in the reaction, the total yield is as high as 86.1% after ten times, and the method has the advantages of low material cost, simple process flow, green safety, high production efficiency and the like.

The invention discloses a low-temperature lithium-sulfur battery based on monatomic catalysis and organic sulfur electrolyte and a preparation method of the low-temperature lithium-sulfur battery. The low-temperature lithium-sulfur battery comprises a lithium negative electrode, a sulfur-carbon positive electrode, an organic sulfur added electrolyte and a monatomic catalyst modified diaphragm, and organic sulfur comprises dimethyl disulfide, tert-butyl disulfide, diphenyl disulfide, p-p-toluene disulfide, bis (2-nitrophenyl) disulfide, dibenzyl disulfide, diallyl disulfide, 4, 4 '-dipyridyl disulfide, 2, 2'-dithiobipyridine, 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The low-temperature lithium-sulfur battery is one or more of 1, 1 '-dithiobis (caprolactam), 3, 3'-dithiobis (1-propanesulfonic acid) disodium salt, 2, 2 '-[dithiobis (methylene)] difuran, 3, 3'-dithiobis (propionitrile) and carbon disulfide. And the organic sulfur is added into the electrolyte to generate an intermediate product organic polysulfide through interaction between the organic sulfur and the polysulfide so as to realize depolymerization of polysulfide clusters in a low-temperature environment.

The invention is directed to an improved process for producing at least one thioether-substituted, preferably thioalkylated, aromatic diamine X. Thioether-substituted aromatic diamines are aromatic diamines with at least one thioether group bound to the aromatic ring via the sulfur atom. They are of particular interest for use as curing agents. Preferred thioether-substituted aromatic diamines are monomethylthiotoluene diamine ("MMTDA") and dimethylthiotoluene diamine ("DMTDA"). In the process according to the invention, an aromatic diamine A is reacted with at least one organic disulfide B in the presence of at least one Lewis-acid catalyst D and at least one polyol E. A and E are obtained by depolymerization of at least one polyurethane PU. Preferably, the organic phase, comprising A, of the depolymerization raw product RP is employed in the reaction of the aromatic diamine with the organic disulfide B. The yield of mono- versus di-thioether substituted aromatic diamines may advantageously be controlled by drying the employed organic phase.

The present invention discloses a method for electrochemically promoting the construction of N-sulfide-substituted sulfoximine derivatives. The synthesis method of the method is as follows: in a three-necked round-bottom flask, tetrabutylammonium iodide, sulfoximine compounds, disulfide compounds, tert-butyl alcohol, and a solvent are added, electrodes are inserted, and the reaction is stirred under power at room temperature. The crude product can be separated and purified to obtain N-sulfide-substituted sulfoximine derivatives. The present invention realizes an efficient coupling reaction of sulfoximine compounds and disulfide compounds under electrochemical conditions, and a series of functionalized N-sulfide sulfoximine derivatives can be constructed by simple operation. In addition, the reaction does not require the addition of a metal catalyst, an oxidant, and a base, and has good functional group tolerance.

The invention provides a method for synthesizing and refining an arbidol hydrochloride intermediate, which comprises the following steps: by taking 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester, diphenyl disulfide and a reducing agent as raw materials, reacting to obtain a crude product of the arbidol hydrochloride intermediate, and refining the crude product to obtain the arbidol hydrochloride intermediate. The reaction product is 6-bromine-5-hydroxyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester, and the reaction product is 6-bromine-5-hydroxyl-1-methyl-2 The arbidol hydrochloride intermediate is prepared from diphenyl disulfide, the raw materials are easy to obtain, and the safety is remarkably improved compared with the prior art; meanwhile, a refining process of the product is developed, the high-purity drug intermediate with the purity up to 99.87% and the total single impurity content less than 0.13% can be prepared, and the refining yield is up to 91% or above; the reaction conditions are mild, the synthesis safety is greatly improved, the product quality is remarkably improved, and industrial large-scale preparation is facilitated.